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CCR7/p-ERK1/2/VEGF signaling promotes retinal neovascularization in a mouse model of oxygen-induced retinopathy

International Journal of Ophthalmology(English edition) 2017年第6期10卷 862-869页

作者： lin-hui Yuan Xiao-Long Chen Yu Di Mei-lin Liu Department of Ophthalmology Shengjing Affiliated Hospital of China Medical University Shenyang 110000 Liaoning Province China

AIM： To investigate the role of CCR7/p-ERKI/2/VEGF signaling in the mouse model of oxygen-induced retinopathy （OIR）. METHODS： Neonatal C57BL/6J mice were evenly randomized into four groups： normoxia, OIR, OIR control （treated with scramble siRNA）, and OIR treated （treated with CCR7 siRNA）. Normoxia group was not specially handled. Postnatal day 7 （P7） mice in the OIR group were exposed to 75%±5% oxygen for 5d （P7-P12） and then maintained under normoxic conditions for 5d （P12-P17）. Mice in the OIR control and OIR treated groups were given injections of scramble or CCR7 siRNA plasmid on P12 before returning to normoxic conditions for 5d （P12-P17）. Retina samples were collected from all mice on P17, stained with adenosine diphosphatase （ADPase）, and retinal neovascularization （RNV） was assessed. Retinas were also stained with hematoxylin and eosin （H＆E） for RNV quantitation. The distribution and expression of CCR7, p-ERKI/2 and vas- cular endothelial growth factor （VEGF） were assessed via immunohistochemistry, Western blot, and quantitative real-time polymerase chain reaction （qRT-PCR）. RESULTS： High oxygen promoted retinal neovascularization （P〈0.05） and increased the number of endothelial nuclei in new vessels extending from the retina to the vitreous body; CCR7 promoted this process （P〈0.05）. CCR7 and VEGF mRNA were expressed at higher levels in the OIR and OIR control groups than in the normoxia and OIR treated groups. CCR7, p-ERK1/2, and VEGF protein were expressed in the retinas of mice in the OIR and OIR control groups. Intravitreal injection of CCR7 siRNA significantly reduced CCR7, p-ERKI/2, and VEGF expression in the OIR mouse model （all P〈0.05）. CCR7 significantly enhancedthe neovascularization and non-perfusion areas in the OIR group （P〈0,05）, CCR7 siRNA significantly reduced levels of p-ERK1/2 and VEGF as compared to OIR controls （P〈0.05）. CONCLUSION： These results suggest that CCR7/p-ERK I/2NEGF signaling plays an important role in OIR, CCR7 may be a p

关键词： chemokine receptor type 7 vascularendothelial growth factor extracellular signal-regulated kinase retinal neovascularization retinopathy ofpremamrity

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Capillaria hepatica in China

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World Journal of Gastroenterology 2010年第6期16卷 698-702页

作者： Li, Chao-Ding Yang, hui-lin Wang, Ying Soochow Univ Dept Orthoped Affiliated Hosp 1 Suzhou 215006 Jiangsu Prov Peoples R China Soochow Univ Dept Hematol Affiliated Hosp 1 Suzhou 215006 Jiangsu Prov Peoples R China

Capillaria hepatica(***) is a parasitic nematode causing hepatic capillariasis in numerous *** studies showed that the first hosts of *** were rodents,among which rats had relatively high infection rates,which explains why *** spreads *** studies showed that the liver was the principal site of colonization by these parasites and physical damage tended to *** *** might lead to serious liver disorders,relevant clinical reports were rare,because of the non-specific nature of clinical symptoms,leading to *** review mainly focuses on the biological characteristics and epidemiology of *** in China and histopathologic changes in the liver,with expectation of gaining a better understanding of the disease and seeking more effective treatment.

关键词： Capillaria hepatica Enoplida infections Liver diseases Host-parasite interactions Diagnosis Treatment

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A highly selective and sensitive fluorescent chemosensor for Zn^(2+)

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Chinese Chemical Letters 2008年第10期19卷 1240-1243页

作者： Xiu Ying Zhang Zuo hui Wang lin Yang School of Chemistry and Environmental Science Key Ltlboratory for Environmental Pallution Control Technology of Henan Province Henan Normal University Xinxiang 453007 China

A new selective Zn^2＋ fluorescent chemosensor, o-vanillin-4-ethoxybenzoylhydrazone （1）, was designed and prepared. Free 1 mainly displayed very weak fluorescence at 480 nm upon excitation at 403 nm. It displayed high selectivity for Zn^2＋ and had a 518- fold fluorescent enhancement upon binding of Zn^2＋, while the other cation ions had only little influence on the fluorescence of 1. Mechanism of enhancement of l＇s fluorescence by Zn^2＋ was briefly discussed.

关键词： Chemosensor Zinc ion Fluorescence enhancement N-Acylhydrazone

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Decoherence,Orbit,and Classical linear Frequency Entropy:Quantum-Classical Correspondence

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Communications in Theoretical Physics 2009年第8期52卷 221-225页

作者： ZHANG Shi-hui JIE Quan-lin WANG Zhuo Department of Physics Wuhan University Wuhan 430072 China

The decoherence process is analyzed for an open quantum system that is classically chaotic,with a classicallinear frequency entropy developed to measure the stability of classical motion,Investigation shows that the decoherencemeasured by the rate of quantum linear entropy production varies significantly with both the underlying classical orbitsand the classical linear frequency *** correspondence is also supported by the further investigation on theLoschmidt Echo.

关键词： decoherence orbit rate of linear entropy classical linear frequency entropy

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Monte Carlo Study of Planar Rotator Model with Weak Dzyaloshinsky-Moriya Interaction

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Communications in Theoretical Physics 2006年第4X期46卷 663-667页

作者： SUN Yun-Zhou LIU hui-Ping YI lin Department of Physics and State Key Laboratory of Laser Technology~ Huazhong University of Science and Technology Wuhan 430074 China

With the help of an improvement Monte Carlo method, the Berezinskii-Kosterlitz-Thouless phase transition arising in two-dimensional planar rotator model with weak Dzyaloshinsky-Moriya （DM） interaction is investigated. The effects of the DM interaction on specific heat, susceptibility, and magnetization are simulated. The critical temperature of transitions is determined by the so-called Binder cumulant and the susceptibility of finite-size scaling. We find that the chiral Z2 symmetry reduced by the DM interactions plays an important role in a two-dimensional XY spin system, typically, the critical temperature is sensitive to weak DM spin couplings.

关键词： Monte Carlo method Berezinskii-Kosterlitz-Thouless phase transition Dzyaloshinsky-Moriya interaction XY model

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Reproductive traits of the gray ratsnake Ptyas korros from three geographically distinct populations

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Current Zoology 2012年第6期58卷 820-827页

作者： Long-hui lin Fei MAO Ce CHEN Xiang JI Hangzhou Key Laboratory for Animal Adaptation and Evolution School of Life SciencesHangzhou Normal UniversityHangzhou 310036ZhejiangChina Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life SciencesNanjing Normal UniversityNanjing 210046JiangsuChina

Abstract We collected gravid gray rat snakes Ptyas korros from three geographically distinct populations in China, Chenzhou （CZ）, Jiangshan （JS） and Dinghai （DH）, to study geographical variation in female reproductive traits. Egg-laying dates differed among the three populations such that at the most northern latitude egg-laying was latest, and earliest at the most southern latitutde. Clutch size, clutch mass, egg mass, egg shape, within clutch variability in egg sizes and relative clutch mass differed among the three populations, whereas post-oviposition body mass did not. Except for egg-laying date, none of the traits examined varied in a geographically continuous trend. CZ and DH females, although separated by a distance of approximately 1100 km as the crow flies, were similar in nearly all traits examined. JS females were distinguished from CZ and DH females by their higher fecundity （clutch size）, greater reproductive output （clutch mass） and more rounded eggs. Our data do not validate the prediction that larger offspring should be produced in colder localities. The absence of an egg size-number trade-off in each of the three populations presumably suggests that P. korros is among species where eggs are well optimized for size within a population.

关键词： Colubridae Life-history Reproductive output Egg size Clutch size Geographical variation Egg-laying date

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Preparation of(R)-2-chloro-1-(m-chlorophenyl)ethanol by Lipozyme TL IM-catalyzed second resolution

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Chinese Chemical Letters 2012年第3期23卷 289-292页

作者： Shi Wen Xia hui lin Yong Zheng Chen College of Bio-information Chongqing University of Posts and TelecommunicationsChongqing 400065China Chengdu Institute of Biology Chinese Academy of SciencesChengdu 610041China Department of Pharmacy Zunyi Medical CollegeZunyi 563003China

（R）-2-Chloro-l-（m-chlorophenyl）ethanol,a precursor of（R）-3-chlorostyrene oxide which is the key chiral intermediate for the preparation of severalβ3-adrenergic receptor agonists was prepared in 40%yield and 99%... 详细信息

关键词： (R)-2-Chloro-1-(m-chlorophenyl)ethanol LipozymeTL IM Enzymatic transesterification Vinyl acetate Second resolution

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Risk Assessment and Ecological Effects of Transgenic Bacillus thuringiensis Crops on Non-Target Organisms

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Journal of Integrative Plant Biology 2011年第7期53卷 520-538页

作者： hui-lin Yu Yun-He Li Kong-Ming Wu State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant Protection Chinese Academy of AgriculturalSciences Beijing 100193 China

The application of recombinant DNA technology has resulted in many insect-resistant varieties by genetic engineering （GE）. Crops expressing Cry toxins derived from Bacillus thuringiensis （Bt） have been planted worldwide, and are an effective tool for pest control. However, one ecological concern regarding the potential effects of insect-resistant GE plants on non-target organisms （NTOs） has been continually debated. In the present study, we briefly summarize the data regarding the development and commercial use of transgenic Bt varieties, elaborate on the procedure and methods for assessing the non-target effects of insect-resistant GE plants, and synthetically analyze the related research results, mostly those published between 2005 and 2010. A mass of laboratory and field studies have shown that the currently available Bt crops have no direct detrimental effects on NTOs due to their narrow spectrum of activity, and Bt crops are increasing the abundance of some beneficial insects and improving the natural control of specific pests. The use of Bt crops, such as Bt maize and Bt cotton, results in significant reductions of insecticide application and clear benefits on the environment and farmer health. Consequently, Bt crops can be a useful component of integrated pest management systems to protect the crop from targeted pests.

关键词： Bt crops non-target organisms risk assessment IPM.

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Mining Functional Gene Modules linked with Rheumatoid Arthritis Using a SNP-SNP Network

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Genomics, Proteomics & Bioinformatics 2012年第1期10卷 23-34页

作者： lin Hua hui lin Dongguo Li lin Li Zhicheng Liu Biomedical Engineering Institute Capital Medical UniversityBeijing 100069China

The identification of functional gene modules that are derived from integration of information from different types of networks is a powerful strategy for interpreting the etiology of complex diseases such as rheumatoid arthritis （RA）. Genetic variants are known to increase the risk of developing RA. Here, a novel method, the construction of a genetic network, was used to mine functional gene modules linked with RA. A polymorphism interaction analy- sis （PIA） algorithm was used to obtain cooperating single nucleotide polymorphisms （SNPs） that contribute to RA disease. The acquired SNP pairs were used to construct a SNP-SNP network. Sub-networks defined by hub SNPs were then extracted and turned into gene modules by mapping SNPs to genes using dbSNP database. We per- formed Gene Ontology （GO） analysis on each gene module, and some GO terms enriched in the gene modules can be used to investigate clustered gene function for better understanding RA pathogenesis. This method was applied to the Genetic Analysis Workshop 15 （GAW 15） RA dataset. The results show that genes involved in func- tional gene modules, such as CD160 （rs744877） and RUNX1 （rs2051179）, are especially relevant to RA, which is supported by previous reports. Furthermore, the 43 SNPs involved in the identified gene modules were found to be the best classifiers when used as variables for sample classification.

关键词： polymorphism interaction analysis hub SNP sub-networks GO enrichment analysis

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Nutrient distributions and nitrogen-anomaly(N^(*))in the tropical North Pacific Ocean

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Acta Oceanologica Sinica 2022年第11期41卷 23-33页

作者： Aiqin Han Yu Wang Yunlong Huo Cai lin Kaiwen Zhou Fangfang Kuang hui lin Third Institute of Oceanography Ministry of Natural ResourcesXiamen 361005China

Based upon cruise observations broadly covering the tropical North Pacific during July-November 2017,together with data obtained from the World Ocean Circulation Experiment Hydrographic Program,this study examined the distribution of dissolved inorganic nitrogen(DIN,nitrate(NO_(3)^(-))+nitrite(NO_(2)^(-))),dissolved inorganic phosphorus(DIP)and related N^(*)(nitrogen-anomaly,N^(*)=N-16P+2.9,where N and P are the concentrations of DIN(>1.0μmol/L)and DIP(>0.1μmol/L)),used as an index of N2fixation,in the upper 1000 m of the water *** concentrations displayed distinct spatial variability in the upper ocean but became relatively constant at a depth of 1000 m:they were high at low latitudes and in the eastern region,with an obvious nutricline at~150 m(DIN,~32.0μmol/L;DIP,~2.4μmol/L)and then generally increased with depth;they decreased markedly(DIN,~1.2μmol/L;DIP,~0.1μmol/L;at~150 m)at high latitudes and in the western region,where a nutricline was not *** N^(*)index showed significant meridional and zonal variation,with the most negative values located at low latitudes and in the eastern region(~10°N,~150°-170°E),while becoming positive towards the northwest(the north of~18°N,~160°E westward).A N^(*)concentration larger than 2.0μmol/L which often used as an indicator of N2fixation,was observed between 155°E and 165°E;N^(*)values were 2.0μmol/L to6.0μmol/L at~15°-28°N,i.e.,much higher than those in the southern sector(0-2.0μmol/L at~5°-10°N).Zonally,N^(*)decreased gradually from west(-2.0μmol/L to 4.0μmol/L,~145°-165°E)to east(-2.0μmol/L to-8.0μmol/L,~155°W)along~10°N,which was consistent with the distribution of Trichodesmium abundance and N2fixation ***,since such region was also supplied with aeolian deposition,high N^(*)was probably not only induced by N2fixation but also influenced by iron and/or nitrogen deposition.

关键词： tropical North Pacific Ocean nutrients nitrogen anomaly nitrogen fixation aeolian deposition

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