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Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines

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Bone Research 2018年第2期6卷 177-188页

作者： Shan-Shan Rao yin hu Ping-Li Xie Jia Cao Zhen-Xing Wang Jiang-hua Liu Hao yin Jie huang Yi-Juan Tan Juan Luo Ming-Jie Luo Si-Yuan Tang Tuan-hui Chen Ling-Qing Yuan Er-Yuan Liao Ran Xu Zheng-Zhao Liu Chun-Yuan Chen hui Xie Movement System Injury and Repair Research Center Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Spine Surgery Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Forensic Science School of Basic Medical SciencesCentral South UniversityChangshaHunan 410013China Xiangya Nursing School Central South UniversityChangshaHunan 410013China Second Xiangya Hospital Central South UniversityChangshaHunan 410011China hunan Key Laboratory of Organ Injury Aging and Regenerative MedicineChangshahunan 410008China Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China China Orthopedic Regenerative Medicine Group(CORMed) ChangshaHunanChina

Osteoporosis is a frequent complication of chronic inflammatory diseases and increases in the pro-inflammatory cytokines make an important contribution to bone loss by promoting bone resorption and impairing bone formation. Omentin-1 is a newly identified adipocytokine that has anti-inflammatory effects, but little is known about the role of omentin-1 in inflammatory osteoporosis. Here we generated global omentin-1 knockout（omentin-1^-/-） mice and demonstrated that depletion of omentin-1 induces inflammatory bone loss-like phenotypes in mice, as defined by abnormally elevated pro-inflammatory cytokines, increased osteoclast formation and bone tissue destruction, as well as impaired osteogenic activities. Using an inflammatory cell model induced by tumor necrosis factor-α（TNF-α）, we determined that recombinant omentin-1 reduces the production of proinflammatory factors in the TNF-α-activated macrophages, and suppresses their anti-osteoblastic and pro-osteoclastic abilities. In the magnesium silicate-induced inflammatory osteoporosis mouse model, the systemic administration of adenoviral-delivered omentin-1 significantly protects from osteoporotic bone loss and inflammation. Our study suggests that omentin-1 can be used as a promising therapeutic agent for the prevention or treatment of inflammatory bone diseases by downregulating the proinflammatory cytokines.

关键词： TNF Omentin-1 prevents inflammation-induced osteoporosis downregulating pro-inflammatory cytokines RANKL

Supporting Cells-a New Area in Cochlear Physiology Study

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Journal of Otology 2008年第1期3卷 9-17页

作者： ZHAO Li-dong, LIU Jun, hu yin-yan, SUN Jian-he, YANG Shi-ming Institute of Otolaryngology, PLA General Hospital, Beijing 100853, China Institute of Otolaryngology PLA General Hospital Beijing 100853 China

For many years, studies about the cochlea have been mainly focused on sensory cells, i.e. the inner hair cell(IHC) and outer hair cell (OHC), and the neuron system. Supporting cells, such as Hensen’s cells and Deiters’ cells are less studied. Their physiological functions and other characteristics are not well documented. Nowadays,supporting cells are a new world attracting to scientists' interests. The scope of this review is to detail the biological properties of the supporting cells, mainly Hensen’s cells and Deiters’ cells in the cochlea. Studies on this subject will be helpful in understanding physiology of the cochlea, and hopefully provide new approaches in treating diseases of inner ear.

关键词： Supporting cells Cochlea

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去氢骆驼蓬碱在骨和软骨代谢方面的研究进展

中南大学学报（医学版） 2016年第3期41卷 328-332页

作者：胡阴谢辉中南大学湘雅二医院代谢内分泌研究所长沙410011 中南大学湘雅医院运动系统损伤修复研究中心长沙410008

去氢骆驼蓬碱是一种β-咔啉类生物碱,广泛分布于植物、动物以及人体组织和体液中。它具有多种药理作用,包括抗菌、抗疟原虫、抗氧化、抗肿瘤、抗诱变、抗糖尿病、舒张血管和兴奋中枢等功能。此外,去氢骆驼蓬碱还可通过影响破骨细胞、成... 详细信息

去氢骆驼蓬碱是一种β-咔啉类生物碱,广泛分布于植物、动物以及人体组织和体液中。它具有多种药理作用,包括抗菌、抗疟原虫、抗氧化、抗肿瘤、抗诱变、抗糖尿病、舒张血管和兴奋中枢等功能。此外,去氢骆驼蓬碱还可通过影响破骨细胞、成骨细胞和软骨细胞的增殖分化调控骨与软骨组织的形成和代谢,发挥对骨及软骨组织的促再生和保护作用,从而为骨质疏松、骨折及骨关节炎等疾病的防治开辟一条新途径。

关键词：去氢骆驼蓬碱成骨细胞破骨细胞软骨细胞代谢疾病

Potential Role and Clinical Value of PPP2CA in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2021年第5期9卷 661-671页

作者： Cheng-Lei Yang Xue Qiu Jin-Yan Lin Xiao-Yu Chen Yu-Mei Zhang Xiao-yin hu Jian-Hong Zhong Shen Tang Xi-Yi Li Bang-De Xiang Zhi-Ming Zhang Department of Hepatobiliary Surgery Guangxi Medical University Cancer HospitalNanningGuangxiChina The First Clinical Medical School Guangxi Medical UniversityNanningGuangxiChina Department of Pathology Guangxi Medical University Cancer HospitalNanningGuangxiChina Department of Medical Oncology Affiliated Tumor Hospital of Guangxi Medical UniversityNanningGuangxiChina School of Basic Medical Sciences Guangxi Medical UniversityNanningGuangxiChina School of Public Health Guangxi Medical UniversityNanningGuangxiChina

Background and Aims:Protein phosphatase 2A(PP2A)is associated with many *** study aimed to clarify whether PPP2CA,which encodes the alpha isoform of the catalytic subunit of PP2A,plays a role in hepatocellular carcinoma(HCC)and to identify the potential underlying molecular ***:Based on bioinformatics,public databases and our in-house RNA-Seq database,we analyzed the clinical value and molecular mechanism of PPP2CA in ***:Data were analyzed from 2,545 patients with HCC and 1,993 controls without HCC indexed in The Cancer Genome Atlas database,the Gene Expression Omnibus database and our in-house RNA-Seq ***2CA expression was significantly higher in HCC tissue than in non-cancerous tissues(standardized mean difference:0.69,95%confidence interval[CI]:0.50–0.89).PPP2CA expression was able to differentiate HCC from non-HCC,with an area under the summary receiver operator characteristic curve of 0.79(95%CI:0.75–0.83).Immunohistochemistry of tissue sections confirmed that PPP2CA protein was up-regulated in HCC *** PPP2CA expression in HCC patients was associated with shorter overall,progression-free and disease-free *** molecular pathways through which PPP2CA may be involved in HCC were determined using miRWalk 2.0 as well as analysis of Gene Ontology categories,Kyoto Encyclopedia of Genes and Genomes pathways,and protein-protein interaction ***:PPP2CA is up-regulated in HCC and higher expression correlates with worse ***2CA shows potential as a diagnostic marker for *** studies should examine whether PPP2CA contributes to HCC through the candidate microRNAs,pathways and hub genes identified in this study.

关键词： Hepatocellular carcinoma PPP2CA Molecular mechanism Diagnostic marker

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开发养老与社保养老并行构想

经济纵横 2008年第5期 29-31页

作者：胡尹燕南开大学经济学院天津300071

本文提出树立开发养老的新观念,主张当前我国养老事业应由传统的单一社保养老机制向开发养老与社保养老的并行机制转换。

关键词：老龄化社保养老开发养老老年人力资源

A Granular Computing Model Based on Tolerance relation

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The Journal of China Universities of Posts and Telecommunications 2005年第3期12卷 86-90页

作者： WANG Guo-yin, hu Feng, huANG Hai, WU YuChongqing University of Posts and Telecommunications, Chongqing 400065, P.R. China Chongqing University of Posts and Telecommunications Chongqing 400065

Granular computing is a new intelligent computing theory based on partition of problem concepts. It is an important problem in Rough Set theory to process incomplete information systems directly. In this paper, a granular computing model based on tolerance relation for processing incomplete information systems is developed. Furthermore, a criteria condition for attribution necessity is proposed in this model.

关键词： incomplete information system granular computing rough set tolerance relation

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半导体制冷服设计方法研究进展

纺织学报 2023年第10期44卷 223-231页

作者：聂思萱尹虎聂亚东北京航空航天大学北京100191

为提高半导体制冷服的制冷效率和穿着热舒适度,梳理了近年来国内外相关研究成果,将半导体制冷服的制冷系统分为冷源模块(包括制冷部分和热端散热部分)和冷端传热模块进行讨论。针对冷源模块,提高冷源制冷效率的方法有改善电源输入和提... 详细信息

为提高半导体制冷服的制冷效率和穿着热舒适度,梳理了近年来国内外相关研究成果,将半导体制冷服的制冷系统分为冷源模块(包括制冷部分和热端散热部分)和冷端传热模块进行讨论。针对冷源模块,提高冷源制冷效率的方法有改善电源输入和提高热端散热性能。热端散热方式有强制风冷、液冷和热管散热,可通过改变不同散热方式下的各种参数来提高热端散热性能。针对冷端传热模块,传热方式有液冷传热、风冷传热和接触传热,可根据不同工况选择合适的传热方式。与传热部分的结构、介质相关的各项参数是影响传热效率和穿着者热舒适度的重要因素。热舒适度实验是评价和优化制冷服的重要方式,实验时需考虑装置、环境、人体等各项因素,建立人体-制冷服-环境的热舒适度模型是一种高效的分析和处理方法。综合各方面研究总结出影响半导体制冷服制冷效率和穿着热舒适度的因素,可为半导体制冷服各部分选型、设计优化和实验评估提供思路。最后提出:轻量便携、智能可控、高舒适性、适用于多场景的半导体制冷服以及利用半导体双制特性研发的空调服将成为未来的研究方向。

关键词：半导体制冷制冷服人体热舒适度传热形式散热方式

米曲菌胰酶联合达立通颗粒治疗功能性消化不良的临床研究

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现代药物与临床 2023年第12期38卷 3041-3046页

作者：罗银虎荆州市中医医院脾胃病科湖北荆州434000

目的探讨达立通颗粒联合米曲菌胰酶片治疗功能性消化不良的临床疗效。方法选取2021年3月—2023年3月在荆州市中医医院收治的82例功能性消化不良患者,根据用药方案不同分为对照组和治疗组,每组各41例。对照组口服达立通颗粒,6 g/次,3次/d... 详细信息

目的探讨达立通颗粒联合米曲菌胰酶片治疗功能性消化不良的临床疗效。方法选取2021年3月—2023年3月在荆州市中医医院收治的82例功能性消化不良患者,根据用药方案不同分为对照组和治疗组,每组各41例。对照组口服达立通颗粒,6 g/次,3次/d;治疗组在对照组基础上口服米曲菌胰酶片,1片/次,3次/d。两组均经14 d治疗。观察两组的临床疗效,比较临床症状改善时间、相关量表评分、胃肠功能指标、胃肠激素指标、血清细胞因子。结果治疗后,治疗组的总有效率是97.56%,远高于对照组的80.49%(P<0.05)。治疗后,治疗组上腹痛、早饱感、恶心、腹胀等症状改善时间上均显著短于对照组(P<0.05)。治疗后,两组胃肠功能分级评定表(GSRS)评分、SID评分均较治疗前显著降低,而生存质量测定量表(WHOQOL-100)评分、NDI评分均显著升高(P<0.05);且治疗后各量表评分均以治疗组改善更为显著(P<0.05)。治疗后,两组胃运动指数、收缩频率、收缩幅度均较同组治疗前显著提高(P<0.05);且治疗后,治疗组胃肠功能指标改善优于对照组(P<0.05)。治疗后,两组血清C反应蛋白(CRP)、促肾上腺皮质激素释放因子(CRF)、白细胞介素-6(IL-6)水平均较同组治疗前显著降低,而神经肽S受体1(NPSR1)、降钙素基因相关肽(CGRP)显著升高(P<0.05);治疗后,治疗组血清学指标水平改善优于对照组(P<0.05)。治疗后,两组胃动素(MTL)、P物质(SP)、胃泌素-17(G-17)、胃泌素(GAS)水平均较治疗前显著升高,而一氧化氮(NO)水平显著降低(P<0.05);治疗后,治疗组胃肠激素指标改善优于对照组(P<0.05)。结论米曲菌胰酶片联合达立通颗粒治疗功能性消化不良可有效改善临床症状,降低机体炎症反应,促进胃肠动力,促进患者生活质量提高,有良好的临床应用价值。

关键词：达立通颗粒米曲菌胰酶片功能性消化不良胃肠功能分级评定表评分 C反应蛋白促肾上腺皮质激素释放因子白细胞介素-6 降钙素基因相关肽

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多级轴流压气机进气畸变模型研究

推进技术 2016年第12期37卷 2278-2287页

作者：尹超胡骏严伟郭晋南京航空航天大学能源与动力学院江苏省航空动力系统重点实验室江苏南京210016

为研究进气畸变对多级轴流压气机性能以及稳定性的影响,基于彻体力模型理论建立了一个模拟多级轴流压气机进气畸变的三维分析模型CSAC,并采用实验与CFD相结合的方法进行了验证。利用CSAC模型模拟了周向总压畸变对四级低速轴流压气机性... 详细信息

为研究进气畸变对多级轴流压气机性能以及稳定性的影响,基于彻体力模型理论建立了一个模拟多级轴流压气机进气畸变的三维分析模型CSAC,并采用实验与CFD相结合的方法进行了验证。利用CSAC模型模拟了周向总压畸变对四级低速轴流压气机性能的影响。结果表明:均匀进气下CSAC与CFD计算特性最大误差不超过1.5%;进口总压畸变传递到第三级时畸变度衰减为0;在低压区的转子出口存在一个高总温畸变区,其强度在向下游传递中逐渐增强,到达第四级时总温最大升高0.4%;高总温影响区域在向下游发展中沿叶片转动方向逐渐扩张,造成压气机性能损失加大,最大总压比下降0.7%。所有结果均显示出CSAC模型是当前分析畸变对压气机性能影响的有力工具。

关键词：多级轴流压气机彻体力模型进气畸变畸变传递