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A novel method to mass-produce PDMS stamps based on nanoimprint

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High Technology Letters 2006年第3期12卷 231-234页

作者：孙洪文 Liu Jingquan Chen di gu Pan National Key Laboratory of Nano/Micro Fabrication Technology Key Laboratory for Thin Film and Micmfabrication of Ministry of Education Institute of Micro and Nano Science and Technology Shanghai Jiaotong University Shanghai 200030 P.R. China

Soft lithography is a low-cost and convenient method for the forming and manufacturing of micro/ nanostructures compared to the traditional optical lithography. In soft lithography, poly（dimethylsiloxane）（PDMS） stamps with relief structures have been widely used to transfer patterns. The traditional fabrication approach of PDMS stamps is time-consuming since the master has been occupied during the curing process. By adding and repeating fast nanoimprint step, many intermediate polymeric molds can be produced from the master and these molds can then be employed to replicate more PDMS stamps while the time used is close to that of the common way. We demonstrated this idea by three masters which were made by the DEM （Deepetching, Electroforming and Microreplicating） and FIB （Focused Ion Beam） techniques. The photos show that the patterns on the PMDS stamps successfully duplicated patterns on the origin masters.

关键词： PDMS stamp soft lithography nanoimprint hot embossing DEM technique FIB MMS technique

Targeting signaling pathways in prostate cancer:mechanisms and clinical trials

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2337-2367页

作者： Yundong He Weidong Xu Yu-Tian Xiao Haojie Huang di gu Shancheng Ren Shanghai Key Laboratory of Regulatory Biology School of Life SciencesEast China Normal UniversityShanghaiChina Department of Urology Shanghai Changzheng HospitalShanghaiChina Department of Urology Shanghai Changhai HospitalShanghaiChina Department of Urology Mayo Clinic College of Medicine and ScienceRochesterMNUSA Department of Urology The First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina

Prostate cancer(PCa)affects millions of men *** to advances in understanding genomic landscapes and biological functions,the treatment of PCa continues to ***,various new classes of agents,which include next-generation androgen receptor(AR)signaling inhibitors(abiraterone,enzalutamide,apalutamide,and darolutamide),bone-targeting agents(radium-223 chloride,zoledronic acid),and poly(ADP-ribose)polymerase(PARP)inhibitors(olaparib,rucaparib,and talazoparib)have been developed to treat *** targeting other signaling pathways,including cyclin-dependent kinase(CDK)4/6,Ak strain transforming(AKT),wingless-type protein(WNT),and epigenetic marks,have successively entered clinical ***,prostate-specific membrane antigen(PSMA)targeting agents such as 177Lu-PSMA-617 are promising theranostics that could improve both diagnostic accuracy and therapeutic *** clinical studies with immune checkpoint inhibitors(ICIs)have shown limited benefits in PCa,whereas subgroups of PCa with mismatch repair(MMR)or CDK12 inactivation may benefit from ICIs *** this review,we summarized the targeted agents of PCa in clinical trials and their underlying mechanisms,and further discussed their limitations and future directions.

关键词： clinical mechanisms summarized

The basic helix-loop-helix transcription factor MdbHLH3 modulates leaf senescence in apple via the regulation of dehydratase-enolase-phosphatase complex 1

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Horticulture Research 2020年第1期7卷 2047-2052页

作者： Da-Gang Hu Cui-Hui Sun Quan-Yan Zhang Kai-di gu Yu-Jin Hao National Key Laboratory of Crop Biology MOA Key Laboratory of Horticultural Crop Biology and Germplasm InnovationCollege of Horticulture Science and EngineeringShandong Agricultural UniversityTai-AnShandong 271018China

Basic helix−loop−helix(bHLH)domain-containing transcription factors are known for their roles in regulating various plant growth and developmental ***,we showed that MdbHLH3 from apple(Malus domestica)has multiple functions,modulating both anthocyanin biosynthesis and cell ***,we show that MdbHLH3 also regulates ethylene biosynthesis and leaf senescence by promoting the expression of dehydratase-enolasephosphatase complex 1(MdDEP1).Therefore,we propose a model whereby MdbHLH3 acts as a crucial factor that modulates anthocyanin biosynthesis and cell acidification in addition to fruit ripening and leaf senescence by regulating distinct target genes.

关键词： Basic processes complex

The application of indocyanine green in guiding prostate cancer treatment

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Asian Journal of Urology 2023年第1期10卷 1-8页

作者： Donghua Xie di gu Ming Lei Cong Cai Wen Zhong Defeng Qi Wenqi Wu guohua Zeng Yongda Liu Department of Urology Minimally Invasive Surgery CenterThe First Affiliated Hospital of Guangzhou Medical UniversityGuangdong Key Laboratory of UrologyGuangzhouChina

Objective:Indocyanine green(ICG)with near-infrared fluorescence absorption is approved by the United States Food and Drug Administration for clinical applications in angiography,blood flow evaluation,and liver function *** has strong optical absorption in the near-infrared region,where light can penetrate deepest into biological *** sought to review its value in guiding prostate cancer ***:All related literature at PubMed from January 2000 to December 2020 were ***:Multiple preclinical studies have demonstrated the usefulness of ICG in identifying prostate cancer by using different engineering *** studies have demonstrated the usefulness of ICG in guiding sentinel node dissection during radical prostatectomy,and possible better preservation of neurovascular bundle by identifying landmark prostatic *** techniques such as adding fluorescein in additional to ICG were tested in a limited number of patients with encouraging *** addition,the use of the ICG was shown to be *** though there are encouraging results,it does not carry sufficient sensitivity and specificity in replacing extended pelvic lymph node dissection during radical ***:Multiple preclinical and clinical studies have shown the usefulness of ICG in identifying and guiding treatment for prostate *** randomized prospective studies are warranted to further test its usefulness and find new modified approaches.

关键词： Indocyanine green Intraoperative imaging Prostate cancer Sentinel lymph node dissection Neurovascular bundle

Ginsenoside 3β-O-Glc-DM(C3DM) Enhances the Antitumor Activity of Taxol on Lewis Lung Cancer by Targeting the Interleukin-6/Jak2/STAT3 and Interleukin-6/AKT Signaling Pathways

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World Journal of Traditional Chinese Medicine 2020年第4期6卷 432-440页

作者： Mei Tang Lu-Lu Huang Qian-Qian Du Chen Yan an-di gu Jin-Ling Yang Yan Li Department of Pharmacology Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation StudyInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College Department of Pharmacology Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College Department of Biosynthesis State Key Laboratory of Bioactive Substance and Function of Natural Medicines and Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning CommissionInstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Objective:Nonsmall-cell lung cancer(NSCLC)is an aggressive,highly chemoresistant *** is an effective chemotherapeutic drug widely used for the treatment of ***,the clinical use of Taxol is limited due to the occurrence of adverse side effects under high therapeutic ***,it is desirable to explore combination therapy to reduce the dose of chemotherapeutic drugs and achieve excellent outcomes.A biosynthetic ginsenoside,3-O-β-D-glucopyranosyl-dammar-24-ene-3β,20 S-diol(3β-O-Glc-DM,C3 DM)is obtained from microbial fermentation by metabolic *** on previous study findings,we aimed to explore the mechanism of combination therapy with C3 DM and Taxol and its increasing antitumor effect on Lewis lung cancer(LLC)in this *** and Methods:A thiazolyl blue tetrazolium bromide(MTT)assay was performed to evaluate cell viability;the apoptotic effect was studied using cell apoptosis *** Lewis tumor xenograft experiment was performed to determine the effects of C3 DM combined with Taxol on tumor growth in vivo,and western blotting was performed to analyze protein ***:C3 DM effectively inhibited the proliferation of NSCLC ***,C3 DM increased the antiproliferative activity of Taxol and significantly enhanced cell apoptosis induced by Taxol in Lewis lung cancer cells.C3 DM alone also suppressed Lewis tumor growth and enhanced the antitumor activity of Taxol in *** blot analysis revealed that the effects of the antiproliferation and apoptosis induction of C3 DM treatment alone or in combination with Taxol on Lewis lung cancer were mediated by inhibiting the interleukin-6(IL-6)/Jak2/STAT3 and IL-6/AKT signaling ***:The results showed that C3 DM has the potential to be used in combination therapy with Taxol against NSCLC.

关键词： Combination therapy enhancing antitumor activity ginsenoside C3DM nonsmall-cell lung cancer paclitaxel

Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1661-1676页

作者： Junhui Chen Qian Zhang Jinan guo di gu Jing Liu Piao Luo Yunmeng Bai Jiayun Chen Xinzhou Zhang Sheng Nie Chunbo Chen Yulin Feng Jigang Wang National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine Jiangxi University of Chinese MedicineNanchang 330006China Department of Pulmonary and Critical Care Medicine Shenzhen Institute of Respiratory Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalFirst Affiliated Hospital of Southern University of Science and TechnologySecond Clinical Medical College of Jinan UniversityShenzhen 518020China School of Traditional Chinese Medicine and School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospitalthe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Urology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Nephrology Shenzhen Key Laboratory of Kidney Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospitalthe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Nephrology Nanfang Hospitalthe First Affiliated Hospital of Southern Medical UniversityGuangzhou 510515China Department of Critical Care Medicine Shenzhen People's Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020China State Key Laboratory for Quality Esurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Oncology the Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China

diabetic nephropathy(DN)is a severe complication of diabetes,characterized by changes in kidney structure and *** natural product rosmarinic acid(RA)has demonstrated therapeutic effects,including anti-inflammation and anti-oxidative-stress,in renal damage or *** this study,we characterized the heterogeneity of the cellular response in kidneys to DN-induced injury and RA treatment at single cell *** results demonstrated that RA significantly alleviated renal tubular epithelial injury,particularly in the proximal tubular S1 segment and on glomerular epithelial cells known as podocytes,while attenuating the inflammatory response of macrophages,oxidative stress,and cytotox-icity of natural killer *** findings provide a comprehensive understanding of the mechanisms by which RA alleviates kidney damage,oxidative stress,and inflammation,offering valuable guidance for the clinical application of RA in the treatment of DN.

关键词： Rosmarinic acid diabetic nephropathy scRNA sequencing Injury Oxidative stress Infiammation Proteomics

The MADS transcription factor CmANR1 positively modulates root system development by directly regulating CmPIN2 in chrysanthemum

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Horticulture Research 2018年第1期5卷 202-217页

作者： Cui-Hui Sun Jian-Qiang Yu Xi Duan Jia-Hui Wang Quan-Yan Zhang Kai-di gu Da-Gang Hu Cheng-Shu Zheng National Key Laboratory of Crop Biology College of Horticulture Science and EngineeringShandong Agricultural UniversityTai-AnShandong271018China Shandong Agricultural and Engineering University Ji-NanShandongChina

Plant root systems are essential for many physiological processes,including water and nutrient ***-box transcription factor(TF)genes have been characterized as the important regulators of root development in plants;however,the underlying mechanism is largely unknown,including ***,it was found that the overexpression of CmANR1,a chrysanthemum MADS-box TF gene,promoted both adventitious root(AR)and lateral root(LR)development in *** transcriptome sequencing analysis revealed a series of differentially expressed unigenes(DEGs)in the roots of CmANR1-transgenic chrysanthemum plants compared to wild-type *** annotation of these DEGs by alignment with Gene Ontology(GO)terms and biochemical pathway Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis indicated that CmANR1 TF exhibited“DNA binding”and“catalytic”activity,as well as participated in“phytohormone signal transduction”.Both chromatin immunoprecipitation–polymerase chain reaction(ChIP-PCR)and gel electrophoresis mobility shift assays(EMSA)indicated the direct binding of CmPIN2 to the recognition site CArG-box motif by ***,a firefly luciferase imaging assay demonstrated the transcriptional activation of CmPIN2 by CmANR1 in ***,our results provide novel insights into the mechanisms of MADS-box TF CmANR1 modulation of both AR and LR development,which occurs by directly regulating auxin transport gene CmPIN2 in chrysanthemum.

关键词： PIN2 Whole alignment

Study on Hydrogen Production System by Coupling with DSSCs

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Green and Sustainable Chemistry 2014年第4期4卷 185-189页

作者： di gu Hongwen gu Yanji Zhu Chuang Zhang dianxu Zhang College of Chemistry and Chemical Engineering Northeast Petroleum University Daqing China Environmental Inspection Team Yi’an County Qiqihar China Daqing Oilfield Engineering Co. Ltd. Qaqing China Daqing Oilfield Production Technology Institute Qaqing China

The consumption of dye-sensitized solar cells (DSSCs) used to produce hydrogen, compared with the traditional water-splitting energy, is much less. First of all it is because of DSSCs’ low cost, easy fabrication process, high conversion efficiency and good stability;secondly it also solves the problem of serious corrosion of the electrode, for the entire solar system is in the air. We use three tandem dye-sensitized photovoltaic cells as a source of power;the open circuit voltage of photoelectric unit shows the feasibility of using dye-sensitized photovoltaic cell decomposition of water to produce hydrogen.

关键词： Dye-Sensitized Solar Cell Coupling Hydrogen System of Water-Splitting for Hydrogen Production

Impact of Dye-Sensitized Solar Cell Anode Preparation on Performance

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Open Journal of Applied Sciences 2014年第9期4卷 467-472页

作者： di gu Qingwei Zhang Qingquan Wu Yanji Zhu China Petroleum Engineering & Construction Corporation Beijing China College of Chemistry and Chemical Engineering Northeast Petroleum University Daqing China The Fourth Oil Extraction Plant Daqing Oilfield Company Limited Daqing China

In this paper, the suitable molecular weight of polyethylene glycol (PEG) and annealing temperature for dye-sensitized solar cells (DSSCs) anode was obtained by assessing the performance of DSSCs. The output current characteristic of the DSSCs is to explore factors that affect cell conversion efficiency and the effect of the mechanism. Experimental results show that the annealing temperature of 500°C and adding PEG of molecular weight 2000, the TiO2 thin film electrode TiO2 film electrode has good optical properties.

关键词： Dye-Sensitized Solar Cells (DSSCs) Anode Annealing Temperature Molecular Weight of PEG