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Mechanism of thalidomide to enhance cytotoxicity of temozolomide in U251-MG glioma cells in vitro

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Chinese Medical Journal 2009年第11期122卷 1260-1266页

作者： GAO Song YANG Xue-jun ZHANG Wen-gao JI Yan-wei pan qiang Department of Neurosurgery Tianjin Medical University General Hospital Tianjin 300052 China

Background Glioma is the most common primary brain tumor with poor prognosis. Temozolomide has been used with thalidomide to treat gliomas. We investigated the synergistic mechanism of these two drugs in vitro. Methods Human malignant glioma cells U251-MG were cultured and assigned to four groups with different treatments for 3 days： temozolomide group （100 μmol/L）, thalidomide group （100 μg/L）, temozolomide （100 μmol/L） plus thalidomide group （100 μg/L） and control group. MTT assay was applied to evaluate the cell viability. Cell cycle was analyzed by flow cytometry. The ultra-structural features of autophagosomes were observed with electron microscope. Acridine orange and monodansylcadaverine were adopted to label autophagosomes and flow cytometry was applied for quantification of autophagosomes. The expression of autophagy-associated protein was detected by Western blotting. Results Proliferation of tumor cell was obviously suppressed by temozolomide with thalidomide treatment than by either drug used alone （P=0.000 for each day）. The combination treatment induced cell cycle arrest at G0/G1 phase. Typical autophagic ultra-structural character was found after the combined treatment. Thalidomide promoted the autophagy induced by temozolomide. The autophagy-associated proteins - microtubule associated protein 1 light chain 3 （MAP1LC3） and Beclinl were more significantly up-regulated by the combined treatment than temozolomide used alone （MAP1LC3, P=0.000; Beclinl, P=0.004）. The expression level of phosphatase and tensin homolog deleted on chromosome ten （PTEN）, which promoted autophagy by suppressing PI3K/Akt/mTOR signaling pathway, was elevated by thalidomide （thalidomide group： P=0.000; combined group： P=0.002）. Conclusions Thalidomide enhances the cytotoxicity of temozolomide by promoting the autophagy induced by temozolomide. Contributing to the up-regulation of PTEN by thalidomide, the expression of autophagy associated protein-MAP1LC3 and Beclinl was enhanced,

关键词： glioma thalidomide temozolomide autophagy

Radiochemical separation of thorium from ^(18)O inducedreaction with natural uranium

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Nuclear Science and Techniques 2001年第2期12卷 81-86页

作者： YANG Wei-Fan, YUAN Shuang-Gui, XIONG Bing, XU Yan-Bing, HE Jian-Jun, pan qiang-Yan, MA Tao-Tao Institute of Modern Physics, the Chinese Academy of Sciences, Lanzhou 730000 中科院近代物理所甘肃兰州 730000

A radiochemical procedure used to separate and purify trace concentration thorium produced in heavy ion reaction with uranium targets is presented. The procedure can rapidly yield thorium fraction suitable for gamma-ray spectroscopy studies. The resultant gamma-ray spectra showed that Th was isolated from a large number of elements produced in the reaction, and there were only a few contaminating activities of isotopes of Sc, Cd, In, etc. The decontamination factors for the main reaction products are given.

关键词：钍放射化学分离天然铀

BL02U1:the relocated macromolecular crystallography beamline at the Shanghai Synchrotron Radiation Facility

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Nuclear Science and Techniques 2023年第12期34卷 146-155页

作者： Ke Liu Huan Zhou Qin Xu Hua‑Ting Kong Kun‑Hao Zhang Wei‑Wei Wang Min‑Jun Li Zhi‑Jun Wang qiang‑Yan pan Xing‑Ya Wang Feng Yu Qi‑Sheng Wang Shanghai Advanced Research Institute Chinese Academy of Sciences239 Zhangheng RoadPudong DistrictShanghai 201204China University of Chinese Academy of Sciences Beijing 100049China

Macromolecular crystallography beamline BL17U1 at the Shanghai Synchrotron Radiation Facility has been relocated,upgraded,and given a new ID(BL02U1).It now delivers X-rays in the energy range of 6–16 keV,with a focused beam of 11.6μm×4.8μm and photon flux greater than 1012 phs/*** high credibility and stability of the beam and good timing synchronization of the equipment significantly improve the experimental *** June 2021,when it officially opened to users,over 4200 h of beamtime have been provided to over 200 research groups to collect data at the *** good performance and stable operation have led to the resolution of several structures based on data collected at the beamline.

关键词： Macromolecular crystallography beamline Shanghai Synchrotron Radiation Facility BL02U1

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科学普及与科技创新关系的演进

科学管理研究 2023年第5期41卷 22-26页

作者：牛盼强上海大学新闻传播学院上海200072

科技创新、科学普及是实现创新发展的两翼,要把科学普及放在与科技创新同等重要的位置。在对科学普及相关概念讨论基础上,结合以往相关研究,分析了科学普及与科技创新关系研究的演进。研究发现,科学普及与科技创新的关系与人们对二者认... 详细信息

科技创新、科学普及是实现创新发展的两翼,要把科学普及放在与科技创新同等重要的位置。在对科学普及相关概念讨论基础上,结合以往相关研究,分析了科学普及与科技创新关系研究的演进。研究发现,科学普及与科技创新的关系与人们对二者认识的进步密切相关,这种关联源于不同科普阶段的对象、目标与科技创新主体的关系,并且二者的关联随着媒介的发展而增强。传统科学普及下,二者基本没有关联,也缺少相关研究;公众理解和参与科学下,理论和实践都提出了科学普及与科技创新密切联系;现代科学传播阶段,科学普及上升到开放式科技创新和科技创新体系层面。未来研究应该基于现代科技特别是新兴媒介科技,采用质化、量化等多种研究方法,研究二者关系的理论、机制,解决新时代中国急需解决的关键创新问题等。

关键词：科学普及科学传播科技创新演进

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操控条件对煤粉密相气体输送特性影响

化学工程 2014年第3期42卷 44-48页

作者：吴跃潘强神华宁夏煤业集团煤炭化学工业分公司研发中心宁夏银川750211

为了获得操控条件对煤粉密相气体输送的影响规律,在上出料输送装置中,各种操作参数,如锥部气流率、底部气流率、调节气流率、输送压力和输送压差对煤粉质量流率、固气比、煤粉速度和表观气速的影响进行研究。结果表明:当锥部气流率改变... 详细信息

为了获得操控条件对煤粉密相气体输送的影响规律,在上出料输送装置中,各种操作参数,如锥部气流率、底部气流率、调节气流率、输送压力和输送压差对煤粉质量流率、固气比、煤粉速度和表观气速的影响进行研究。结果表明:当锥部气流率改变时,煤粉质量流量改变不超过8%,且其他输送参数改变也较小;当底部气流率为0,煤粉仍可实现输送。随着底部气流率的增加,输送量和固气比呈现下降趋势,但表观气速和煤粉流速却呈现相反的趋势;当调节气流率从0增加到0.9 m3/h时,输送量从1 548 kg/h增加到1 582 kg/h,仅增加2.2%,但表观气速、煤粉流速和固气比变化却较大;当压力大于1 000 kPa,压力对输送特性的影响变小;输送参数都随着输送压差的增加显著增加。研究结果将为大规模干煤粉气化技术的密相输送操作提供重要参考。

关键词：粉体粉体技术二相流气体输送浓相

Facile synthesis of porous LiNiVO_4 powder as high-voltage cathode material for lithium-ion batteries

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Transactions of Nonferrous Metals Society of China 2016年第12期26卷 3232-3237页

作者： Mu-lan QIN Wan-min LIU Shu-quan LIANG an-qiang pan School of Chemistry and Chemical Engineering Hunan Institute of Engineering Xiangtan 411104 China School of Materials Science and Engineering Central South University Changsha 410083 China Key Laboratory of Nonferrous Metals Materials Science and Engineering Ministry of EducationCentral South University Changsha 410083 China

Porous LiNiVO4 powder was synthesized via solution combustion synthesis method using lithium nitrate, nickel nitrate,ammonium metavanadate and citric acid as raw materials. Thermogravimetry (TG) and differential scanning calorimetry (DSC),X-ray diffraction (XRD), Fourier-transform infrared (FT-IR) spectroscopy and transmission electron microscopy (TEM) were used toevaluate the structures and morphologies of samples. The results show that the calcination temperature has significant effect on thecrystallinity and morphologies. Pure LiNiVO4 flaky nanoparticles with a mean particle size around 20 nm can be readily prepared bycalcining the precursor in air at 500 °C for 2 h. As a cathode material for lithium-ion batteries, the porous LiNiVO4 powder exhibits agood structural reversibility.

关键词： lithium-ion battery LiNiVO4 cathode material solution combustion synthesis nanoparticle

Adaptive polarization i mage fusion based on regional energy dynamic weighted average

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Optoelectronics Letters 2005年第3期1卷 224-227页

作者： ZHAO Yong-qiang pan Quan ZHANG Hong-cai College of Automation Northwest Polytechnic University Xi＇an 710072 China

According to the principle of polarization imaging and the relation between Stokes parameters and the degree of linear polarization, there are much redundant and complementary information in polarized images. Since man-made objects and natural objects can be easily distinguished in images of degree of linear polarization and images of Stokes parameters contain rich detailed information of the scene, the clutters in the images can be removed efficiently while the detailed information can be maintained by combining these images. An algorithm of adaptive polarization image fusion based on regional energy dynamic weighted average is proposed in this paper to combine these images. Through an experiment and simulations,most clutters are removed by this algorithm. The fusion method is used for different light conditions in simulation, and the influence of lighting conditions on the fusion results is analyzed.

关键词：偏振现象图象处理参数设计模拟算法