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Plerixafor-based mobilization and mononuclear cell counts in graft increased the risk of engraftment syndrome after autologous hematopoietic stem cell transplantation

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Blood Science 2024年第3期6卷 48-54页

作者： Le-qing cao qi Wen Bo-Ning Liu Zhen-Yu Zhao Xiao-Hui Zhang Lan-Ping Xu Huan chen Yu Wang Lu Yu Feng-Rong Wang Xiao-Jun Huang Xiao-Dong mo Peking University People’s Hospital Peking University Institute of HematologyNational Clinical Research Center for Hematologic DiseaseBeijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijingChina Hainan General Hospital Hainan Affiliated Hospital of Hainan Medical UniversityHaikouChina Peking-Tsinghua center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijingChina Research Unit of Key Technique for Diagnosis and Treatments of Hematologic malignancies Chinese Academy of Medical SciencesBeijing 2019RU029China

Engraftment syndrome(ES)is one of the most common complications in the early phase after autologous hematopoietic stem cell transplantation(AScT),and we aimed to evaluate the incidence and risk factors for ES patients receiving AScT in the era of plerixafor-based mobilization.A total of 294 were enrolled,and 16.0%(n=47)experienced ES after *** main clinical manifestations were fever(100%),diarrhea(78.7%),skin rash(23.4%),and hypoxemia/pulmonary edema(12.8%).Plerixafor-based mobilization was associated with higher counts of cD3^(+)cells,cD4^(+)cells,and cD8^(+)cells in *** univariate analysis of the total cohort,age≥60 years,receiving AScT at complete remission(cR),higher number of mononuclear cell(mNc),cD3^(+)cell counts,cD4^(+)cells as well as cD8^(+)cells transfused and plerixafor-based mobilization were associated with ES after *** analysis showed that age≥60 years(P=0.0014),receiving AScT at cR(P=0.002),and higher number of mNc transfused(P=0.026)were associated with ES in total *** plasma cell disease subgroup,age≥60 years(P=0.013),plerixafor-based mobilization(P=0.036),and receiving AScT at cR(P=0.002)were associated with *** with more risk factors had a higher risk of *** 1-year probabilities of relapse,non-relapse mortality,and survival were comparable between patients with and without ***,plerixafor-based mobilization may influence the composition of T lymphocytes in grafts and increase the risk of ES,particularly in patients with plasma cell disease.

关键词： Autologous stem cell transplantation Engraftment syndrome Plerixafor Risk factors

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高燃烧效率含卤氧化剂包覆硼粉的制备及性能

含能材料 2024年第10期32卷 1068-1079页

作者：刘睿杨丹锋张云龙聂洪奇严启龙西北工业大学固体推进全国重点实验室陕西西安710072

为了提升硼粉的点火燃烧性能,采用高能球磨与喷雾干燥相结合的技术制备了4种微纳米B-Fe-Bi_(2)O_(3)@AP/PVDF复合物,根据其高热值和高燃烧效率的特点将四种复合物命名为μBHH_(c)、μBHc_(e)、nBHH_(c)及nBHc_(e),并对其形貌结构、热反... 详细信息

为了提升硼粉的点火燃烧性能,采用高能球磨与喷雾干燥相结合的技术制备了4种微纳米B-Fe-Bi_(2)O_(3)@AP/PVDF复合物,根据其高热值和高燃烧效率的特点将四种复合物命名为μBHH_(c)、μBHc_(e)、nBHH_(c)及nBHc_(e),并对其形貌结构、热反应性、点火延迟、质量燃速和凝聚相产物进行了表征分析。结果表明,μBHH_(c)和μBHc_(e)复合物在氩气中最大热值达9.7 k J·g^(-1),最高燃烧效率达66.2%;在氧气中最大热值达14.6 k J·g^(-1),最高燃烧效率达93.3%,空气中氧化峰温在750~760℃之间。n BHH_(c)和n BHc_(e)复合物在氩气中最大热值达9.9 k J·g^(-1),最高燃烧效率达68.9%;在氧气中最大热值达14.8 k J·g^(-1),最高燃烧效率达97.2%,空气中氧化峰温在595~600℃之间。各类复合物的最高燃烧温度达1954~2011℃,其中n BHH_(c)复合物的点火延迟最短(26 ms),且质量燃速最高(1.84 g·s^(-1));μBHc_(e)复合物的点火延迟最长(39 ms),质量燃速也最低(0.80 g·s^(-1))。各类复合物燃烧产物主要由B_(2)O_(3)、B_(4)c及少量未完全燃烧的硼组成,形貌包含5~10μm的球体及10~20μm的片状物质。

关键词：改性硼粉表界面修饰氧化剂/燃料一体化设计点火燃烧性能

Inconel718高温合金Laves相及碳化物析出机理

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金属热处理 2024年第3期49卷 190-197页

作者：郭续龙周扬陈琦成都先进金属材料产业技术研究院股份有限公司四川成都610303

为得到Inconel718高温合金Laves相及碳化物的析出规律,利用Thermal-calc软件中的镍基数据库计算了平衡态下合金的相组成,采用光学显微镜、扫描电镜和场发射电子探针显微分析仪对合金进行了显微组织观察和能谱分析,并对析出相中的元素偏... 详细信息

为得到Inconel718高温合金Laves相及碳化物的析出规律,利用Thermal-calc软件中的镍基数据库计算了平衡态下合金的相组成,采用光学显微镜、扫描电镜和场发射电子探针显微分析仪对合金进行了显微组织观察和能谱分析,并对析出相中的元素偏析状况进行了研究。最后利用高温激光共聚焦显微镜探究了合金的熔化与凝固规律。结果表明,平衡状态下Inconel718合金冷却过程中的相变顺序为液相、L+γ相、L+γ+mc相、L+γ+mc+δ相、γ+mc+δ+η相、γ+mc+δ+η+σ相、γ+mc+δ+η+m23c6相;合金中Ni、cr和Fe元素表现为负偏析,以枝晶干分布为主,Nb元素表现为正偏析,以枝晶间分布为主;合金的固相线温度为1380℃,在凝固过程中,随着冷却速率的增加,合金开始凝固的温度逐渐降低,实现完全凝固所需的时间减少,液相分数随温度的升高也逐渐减小;此外根据凝固过程中析出相及组织变化,将整个凝固过程分为初始、稳定和最后凝固阶段;凝固结束后合金中二次枝晶间距与冷却速率的1/3次方成反比。

关键词： Inconel718高温合金析出相熔化和凝固二次枝晶间距冷却速率

Performance of a data-driven technique applied to changes in wave height and its effect on beach response

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Water Science and Engineering 2016年第1期9卷 42-51页

作者： José m.Horrillo-caraballo Harshinie Karunarathna Shun-qi Pan Dominic Reeve Energy&Environment Research Group Zienkiewicz Centre for Computational EngineeringSwansea UniversityBay CampusSwansea SA1 8ENUK Hydro-environmental Research centre School of EngineeringCardiff UniversityCardiff CF24 3AAUK

In this study the medium-term response of beach profiles was investigated at two sites： a gently sloping sandy beach and a steeper mixed sand and gravel beach. The former is the Duck site in North carolina, on the east coast of the USA, which is exposed to Atlantic Ocean swells and storm waves, and the latter is the milford-on-Sea site at christchurch Bay, on the south coast of England, which is partially sheltered from Atlantic swells but has a directionally bimodal wave exposure. The data sets comprise detailed bathymetric surveys of beach profiles covering a period of more than 25 years for the Duck site and over 18 years for the milford-on-Sea site. The structure of the data sets and the data-driven methods are described. canonical correlation analysis （ccA） was used to find linkages between the wave characteristics and beach profiles. The sensitivity of the linkages was investigated by deploying a wave height threshold to filter out the smaller waves incrementally. The results of the analysis indicate that, for the gently sloping sandy beach, waves of all heights are important to the morphological response. For the mixed sand and gravel beach, filtering the smaller waves improves the statistical fit and it suggests that low-height waves do not play a primary role in the medium-term morohological resoonse, which is primarily driven by the intermittent larger storm waves.

关键词： Beach profile canonical correlation analysis Data-driven technique Empirical orthogonal function Forecast Statistical model Wave height threshold

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铁酸钙与TiO_(2)的扩散反应特征

东北大学学报（自然科学版） 2024年第2期45卷 193-200页

作者：曹晓舟邵胜琦岳宏瑞东北大学冶金学院辽宁沈阳110819

钒钛磁铁矿烧结过程中,TiO_(2)会与Fe_(2)O_(3)竞争caO,抑制铁酸钙(c_(x)F)的形成,进而影响烧结矿品质.通过制备c_(x)F/TiO_(2)扩散偶的方法,直观地研究caO-Fe_(2)O_(3)-TiO_(2)体系的扩散反应.运用电子探针和X射线衍射分析仪等手段对... 详细信息

钒钛磁铁矿烧结过程中,TiO_(2)会与Fe_(2)O_(3)竞争caO,抑制铁酸钙(c_(x)F)的形成,进而影响烧结矿品质.通过制备c_(x)F/TiO_(2)扩散偶的方法,直观地研究caO-Fe_(2)O_(3)-TiO_(2)体系的扩散反应.运用电子探针和X射线衍射分析仪等手段对反应界面不同位置处的生成物进行分析和表征,研究了在扩散温度为900~1050℃,时间为1~4 h的条件下c_(x)F与TiO_(2)界面的反应特征;分析了温度及时间对生成相的种类、分布及形貌特征的影响.结果表明,从c_(x)F一侧到TiO_(2)一侧,主要的物相有c_(x)F,cF,Fe_(2)O_(3),caTiO_(3),TiO_(2),其中钙钛矿(caTiO_(3))是主要的生成产物.随温度从900℃升高至1050℃,caTiO_(3)的厚度从8.1μm增大至90.2μm;随时间从1 h延长至4 h,caTiO_(3)的厚度从47.4μm增大至121.4μm.同时,caTiO_(3)的扩散厚度与扩散时间的平方根呈良好的线性关系,这表明caTiO_(3)的生成受扩散过程控制.进一步地,使用空位扩散机理解释了caTiO_(3)在caO-Fe_(2)O_(3)-TiO_(2)体系的生成过程.

关键词：铁酸钙 TiO_(2) 扩散偶扩散厚度空位扩散机理

Stratigraphic framework and sedimentary evolution during the cryogenian-Ediacaran transition in northeastern Sichuan Basin,South china

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Petroleum Science 2024年第2期21卷 823-835页

作者： Yi Zhang Hong-Wei Kuang Yong-qing Liu qiang Shi Dong-Ge Wang Ke-Ning qi Yu-chong Wang Da-Wei qiao Xiao-Shuai chen Li-Zhi Wu meng Tian Long chen Yi Wei Liao-Yuan Song Jian Li Zi-Gang Wu Yun-qian Liu Xuan-chun Liu An-qing chen Zhi-Wei Liao Institute of Geology Chinese Academy of Geological SciencesBeijing100037China State Key Laboratory of coal mine Disaster Dynamics and control School of Resources and Safety EngineeringChongqing UniversityChongqing400044China No.205 Geological Team Chongqing Bureau of Geology and Minerals ExplorationChongqing401121China chongqing Institute of Geological Survey Chongqing401122China Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of ministry of Natural Resources Chengdu University of TechnologyChengdu610059SichuanChina

The northeastern Sichuan area in the northern Yangtze margin has unique Ediacaran geological records,especially the Doushantuo Formation(DST),and become a hot research area in recent ***,the cryogenian-Ediacaran(c-E)boundary has not been precisely identified,which restricts the in-depth study of geological information during this crucial transitional period and is unfavorable for a systematic and complete understanding of the Yangtze Block and even the global paleogeographic *** study conducted stratigraphy,sedimentology,and chronostratigraphy to establish the stratigraphic framework and sedimentary evolution of the c-E transition strata in northeastern *** results showed that the Ediacaran sediments,without the cap dolomite,unconformably overlaid the cryogenian sediments in the studied *** member II of the DST,characterized by 50-160 m of red-green sandstone(approximately equivalent to the original chengkou“Guanyinya Formation”),directly overlaid the cryogenian sediments and displayed a 623±2.3 ma maximum depositional age from the detrital zircon U-Pb *** stratigraphic correlations indicate that the c-E transition strata in northeastern Sichuan had a consistent lithological association and sedimentary sequence characteristics but differed from the Three ***,the upper Nantuo massive glacial diamictites transition to the icebergs rafted lonestone-bearing mudstones at the top,then change upward to DST barrier coast *** proposed DST of the northeastern Sichuan Basin was divided into three lithostratigraphic members without the regional member I cap dolomite:(i)member II purple-red,gray-green sandstone strata,(ii)memberⅢblack mudstone strata,and(iii)member IV P-mn bearing *** the c-E transition,the study area experienced(i)the global deglaciation stage in the terminal marinoan glaciation and(ii)the filling-leveling up stage with clastic rocks in the early ***,the early Ediacaran

关键词： marinoan glaciation Doushantuo formation cap dolomite Deglacial and coastal deposits Detrital zircon U-Pb dating

Determination of the number ofψ(3686)events taken at BESⅢ

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chinese Physics c 2024年第9期48卷 8-20页

作者： m.Ablikim m.N.Achasov P.Adlarson O.Afedulidis X.c.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger m.Berlowski m.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.cai X.cai A.calcaterra G.F.cao N.cao S.A.cetin J.F.chang G.R.che G.chelkov c.chen c.H.chen chao chen G.chen H.S.chen H.Y.chen m.L.chen S.J.chen S.L.chen S.m.chen T.chen X.R.chen X.T.chen Y.B.chen Y.Q.chen Z.J.chen Z.Y.chen S.K.choi G.cibinetto F.cossio J.J.cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich c.Q.Deng Z.Y.Deng A.Denig I.Denysenko m.Destefanis F.De mori B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong m.Y.Dong X.Dong m.c.Du S.X.Du Y.Y.Duan Z.H.Duan P.Egorov Y.H.Fan J.Fang J.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici c.Q.Feng J.H.Feng Y.T.Feng m.Fritsch c.D.Fu J.L.Fu Y.W.Fu H.Gao X.B.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia L.Ge P.T.Ge Z.W.Ge c.Geng E.m.Gersabeck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna m.Greco m.H.Gu Y.T.Gu c.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo m.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han F.Hanisch X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius c.H.Heinz Y.K.Heng c.Herold T.Holtmann P.c.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.m.Hu J.F.Hu S.L.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.Hölzken N.Hüsken N.in der Wiesche J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.c.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin m.Q.Jing X.m.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang m.Kavatsyuk B.c.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf m.Kuessner X.Kui N.Kumar A.Kupsc W.Kühn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei m.Lellmann T.Lenz c.Li c.Li c.H.Li cheng Li D.m.Li F.Li G.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li Ke Li L.J.Li L.K.Li Lei Li m.H.Li P.R.Li Q.m.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Z.Li Xi Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia carnegie mellon University PittsburghPennsylvania 15213USA central china Normal University Wuhan 430079China central South University Changsha 410083China china center of Advanced Science and Technology Beijing 100190China china University of Geosciences Wuhan 430074China chung-Ang University Seoul06974Republic of Korea cOmSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute mainz Staudinger Weg 18D-55099MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan college Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner mongolia University Hohhot 010021China Institute of modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile Jilin University Changchun 130012China Joha

The number ofψ(3686)events collected by the BESⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)hadronic *** uncertainty is systematic and the statistical uncertainty is ***,the numbers ofψ(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers are consistent with the previous measurements within one standard *** total number ofψ(3686)events in the three data samples is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process Hadronic events BESⅢdetector

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页岩油微生物采油菌株筛选与性能评价

应用化工 2024年第4期53卷 753-756,780页

作者：于洋刘琦范煜中国石油大学(北京)非常规油气科学技术研究院油气资源与探测国家重点实验室北京102249 中国石油大学(北京)重质油国家重点实验室北京102249

从页岩油藏中筛选得到了一株产表面活性剂菌株Y2,利用16s rDNA基因测序对其进行鉴定;通过表/界面张力测试,优化菌株的培养条件并考察其在不同pH值、温度和盐浓度下的稳定性;通过FTIR和Lc-mS分析表征菌株所产生物表面活性剂的理化性质。... 详细信息

从页岩油藏中筛选得到了一株产表面活性剂菌株Y2,利用16s rDNA基因测序对其进行鉴定;通过表/界面张力测试,优化菌株的培养条件并考察其在不同pH值、温度和盐浓度下的稳定性;通过FTIR和Lc-mS分析表征菌株所产生物表面活性剂的理化性质。结果表明:菌株Y2(枯草芽孢杆菌,Bacillus subtilis)在以葡萄糖为碳源、硝酸铵为氮源的培养基中所产生物表面活性剂表面活性最优,菌株上清液的表面张力值27.61 mN/m,与页岩油JHW151和JHW07121之间的界面张力值分别为0.062 mN/m和0.047 mN/m。该菌株所产生物表面活性剂为c_(15)-Surfactin和c_(16)-Fengycin的脂肽混合物,其表面活性在温度为40~80℃和pH值为1~11范围内稳定性较好,但随着Nacl浓度的增加界面张力值变小。可见,Y2菌株具有较好的表面活性,能够有效降低油/水界面张力从而提高页岩油采收率,为吉木萨尔页岩油微生物驱的高效开发提供了一项潜在可行的技术路线。

关键词：提高采收率页岩油生物表面活性剂脂肽

Atomically dispersed dual-metal-site PGm-free electrocatalysts for oxygen reduction reaction:Opportunities and challenges

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Susmat 2022年第5期2卷 569-590页

作者： Xiaoxuan Yang cameron priest Yang Hou Gang Wu college of chemical and Biological Engineering Zhejiang UniversityHangzhouChina Department of chemical and Biological Engineering University at BuffaloThe State University of New YorkBuffaloNew YorkUSA Institute of Zhejiang University-Quzhou QuzhouChina School of Biological and chemical Engineering NingboTech UniversityNingboChina

Atomically dispersed and nitrogen coordinated single metal site(mNx,m=Fe,co,or mn)moieties embedded in partially graphitized carbon(denoted as m–N–c)are recognized as the most promising platinum group metal-free catalysts for the oxygen reduction reaction(ORR)in proton exchange membrane fuel ***,simply regulating their coordination environments and local structures of single metal sites cannot fundamentally change active site structure,which leads to insufficient activity and stability.A second transition metal can be incorporated to design dual-metal sites,offering a new opportunity to modulate the electronic and geometric structures of m–N–c ***,exploring optimal atomically dispersed dual-metal-site is essential to designing new active sites with enhanced ORR activity,and stability,especially breaking the activity-stability *** review provides a comprehensive analysis of the advances in developing atomically dispersed dual-metal site catalysts for the ORR,including innovative synthesis methods,primary structural configurations,and the mechanisms to promote catalytic *** aim to elucidate the crucial structure–property correlation,emphasizing the inherent electronic and geometric effects of dual metal ***,we discuss the current challenges of dual-metal site catalysts concerning rational design,precise synthesis,and high-fidelity structural characterization.

关键词： dual metal sites electrocatalysis fuel cells oxygen reduction PGm-free catalyst