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Chinese Chemical Letters 2024年第6期35卷 502-506页

作者： Chaozheng He Pei Shi Donglin Pang Zhanying Zhang long lin Yingchun Ding Department of Chemistry and Chemical Engineering Liaocheng UniversityLiaocheng 252059China Henan Key Laboratory of Materials on Deep-Earth Engineering School of Materials Science and EngineeringHenan Polytechnic UniversityJiaozuo 454000China School of Materials Science and Engineering Henan Polytechnic UniversityJiaozuo 454000China Department of Basic Medicine North Sichuan Medical CollegeNanchong 637000China

Single atom catalysts(SACs)have been in the forefront of catalysts research because of their high efficiency and low cost and provide new ideas for development of renewable energy conversion and storage ***,the relationship between the intrinsic properties of materials such as lattice thermal conductivity and catalysis remains to be *** this work,the lattice thermal conductivity of BN and graphene was calculated by Sheng *** addition,the adsorption properties of 3d-TM(TM=V,Cr,Mn,Fe,Co,Ni)on BN and graphene were investigated using first-principles methods,and it was found that Ni atom can form relatively stable SACs compared to other *** molecular dynamics(MD)simulation and migration barrier of Ni loaded on BN and graphene were *** study found that graphene has higher thermal conductivity and is easier to form SACs than BN,but the SACs formed on BN surface have higher thermodynamic stability.

关键词： First-principles calculation Thermal conductivity Single atom catalysts Graphene BN

Relationship between dietary niacin intake and erectile dysfunction:a population-based study

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Asian Journal of Andrology 2024年第4期26卷 382-388页

作者： Wei-long lin Cheng Zheng Hao-Xu Wang Wei Zhang Ming-En lin Department of Urology The First Affiliated Hospital of Shantou University Medical CollegeMedical College of Shantou UniversityShantou 515041China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510260China.

Existing research on the precise link between dietary niacin intake and erectile dysfunction(ED)is ***,this study aimed to investigate the potential association between dietary niacin intake and the risk of *** logistic regression and restricted cubic splines(RCSs)were used to examine the relationship between dietary niacin intake and *** interaction analysis was performed to assess the impact of different subgroups on the study *** addition,1:1 propensity score matching(PSM)was employed to adjust for potential confounding factors,ensuring the reliability of the *** analyzed data were collected from the 2001–2004 National Health and Nutrition Examination Survey(NHANES)in the *** study encompassed 3184 adults,among whom 863 participants were identified as having *** adjustments for potential confounders,the findings revealed that higher niacin intake,specifically in the highest tertile,was associated with a decreased risk of ED compared to that in the lowest tertile,showing an odds ratio(OR)of 0.56(95%confidence interval[CI]:0.37–0.85).Analysis of dose–response curves illustrated a negative correlation between dietary niacin intake and the risk of *** and interaction analyses fortified the consistency of these ***,PSM corroborated the validity of the *** study suggests an inverse association between dietary niacin intake and the risk of ***,establishing a cause-and-effect relationship remains elusive,and defining the safe threshold of niacin intake to prevent ED requires further investigation.

关键词： dietary niacin erectile dysfunction National Health and Nutrition Examination Survey propensity score matching

RIOK1 synergizes with TRIP13 by regulating the E2F-Rb signaling pathway to promote the proliferation of esophageal cancer cells

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Genes & Diseases 2024年第3期11卷 55-58页

作者： Chengyu Li Deyuan Pan Wan lin Danxia Deng Yingxin Zhou Hui Zhao Feng Pan Liyan Xu Enmin Li lin long The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area Department of Biochemistry and Molecular BiologyShantou University Medical CollegeShantouGuangdong 515041China Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology Institute of Oncologic PathologyShantou University Medical CollegeShantouGuangdong 515041China Institute of Basic Medical Science Cancer Research CenterShantou University Medical CollegeShantouGuangdong 515041China Clinical Research Center Shantou Central HospitalShantouGuangdong 515041China

Esophageal cancer is one of the leading causes of cancer death in the world,with approximately half of the new cases occurring in China every year.^(1)Esophageal squamous cell carcinoma(ESCC)is the main subtype,accounting for more than 90%,and the five-year survival rate is less than 10%.Using large-scale genome analysis,many driver mutations and key pathways associated with ESCC have been ***,these genomic signatures have not improved the clinical management of EscC patients,or established effective targeted therapy.^(2)Esophageal cancer still lacks representative molecular markers.

关键词： cancer esophageal Esophageal

Study on psychological resilience and associated influencing factors in lung cancer patients with bone metastases

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World Journal of Psychiatry 2024年第9期14卷 1326-1334页

作者： Chao-Fan Guo Li-Li Wu Zhong-Zhong Peng Hua-long lin Jie-Ni Feng Department of Orthopedics The Third Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325200Zhejiang ProvinceChina Department of Medical Oncology The Third Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325200Zhejiang ProvinceChina Department of Medical Oncology Ningbo Hangzhou Bay HospitalNingbo 315336Zhejiang ProvinceChina

BACKGROUND Evaluating the psychological resilience of lung cancer(LC)patients helps understand their mental state and guides future ***,there is limited research on the psychological resilience of LC patients with bone *** To explore the psychological resilience of LC patients with bone metastases and identify factors that may influence psychological *** LC patients with bone metastases who met the inclusion criteria were screened from those admitted to the Third Affiliated Hospital of Wenzhou Medical *** psychological scores of the enrolled patients were *** were then grouped based on the mean psychological score:Those with scores lower than the mean value were placed in the low-score group and those with scores equal to or greater than the mean value was placed in the high-score *** baseline data(age,gender,education level,marital status,residence,monthly income,and religious beliefs),along with self-efficacy and medical coping mode scores,were *** This study included 142 LC patients with bone metastases admitted to our hospital from June 2022 to December 2023,with an average psychological resilience score of 63.24±9.96 *** grouping,the low-score group consisted of 69 patients,including 42 males and 27 females,with an average age of 67.38±9.55 *** high-score group consisted of 73 patients,including 49 males and 24 females,with a mean age of 61.97±5.00 years.χ2 analysis revealed significant differences between the two groups in education level(χ2=6.604,P=0.037),residence(χ2=12.950,P=0.002),monthly income(χ2=9.375,P=0.009),and medical coping modes(χ2=19.150,P=0.000).Independent sample t-test showed that the high-score group had significantly higher self-efficacy scores(t=3.383,P=0.001)and lower age than the low-score group(t=4.256,P<0.001).Furthermore,multivariate logistic regression hazard analysis confirmed that self-efficacy is an independent protective factor for psy

关键词： Lung cancer Bone metastases Psychological resilience Influencing factors Clinical evaluation

载药微球对比传统化疗栓塞治疗分支门脉癌栓肝癌的临床研究

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介入放射学杂志 2024年第6期33卷 616-622页

作者：周腾超龙林孙林龙瑶湖南师范大学附属第一医院(湖南省人民医院)介入血管外科湖南长沙410002

目的对比不同经导管动脉内化疗栓塞(TACE)方式应用于分支门脉癌栓(PVTT)肝细胞癌(HCC)患者的疗效及安全性。方法回顾性纳入自2019年12月至2022年8月符合纳排标准的122例有分支PVTT的HCC患者,根据不同的TACE方式分为载药微球组(DEB-TACE... 详细信息

目的对比不同经导管动脉内化疗栓塞(TACE)方式应用于分支门脉癌栓(PVTT)肝细胞癌(HCC)患者的疗效及安全性。方法回顾性纳入自2019年12月至2022年8月符合纳排标准的122例有分支PVTT的HCC患者,根据不同的TACE方式分为载药微球组(DEB-TACE)和传统TACE组(cTACE)。通过比较两组患者术后并发症、疼痛来评估两者的安全性。比较两组患者术后1个月的肿瘤反应率、术后的无进展生存时间(PFS)和总体生存时间(OS),探究哪一种TACE方式对有分支PVTT的HCC患者疗效更优。结果两组的术后疼痛分级和并发症发生率基本无差异。TACE后1个月,DEB-TACE组的ORR(P=0.033)及DCR(P=0.096)优于cTACE组。DEB-TACE组和c TACE组的中位PFS分别为10.5个月及6.4个月(P=0.003),中位OS为19.3个月及16.8个月(P=0.019)。结论TACE应用于分支PVTT的HCC患者是有效、安全的,DEB-TACE的术后疗效优于c TACE。为提高这部分患者的预后,我们更应该推荐DEBTACE作为初次介入治疗的方式。

关键词：经导管动脉内化疗栓塞载药微球碘油分支门脉癌栓疗效

Mex-3 RNA binding family member A(MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2091-2103页

作者： Ri-Xin Chen Shui-Dan Xu Min-Hua Deng Shi-Hui Hao Jie-Wei Chen Xiao-Dan Ma Wei-Tao Zhuang Jing-Hua Cao Yong-Rui Lv Jin-long lin Si-Yu Li Gui-Bin Qiao Dan Xie Feng-Wei Wang Department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Medical Research Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060China

RNA-binding proteins(RBPs)-RNA networks have contributed to cancer *** RNAs(circRNAs)are considered as protein recruiters;nevertheless,the patterns of circRNA-protein interactions in colorectal cancer(CRC)are still *** bodies(PBs)formed through liquid-liquid phase separation(LLPS)are membrane-less organelles(MLOs)consisting of RBPs and *** evidence suggests a connection between PBs dynamics and cancer *** the increasingly acknowledged crucial role of RBPs and RNA in the accumulation and maintenance of MLOs,there remains a lack of specific research on the interactions between PBs-related RBPs and circRNAs in ***,we identify that MEX-3 RNA binding family member A(MEX3A),frequently upregulated in CRC tissues,predicts poorer patient *** MEX3A accelerates malignance and inhibits autophagy of CRC ***,MEX3A undergoes intrinsically disordered regions(IDRs)-dependent LLPS in the ***,circMPP6 acts as a scaffold to facilitate the interaction between MEX3A and PBs *** MEX3A/circMPP6 complex modulates PBs dynamic and promotes UPF-mediated phosphodiesterase 5A(PDE5A)mRNA degradation,consequently leading to the aggressive properties of CRC ***,CRC patients exhibiting high MEX3A expression and low PDE5A expression have the poorest overall *** findings reveal a collaboration between MEX3A and circMPP6 in the regulation of mRNA decay through triggering the PBs aggregation,which provides prognostic markers and/or therapeutic targets for CRC.

关键词： colorectal inhibiting MPP

考虑二次受力的UHPC加固RC墩偏压极限承载力

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工程力学 2024年第7期41卷 212-225页

作者：夏樟华王明鎏林上顺林龙镁黎雅乐福州大学土木工程学院福建福州350108 福建省土木工程新技术与信息化重点试验室(福建工程学院) 福建福州350118 江苏开放大学建筑工程学院江苏南京210036

为揭示考虑二次受力UHPC加固桥墩偏压受力的损伤机理和极限状态,设计制作了UHPC加固RC墩和未加固墩构件,并进行了相应的试验研究和理论分析,并与未加固墩进行了比较。开展了考虑二次受力的UHPC增大截面法加固RC桥墩的小偏压试验,研究了... 详细信息

为揭示考虑二次受力UHPC加固桥墩偏压受力的损伤机理和极限状态,设计制作了UHPC加固RC墩和未加固墩构件,并进行了相应的试验研究和理论分析,并与未加固墩进行了比较。开展了考虑二次受力的UHPC增大截面法加固RC桥墩的小偏压试验,研究了不同初始受力条件下加固墩的破坏模式和极限承载力。结合有限元模型讨论了UHPC抗压强度、加固层的厚度和配筋率对极限承载力的影响。根据极限状态下的受力特性和平衡关系,推导了UHPC加固RC墩偏压极限承载力计算公式。结果表明:UHPC搭配钢筋网加固墩小偏压承载力与未加固墩相比,提升幅度达到了183%以上。UHPC强度对试件极限承载力的影响较大,UHPC厚度增大对加固试件承载力提高也较明显,加固层配筋率对构件承载力的提高影响较小。初始荷载的增大会降低原墩的混凝土利用率,降低加固墩的极限承载力。所提出考虑二次受力公式的计算承载力与实测值误差在3%之内,与有限元计算值误差在8%之内,具有较高的计算精度。研究结果可以为UHPC加固RC墩偏压承载力计算提供理论依据。

关键词：桥墩 UHPC加固二次受力偏压极限承载力

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基于广义改进分解策略的多目标代理优化方法

控制与决策 2024年第6期39卷 1829-1839页

作者：林成龙马义中肖甜丽南京理工大学经济管理学院南京210094

为解决多目标代理优化方法中代理模型选择单一问题,提出基于广义改进函数分解策略的多目标代理优化方法.该方法充分利用模型预测信息构建广义改进多目标分解准则和广义改进R2指标准则,有效拓展多目标代理优化中代理模型的选择空间.所提... 详细信息

为解决多目标代理优化方法中代理模型选择单一问题,提出基于广义改进函数分解策略的多目标代理优化方法.该方法充分利用模型预测信息构建广义改进多目标分解准则和广义改进R2指标准则,有效拓展多目标代理优化中代理模型的选择空间.所提两种准则通过随机均匀权重实现全局探索和局部搜索能力的自适应平衡.研究结果表明,所提方法在有限仿真条件下拥有良好的寻优性能,获得Pareto前沿在收敛性、多样性及空间分布性方面均具有一定优势.相比同类方法,该方法具有优势:(1)不需要模型预测不确定性信息,适用于基于不同种类代理模型的代理优化方法;(2)实现简单且计算复杂度低,能够有效提升昂贵黑箱问题优化效率.

关键词：昂贵多目标优化代理模型多目标代理优化方法广义改进多目标分解准则广义改进R2指标准则

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政府还贷高速公路前期工作研究与分析

广东公路交通 2024年第3期50卷 74-80页

作者：林龙广东省南粤交通投资建设有限公司广东广州510623

2012年以来,广东省政府还贷高速公路实现跨越式发展,在行政审批、投融资、工可研究等方面积累的诸多成功经验尚未系统梳理,同时随着高速公路行业发展形势的变化,目前行业发展又面临着一些困难和挑战,本文旨在总结梳理过去的前期工作经验... 详细信息

2012年以来,广东省政府还贷高速公路实现跨越式发展,在行政审批、投融资、工可研究等方面积累的诸多成功经验尚未系统梳理,同时随着高速公路行业发展形势的变化,目前行业发展又面临着一些困难和挑战,本文旨在总结梳理过去的前期工作经验,并针对存在问题提出解决思路,为后续政府还贷高速公路建设提供参考。

关键词：政府还贷高速公路前期工作投融资

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对生态补偿纳入耕地占补平衡的思考

甘肃农业 2024年第8期 96-101页

作者：林龙福建农林大学公共管理与法学院福州350000

将生态补偿纳入耕地占补平衡不仅能为农村生态环境安全提供重要保障,也能为农业可持续发展奠定坚实基础,且有利于实现耕地占补平衡区域之间利益均衡。然而,现有的占补平衡主要体现在数量和质量上的平衡,并未充分考虑生态功能平衡问题。... 详细信息

将生态补偿纳入耕地占补平衡不仅能为农村生态环境安全提供重要保障,也能为农业可持续发展奠定坚实基础,且有利于实现耕地占补平衡区域之间利益均衡。然而,现有的占补平衡主要体现在数量和质量上的平衡,并未充分考虑生态功能平衡问题。因此,应当明确将补充耕地生态保护成本与对补充耕地生态损害的补偿纳入占补平衡生态补偿的范围,设立生态保护专项基金为生态损害补偿提供资金保障,同时建立耕地碳汇交易制度,以促进耕地占补平衡生态补偿方式多元化。此外,应加强对耕地占补平衡生态补偿工作的监督,并明确耕地占补平衡生态损害的追责主体。

关键词：耕地占补平衡生态补偿