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Light-induced stepped thermal relaxation in a Hofmann-type metal-organic framework

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Science China Chemistry 2024年第6期67卷 1983-1989页

作者： Wen Cui Wei-Wei wu Ze-Yu Ruan Yan-Cong Chen Guang-Jun Zeng Guan-Xi Chen Si-guo wu Zhao-Ping Ni Ming-Liang Tong Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of ChemistryInstitute of Green Chemistry and Molecular EngineeringGuangdong Basic Research Center of Excellence for Functional Molecular EngineeringSun Yat-sen UniversityGuangzhou510275China

Spin-crossover(SCO)materials with light-induced multistability have potential applications in multi-addressable opto-magnetic memory devices and multiple ***,we reported a three-dimensional Hofmann-type metal-organic framework(MOF)[Fe(bpy){Pt(CN)_(4)}]·coumarin(1·coumarin,bpy=4,4′-bipyridine),which exhibits an incomplete and hysteretic SCO *** importantly,the light-induced stepped thermal relaxation(LISTR)with obvious magnetic plateau for a hidden intermediate spin state is firstly *** hidden spin state is also observed for the first time in the thermal relaxation after light-assisted spin state annealing(LASSA).Meanwhile,an extremely rare bi-directional light-induced excited spin-state trapping(LIESST)with the highest reverse-LIESST temperature is ***,five spin states can be captured in 1·coumarin and the tristability can be modulated below 102 K through the excitation-relaxation ***,the light-and temperatureinduced multistability provides a new strategy for developing multistable materials.

关键词： light magnetic multistability iron metal-organic framework spin-crossover

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Somatic GNA11/GNAQ variants in a cohort of Chinese children with phakomatosis pigmentovascularis

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Pediatric Investigation 2024年第2期8卷 117-125页

作者： Bin Zhang Rui He Riga wu Zhou Yang Man Hu Nan Zhang wu guo Zigang Xu Lin Ma Department of Dermatology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of Dermatology Zhengzhou UniversityAffiliated Children’s HospitalHenan Children’s HospitalZhengzhou Children’s HospitalZhengzhouChina Department of Dermatology Affiliated Hospital of Inner Mongolia Medical UniversityHohhotChina Department of Ophthalmology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina Department of Pathology Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthBeijingChina

Importance:Postzygotic mutations in the GNAQ/GNA11 genes,which encode the G-protein nucleotide binding protein alpha subunits,have been identified in patients with phakomatosis pigmentovascularis(PPV).However,little is known about the Chinese ***:To identify pathogenic mutations in pediatric patients with PPV within the Chinese ***:We performed whole-exome sequencing(WES)using skin lesion tissues from pediatric patients diagnosed with ***,ultradeep-targeted sequencing was conducted to validate the somatic mutations.A genotype-phenotype correlation was analyzed by integrating data from previous reports with the findings of the present ***:Thirteen patients were enrolled,all diagnosed with the cesioflammea type of PPV,except for one patient with an unclassifiable *** identified somatic GNA11 c.547C>T(p.R183C)variant in seven patients and GNAQ c.548G>A(p.R183Q)in four patients,with low allelic fractions ranging from 2.1%to 8.6%through ultradeep ***,a GNAQ c.548G>A(p.R183Q)variant was detected through targeted sequencing in one of two patients who did not exhibit detectable variants via *** genotype-phenotype correlation analysis,involving 15 patients with a GNA11 variant and 10 with a GNAQ variant,revealed that facial capillary malformation(87%vs.50%,P=0.075)and ocular melanocytosis(80%vs.40%,P=0.087)appeared to be more frequent in patients with GNA11 mutation compared to those with GNAQ *** four patients diagnosed with cesiomarmorata type or overlapping cesioflammea and cesiomarmorata type PPV carried the GNA11 ***:Our study demonstrated that the majority of PPV patients in the Chinese population carried a postzygotic variant of GNAQ/GNA11,thus further confirming the pathogenic role of GNAQ/GNA11 mosaicism in the development of PPV cesioflammea type.

关键词： Phakomatosis pigmentovascularis GNA11 GNAQ Somatic variant

DIR:Dynamic Request Interleaving for Improving the Read Performance of Aged Solid-State Drives

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Journal of Computer Science & Technology 2024年第1期39卷 82-98页

作者：聂世强张驰伍卫国 Department of Computer Science and Technology Xi'an Jiaotong UniversityShaanci 710049China

Triple-level cell(TLC)NAND flash is increasingly adopted to build solid-state drives(SSDs)for modern computer *** TLC NAND flash effectively improves storage density,it faces severe reliability issues;in partic-ular,the pages exhibit different raw bit error rates(RBERs).Integrating strong low-density parity-check(LDPC)code helps to improve reliability but suffers from prolonged and proportional read latency due to multiple read retries for worse *** straightforward idea is that dispersing page-size data across several pages in different types can achieve a low-er average RBER and reduce the read ***,directly implementing this simple idea into flash translation lay-er(FTL)induces the read amplification issue as one logic page residing in more than one physical page brings several read *** this paper,we propose the Dynamic Request Interleaving(DIR)technology for improving the performance of TLC NAND flash-based SSDs,in particular,the aged ones with large *** exploits the observation that the la-tency of an I/O request is determined,without considering the queuing time,by the access of the slowest device page,i.e.,the page that has the highest *** grouping consecutive logical pages that have high locality and interleaving their encoded data in different types of device pages that have different RBERs,DIR effectively reduces the number of read re-tries for LDPC with limited read *** meet the requirement of allocating hybrid page types for interleaved data,we also design a page-interleaving friendly page allocation scheme,which splits all the planes into multi-plane re-gions for storing the interleaved data and single-plane regions for storing the normal *** pages in the multi-plane re-gion can be read/written in parallel by the proposed multi-plane command and avoid the read amplification *** on the DIR scheme and the proposed page allocation scheme,we build DIR-enable FTL,which integrates the pro

关键词： triple-layer cell solid-state drive(TLC SSD) performance interleaving data unbalanced bit error rate

Analysis of risk factors leading to anxiety and depression in patients with prostate cancer after castration and the construction of a risk prediction model

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World Journal of Psychiatry 2024年第2期14卷 255-265页

作者： Rui-Xiao Li Xue-Lian Li guo-Jun wu Yong-Hua Lei Xiao-Shun Li Bo Li Jian-Xin Ni Urology Hospital Xi'an People's Hospital(Xi'an Fourth Hospital)Xi'an 710199Shaanxi ProvinceChina Department of Surgery Xi'an Hospital of Traditional Chinese MedicineXi'an 710199Shaanxi ProvinceChina

BACKGROUND Cancer patients often suffer from severe stress reactions psychologically,such as anxiety and *** cancer(PC)is one of the common cancer types,with most patients diagnosed at advanced stages that cannot be treated by radical surgery and which are accompanied by complications such as bodily pain and bone ***,attention should be given to the mental health status of PC patients as well as physical adverse events in the course of clinical *** To analyze the risk factors leading to anxiety and depression in PC patients after castration and build a risk prediction *** A retrospective analysis was performed on the data of 120 PC cases treated in Xi'an People's Hospital between January 2019 and January *** patient cohort was divided into a training group(n=84)and a validation group(n=36)at a ratio of 7:*** patients’anxiety symptoms and depression levels were assessed 2 wk after surgery with the Self-Rating Anxiety Scale(SAS)and the Selfrating Depression Scale(SDS),*** regression was used to analyze the risk factors affecting negative mood,and a risk prediction model was *** In the training group,35 patients and 37 patients had an SAS score and an SDS score greater than or equal to 50,*** on the scores,we further subclassified patients into two groups:a bad mood group(n=35)and an emotional stability group(n=49).Multivariate logistic regression analysis showed that marital status,castration scheme,and postoperative Visual Analogue Scale(VAS)score were independent risk factors affecting a patient's bad mood(P<0.05).In the training and validation groups,patients with adverse emotions exhibited significantly higher risk scores than emotionally stable patients(P<0.0001).The area under the curve(AUC)of the risk prediction model for predicting bad mood in the training group was 0.743,the specificity was 70.96%,and the sensitivity was 66.03%,while in the validation

关键词： Prostate cancer Castration Anxiety and depression Risk factors Risk prediction model

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基于自注意力机制的音频对抗样本生成方法

数据采集与处理 2024年第2期39卷 416-423页

作者：李珠海郭武中国科学技术大学语音及语言信息处理国家工程研究中心合肥230027

随着个人语音数据在网络上的传播以及自动说话人识别算法的发展,个人的声纹特征面对着泄露的风险。音频对抗样本可以在人耳主观听觉不变的前提下,使得自动说话人识别算法失效,从而保护个人的声纹特征。本文在典型的音频对抗样本生成算法... 详细信息

随着个人语音数据在网络上的传播以及自动说话人识别算法的发展,个人的声纹特征面对着泄露的风险。音频对抗样本可以在人耳主观听觉不变的前提下,使得自动说话人识别算法失效,从而保护个人的声纹特征。本文在典型的音频对抗样本生成算法FoolHD模型的基础上引入了自注意力机制来改进对抗样本生成,该方法称为FoolHD-MHSA。首先,使用卷积神经网络作为编码器来提取输入音频频谱的对抗扰动谱图;然后利用自注意力机制从全局角度提取扰动谱不同部分特征的关联特征,同时将网络聚焦到扰动谱中的关键信息、抑制无用信息;最后,使用解码器将处理后的扰动谱隐写到输入频谱中得到对抗样本频谱。实验结果表明,FoolHD-MHSA方法生成的对抗样本相比FoolHD方法有着更高的攻击成功率和平均客观语音质量评估(Perceptual evaluation of speech quality,PESQ)得分。

关键词：自注意力机制对抗样本说话人识别深度神经网络

Limonin inhibits the stemness of cancer stem-like cells derived from colorectal carcinoma cells potentially via blocking STAT3 signaling

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World Journal of Clinical Oncology 2024年第2期15卷 317-328页

作者： Wei-Feng Zhang Cheng-Wei Ruan Jun-Bo wu guo-Liang wu Xiao-Gan Wang Hong-Jin Chen Department of Colorectal Surgery The Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Anorectal Section The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Colorectal Surgery Hengyang Central HospitalHengyang 421000Hunan ProvinceChina The First College for Clinical Medicine Nanjing University Of Chinese MedicineNanjing 210023Jiangsu ProvinceChina

BACKGROUND Limonin is one of the most abundant active ingredients of Tetradium *** exerts antitumor effects on several kinds of cancer ***,whether limonin exerts antitumor effects on colorectal cancer(CRC)cells and cancer stem-like cells(CSCs),a subpopulation responsible for a poor prognosis,is *** To evaluate the effects of limonin on CSCs derived from CRC *** CSCs were collected by culturing CRC cells in serum-free *** cytotoxicity of limonin against CSCs and parental cells(PCs)was determined by cholecystokinin octapeptide-8 *** effects of limonin on stemness were detected by measuring stemness hallmarks and sphere formation *** As expected,limonin exerted inhibitory effects on CRC cell behaviors,including cell proliferation,migration,invasion,colony formation and tumor formation in soft agar.A relatively low concentration of limonin decreased the expression stemness hallmarks,including Nanog andβ-catenin,the proportion of aldehyde dehydrogenase 1-positive CSCs,and the sphere formation rate,indicating that limonin inhibits stemness without presenting ***,limonin treatment inhibited invasion and tumor formation in soft agar and in nude ***,limonin treatment significantly inhibited the phosphorylation of STAT3 at Y705 but not S727 and did not affect total STAT3 *** of Nanog andβ-catenin expression and sphere formation by limonin was obviously reversed by pretreatment with 2μmol/L *** Taken together,these results indicate that limonin is a promising compound that targets CSCs and could be used to combat CRC recurrence and metastasis.

关键词： Limonin Colorectal cancer STAT3 signaling Cancer stem-like cells STAT3 Aldehyde dehydrogenase 1

Efficient and selective removal of Pb(Ⅱ) from landfill leachate using L-serine-modified polyethylene/polypropylene nonwoven fabric synthesized via radiation grafting technique

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Nuclear Science and Techniques 2024年第4期35卷 144-155页

作者： Xin-Xin Feng Cheng Li Xuan-Zhi Mao Wan-Ning Ren Yang Gao Yu-Long He Zhe Xing Rong Li guo-Zhong wu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China

In this study,to efficiently remove Pb(Ⅱ) from aqueous environments,a novel L-serine-modified polyethylene/polypropylene nonwoven fabric sorbent(NWF-serine)was fabricated through the radiation grafting of glycidyl methacrylate and subsequent L-serine *** effect of the absorbed dose was investigated in the range of 5–50 ***-serine was characterized by Fourier transform infrared spectroscopy,thermogravimetric analysis,and scanning electron *** adsorption tests were conducted to investigate the influences of pH,adsorption time,temperature,initial concentration,and sorbent dosage on the Pb(Ⅱ) adsorption performance of *** results indicated that Pb(Ⅱ) adsorption onto NWF-serine was an endothermic process,following the pseudo-second-order kinetic model and Langmuir isotherm *** saturated adsorption capacity was 198.1 mg/***-serine exhibited Pb(Ⅱ) removal rates of 99.8% for aqueous solutions with initial concentrations of 100 mg/L and 82.1% for landfill leachate containing competitive metal ions such as Cd,Cu,Ni,Mn,and ***,NWF-serine maintained 86% of its Pb(Ⅱ) uptake after five use *** coordination of the carboxyl and amino groups with Pb(Ⅱ) was confirmed using X-ray photoelectron spectroscopy and extended X-ray absorption fine structure analysis.

关键词： Landfill leachate Radiation grafting Polyethylene/polypropylene nonwoven fabric Pb(Ⅱ)removal

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玻璃幕墙的施工部署及质量安全保证措施研究

商业银行数字化转型的组态路径研究——基于模型集定性比较分析

建筑与装饰 2024年第11期 43-45页

作者：吴国威中国水利水电第十一工程局有限公司河南郑州 450000

玻璃幕墙是现代高层建筑常见的外墙围护结构,具有施工简单、美观性较高、采光率较好等特点,对现代高层建筑建设具有重要意义.本文以某建筑工程为例,通过对该建筑工程基本情况的简单介绍,详细论述玻璃幕墙的施工部署方案,并提出玻璃幕墙... 详细信息

玻璃幕墙是现代高层建筑常见的外墙围护结构,具有施工简单、美观性较高、采光率较好等特点,对现代高层建筑建设具有重要意义.本文以某建筑工程为例,通过对该建筑工程基本情况的简单介绍,详细论述玻璃幕墙的施工部署方案,并提出玻璃幕墙施工质量与安全保证措施,为高层建筑玻璃幕墙能够更好地施工提供支持.

关键词：玻璃幕墙施工部署质量保证措施安全保证措施

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财经科学 2024年第8期 32-44页

作者：吴过江春上海杉达学院胜祥商学院武汉大学经济发展研究中心

数字化转型作为科技与金融深度融合发展的重要内容,既是商业银行创新发展的必然趋势,也是其增强自身竞争力的首选战略。本文基于“组态视角”,运用模糊集定性比较分析法,旨在厘清我国商业银行实现高数字化转型水平的组态路径。研究表明:... 详细信息

数字化转型作为科技与金融深度融合发展的重要内容,既是商业银行创新发展的必然趋势,也是其增强自身竞争力的首选战略。本文基于“组态视角”,运用模糊集定性比较分析法,旨在厘清我国商业银行实现高数字化转型水平的组态路径。研究表明:(1)商业银行数字化转型的实现需要经营、管理和要素三个维度的条件因素组合,并非由单一条件因素所决定;(2)高的科技资本投入和良好的董事会结构在实现数字化转型中发挥着关键作用,优秀的经营条件和积极的ESG实践也能起到重要的辅助作用;(3)存在“资本驱动型”“管理驱动型”和“综合驱动型”三种数字化转型模式,不同类型银行对应不同的最优组态路径。本文研究结果明确了数字化转型的关键条件因素和组态路径选择,期望能为各类商业银行制定差异化和系统性的实施战略提供有价值的参考指导.

关键词：数字化转型 fsQCA 商业银行组态路径