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Gut microbiota shifts in hepatitis B-related portal hypertension after transjugular intrahepatic portosystemic shunt:Mechanistic and clinical implications

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World Journal of Gastroenterology 2025年第3期31卷 134-137页

作者： qi-Rong jiang Da-Wu Zeng Department of Hepatology Hepatology Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350004Fujian ProvinceChina

In this article,we provide commentary on the recent article by Zhao et *** focus on the shifts in the gut microbiota of patients with hepatitis B virus(HBV)-associated cirrhosis/portal hypertension(PH)following transjugular intrahepatic portosystemic shunt(TIPS)and the implications for understanding the mechanisms,diagnosis,and *** comparing the gut microbiota composition and dynamic changes before and after TIPS in patients with and without hepatic encephalopathy,the authors found an increase in non-probiotic bacteria in those who developed hepatic encephalopathy post-TIPS,with Morganella species present only in the hepatic encephalopathy *** gut microbiota changes post-TIPS among patients without the occurrence of hepatic encephalopathy suggest potential therapeutic benefits through prophylactic microbiome ***,the specific gut microbiota alterations may hold promise to predict the risk of hepatic encephalopathy in individuals undergoing TIPS for HBVrelated *** these promising findings,future studies are needed to address limitations,including a small sample size,a relatively short evaluation period for gut microbiota alterations,the absence of data on dynamic alterations in gut microbiota post-TIPS and their correlation with blood ammonia levels,and the lack of validation in animal *** conclusion,Zhao et al's study has shed new light on the link of gut microbiota with post-TIPS hepatic encephalopathy,potentially through the intricate gut-liver axis,and has important clinical implications for improving the management of patients with HBV-related PH.

关键词： Hepatitis B virus Cirrhosis Portal hypertension Hepatic encephalopathy Transjugular intrahepatic portosystemic shunt Gut microbiota

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Correlation analyse between thyroid hormone levels and severity of schizophrenia symptoms

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World Journal of Psychiatry 2025年第1期15卷 63-71页

作者： qi-Hui jiang Wei-Dong Gong Department of Endocrinology and Metabolism Hengyang Central HospitalHengyang 421000Hunan ProvinceChina Breast Tumor Surgical Outpatient Hengyang Central HospitalHengyang 421000Hunan ProvinceChina

BACKGROUND The imbalance of hormone levels in the body is closely related to the occurrence and progression of schizophrenia,especially thyroid *** To study the relationship between triiodothyronine(T3),thyroxine(T4),free T3(FT3),free T4(FT4),thyroid stimulating hormone(TSH)and *** In this study,100 schizophrenia patients were selected from our hospital between April 2022 and April *** clinical data were analyzed *** on the Positive and Negative Syndrome Scale(PANSS)score,patients were divided into mild(1-3 points,n=39),moderate(4 points,n=45),and severe groups(5-7 points,n=16).Additionally,55 healthy individuals served as a control *** blood samples were collected to measure T3,T4,FT3,FT4,TSH,and cortisol concentrations,analyzing their relationship with PANSS *** The serum levels of T3,FT3,FT4,TSH and cortisol in the schizophrenia group were lower than those in the control group(P<0.05).With the increase of the severity of the disease,the concentrations of T3 and T4 decreased,while the con-centrations of TSH and cortisol increased(P<0.05).The concentrations of TSH and cortisol were positively correlated with the PANSS score,while T3 and T4 were negatively correlated with the PANSS score(P<0.05).The receiver ope-rating characteristic curve results showed that T3,T4,TSH,and cortisol had good efficacy in the diagnosis of *** results showed that decreased T3 level,decreased T4 level,decreased TSH level and increased cortisol level may be independent risk factors for *** Thyroid hormone levels are associated with the severity of schizophrenia symptoms,which can provide new solutions for the diagnosis and treatment of schizophrenia.

关键词： Thyroid hormone Schizophrenia Symptom severity Positive and Negative Syndrome Scale score Cortisol

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Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao Zhang Li Jia Xiu-Jun Zhan Charity Ngina qing-Rui Zhang Xiao-Ge Li qi-Bao jiang Shi Bai Miao-Miao jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

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Theoretical Study on the Structures and Electronic Spectra of the Derivatives of C_(60)-P-2,4,6-Triphenyl Borazinc

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Chinese Journal of Structural Chemistry 2005年第10期24卷 1140-1144页

作者： jiang qi-Jun Department of Chemistry Xiaogan University Xiaogan 432000 China

The structures and electronic spectra of the derivatives of C60-P-2,4,6-triphenyl borazinc have been studied by using AM 1 method. The calculated results indicate that this kind of compounds has a lower energy difference between HOMO and LUMO. It is found that the electron cloud on unoccupied frontier orbital mainly comes from the contribution of C60, while that on occupied frontier orbital mainly concentrates on the side chain. A long-lived charge-separated state may occur in the objective compounds.

关键词： derivatives of C60-P-2,4,6-triphenyl borazinc electronic spectra charge-separated state AM1

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Nearly golden-ratio order in Ta metallic glass

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Chinese Physics B 2020年第4期29卷 360-367页

作者： Yuan-qi jiang Ping Peng Department of Physics Nanchang Normal UniversityNanchang 330032China College of Physics Jilin UniversityChangchun 130012China School of Material Science&Engineering Hunan UniversityChangsha 410082China

The formation of mono-atomic tantalum(Ta)metallic glass(MG)through ultrafast liquid cooling is investigated by ab-initio molecular dynamics(MD)*** is found that there exists nearly golden ratio order(NGRO)between the nearest and second nearest atoms in Ta MG,which has been indirectly confirmed by Khmich et *** Liang et al..The NGRO is another universal structural feature in metallic glass besides the local five-fold symmetry(LFFS).Further analyzing of electronic structure shows that the obvious orientation of covalent bond could be attributed to the NGRO in amorphous Ta at 300 K.

关键词： nearly golden ratio order(NGRO) metallic glass tantalum ab-initio molecular dynamics(MD)simulation

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Effect of turbulence on NO formation in swirling combustion

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Chinese Journal of Aeronautics 2014年第4期27卷 797-804页

作者： Wang Fang Xie Xiang jiang qi Zhou Lixing Aero-engine Numerical Simulation Research Center School of Energy and Power Engineering Beihang University Department of Engineering Mechanics Tsinghua University

Turbulence affects both combustion and NO formation. Fluctuation correlations are ideally used for quantitative analysis. From the instantaneous chemical reaction rate expression,ignoring the third-order correlation terms, the averaged reaction rate will have four terms, including the term of averaged-variable product, a concentration fluctuation correlation term, and temperature-concentration fluctuation correlation term. If the reaction-rate coefficient is denoted as K, the temperature fluctuation would be included in the K fluctuation. In order to quantitatively study the effect of turbulence on NO formation in methane-air swirling combustion, various turbulencechemistry models are tested. The magnitudes of various correlations and their effects on the time-averaged reaction rate are calculated and analyzed, and the simulation results are compared with the experimental measurement data. The results show that among various correlation moments, the correlation between the reaction-rate coefficient K fluctuation with the concentration fluctuation is most important and is a strong nonlinear term.

关键词： NO formation Numerical simulation Reaction-rate coefficient Second-order moment model Turbulent combustion model

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Effect of the volute tongue cut on pressure pulsations of a low specific speed centrifugal pump

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Journal of Hydrodynamics 2020年第4期32卷 758-770页

作者： Ning Zhang Bo Gao Bin Xia qi-feng jiang School of Energy and Power Engineering Jiangsu UniversityZhenjiang 212013China School of Mechanical Technology Wuxi Institute of TechnologyWuxi 214121China Key Laboratory of Fluid and Power Machinery Ministry of EducationXihua UniversityChengdu 610039China

The volute tongue,as the crucial component inducing rotor-stator interaction,is detrimental to unsteady pressure pulsations of centrifugal *** the present paper,to investigate the effect of the volute tongue cut on pressure pulsations of a low specific speed centrifugal pump,three volute tongues are obtained through twice cuts,named cases 1,2,*** measuring points are evenly mounted on periphery of the volute casing to obtain unsteady pressure signals using high response *** amplitudes at the blade passing frequency fBPF and root mean square(rms)values in 0 Hz-500 Hz frequency band are applied to evaluate the cutting *** show that pressure spectrum is significantly affected by the volute tongue cut,especially for the component at *** different measuring points,influences of the volute tongue cut on three cases are not *** nns values,it is evident that cutting the volute tongue will lead to pressure energy increasing for most of the concerned measuring points,especially for the points at the far away region from the volute ***,from comparison with the original shape case 1,the averaged increment of the twenty points is more than 20%.So it is concluded that for this type centrifugal pump,cutting the volute tongue is not reasonable considering low pressure pulsation requirement.

关键词： Centrifugal pump volute tongue cut pressure pulsation spectrum analysis

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An overview of prostate diseases and their characteristics specific to Asian men

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Asian Journal of Andrology 2012年第3期14卷 458-464,I0008页

作者： Shu-Jie Xia Di Cui qi jiang Department of Urology The First People's Hospital Affiliated to Shanghai Jiao Tong UniversityShanghai 200080China

In this paper, we reviewed the features of common prostate diseases, such as benign prostatic hyperplasia （BPH）, prostate cancer （PCa） and chronic prostatitis （CP） that are specific to Asian men. Compared to the Westerners, Asians exhibit particular characteristics of prostate diseases. Through summarizing the epidemiology, symptomatology, diagnostics and therapeutics of these diseases, we find that Asians have a lower incidence of PCa than whites, but the incidences of BPH and CP are similar. Asian men with CP often suffer from fewer disease sites, but have a higher frequency of pain during urination rather than after sexual climax. Prostate-specific antigen （PSA） is a widely used marker for the diagnosis of PCa in both Asian and Western countries. Although the PSA level may be lower in Asians, the threshold used is based on whites. After reviewing the treatments available for these diseases, we did not find a fundamental difference between Asians and whites. Furthermore, the selection for the most appropriate treatment based on the individual needs of patients remains a challenge to urologists in Asia. After considering the traits of prostate diseases that are specific to Asian men, we hope to pave the way for the development of specific diagnostic and therapeutic strategies targeted specifically to Asian men.

关键词： Asians benign prostatic hyperplasia chronic prostatitis prostate cancer

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Fast nonnegative tensor ring decomposition based on the modulus method and low-rank approximation

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Science China(Technological Sciences) 2021年第9期64卷 1843-1853页

作者： YU YuYuan XIE Kan YU JinShi jiang qi XIE ShengLi School of Automation Guangdong University of TechnologyGuangzhou 510006China Guangdong-Hong Kong-Macao Joint Laboratory for Smart Manufacturing Guangzhou 510006China Key Laboratory of Intelligent Detection and The Internet of Things in Manufacturing Ministry of EducationGuangzhou 510006China Guangdong Key Laboratory of IoT Information Technology Guangdong University of TechnologyGuangzhou 510006China

Nonnegative tensor ring(NTR) decomposition is a powerful tool for capturing the significant features of tensor objects while preserving the multi-linear structure of tensor data. The existing algorithms rely on frequent reshaping and permutation operations in the optimization process and use a shrinking step size or projection techniques to ensure core tensor nonnegativity, which leads to a slow convergence rate, especially for large-scale problems. In this paper, we first propose an NTR algorithm based on the modulus method(NTR-MM), which constrains core tensor nonnegativity by modulus transformation. Second, a low-rank approximation(LRA) is introduced to NTR-MM(named LRA-NTR-MM), which not only reduces the computational complexity of NTR-MM significantly but also suppresses the noise. The simulation results demonstrate that the proposed LRA-NTR-MM algorithm achieves higher computational efficiency than the state-of-the-art algorithms while preserving the effectiveness of feature extraction.

关键词： nonnegative tensor ring decomposition modulus method low-rank approximation

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Additive manufacturing of metallic glasses and high-entropy alloys:Significance,unsettled issues,and future directions

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Journal of Materials Science & Technology 2023年第9期140卷 79-120页

作者： Haishun Liu Dengfeng Yang qi jiang Yangyang jiang Weiming Yang Lin Liu Lai-Chang Zhang School of Materials Sciences and Physics China University of Mining and TechnologyXuzhou 221116China State Key Laboratory for Geomechanics and Deep Underground Engineering School of Mechanics and Civil EngineeringChina University of Mining and TechnologyXuzhou 221116China State Key Laboratory of Material Processing and Die&Mould Technology and School of Materials Science and Engineering Huazhong University of Science and TechnologyWuhan 430074China School of Engineering Edith Cowan University270 Joondalup DriveJoondalupPerthWA 6027Australia

As two kinds of well-known prominent high-performance alloys,metallic glasses(MGs)and high-entropy alloys(HEAs)have attracted increasing *** of them contain multiple alloying components,demonstrate intriguing microstructures,and exhibit excellent properties;however,their unique performances are closely dependent on the fabrication process,although they are limited due to the need for rapid solidification during *** the other hand,additive manufacturing(AM)can be used to fabricate complex parts via rapid solidification,thus saving *** advantages provide AM with a great possibility to produce MG and HEA materials with tunable microstructures therefore properties,and corresponding parts with complex geometries,large dimensions,and more *** paper provides a comprehensive and systematic overview of the manufacturing and properties of MGs and HEAs using AM *** correlation between MGs and HEAs with conventional manufacturing meth-ods and the difficulties encountered are retrospectively ***,this review specifically focuses on the recent research advances in MGs and HEAs fabricated using AM ***,various properties of the AM-fabricated MGs and HEAs are ***,the remaining issues and potential solutions,challenges,and future directions on the AM of MGs and HEAs are also presented.

关键词： Additive manufacturing Powder bed fusion Metallic glasses High-entropy alloys Research status

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