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Structure of the Phytoplankton Community and Its Relationship to Water Quality in Donghu Lake, Wuhan, China

Journal of Integrative Plant Biology 2005年第1期47卷 27-37页

作者： an-pinglei Zhang-LiHU JianWANG Zhi-XinSHI Fung-YeeNoraTAM CollegeofLifeSciences ShenzhenUniversityShenzhen518060China InstituteofHydrobiology theChineseAcademyofSciencesWuhan430072China DepartmentofBiologyandChemistry CityUniversityofHongKongHongKongChina

: The phytoplankton community structure, in terms of species composition, total standing crop, and abundance of the dominant algal species, at four stations in Donghu Lake, Wuhan, China, was investigated monthly from January 1994 to December 1996. A total of 260 taxa was observed, of which Chlorophyta (106 taxa) contributed the highest portion of the total number of taxa, followed by Bacillariophyta (82 taxa) and Cyanophyta (32 taxa). The total standing crop measured by means of chlorophyll a content, cell density, and cell biovolume, as well as the abundance of the dominant species, declined in the order of Station I to Station IV. Seasonal changes of the standing crop varied greatly among the four stations. Although the cell density at the four stations showed a single peak within a year, the peak density varied from July to November, dependent on the sampling year and the station. For chlorophyll a content and cell biovolume, multiple peaks were observed at Stations I and II, but a single peak was found at Stations III and IV. The phytoplankton community structure indicated that the trophic status was the highest at Station I (most eutrophic), followed by Station II; Stations III and IV were the least trophic areas. The long-term changes in phytoplankton community structure further suggested that changes in phytoplankton community structure were correlated with water quality, and eutrophication of Donghu Lake had been aggravated since the 1950s.

关键词： dominant groups eutrophication Donghu Lake phytoplankton species composition standing crop

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The Inhibitory Effects of Mouse ICOS-Ig Gene-Modified Mouse Dendritic Cells on T Cells

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Cellular & Molecular Immunology 2004年第2期1卷 153-157页

作者： GuohuaWang LijuanZhu PingHu HuifenZhu pinglei WenjunLiao BingYu FeiliGong GuanxinShen InstituteofBiochemistryandMolecularBiology HubeiUniversityWuhan430062China DepartmentofImmunology TongjiMedicalCollegeofHuazhongUniversityofScienceandTechnologyWuhan430030China

The main approach to reduce graft rejection has been focused on the development of immunosuppressive agents at *** these strategies have reportedly reduced graft rejection,there has been a reciprocal increase in more severe immunosuppression and lethal infections,as well as severe side *** of costimulatory T cell response has been proved as one of useful strategies to reduce graft ***, it has been shown that infusion of dendritic cells(DCs)with a potent negative regulatory ability for T cells could prolong allograft *** this study mouse DCs(mDCs)were transfected with the recombinant plasmid pcDNA3.0 containing mouse inducible costimulator-Ig(mICOS-Ig) cDNA by *** transient expression of mICOS-Ig in mDC could be detected by ELISA and *** ICOS-Ig fusion protein expressed in mDC and mICOS-Ig gene-modified mDC could inhibit lymphocyte proliferation in mixed lymphocyte culture(MLC)in ***,mICOS-Ig gene-modified mDC could inhibit lymphocyte proliferation in recipient *** results suggested that mICOS-Ig gene-modified mDC exerted inhibitory effects on T cells,and might be suitable for treatment or prevention of graft rejection and immunopathologic *** & Molecular Immunology.2004;1(2):153-157.

关键词： dendritic cell inducible costimulator mixed lymphocyte culture

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Eocene Basins on the SE Tibetan Plateau: Markers of Minor Offset along the Xuelongshan–Diancangshan–Ailaoshan Structural System

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Acta Geologica Sinica(English Edition) 2020年第4期94卷 1020-1041页

作者： LIAO Cheng YANG Tiannan XUE Chuandong LIANG Mingjuan XIN Di XIANG Kun JIANG Lili SHI Pengliang ZHU Wenbin WAN Liangchun TANG Jing YU Jing WU pinglei Key Laboratory of Deep–Earth Dynamics of Ministry of Natural Resources Institute of GeologyChinese Academy of Geological SciencesBeijing 100037China School of Earth and Space Sciences Peking UniversityBeijing 100871China Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming 650093China China University of Geosciences Beijing 100083China

The offset of geological bodies provides robust evidence of displacement along a fault or ductile shear zone. The amount of displacement along the Xuelongshan–Diancangshan–Ailaoshan structural system, southeastern Tibetan Plateau, is uncertain because of the lack of offset geological markers. This NNW–SSE-trending system is developed in three isolated metamorphic complexes and interjacent nonmetamorphosed rocks. They are expected to record similar post-Eocene strain, although their structural patterns should be distinct. Geological mapping in the area between the Xuelongshan and Diancangshan metamorphic complexes has revealed a small Eocene basin, the Madeng Basin, located to the west of the structural system. The sedimentary and volcanic successions of the Madeng Basin are comparable to those of the Jianchuan Basin, which is located to the east of the structural system. Zircon U–Pb geochronological and bulk geochemical data demonstrate that the volcanic rocks of both basins formed during 37–34 Ma and share the same geochemical features. These data suggest that the Madeng and Jianchuan basins previously constituted a single basin, with the distribution of high-K volcanic rocks in the basins defining an ENE–WSW-trending volcanic belt that shows a limited dextral offset of ≤20 km across the Xuelongshan–Diancangshan–Ailaoshan structural system. Therefore, the northern segment of the structural system records no evidence of large-scale lateral movement/displacement. The results suggest that the Indochina block, which is bounded by the Xuelongshan–Diancangshan–Ailaoshan structural system to the east and the Sagaing Fault to the west, has not extruded southward as a whole but rather has been deformed by pervasive crustal shortening.

关键词： offset marker Eocene basin Xuelongshan–Diancangshan–Ailaoshan structural system southeastern Tibetan Plateau India–Eurasia collision

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Human scFv antibody fragments specific for hepatocellular carcinoma selected from a phage display library

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World Journal of Gastroenterology 2005年第26期11卷 3985-3989页

作者： BingYu MingNi Wen-HanLi pinglei WeiXing Dai-WenXiao YuHuang Zhen-JieTang Hui-FenZhu Guan-XinShen DepartmentofImmunology TongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyWuhan430030HubeiProvinceChina DepartmentofInfectiousDiseases TongjiHospitalTongjiMedicalCollegeHuazhongUniversityofScienceandTechnologyWuhan430030HubeiProvinceChina

AIM:To identify the scFv antibody fragments specific for hepatocellular carcinoma by biopanning from a large human naive scFv phage display library. METHODS: A large human naive scFv phage library was used to search for the specific targets by biopanning with the hepatocellular carcinoma cell line HepG2 for the positive-selecting and the normal liver cell line L02 for the counter-selecting. After three rounds of biopanning, individual scFv phages binding selectively to HepG2 cells were picked out. PCR was carried out for identification of the clones containing scFv gene sequence. The specific scFv phages were selected by ELISA and flow cytometry. DMA sequences of positive clones were analyzed by using Applied Biosystem Automated DNA sequencers 3 730. The expression proteins of the specific scFv antibody fragments in *** HB2151 were purified by the affinity chromatography and detected by SDS-PAGE, Western blot and ELISA. The biological effect of the soluble antibody fragments on the HepG2 cells was investigated by observing the cell proliferation. RESULTS: Two different positive clones were obtained and the functional variable sequences were identified. Their DNA sequences of the scFv antibody fragments were submitted to GenBank (accession nos: AY686498 and AY686499). The soluble scFv antibody fragments were successfully expressed in *** HB2151. The relative molecular mass of the expression products was about 36 ku, according to its predicted M, value. The two soluble scFv antibody fragments also had specific binding activity and obvious growth inhibition properties to HepG2 cells. CONCLUSION: The phage library biopanning permits identification of specific antibody fragments for hepatocellular carcinoma and affords experiment evidence for its immunotherapy study.

关键词： ScFv Biopanning HCC IMAC Phage display

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Can HB vaccine yield a booster effect on individuals with positive serum anti-HBs and anti-HBc markers?

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World Journal of Gastroenterology 2004年第2期10卷 306-308页

作者： Ru-XiangWang YingGuo Chang-HongYang YuSong JuanChen Fu-ShengPang Shao-pinglei Xiao-MingJia Jin-YingWen ChristinaY.Shi ShenyangCenterforDiseaseControlandPrevention Shenyang110031LiaoningProvinceChina DonglingDistrictAnti-epidemicStation DonglingDistrictShenyang110015LiaoningProvinceChina LiaoningCenterforDiseaseControlandPrevention Shenyang110003LiaoningProvinceChina HospitalofInstituteofShenyangElectricityPower Shenyang110031LiaoningProvinceChina No.2HospitalofChinaMedicalUniversity Shenyang110004LiaoningProvinceChina Shenyang6-06Hospital Shenyang110015LiaoningProvinceChina Vita-TechCanada 1345DenisonStreetMarkhamOntarioCanadaL3R5V2

AIM:To evaluate if HB vaccination can yield a booster effect on the anti-HBs level of those naturally acquired HBV positive ***:Sera were collected from 1399 newly enrolled university students aged between 18-20 years at the entrance medical examination in ***-four students (28 males and 16 females) with positive serum anti-HBs and anti-HBc markers served as an observation group and another 44 students (24 males and 20 females) without any HBV markers as the control. HB vaccination was given to all the students without positive serum HBsAg according to 0,1, 6 month regimen and the peripheral venous blood was sampled from those of both observation and control groups for anti-HBs detection one month after the second and third ***-HBs levels were measured by ***:The seroconversion rate of anti-HBs in the control group was 100% after the second dose,but the geometric mean titers (GMTs) were *** tendency of serum anti-HBs changes after the 3^rd dose was completely different between the two *** more than half of those with positive anti-HBs and anti-HBc showed a mild increase of anti-HBs levels after the 2na boosting dose (mean antiHBs level was 320:198 mIU),but the increase of serum anti-HBs titer was much smaller than that in the control *** averages of their initial serum anti-HBs levels and the levels after the 2^nd and 3^rd doses were 198, 320 and 275 mIU respectively. All the subjects from the control group had an obvious increase in their serum anti-HBs levels which was nearly 4 times the baseline level (302:78 mIU).CONCLUSION: HB vaccination can not enhance anti-HBs levels in those with positive serum anti-HBs and anti-HBc markers.

关键词：乙型病毒性肝炎血清标志物乙肝表面抗原乙肝表面抗体酶联免疫吸附法

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Is a low dose of hepatitis B vaccine enough for a rapid vaccination scheme?

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World Journal of Gastroenterology 2003年第10期9卷 2353-2355页

作者： Ru-XiangWang GreetBoland YingGuo Shao-pinglei Chang-HongYang JuanChen JieTian Jin-YingWen Ke-HongDu JanvanHattum GijsbertC.deGast ShenyangCenterforDiseaseControlandPrevention Shenyang110031LiaoningProvinceChina DepartmentofGastroenterology UniversityHospitalUtrechtNetherlands HospitalofInstituteofShenyangElectricityPower Shenyang110031LiaoningProvinceChina DonglingDistrictAnti-epidemicStation DonglingDistrictShenyang110031LiaoningProvinceChina ShenyangNo.4Hospital Shenyang110031LiaoningProvinceChina Shenyang606Hospital Shenyang110031LiaoningProvinceChina ShenzhenKangtaiBiologicalProductsCompany Shenzhen518000GuangdongProvinceChina NetherlandsCancerInstitute AmsterdamNetherlands

AIM: To determine whether or not a low dose of HB vaccine can be effectively used in the rapid ***: Rapid vaccination (0, 1, 2 months) with low dose (5 μg) or routine dose (10 μg) HB vaccine was studied in 250 subjects (130 school children and 120 university students). Serum from all the participants was tested for HBsAg, anti-HBs and anti-HBc at 1, 3 and 7 months after the first dose of vaccination and all subjects were serum HBV marks negative before the vaccination. Non-responders to a complete initial vaccination from university students were given an additional vaccination with 10 μg of HB vaccine and their serum anti-HBs was tested again one month ***: One month after the third dose of vaccination (third month) sero-conversion rates and geometric mean titer (GMTs) were significantly (P＜0.01) higher in the routine dose (resp. 89 % and 106.8) than in the low dose group (resp. 72 % and 59.5). Sero-conversion rates and GMTs were maintained stable for another 4 months in both *** an additional vaccination to non-responders with 10 μg HB vaccine, 17/23 subjects (13/15 from those vaccinated with 5 μg vaccine and 4/8 from those vaccinated with 10 μg vaccine) became anti-HBs positive, yielding similar seroconversion rates for both dose ***: Higher sero-conversion rates and GMTs were reached in those vaccinated with 10 μg HB vaccine than in those vaccinated with 5 μg HB vaccine after a comp^te vaccination with a 0, 1, 2 month scheme. But the subjects vaccinated with 5 μg vaccine can also reach the similar sero-conversion rate after an additional vaccination.

关键词：乙型肝炎病毒乙肝疫苗剂量免疫接种乙型肝炎

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基于知识增强对比学习的长尾用户序列推荐算法

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通信学报 2024年第6期45卷 210-222页

作者：任永功周平磊张志鹏辽宁师范大学计算机与人工智能学院辽宁大连116029

序列推荐根据目标用户的历史交互序列,预测其可能感兴趣的下一个物品。现有的序列推荐方法虽然可以有效捕获用户的历史交互序列中的长期依赖关系,但是无法为交互序列较短且用户数量庞大的长尾用户提供精确推荐。为了解决此问题,提出了... 详细信息

序列推荐根据目标用户的历史交互序列,预测其可能感兴趣的下一个物品。现有的序列推荐方法虽然可以有效捕获用户的历史交互序列中的长期依赖关系,但是无法为交互序列较短且用户数量庞大的长尾用户提供精确推荐。为了解决此问题,提出了一种基于知识增强对比学习的长尾用户序列推荐算法。首先,基于知识图谱中的丰富实体关系信息,构建一个基于语义的物品相似度度量,分别提取原始序列中物品的协同关联物品。然后,基于不同学习序列提出2种序列增强算子,通过增强自监督信号解决长尾用户序列训练数据不足的问题。最后,通过对比自监督任务和推荐主任务的网络参数共享的联合训练,为长尾用户提供更精确的序列推荐结果。在实际数据集上的实验结果表明,所提算法可以有效提高针对长尾用户的序列推荐精度。

关键词：序列推荐长尾用户知识图谱对比学习

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颠覆性创新视角下广西瞪羚企业创新能力的提升研究

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桂林航天工业学院学报 2022年第4期27卷 501-509页

作者：徐平磊桂林航天工业学院管理学院广西桂林541004

瞪羚企业是区域经济发展的新动能。然而,受经济发展水平和资源条件限制,广西瞪羚企业整体的创新基础薄弱、创新资源少,难以利用扶持政策和外部资本进行创新。颠覆性创新理论为瞪羚企业提升创新能力提供了新的发展路径。文章通过梳理企... 详细信息

瞪羚企业是区域经济发展的新动能。然而,受经济发展水平和资源条件限制,广西瞪羚企业整体的创新基础薄弱、创新资源少,难以利用扶持政策和外部资本进行创新。颠覆性创新理论为瞪羚企业提升创新能力提供了新的发展路径。文章通过梳理企业进行颠覆性创新的内在逻辑和影响因素,分析广西瞪羚企业运用颠覆性创新理论进行创新能力提升的优势和劣势、外部环境中的机会和威胁,应用态势分析方法(SWOT)提出广西瞪羚企业创新能力提升的对策。

关键词：瞪羚企业颠覆性创新创新能力

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印度和美国的创业教育模式对比与中国的创业教育对策

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中国高教研究 2006年第9期 45-46,47-48页

作者：陈浩凯徐平磊长沙理工大学长沙理工大学管理学院硕士研究生湖南长沙410076

通过对比美国和印度部分大学的创业教育模式、创业影响因素和创业教育效果,找出两国创业教育相通之处和差异所在,并从战略角度分析了其中的原因。在此基础上,从我国高校创业教育发展中的问题入手,得出在课程设置、产学研结合、评估机构... 详细信息

通过对比美国和印度部分大学的创业教育模式、创业影响因素和创业教育效果,找出两国创业教育相通之处和差异所在,并从战略角度分析了其中的原因。在此基础上,从我国高校创业教育发展中的问题入手,得出在课程设置、产学研结合、评估机构方面的几点建议和措施,以期对我国借鉴国外经验发展创业教育和解决创业教育中现存问题有所启示。

关键词：印度与美国创业教育对比中国创业教育对策

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基于Pro/E软件设计中不规则表面上阵列的研究

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机械工程师 2017年第5期 83-85页

作者：祝平蕾中山市技师学院广东中山528429

在不规则表面的上使用Pro/E软件绘制相同或相似特征形状时直接使用阵列不易达到所需效果,针对不规则表面上的阵列问题进行了研究,文中阐述了设计中常见的两种形状的阵列方法,为同类产品设计提供参考与借鉴。

关键词： Pro/E 不规则表面阵列

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