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Hierarchical learning of gastric cancer molecular subtypes by integrating multi-modal DNA-level omics data and clinical stratification

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Quantitative Biology 2024年第2期12卷 182-196页

作者： Binyu Yang Siying Liu Jiemin Xie Xi Tang Pan Guan Yifan Zhu Xuemei Liu Yunhui Xiong Zuli Yang Weiyao Li Yonghua Wang wen chen Qingjiao Li Li c.Xia Department of Statistics and Financial Mathematics School of MathematicsSouth China University of TechnologyGuangzhouChina School of Physics and Optoelectronics South China University of TechnologyGuangzhouChina Department of Pathology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouChina School of Food Science and Engineering South China University of TechnologyGuangzhouChina Department of Laboratory Medicine the Eighth Affiliated HospitalSun Yat-sen UniversityShenzhenChina

Molecular subtyping of gastric cancer(Gc)aims to comprehend its genetic ***,the efficacy of current subtyping methods is hampered by their mixed use of molecular features,a lack of strategy optimization,and the limited availability of public Gc *** is a pressing need for a precise and easily adoptable subtyping approach for early DNA-based screening and *** on TcGA subtypes,we developed a novel DNA-based hierarchical classifier for gastric cancer molecular subtyping(HcG),which employs gene mutations,copy number aberrations,and methylation patterns as *** incorporating the closely related esophageal adenocarcinomas dataset,we expanded the TcGA Gc dataset for the training and testing of HcG(n=453).The optimization of HcG was achieved through three hierarchical strategies using Lasso-Logistic regression,evaluated by their overall the area under receiver operating characteristic curve(auROc),accuracy,F1 score,the area under precision-recall curve(auPRc.and their capability for clinical stratification using multivariate survival ***-specific DNA alteration biomarkers were discerned through difference tests based on HcG defined *** HcG classifier demonstrated superior performance in terms of overall auROc(0.95),accuracy(0.88),F1 score(0.87)and auPRc(0.86),significantly improving the clinical stratification of patients(overall p-value=0.032).Difference tests identified 25 subtype-specific DNA alterations,including a high mutation rate in the SYNE1,ITGB4,and cOL22A1 genes for the MSI subtype,and hypermethylation of ALS2cL,KIAA0406,and RPRD1B genes for the EBV *** is an accurate and robust classifier for DNA-based Gc molecular subtyping with highly predictive clinical stratification *** training and test datasets,along with the analysis programs of HcG,are accessible on the GitHub website(***/LabxScUT).

关键词： DNA alterations gastric cancer hierarchical classification molecular subtyping multi-omics

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Effect of tungsten carbide particles on microstructure and mec.anical properties of cu alloy composite bit matrix

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Journal of Iron and Steel Research(International) 2024年第2期31卷 519-530页

作者： Ding-qian Dong Feng-yuan He Xin-hui chen Hui Li Kai-hua Shi Hui-wen Xiong Xin Xiang Li Zhang college of Mec.anical Engineering Sichuan University of Science and EngineeringZigong643000SichuanChina State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083HunanChina Zigong cemented carbide co. Ltd.Zigong643011SichuanChina Material corrosion and Protection Key Laboratory of Sichuan Province Sichuan University of Science and EngineeringZigong643000SichuanChina

copper alloy composite bit matrix was prepared by pressureless vacuum infiltration,using at least one of the three kinds of tungsten carbide particles,for example,irregular cast tungsten carbide,monocrystalline tungsten carbide and sintered reduced tungsten carbide *** effects of powder particle morphology,particle size and mass fraction of tungsten carbide on the microstructure and mec.anical properties of copper alloy composite were investigated by means of scanning electron microscopy,X-ray diffraction and abrasive wear test in *** results show that tungsten carbide morphology and particle size have obvious effects on the mec.anical properties of copper alloy *** tungsten carbide partially dissolved in the copper alloy binding phase,and layers of cu_(0.3)W_(0.5)Ni_(0.1)Mn_(0.1)c phase with a thickness of around 8–15μm were formed on the edge of the cast tungsten *** 45%irregular crushed fine cast tungsten carbide and 15%monocrystalline cast tungsten carbide were used as the skeleton,satisfactory comprehensive performance of the reinforced copper alloy composite bit matrix was obtained,with the bending strength,impact toughness and hardness reaching 1048 MPa,4.95 J/cm^(2) and 43.6 HRc,*** main wear mec.anism was that the tungsten carbide particles firstly protruded from the friction surface after the copper alloy matrix was worn,and then peeled off from the matrix when further wear occurred.

关键词： Polycrystalline diamond compact Pressureless vacuum infiltration copper alloy composite bit matrix Microstructure characterization Abrasive wear behavior

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Enhanced direct gaseous cO_(2) fixation into higher bio-succinic acid production and selectivity

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Journal of Environmental Sciences 2024年第9期143卷 164-175页

作者： Ziyi Yang Wanling Wu Qing Zhao Irini Angelidaki Samuel Gyebi Arhin Dongliang Hua Yuxiao Zhao Hangyu Sun Guangqing Liu wen Wang Biomass Energy and Environmental Engineering Research center Beijing University of Chemical TechnologyBeijing 100029China college of chemical Engineering Beijing University of Chemical TechnologyBeijing 100029China Department of chemical and Biochemical Environmental Engineering Technical University of DenmarkDK-2800Kgs LyngbyDenmark Energy Research Institute Qilu University of Technology(Shandong Academy of Sciences)Shandong Provincial Key Laboratory of Biomass Gasification TechnologyJinan 250014China

Utilizing cO_(2)for bio-succinic acid production is an attractive approach to achieve carbon capture and recycling(ccR)with simultaneous production of a useful platform *** succinogenes and Basfia succiniciproducens were selected and investigated as microbial ***,the type and concentration of inorganic carbon concentration and glucose concentration were evaluated.6 g c/L MgcO_(3)and 24 g c/L glucose were found to be the optimal basic operational conditions,with succinic acid production and carbon yield of over 30 g/L and over 40%,***,for maximum gaseous cO_(2)fixation,carbonate was replaced with cO_(2)at different ***“less carbonate more cO_(2)”condition of the inorganic carbon source was set as carbonate:cO_(2)=1:9(based on the mass of carbon).This condition presented the highest availability of cO_(2)by well-balanced chemical reaction equilibrium and phase equilibrium,showing the best performance with regarding cO_(2)fixation(about 15 mg c/(L·hr)),with suppressed lactic acid *** to key enzymes analysis,the ratio of phosphoenolpyruvate carboxykinase to lactic dehydrogenase was enhanced at high ratios of gaseous cO_(2),which could promote glucose conversion through the succinic acid *** further increase gaseous cO_(2)fixation and succinic acid production and selectivity,stepwise cO_(2)addition was evaluated.50%-65%increase in inorganic carbon utilization was obtained coupled with 20%-30%increase in succinic acid *** was due to the promotion of the succinic acid branch of the glucose metabolism,while suppressing the pyruvate branch,along with the inhibition on the conversion from glucose to lactic acid.

关键词： Succinic acid cO_(2) fixation Actinobacillus succinogenes Basfia succiniciproducens Lactic acid

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3D printed silicon-based micro-lattices with ultrahigh areal/gravimetric capacities and robust structural stability for lithium-ion batteries

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Nano Research 2024年第4期17卷 2693-2703页

作者： Jie Fu Dong Wang Yan Li Xianzheng Liu Rui Zhang Zhiyuan Liu Pengdong Liu Lijuan Zhang Xuefei Li Guangwu wen School of Materials Science and Engineering Shandong University of TechnologyZibo 255000China Shandong Si-Nano Materials Technology co. Ltd.Zibo 255000China

Nanostructured silicon anodes have shown extraordinary lithium storage properties for lithium-ion batteries(LIBs)but are usually achieved at low areal loadings(<1.5 mg·cm^(-2))with low areal *** sound electrochemical... 详细信息

Nanostructured silicon anodes have shown extraordinary lithium storage properties for lithium-ion batteries(LIBs)but are usually achieved at low areal loadings(cm^(-2))with low areal *** sound electrochemical performance at high loading requires proportionally higher ion/electron currents and robust structural stability in the thicker ***,we report a three-dimensional(3D)printed silicon-graphene-carbon nanotube(3D-Si/G/c)electrode for simultaneously achieving ultrahigh areal/gravimetric capacities at high mass *** periodically arranged vertical c.annels and hierarchically porous filaments facilitate sufficient electrolyte infiltration and rapid ion diffusion,and the carbonaceous network provides excellent electron transport properties and mec.anical integrity,thus endowing the printed 3D-Si/G/c electrode with fast electrochemical reaction kinetics and reversibility at high mass ***,the 3D-Si/G/c with high areal mass loading of 12.9 mg·cm^(-2) exhibits excellent areal capacity of 12.8 mAh·cm^(-2) and specific capacity of 1007 mAh·g^(-1),***-situ optical microscope and ex-situ scanning electron microscope(SEM)confirm that the hierarchically porous filaments with interconnected carbon skeletons effectively suppress the volume c.ange of silicon and maintain stable micro-lattice architecture.A 3D printed 3D-Si/G/c-1||3D-LiFePO_(4)/G full cell holds excellent cyclic stability(capacity retention rate of 78%after 50 cycles)with an initial coulombic efficiency(IcE)of 96%.This work validates the feasibility of 3D printing on constructing high mass loading silicon anode for practical high energy-density LIBs.

关键词： silicon anode areal capacity three-dimensional(3D)printing lithium-ion batteries

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Sulfur doped iron-nitrogen-hard carbon nanosheets as efficient and robust noble metal-free catalysts for oxygen reduction reaction in PEMFc

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Journal of Energy chemistry 2024年第2期89卷 422-433,I0010页

作者： Bin Liu Jiawang Li Bowen Yan Qi Wei Xingyu wen Huarui Xie Huan He Pei Kang Shen Zhi Qun Tian collaborative Innovation center of Sustainable Energy Materials School of Physical Science and TechnologyGuangxi UniversityGuangxi Key Laboratory of Electrochemical Energy MaterialsState Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite StructuresNanning 530004GuangxiChina

Transition metal-nitrogen-carbon(M-N-c)as a promising substitute for the conventional noble metalbased catalyst still suffers from low activity and durability for oxygen reduction reaction(ORR)in proton exc.ange membrane fuel cells(PEMFcs).To tackle the issue,herein,a new type of sulfur-doped ironnitrogen-hard carbon(S-Fe-N-Hc)nanosheets with high activity and durability in acid media were developed by using a newly synthesized precursor of amide-based polymer with Fe ions based on copolymerizing two monomers of 2,5-thiophene dicarboxylic acid(TDA)as S source and 1,8-diaminonaphthalene(DAN)as N source via an amination *** as-synthesized S-Fe-N-Hc features highly dispersed atomic Fe Nxmoieties embedded into rich thiophene-S doped hard carbon nanosheets filled with highly twisted graphite-like microcrystals,which is distinguished from the majority of M-N-c with soft or graphitic carbon *** unique characteristics endow S-Fe-N-Hc with high ORR activity and outstanding durability in 0.5 M H_(2)SO_(4).Its initial half-wave potential is 0.80 V and the corresponding loss is only 21 m V after 30,000 ***,its practical PEMFc performance is a maximum power output of 628.0 mW cm^(-2)and a slight power density loss is 83.0 m W cm^(-2)after 200-cycle practical ***,theoretical calculation shows that the activity of Fe Nxmoieties on ORR can be further enhanced by sulfur doping at meta-site near FeN_(4)*** results evidently demonstrate that the dual effect of hard carbon substrate and S doping derived from the precursor platform of amid-polymers can effectively enhance the activity and durability of Fe-N-c catalysts,providing a new guidance for developing advanced M-N-c catalysts for ORR.

关键词： Transition metal-nitrogen-carbon Oxygen reduction reaction Hard carbon Amide based polymer reaction Proton exc.ange membrane cells

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Lenvatinib combined with sintilimab plus transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma

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World Journal of clinical cases 2024年第2期12卷 285-292页

作者： Sha-Sha Sun Xiao-Di Guo wen-Dong Li Jing-Long chen Department of Oncology Capital Medical University Affiliated Beijing Ditan HospitalBeijing 100015China

BAcKGROUND Recently,combination therapy has shown a better trend towards improved tumour response and survival outcomes than monotherapy in patients with hepatocellular carcinoma(Hcc).However,research on triple therapy[lenvatinib+sintilimab+transarterial chemoembolization(TAcE)]as a first-line treatment for advanced Hcc is *** To evaluate the safety and efficacy of triple therapy as a first-line treatment for advanced *** Hcc patients with Barcelona clinic Liver cancer stage c treated with triple therapy were *** patients were treated with lenvatinib every day and sintilimab once every 3 ***,TAcE was performed every 4-6 wk if *** primary outcome of the study was overall survival(OS).The secondary outcomes were the objective response rate(ORR),disease control rate(DcR),and incidence of adverse *** Forty Hcc patients who underwent triple therapy were retrospectively analysed from January 2019 to January *** a median follow-up of 8.5 months,the 3-,6-,and 12-mo OS rates were 100%,88.5%,and 22.5%,*** ORR and DcR were 45%and 90%,*** median progressive free survival and median OS were not *** complications were observed in 76%of the patients(grade 3,15%;grade 4,2.5%).cONcLUSION combination therapy comprising lenvatinib,sintilimab and TAcE achieved promising outcomes in advanced Hcc patients and had manageable effects.

关键词： Lenvatinib Sintilimab Advanced hepatocellular carcinoma combination therapy Tumor response

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Role of savolitinib in advanced gastric adenocarcinoma with meningeal carcinomatosis and cerebellar metastasis:A case report

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World Journal of clinical cases 2024年第15期12卷 2636-2641页

作者： Zhi-Yun weng wen-Ye Huang Bin-Kan Shi Jian-Jia Pan Department of Hematology The Affiliated Yueqing Hospital of Wenzhou Medical UniversityYueqing 325600Zhejiang ProvinceChina

BAcKGROUND Brain metastases(BM)are very rare in gastric adenocarcinoma(Gac),and patients with BMs have a higher mortality rate due to stronger tumor ***,its pathogenesis remains *** testing revealed cellular-mesenchymal epithelial transition factor receptor(MET)***,treatment with savolitinib,a small molecule inhibitor of c-Met,was *** SUMMARY A 66-year-old woman was diagnosed with advanced Gac 6 months prior to presentation due to back *** and meningeal metastases were observed during candonilimab combined with oxaliplatin and capecitabine *** patient experienced frequent generalized seizures and persistent drowsiness in the emergency *** testing of cerebrospinal fluid and peripheral blood revealed increased MET *** discussing treatment options with the patient,savolitinib tablets were *** a month of treatment,the intrac.anial lesions shrank *** BM is very rare in advanced Gac,especially in meningeal cancer,that is characterized by rapid disease *** are very few effective treatment options available;however,technological breakthroughs in genomics have provided a basis for personalized ***,MET amplification may be a key driver of BM in gastric cancer;however,this conclusion requires further investigation.

关键词： cellular-mesenchymal epithelial transition factor receptor Savolitinib Meningeal carcinomatosis Gastric adenocarcinoma case report

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Quenching and flow of charm and bottom quarks via semi-leptonic decay of D and B mesons in Pb+Pb collisions at the LHc

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chinese Physics c 2024年第8期48卷 190-197页

作者： Shu-Qing Li wen-Jing Xing Shanshan cao Guang-You Qin School of Physics and Electronic Engineering Jining UniversityQufu 273155China Institute of Frontier and Interdisciplinary Science Shandong UniversityQingdao 266237China Institute of Particle Physics and Key Laboratory of Quark and Lepton Physics(MOE) Central China Normal UniversityWuhan 430079China

Heavy flavor particles provide important probes of the microscopic structure and thermodynamic properties of the quark-gluon plasma(QGP)produced in high-energy nucleus-nucleus *** studied the energy loss and flow of charm and bottom quarks inside the QGP via the nuclear modification factor(R_(AA))and elliptic flow coefficient(v_(2))of their decayed leptons in heavy-ion collisions at the *** dynamical evolution of the QGP was performed using the cLVisc(3+1)-dimensional viscous hydrodynamics model;the evolution of heavy quarks inside the QGP was simulated with our improved Langevin model that considers both collisional and radiative energy loss of heavy quarks;the hadronization of heavy quarks was simulated via our hybrid coalescence-fragmentation model;and the semi-leptonic decay of D and B mesons was simulated via *** the same spatial diffusion coefficient for charm and bottom quarks,we obtained smaller R_(AA) and larger v_(2) of charm decayed leptons than bottom decayed leptons,indicating stronger energy loss of charm quarks than bottom quarks inside the QGP within our current model setup.

关键词： quark-gluon plasma heavy-ion collisions jet quenching anisotropic flow heavy quark heavy flavor muon

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Ultracycles consisting of macrocycles

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chinese chemical Letters 2024年第5期35卷 183-188页

作者： wen-Hui Mi Teng-Yu Huang Yu-Fei Ao Xu-Dong Wang Qi-Qiang Wang De-Xian Wang Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of chinese Academy of Sciences Beijing 100049China

Presented here is a one-pot strategy starting from rationally designed macrocyclic precursors for the diverse construction of sophisticated *** type and amount of the base were found to significantly influence the macrocyclization *** use of 4.0 *** resulted in ultracycles of both types A and B while the presence of csF larger than 6.0 *** only type B *** of anion template increased the total yields and affected the distribution of the *** ultracycles can accommodate large organic dicarboxylates anions via multiple anion-πand hydrogen bonds,and show selectivity to the size-matched heptanedioate(c7^(2−)).Based on all possible species and relevant equilibrium constants as well as material and charge balances,a numerical iterative algorithm was developed and applied to fit the association constants of B2H with dicarboxylates from glutarate(c5^(2−))to oc.anedioate(c8^(2−)),which gave association constants up to 10^(3) L/mol.

关键词： Ultracycles Diversity-oriented synthesis Anion recognition Anion-πinteraction

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Observation of spectral lines in the exceptional GRB 221009A

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Science china(Physics,Mec.anics & Astronomy) 2024年第8期67卷 187-206页

作者： Yan-Qiu Zhang Shao-Lin Xiong Ji-Rong Mao Shuang-Nan Zhang Wang-chen Xue chao Zheng Jia-cong Liu Zhen Zhang Xi-Lu Wang Ming-Yu Ge Shu-Xu Yi Li-Ming Song Zheng-Hua An ce cai Xin-Qiao Li wen-Xi Peng wen-Jun Tan chen-Wei Wang Xiang-Yang wen Yue Wang Shuo Xiao Fan Zhang Peng Zhang Shi-Jie Zheng Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of chinese Academy of Sciences Beijing 100049China Yunnan Observatories Chinese Academy of SciencesKunming 650011China center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100012China Key Laboratory for the Structure and Evolution of celestial Objects Chinese Academy of SciencesKunming 650216China college of Physics and Hebei Key Laboratory of Photophysics Research and Application Hebei Normal UniversityShijiazhuang 050024China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China college of Electronic.and Information Engineering Tongji UniversityShanghai 201804China

As the brightest gamma-ray burst ever observed,GRB 221009A provided a precious opportunity to explore spectral line *** this article,we performed a comprehensive spectroscopy analysis of GRB 221009A jointly with GEcAM-c.and Fermi/GBM data to search for emission and absorption *** the first time we investigated the line feature throughout this GRB including the most bright part where many instruments suffered problems,and identified prominent emission lines in multiple time *** central energy of the Gaussian emission line evolves from about 37 to 6 MeV,with a nearly constant ratio(about 10%)between the line width and central ***,we find that both the central energy and the energy flux of the emission line evolve with time as a power law decay with power law index of–1 and–2,*** suggest that the observed emission lines most likely origin from the blue-shifted electron positron pair annihilation 511 ke V *** find that a standard high latitude emission scenario cannot fully interpret the observation,thus we propose that the emission line comes from some dense clumps with electron positron pairs traveling together with the *** this scenario,we can use the emission line to directly,for the first time,measure the bulk Lorentz factor of the jet(Γ)and reveal its time evolution(i.e.,Γ~t^(-1))during the prompt ***,we find that the flux of the annihilation line in the co-moving frame keeps *** discoveries of the spectral line features shed new and important lights on the physics of GRB and relativistic jet.

关键词： GRB GRB 221009A emission line

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