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Insights from an academic endeavor into central nervous system drug discovery

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Neural Regeneration Research 2025年第6期20卷 1717-1718页

作者： Lieve van Veggel An m.Voets Tim.vanmierlo Rudy Schreiber BIOmED Biomedical Research Institute Faculty of Medicine and Life SciencesHasselt UniversityHasseltBelgium Department of Psychiatry and Neuropsychology Division of Translational NeuroscienceEuropean Graduate School of NeuroscienceSchool for Mental Health and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands Section of Psychopharmacology Neuropsychology and PsychopharmacologyFaculty of Psychology and NeuroscienceMaastricht UniversityMaastrichtThe Netherlands University mS Center(UmSC) Hasselt-PeltBelgium

Historically,"big pharma"did most central nervous system drug discovery R&D ***,in modern times their"management reductionism"resulted in disappointing pipelines and pharma resided to(late)development,regulatory approval,and marketing(Thong,2015).This had significant consequences for financing and executing research,resulting in a larger role for funding by governments and patient-organizations and a shift of research to academia(mazzucato,2013).

关键词： academic approval consequences

James Hogarth Pringle and his time-honored maneuver

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 391-392页

作者： Thomas m.van Gulik Department of Surgery Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands

The classical method to control blood loss during parenchymal transection of the liver is the Pringle *** his landmark article in the Annals of Surgery in 1908,James Hogarth Pringle occluded the afferent vessels to the liver by compressing the hepatoduodenal ligament between his thumb and index finger(1).He applied this maneuver in eight patients who required emergency laparotomy for major hemorrhage after severe liver *** he succeeded in controlling blood loss,the eight patients he described unfortunately all *** outcome did not prevent the Annals of Surgery from publishing his report after which James Hogarth Pringle was ready to enter the‘Hall of Fame’.Vascular inflow occlusion,applied in a continuous or intermittent fashion,became the mainstay technique for reducing blood loss during liver transection,and has remained so in the present era of laparoscopic and robotic liver resection(2).

关键词： Pringle Surgery patients

*** of Assisi receives the stigma on his liver

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 300-301页

作者： Thomas m.van Gulik Department of Surgery Amsterdam University Medical CentersUniversity of AmsterdamAmsterdamThe Netherlands

A remarkable painting of *** of Assisi is on display in the Indianapolis museum of Art at Newfields,USA,painted by the Italian master Pietro da Rimini around 1330(Figure 1)(1).The painting is entitled‘Saint Francis receives the stigmata’,and depicts the saint experiencing a vision as he *** sees Christ,bearing the wounds from his crucifixion,flying with an angel-like creature called a *** wounds of Christ represent the four places where nails were driven through his hands and feet during his crucifixion,each denoting a stigma.A fifth stigma appears as a wound on the right side of his chest,where he was stabbed with a lance between the ribs by the Roman soldier who wanted to ascertain his death.

关键词： Italian Figure painting

Liver anatomy by Francis Glisson

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 502-503页

作者： Thomas m.van Gulik Department of Surgery Amsterdam University Medical CentersUniversity of AmsterdamAmsterdamThe Netherlands

Francis Glisson(1598-1677)was born in Bristol and studied to become a doctor at Caius College,Cambridge,where he eventually was appointed as professor of *** wrote the first monograph on the anatomy of the liver in hi... 详细信息

关键词： anatomy College eventually

Babylonian clay tablet of the liver

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Hepatobiliary Surgery and Nutrition 2023年第1期12卷 1-2页

作者： Thomas m.van Gulik Department of Surgery Amsterdam University Medical CentersUniversity of AmsterdamAmsterdamThe Netherlands

The Babylonians were an ancient people living from approximately 2000 BC to 1600 BC in southern mesopotamia,a fertile region situated between the Tigris and Euphrates river,an area for the greater part corresponding with modern *** reached a high level of civilization with their own Akkadian language,writings and *** the realm of their religion,they worshipped a host of gods and goddesses,each with different names and distinct functions.

关键词： situated approximate realm

The miracle transplantation of a black leg by the surgeon saints Cosmas and Damian

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Hepatobiliary Surgery and Nutrition 2024年第1期13卷 1-2页

作者： Thomas m.van Gulik Department of Surgery Amsterdam University Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands

The miracle of the saints Cosmas and Damian refers to transplantation of a black leg onto a white man that took place in medieval Rome(Figure 1)(1).A sexton of a church in Rome was seriously affected by cancer in his right *** into a delirious fever,he dreamed that the holy surgeons,saint Cosmas and saint Damian,visited him and skilled as they were,decided to remove the affected leg and replace it with a healthy *** went to the grave of a recently deceased Ethiopian man and retrieved the right leg of this black man and took it to the *** sick leg of the sexton was amputated and they transplanted onto him the leg of the black *** their miracle operation,Cosmas and Damian have been elevated to patron saints of the surgical profession and many surgical societies have adopted their names in honor of them.

关键词： black Figure replace

Couinaud’s corrosion casts of the liver

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Hepatobiliary Surgery and Nutrition 2022年第2期11卷 174-175页

作者： Thomas m.van Gulik Department of Surgery Amsterdam University Medical CentersUniversity of AmsterdamAmsterdamThe Netherlands

Claude Couinaud[1922-2008],a French surgeon-anatomist,became famous for his classification of the segmental division of the *** defined each segment by its distinct portal venous anatomy and its intersegmental,watershed *** segment would function as an independent functional unit with its own biliary ductal system draining into the central bile *** from all segments is collected into the three main hepatic veins that drain into the caval vein.

关键词： drain watershed Blood

Tumor progression in two-stage liver resections—is the shorter inter-stage period in associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) of benefit to the patient?

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Hepatobiliary Surgery and Nutrition 2019年第3期8卷 316-317页

作者： Ernesto Sparrelid Thomas m.van Gulik Division of Surgery Department of Clinical ScienceIntervention and TechnologyKarolinska InstitutetKarolinska University HospitalStockholmSweden Department of Surgery Amsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands

A two-stage liver resection is a surgical option in patients with bilobar liver tumors in whom a single procedure is not feasible because of insufficient functional volume of the future liver *** use of unilateral portal vein occlusion,such as portal vein embolization,induce hypertrophy of the future liver remnant in order to enable subsequent *** enhancement of tumor growth along with the hypertrophy response has raised concerns regarding oncological outcomes of the procedure.

关键词： occlusion portal partition

Longwall mining,shale gas production,and underground miner safety and health

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International Journal of mining Science and Technology 2021年第3期31卷 523-529页

作者： D.W.H.Su P.Zhang H.Dougherty m.van Dyke R.Kimutis Center for Disease Control and Prevention(CDC) National Institute for Occupational Safety and Health(NIOSH)Pittsburgh Mining Research Division(PMRD)PittsburghPA 15236USA

This paper presents the results of a unique study conducted by the National Institute for Occupational Safety and Health(NIOSH)from 2016 to 2019 to evaluate the effects of longwall-induced subsurface deformations on shale gas well casing integrity and underground miner safety and *** both deep-cover and shallow-cover instrumentation sites,surface subsidence measurements,subsurface inplace inclinometer measurements,and underground pillar pressure measurements were conducted as longwall panels were *** of the deep-cover and shallow-cover test site results with those from a similar study under medium cover reveal an interesting longwall-induced response *** shallow and medium covers,measured horizontal displacements within the abutment pillar are one order of magnitude higher than those measured under deep *** the other hand,measured vertical compressions under deep cover are one order of magnitude higher than those under shallow and medium ***,FLAC3 Dsimulations of the casings indicate that,in all three cases,the P-110 production casings remain intact under longwall-induced deformations and compressions,which has serious implications for future mine design in areas where shale gas wells have been drilled ahead of mining.

关键词： Longwall mining Coal Gas miner Safety Health