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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li yin wang Peifeng Li Hai Zhu Dong wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Tight formation control of multiple unmanned aerial vehicles through an adaptive control method

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Science China(Information Sciences) 2017年第7期60卷 96-98页

作者： yin wang Daobo wang State Key Laboratory of Virtual Reality Technology and Systems Beihang University College of Astronautics Nanjing University of Aeronautics and Astronautics College of Automation Engineering Nanjing University of Aeronautics and Astronautics

Cooperative formation control for unmanned aerial vehicles(UAV)is a fundamental yet essential component toward the development of highlevel autonomous flight control *** UAVs are flying in a tight formation,the power requirements for the following aircraft(s)can be significantly reduced because of the vortices effect of the leading ***,this also introduces an aerodynamic interaction to the formation dynamics,complicating the formation control *** control methods can be

关键词： UAV Tight formation control of multiple unmanned aerial vehicles through an adaptive control method ETP

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Variable thrust directional control technique for plateau unmanned aerial vehicles

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Science China(Information Sciences) 2016年第3期59卷 204-207页

作者： yin wang Daobo wang College of Astronautics Nanjing University of Aeronautics and Astronautics College of Automation Engineering Nanjing University of Aeronautics and Astronautics

In order to increase the lift force of the unmanned aerial vehicles(UAV) in plateau areas, the UAV is commonly equipped with high span chord ratio wings. However, it may decrease the maneuverability of the aircraft, and thus increasing the risk of flight in complex terrain regions. Thrust vector control is a direct force flight control technique, which enhances the maneuverability and introduces the residual of the flight control system. In this paper, we develop a novel variable thrust direction mechanism, which provides the normal propeller UAV with the capability of directional force control. We propose a combinational flight control strategy for the newly developed UAV. Simulations and real flight test demonstrate the performance of the proposed technique in increasing the maneuverability of the conventional propeller UAV.

关键词： unmanned aerial vehicle thrust vectoring control combination control plateau application pro peller engine

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A data driven approach for detection and isolation of anomalies in a group of UAVs

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Chinese Journal of Aeronautics 2015年第1期28卷 206-213页

作者： wang yin wang Daobo wang Jianhong College of Astronautics Nanjing University of Aeronautics and Astronautics College of Automation Nanjing University of Aeronautics and Astronautics The 28th Research Institute of China Electronics Technology Group Corporation

The use of groups of unmanned aerial vehicles（UAVs） has greatly expanded UAV＇s capabilities in a variety of applications, such as surveillance, searching and mapping. As the UAVs are operated as a team, it is important to detect and isolate the occurrence of anomalous aircraft in order to avoid collisions and other risks that would affect the safety of the team. In this paper, we present a data-driven approach to detect and isolate abnormal aircraft within a team of formatted flying aerial vehicles, which removes the requirements for the prior knowledge of the underlying dynamic model in conventional model-based fault detection algorithms. Based on the assumption that normal behaviored UAVs should share similar（dynamic） model parameters, we propose to firstly identify the model parameters for each aircraft of the team based on a sequence of input and output data pairs, and this is achieved by a novel sparse optimization technique. The fault states of the UAVs would be detected and isolated in the second step by identifying the change of model *** results have demonstrated the efficiency and flexibility of the proposed approach.

关键词： sparse aircraft surveillance searching identifying prior isolation assumption flexibility aerial

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Recent advances of rhenium separation and enrichment in China： Industrial processes and laboratory trials

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Chinese Chemical Letters 2018年第3期29卷 345-352页

作者： yin wang Congyang wang Radiochemistry Laboratory School of Nuclear Science and Technology Lanzhou University Lanzhou 730000 China Key Laboratory of Special Function Materials and Structure Design Ministry of Education Lanzhou 730000 China Beijing National Laboratory for Molecular Sciences CA5 Key Laboratory of Moiecular Recognition and Function CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100049 China

China is a major producer of rhenium, which is widely used in aerospace technologies （as superalloy） and petrochemical industries （as catalyst）. There is a gap between the demand and fact for the enrichment of rhenium, due to its rather small content （10-9） in the earth＇s crust. Also, there is no available single occurrence of mineral rhenium. Instead, the rhenium is associated with either molybdenum or copper （of up to 0.2% in content） as a by-product in metallurgical industry. This makes the separation of rhenium from the major mineral metals a challenge. The recent progresses in the separation and enrichment of rhenium were reviewed in this paper, especially, the advances in China. The details of varied separation methods used either in laboratories or factories, such as ion-exchange, solvent extraction, separation utilizing extractive resins, liquid membrane, or novel materials, etc., were elaborated. Comparison of the different methods was disclosed and an outlook on the rhenium chemistry and industry in the future was brought forward.

关键词： Rhenium Separation Enrichment Ion exchange Solvent extraction

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Optimization of rhizogenesis for in vitro shoot culture of Pinus massoniana Lamb.

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Journal of Forestry Research 2021年第1期32卷 203-209页

作者： yin wang Ruiling Yao Guangxi Forestry Research Institute Nanning 530002GuangxiPeople’s Republic of China

The rooting capacity of Pinus massoniana is poor,especially for mature trees,and has prevented the development of clonal forestry for *** this study,we varied explant types,subculture times and exogenous hormones for plantlet regeneration and assessed shoots for rooting rate and root number for *** fi ve repetitive grafts,new shoots from grafts used as explant sources were rejuvenated as observed from juvenile shoot morphology and anatomy,leading to greatly enhanced plant regeneration in comparison to that of mature materials from 26-year-old *** *** rooting capacity of subcultured shoots increased with successive subcultures,reaching a peak at 20 subcultures with 35–40 days per ***,rooting performance was signifi cantly reduced after 30 *** addition of naphthaleneacetic acid(NAA)plus indoleacetic acid in the medium improved the root number,but the combination of exogenous NAA with paclobutrazol(PBZ)increased rooting rate and root *** thus greatly improved the rooting capacity of mature *** trees by optimizing explant types(rejuvenated),subculture times(20 subcultures,35–40 days per subculture)and addition of NAA+PBZ to the rooting *** conditions can be used for effi cient plantlet regeneration of ***.

关键词： Exogenous hormones Pine trees Rejuvenation Rhizogenesis Subculture cycles

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Synthesis,Electrical Conductivity and Seebeck Coefficient of La_(0.9)A_(0.1)FeO_3(A=Mg,Ca,Sr,Ba)

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Journal of Materials Science & Technology 2010年第12期26卷 1103-1106页

作者： Na yin Hongchao wang Chunlei wang School of Physics State Key Laboratory of Crystal Materials Shandong University Jinan 250100 China

Lanthanum ferrites ceramics La0.9A0.1FeO3 （A=Mg, Ca, Sr, Ba） have been prepared by solid state reaction. X-ray power diffraction analysis reveals that all samples are of pure perovskite structure with orthorhombic phase. Electrical conductivity and Seebeck coefficient have been measured in vacuum within the temperature range between room temperature and 800℃. The electrical conductivity shows semiconducting behavior. Temperature dependence of electrical conductivity indicates that adiabatic small-polaron hopping mechanism is dominant for their electric transportations. Seebeck coefficients are positive for samples, suggesting ptype conduction in the whole temperature range. The highest Seebeck coefficient is found to be 654 μV/K for La0.9A0.1FeO3. Except La0.9A0.1FeO3, the electrical conductivity of La0.9A0.1FeO3 increases with increasing atomic number of the A-site element, while Seebeck coefficient decreases.

关键词： La0.9A0.1FeO3 ceramics Electrical conductivity Seebeck coefficient

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14种市售麻椒鸡的品质及风味分析

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食品工业科技 2025年第1期46卷 302-316页

作者：刘聪刘欣王鹏徐幸莲王寅李建超南京农业大学肉品质量控制与新资源创制全国重点实验室江苏南京210095 江苏立华食品有限公司江苏常州213200

为明确麻椒鸡产品的品质特性及风味特征,本研究以14种不同品牌的市售麻椒鸡(以A~N字母表示)作为研究对象,测定了其色泽、质构、剪切力、电子鼻、挥发性风味物质和电子舌,并结合感官评价进一步探究感官评价指标与仪器分析指标之间的相关... 详细信息

为明确麻椒鸡产品的品质特性及风味特征,本研究以14种不同品牌的市售麻椒鸡(以A~N字母表示)作为研究对象,测定了其色泽、质构、剪切力、电子鼻、挥发性风味物质和电子舌,并结合感官评价进一步探究感官评价指标与仪器分析指标之间的相关性。结果表明:14种麻椒鸡鸡胸的硬度范围为1742.81~4587.54 g,剪切力范围为14.41~35.07 N;鸡腿的硬度范围为797.09~3389.61 g,剪切力范围为7.70~26.34 N。电子鼻评价结果显示,14种麻椒鸡的主要挥发性气味成分为氮氧化合物、无机硫化物、有机硫化物和短链烷烃。气相色谱-离子迁移谱(GCIMS)显示,麻椒鸡风味的形成是鸡肉本身带有的香气和香辛料赋予香气整体协调的结果,14种麻椒鸡中共鉴定出77种挥发性化合物,结合正交偏最小二乘判别分析(OPLS-DA)发现,丁醛、芳樟醇、α-蒎烯、丙烯酸乙酯、α-松油醇、2-庚酮、1-辛烯-3-醇等26种物质为麻椒鸡产品的特征风味物质。电子舌评价结果显示,鲜味和咸味对麻椒鸡的滋味贡献较突出。相关性分析结果表明,感官评价中的总体喜爱度与丁醛、芳樟醇、α-蒎烯、丙烯酸乙酯、α-松油醇、2-庚酮、1-辛烯-3-醇、W5S、W1W、W2W、W1S、咸味、L^(*)和b^(*)值等指标呈现极显著正相关(P<0.01)。本研究可以为麻椒鸡产品风味品质的研究与调控、原辅料的选择、麻椒鸡产品工业化水平的提升提供参考。

关键词：麻椒鸡风味特征气相色谱-离子迁移谱品质特性相关性

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Recent advances in Ni-Al bimetallic catalysis for unreactive bond transformation

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Science China Chemistry 2018年第8期61卷 1004-1013页

作者： yin-Xia wang Mengchun Ye State Key Laboratory and Institute of Elemento-Organic Chemistry Nankai University Tianjin 300071 China Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin 300071 China

Ni-Al bimetallic catalysis proves to be an efficient catalytic strategy for unreactive bond transformations. Recently, chiral bifunctional ligands, especially amphoteric secondary phosphine oxide(SPO) ligand, are used for a more powerful synergistic effect in the bimetal-catalyzed reactions, providing not only milder reaction conditions and higher reactivity but also excellent reaction selectivity. Herein, we give a brief review on the development of Ni-Al bimetallic catalytic system and highlight recent advances in enantioselective Ni-Al bimetallic catalysis for unreactive bond transformation.

关键词： nickel aluminum bimetallic catalysis SPO ligand unreactive bond

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Incremental harmonic balance method for periodic forced oscillation of a dielectric elastomer balloon

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Applied Mathematics and Mechanics(English Edition) 2020年第3期41卷 459-470页

作者： yin wang Ling ZHANG Jinxiong ZHOU State Key Laboratory Base of Eco-hydraulic Engineering in Arid Area Xi’an University of TechnologyXi’an 710048China State Key Laboratory for Strength and Vibration of Mechanical Structures Shaanxi Engineering Laboratory for Vibration Control of Aerospace StructuresSchool of AerospaceXi’an Jiaotong UniversityXi’an 710049China

Dielectric elastomer(DE) is suitable in soft transducers for broad applications,among which many are subjected to dynamic loadings, either mechanical or electrical or both. The tuning behaviors of these DE devices call for an efficient and reliable method to analyze the dynamic response of DE. This remains to be a challenge since the resultant vibration equation of DE, for example, the vibration of a DE balloon considered here is highly nonlinear with higher-order power terms and time-dependent coefficients. Previous efforts toward this goal use largely the numerical integration method with the simple harmonic balance method as a supplement. The numerical integration and the simple harmonic balance method are inefficient for large parametric analysis or with difficulty in improving the solution accuracy. To overcome the weakness of these two methods,we describe formulations of the incremental harmonic balance(IHB) method for periodic forced solutions of such a unique system. Combined with an arc-length continuation technique, the proposed strategy can capture the whole solution branches, both stable and unstable, automatically with any desired accuracy.

关键词： dielectric elastomer nonlinear oscillation incremental harmonic method arc-length continuation

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