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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu xin-Yian guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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Integrated interface between composite electrolyte and cathode with low resistance enables ultra-long cycle-lifetime in solid-state lithium-metal batteries

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Science China Chemistry 2021年第4期64卷 673-680页

作者： Zhuo Li xin guo State Key Laboratory of Material Processing and Die&Mould Technology Laboratory of Solid State IonicsSchool of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

We report a three-dimensional(3D)nanofiber-reinforced solid composite electrolyte with a 3D Li^(+)-conducting ceramic network of Li_(6.2)5Ga_(0.25)La_(3)Zr_(2)O_(12)(LLZO)*** from the 3D structure,the composite shows a high ionic conductivity of 3.2×10^(-4)S cm^(-1)and Li-ion transference number of 0.32 at room *** interfacial resistance between the composite solid electrolyte and cathode is mitigated by creating an integrated interfacial structure,in which the polyethylene oxide(PEO)-lithiumbis(trifluoromethylsulphonyl)imide(LiTFSI)binder and ionic liquids(ILs)form a viscoelastic ***,intimate contact,low interfacial impedance,and fast ion-transport between the cathode and the solid electrolyte are simultaneously ***-state lithium metal batteries with the Li Fe PO_(4) cathode deliver a superior capacity(158.0 m A h g^(-1))and significant capacity retention(90.4%retention after 800 cycles)at 60℃.Moreover,the smooth and uniform Li surface after long-term cycling confirms the successful suppression of the dendrite *** integrated interfacial structure provides a solution to the interfacial problem and improves the cycling performance in solid-state Li-metal batteries.

关键词： composite solid electrolyte Li_(7)La_(3)Zr_(2)O_(12)nanofiber interfacial resistance solid-state battery

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Rigidity Theorem of Hypersurfaces with Constant Scalar Curvature in a Unit Sphere

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Acta Mathematica Sinica,English Series 2007年第6期23卷 1075-1082页

作者： guo xin WEI Department of Mathematical Sciences Tsinghua University Beijing 100084 P. R. China

In this paper, we give a characterization of tori S^1 （ √ nr＋2-n/nr）×S^n-1（√ n-2/nr） and S^m （ √n/m ） ×S^n-m （√n-m/n）. Our result extends the result due to Li （1996）on the condition that M is an n-dimensional complete hypersurface in Sn＋1 with two distinct principal curvatures. Keywords principal curvature, Clifford torus, Gauss equations

关键词： principal curvature Clifford torus Gauss equations

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Evolution Equation of the Gauss Curvature under Hypersurface Flows and Its Applications

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Acta Mathematica Sinica,English Series 2010年第7期26卷 1299-1308页

作者： Hong xin guo School of Mathematics and Information Science Wenzhou University Wenzhou 325035 P. R. China

In this paper, we derive evolution equation of the integral of the Gauss curvature on an evolving hypersurface. As an application, we obtain a monotone quantity on the level surface of the potential function on a 3-dimensional steady gradient Ricci soliton with positive sectional curvature, and prove that such a soliton is rotationally symmetric outside of a compact set under a curvature decaying assumption. Along the way we will also apply our evolution equation to some other cases.

关键词： steady gradient Ricci soliton Gauss curvature principal curvature

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驱控一体的旋拧式果实采摘执行器设计与试验

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农机化研究 2025年第3期47卷 48-55页

作者：严童杰冯青春郭鑫杨宁江苏大学电气信息工程学院江苏镇江212000 北京市农林科学院智能装备技术研究中心北京100097 国家农业智能装备工程技术研究中心北京100097 农业智能装备技术北京市重点实验室北京100097

针对果园智能化采收作业需要,设计了支持总线扩展的驱控一体旋拧采摘末端执行器,旨在为多臂并行采摘机器人研发提供支撑。在对标准苹果树果实物理形态统计分析基础上,结合人工采摘方法,提出了“吸附-夹持-旋拧”的采摘机械操作方法,并... 详细信息

针对果园智能化采收作业需要,设计了支持总线扩展的驱控一体旋拧采摘末端执行器,旨在为多臂并行采摘机器人研发提供支撑。在对标准苹果树果实物理形态统计分析基础上,结合人工采摘方法,提出了“吸附-夹持-旋拧”的采摘机械操作方法,并设计了基于双舵机驱动的紧凑型采摘执行机构,对其吸盘、夹持和旋拧电机的关键参数进行了优化设计。面向多执行并行采摘需要,设计了基于CANopen通讯的采摘操作驱动器,实现了多执行器的总线扩展。通过现场试验对执行器作业性能进行了测试,结果表明:果实大小在60~100 mm之间,采摘成功率可达到90%,吸盘最优停留时间为1.00 s,吸盘最优接近距离为1.0 mm,最优旋拧角度为360°。

关键词：采摘机器人驱控一体旋拧采摘 CANopen

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HYDRAULIC PRESSURE SIGNAL DENOISING USING THRESHOLD SELF-LEARNING WAVELET ALGORITHM

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Journal of Hydrodynamics 2008年第4期20卷 433-439页

作者： guo xin-lei YANG Kai-lin guo Yong-xin Department of Hydraulics China Institute of Water Resources and Hydropower Research Beijing 100044 China

A pre-filter combined with threshold self-learning wavelet algorithm is proposed for hydraulic pressure signals denoising. The denoising threshold is self-learnt in the steady flow state, and then modified under a given limit to make the mean square errors between reconstruction signals and desirable outputs minimum, so the corresponding optimal denoising threshold in a single operating case can be obtained. These optimal thresholds are used for the whole signal denoising and are different in various cases. Simulation results and comparative studies show that the present approach has an obvious effect of noise suppression and is superior to those of traditional wavelet algorithms and back-propagation neural networks. It also provides the precise data for the next step of pipeline leak detection using transient technique.

关键词： hydraulic pressure signal wavelet threshold denoising self-learning neural network

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Effects of air relief openings on the mitigation of solitary wave forces on bridge decks

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Journal of Hydrodynamics 2019年第3期31卷 594-602页

作者： Sheng-chao Xiao an-xin guo Ministry-of-Education Key Laboratory of Structural Dynamic Behavior and Control School of Civil Engineering Harbin Institute of Technology Harbin 150090 China Department of Civil Engineering The University of Queensland Brisbane 4072 Australia

For inverted T-type bridge decks, the air entrapped in the chambers between adjacent girders could increase the wave forces and lead to the destruction of the bridge decks. This paper studies the effects of the air relief openings (ARO) on the mitigation of the solitary wave-induced forces on the bridge decks. Hydrodynamic experiments are conducted for three inverted T-type decks with four, five, and six girders with different wave properties and deck clearances. The open source computational fluid dynamics toolbox OpenFOAM is adopted to conduct numerical simulations for the effects of the AROs. Since the numerical results correlate well with the measurements, the mechanism of the wave-structure interaction can be revealed by the numerical flow fields. Furthermore, the relationship between the shape and the volume of the ARO and the wave forces on the bridge decks, as well as the contribution of each ARO to the effect of the wave force mitigation, is also obtained from the numerical results of the OpenFOAM. Experimental and numerical results demonstrate that the AROs could effectively reduce the vertical wave forces on the bridge decks. The effects of the AROs increase with the increase of the volume of the ARO, while the shape of the ARO has no effect on the reduction of the wave forces.

关键词： Air entrapped hydrodynamic experiment solitary wave forces bridge decks OpenFOAM

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Environmental changes in Jiaozhou Bay of northern China during the past 90 years using metals and biogenic elements in sediments

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Journal of Environmental Sciences 2017年第3期29卷 301-312页

作者： Zhao-Hui Wang xin guo Ke Zhang xin-xin Lu College of Life Science and Technology Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education InstitutesJinan UniversityGuangzhou 510632China

Metals and biogenic elements were analyzed from surface sediments and a 100 cm core collected from Jiaozhou Bay in July 2009, to determine how the environment has changed over the past 90 years due to increasing anthropogenic influences in this region. High concentrations of biogenic silica （BSi） represented the dominance of diatoms in the bay. Most metals were lower than the marine sediment quality guidelines; however, Hg, Zn, and Mn were at polluted levels. The vertical profiles of biogenic elements and metals in the sediment core suggest that the most significant environmental changes occurred since the 1990s, and three stages could be defined：（1） before 1950, characterized by low concentrations of biogenic elements and metals; （2） between 1950 and 1990, displaying an obvious increase of rig and a slow increase ofbiogenic elements; （3） after 1990, reflected by a significant increase of total organic carbon （TOG）, total nitrogen （TN）, total phosphate （TP）, and most metals, but a decrease of BSi. Correlation and principal component analyses indicated that most metals originated from lithogenic sources, industrial and domestic discharges as well as maricultural activities.

关键词： MetalsBiogenic elementsSedimentsEnvironmental changesJiaozhou BayYellow Sea

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Bionic stab-resistant body armor based on triangular pyramid structure

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Defence Technology（防务技术） 2021年第3期17卷 792-799页

作者： Ya-xin guo Meng-qi Yuan xin-ming Qian State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China

A stab-resistant substrate was designed and realized with a triangular pyramidal structure, inspired by the biological armor model in nature. The stab-resistance behavior and dynamic response mechanisms were studied through numerical simulation and experimental testing of a knife impacting a substrate,and an optimal structural design was obtained accordingly, with a tilted angle of 22.5and optimal thickness of 1.2 mm. It was shown that the triangular pyramidal structure generated twice the internal energy of the knife than the flat substrate due to the dispersing effect of the structure. The force parallel to the inclination caused a significant scratch on the substrate surface, while the force perpendicular caused obvious substrate deformation. A new riveting method was used to form the total layer, which passed the GA 68-2008 standard. The stab-resistant clothing coupled with the reduced wearing burden could provide effective protection and avoid fatal injuries on security personnel working in dangerous environments. The method provided may enlighten the future design and manufacturing of stabresistant clothing.

关键词： Stab resistant Impact behavior Body armor Finite element analysis

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二氢杨梅素分子结构与性质的密度泛函理论研究

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原子与分子物理学报 2025年第1期42卷 29-34页

作者：辛国鹏毛敏刘信平马文涛马杰张煜湖北民族大学化学与环境工程学院恩施445000

本文基于密度泛函理论(DFT),采用B3LYP泛函结合6-31G基组上对二氢杨梅素的分子几何结构进行了优化,在此基础上以水为溶剂计算二氢杨梅素分子的活性位点以及红外光谱进行分析.静电势结果表明二氢杨梅素的亲核活性位点位于酚羟基氢原子(H... 详细信息

本文基于密度泛函理论(DFT),采用B3LYP泛函结合6-31G基组上对二氢杨梅素的分子几何结构进行了优化,在此基础上以水为溶剂计算二氢杨梅素分子的活性位点以及红外光谱进行分析.静电势结果表明二氢杨梅素的亲核活性位点位于酚羟基氢原子(H23)附近;而亲电活性位点位于氧原子(O32)及其附近.前线分子轨道研究结果表明二氢杨梅素分子的最高占据轨道(HOMO)都位于酮基氧(O32)和羟基氧(O20)附近,说明这些位点易与亲电试剂反应.而最低空轨道(LUMO)位于碳原子(C12、C13、C14)区域,表明这些区域可与亲核试剂反应.简缩福井函数(f)结果证实了位于C-O-C键中的氧原子的f-值的亲电活性较其他位点氧原子大;而位于C8碳原子的f^(+)值较大,因此该位点亲核活性较强.通过理论计算所得到的二氢杨梅素的红外光谱数据与实验所得到的红外光谱数据相差不大,这就说明理论计算结果是较为可靠的.从而为实验和理论研究二氢杨梅素结构与性质的关系提供了一定的理论参考.

关键词：二氢杨梅素密度泛函理论反应活性位点量子化学计算

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