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Resist Thermal Shock Through Viscoelastic Interface Encapsulation in Perovskite Solar cells

Energy & Environmental materials 2024年第6期7卷 238-245页

作者： Sai ma Jiahong Tang Guizhou Yuan Ying Zhang Yan Wang Yuetong Wu cheng Zhu Yimiao Wang Shengfang Wu Yue Lu Shumeng chi Tinglu Song Huanping Zhou manling Sui Yujing Li qi chen Beijing Key Laboratory of construction Tailorable Advanced Functional materials and Green Applications MIIT Key Laboratory for Low-dimensional Quantum Structure and DevicesExperimental Center of Advanced MaterialsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of microstructure and Properties of Solids College of Materials Science and EngineeringBeijing University of TechnologyBeijing 100124China Analysis and Testing center Jiangnan UniversityWuxi 214122China School of materials Science and Engineering Peking UniversityBeijing 100871China

Enhancing the lifetime of perovskite solar cells(PScs)is one of the essential challenges for their *** the external encapsulation protects the perovskite device from the erosion of moisture and oxygen under various harsh ***,the perovskite devices still undergo static and dynamic thermal stress during thermal and thermal cycling aging,respectively,resulting in irreversible damage to the morphology,component,and phase of stacked ***,the viscoelastic polymer polyvinyl butyral(PVB)material is designed onto the surface of perovskite films to form flexible interface *** PVB interface encapsulation,the surface modulus of perovskite films decreases by nearly 50%,and the interface stress range under the dynamic temperature field(−40 to 85°c)drops from−42.5 to 64.8 mPa to−14.8 to 5.0 ***,PVB forms chemical interactions with FA+cations and Pb^(2+),and the macroscopic residual stress is regulated and defects are reduced of the PVB encapsulated perovskite *** a result,the optimized device's efficiency increases from 22.21%to 23.11%.Additionally,after 1500 h of thermal treatment(85°c),1000 h of damp heat test(85°c&85%RH),and 250 cycles of thermal cycling test(−40 to 85°c),the devices maintain 92.6%,85.8%,and 96.1%of their initial efficiencies,respectively.

关键词： device stability perovskite solar cells stress field surface modulus thermal shock

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Heavy neutral leptons in gauged U(1)Lμ-Lτ at muon collider

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chinese Physics c 2024年第9期48卷 36-49页

作者： Ru-Yi He Jia-qi Huang Jin-Yuan Xu Fa-Xin Yang Zhi-Long Han Feng-Lan Shao School of Physics and Technology University of JinanJinan 250022China School of Physics and Physical Engineering Qufu Normal UniversityQufu 273165China

Heavy neutral leptons N are the most appealing candidates to generate tiny neutrino *** studied the signature of heavy neutral leptons in gauged U(1)Lμ-Lτ at a muon *** under the U(1)Lμ-Lτ symmetry,the heavy neutral leptons can be pair produced via the new gauge boson Z' at the muon collider as μ^(+)μ^(-)→Z′*→NN AND μ^(+)μ^(-)→Z′(*)γ→NNγ.We then performed a detailed analysis on the lepton number violation signature μ^(+)μ^(-)→NN→μ^(±)μ^(±)W■W■ and μ^(+)μ^(-)→NN→μ^(±)μ^(±)W■W■γ at the 3 TeV muon collider,where the hadronic decays of W boson are treated as fat-jets *** lepton number violation signatures have quite clean backgrounds at the muon *** simulation shows that a wide range of viable parameter space is within the reach of the 3 TeV muon *** instance,with new gauge coupling g'=0.6 and an integrated luminosity of 1000 fb^(-1),the μ^(±)μ^(±)JJ signal could probe m_(Z′)■13 ***,if the gauge boson mass satisfies 2m_(N)more promising than the μ^(±)μ^(±)JJ signature.

关键词： heavy neutral leptons gauged U(1)_(Lμ-Lτ) muon collider lepton number violation

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TBc1D1 is an energy-responsive polarization regulator of macrophages via governing ROS production in obesity

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Science china(Life Sciences) 2024年第9期67卷 1899-1914页

作者： qi Wang Ping Rong Wen Zhang Xinyu Yang Liang chen Ye cao minjun Liu Weikuan Feng qian Ouyang qiaoli chen Hailong Li Hui Liang Fanguo meng Hong-Yu Wang Shuai chen State Key Laboratory of Pharmaceutical Biotechnology Department of CardiologyNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolModel Animal Research CenterSchool of MedicineNanjing UniversityNanjing 210061China mOE Key Laboratory of model Animal for Disease Study Department of EndocrinologyNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolModel Animal Research CenterSchool of MedicineNanjing UniversityNanjing 210061China college of Life Science Anhui Medical UniversityHefei 230032China Redox medical center for Public Health Medical College of Soochow UniversitySuzhou 215123China Department of General Surgery First Affiliated HospitalNanjing Medical UniversityNanjing 210029China

Energy status is linked to the production of reactive oxygen species(ROS)in macrophages,which is elevated in ***,it is unclear how ROS production is upregulated in macrophages in response to energy overload for mediating the development of ***,we show that the Rab-GTPase activating protein(Rab GAP)TBc1D1,a substrate of the energy sensor AmP-activated protein kinase(AmPK),is a critical regulator of macrophage ROS production and consequent adipose inflammation for obesity ***1D1 deletion decreases,whereas an energy overload-mimetic non-phosphorylatable TBc1D1^(S231A)Amutation increases,ROS production and m1-like polarization in ***,TBc1D1 and its downstream target Rab8a form an energy-responsive complex with NOX2 for ROS *** of TBc1D1^(S231A)bone marrow aggravates diet-induced obesity whereas treatment with an ultra-stable Tt SOD for removal of ROS selectively in macrophages alleviates both TBc1D1~(S231A)mutation-and diet-induced *** findings therefore have implications for drug discovery to combat obesity.

关键词： TBc1D1 AmPK Rab8a NOX2 ROS inflammation macrophage obesity

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STcF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： m.Achasov X.c.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu F.m.cai H.cai J.J.cao Q.H.cao X.cao Z.cao Q.chang K.T.chao D.Y.chen H.chen H.X.chen J.F.chen K.chen L.L.chen P.chen S.L.chen S.m.chen S.chen S.P.chen W.chen X.chen X.F.chen X.R.chen Y.chen Y.Q.chen H.Y.cheng J.cheng S.cheng T.G.cheng J.P.Dai L.Y.Dai X.c.Dai D.Dedovich A.Denig I.Denisenko J.m.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.S.Du Y.J.Du Z.G.Du L.m.Duan D.Epifanov Y.L.Fan S.S.Fang Z.J.Fang G.Fedotovich c.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.S.Ge c.Q.Geng L.S.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.c.Gui A.Q.Guo F.K.Guo J.c.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han m.Han X.Q.Hao J.B.He S.Q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou Y.R.Hou c.Y.Hu H.m.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.c.Hu J.Hua G.S.Huang J.S.Huang m.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.S.Kang B.c.Ke m.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev c.H.Li c.Li D.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.m.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li S.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao c.X.Lin D.X.Lin X.S.Lin B.J.Liu c.W.Liu D.Liu F.Liu G.m.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu S.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long c.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu Z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.ma P.ma Y.ma Y.m.ma F.maas S.malde D.matvienko Z.X.meng R.mitchell A.Nefediev Y.Nefedov S.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters S.Pivovarov E.Pyata B.B.qi Y.Q.qi W.B.qian Y.qian c.F.qiao J.J.qin J.J.qin L.Q.qin X.S.qin T.L.qiu J.Rademacker c.F.Redmer H.Y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia cAS Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom central china Normal University Wuhan 430079China central South University Changsha 410083China china University of Geosciences Wuhan 430074China china University of mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics center Chung-Ang UniversitySeoul 06974Korea Higher School of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of Science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner mongolia University Hohhot 010021China Institute of Advanced Science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(STcF)is an electron–positron collider proposed by the chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** STcF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPcII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the Standard *** STcF project in china is under development with an extensive R&D *** document presents the physics opportunities at the STcF,describes conceptual designs of the STcF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity STcF detector conceptual design

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Amplitude analysis of the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)

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chinese Physics c 2024年第8期48卷 6-33页

作者： m.Ablikim m.N.Achasov P.Adlarson O.Afedulidis X.c.Ai R.Aliberti A.Amoroso Q.An Y.Bai O.Bakina I.Balossino Y.Ban H.-R.Bao V.Batozskaya K.Begzsuren N.Berger m.Berlowski m.Bertani D.Bettoni F.Bianchi E.Bianco A.Bortone I.Boyko R.A.Briere A.Brueggemann H.cai X.cai A.calcaterra G.F.cao N.cao S.A.cetin J.F.chang W.L.chang G.R.che G.chelkov c.chen c.H.chen chao chen G.chen H.S.chen m.L.chen S.J.chen S.L.chen S.m.chen T.chen X.R.chen X.T.chen Y.B.chen Y.Q.chen Z.J.chen Z.Y.chen S.K.choi X.chu G.cibinetto F.cossio J.J.cui H.L.Dai J.P.Dai A.Dbeyssi R.E.de Boer D.Dedovich c.Q.Deng Z.Y.Deng A.Denig I.Denysenko m.Destefanis F.De mori B.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici c.Q.Feng J.H.Feng Y.T.Feng K.Fischer m.Fritsch c.D.Fu J.L.Fu Y.W.Fu H.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia P.T.Ge Z.W.Ge c.Geng E.m.Gersabeck B.Ding X.X.Ding Y.Ding Y.Ding J.Dong L.Y.Dong m.Y.Dong X.Dong m.c.Du S.X.Du Z.H.Duan P.Egorov Y.H.Fan J.Fang JA.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna m.Greco m.H.Gu Y.T.Gu c.Y.Guan Z.L.Guan A.Q.Guo L.B.Guo m.J.Guo R.P.Guo Y.P.Guo A.Guskov J.Gutierrez K.L.Han T.T.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius c.H.Heinz Y.K.Heng c.Herold T.Holtmann P.c.Hong G.Y.Hou X.T.Hou Y.R.Hou Z.L.Hou B.Y.Hu H.m.Hu J.F.Hu T.Hu Y.Hu G.S.Huang K.X.Huang L.Q.Huang X.T.Huang Y.P.Huang T.Hussain F.H\"olzken N.H\"usken N.in der Wiesche m.Irshad J.Jackson S.Janchiv J.H.Jeong Q.Ji Q.P.Ji W.Ji X.B.Ji X.L.Ji Y.Y.Ji X.Q.Jia Z.K.Jia D.Jiang H.B.Jiang P.c.Jiang S.S.Jiang T.J.Jiang X.S.Jiang Y.Jiang J.B.Jiao J.K.Jiao Z.Jiao S.Jin Y.Jin m.Q.Jing X.m.Jing T.Johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang m.Kavatsyuk B.c.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.B.Kolcu B.Kopf m.Kuessner X.Kui A.Kupsc W.K\"uhn J.J.Lane P.Larin L.Lavezzi T.T.Lei Z.H.Lei H.Leithoff m.Lellmann T.Lenz c.Li c.Li c.H.Li cheng Li D.m.Li F.Li G.Li H.Li H.B.Li H.J.Li H.N.Li Hui Li J.R.Li J.S.Li K.Li L.J.Li L.K.Li Lei Li m.H.Li P.R.Li Q.m.Li Q.X.Li R.Li S.X.Li T.Li W.D.Li W.G.Li X.Li X.H.Li X.L.Li X.Y.Li Y Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Beihang University Beijing 100191China Bochum Ruhr-University D-44780 BochumGermany Budker Institute of Nuclear Physics SB RAS(BINP) Novosibirsk 630090Russia carnegie mellon University PittsburghPennsylvania 15213USA central china Normal University Wuhan 430079China central South University Changsha 410083China china center of Advanced Science and Technology Beijing 100190China china University of Geosciences Wuhan 430074China chung-Ang University Seoul06974Republic of Korea cOmSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China Hangzhou Normal University Hangzhou 310036China Hebei University Baoding 071002China Helmholtz Institute mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China Henan University of Science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan college Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN Sezione di Ferrara University of FerraraI-44122FerraraItaly Inner mongolia University Hohhot 010021China Institute of modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de A

Using e^(+)e^(−)annihilation data corresponding to an integrated luminosity of 2.93 fb^(−1)taken at the center-of-mass energy√s=3.773 GeV with the BESIII detector,a joint amplitude analysis is performed on the decays D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η).The fit fractions of individual components are obtained,and large interferences among the dominant components of the decays D^(0)→a_(1)(1260)π,D^(0)→π(1300)π,D^(0)→ρ(770)ρ(770),and D^(0)→2(ππ)_(S)are observed in both *** the obtained amplitude model,the cP-even fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are determined to be(75.2±1.1_(stat).±1.5_(syst.))%and(68.9±1.5_(stat).±2.4_(syst.))%,*** branching fractions of D^(0)→π^(+)π^(−)π^(+)π^(−)and D^(0)→π^(+)π^(−)π^(0)π^(0)(non-η)are measured to be(0.688±0.010_(stat.)±0.010_(syst.))%and(0.951±0.025_(stat.)±0.021_(syst.))%,*** amplitude analysis provides an important model for the binning strategy in measuring the strong phase parameters of D^(0)→4πwhen used to determine the cKm angleγ(ϕ_(3))via the B^(−)→DK^(−)decay.

关键词： BESIII D^(0)meson decays amplitude analysis cP-even fraction

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microvascular alterations of the ocular surface and retina in connective tissue disease-related interstitial lung disease

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1869-1879页

作者： Li-ming chen min Kang Jun-Yi Wang San-Hua Xu cheng chen Hong Wei qian Ling Liang-qi He Jie Zou Yi-Xin Wang Xu chen Ping Ying Hui Huang Yi Shao Rui Wu Department of Rheumatology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina The First School of clinical medicine of Nanchang University Jiangxi Medical College of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina School of Optometry and Vision Science Cardiff UniversityCardiffCF244HQWalesUK Ophthalmology centre of maastricht University Maastricht 6200MSLimburg ProvincieNetherlands Department of Ophthalmology Eye&ENT Hospital of Fudan UniversityShanghai 200030China

AIm:To examine the disparities in macular retinal vascular density between individuals with connective tissue disease-related interstitial lung disease(cTD-ILD)and healthy controls(Hcs)by optical coherence tomography angiography(OcTA)and to investigate the changes in microvascular density in abnormal ***:For a retrospective case-control study,a total of 16 patients(32 eyes)diagnosed with cTD-ILD were selected as the ILD *** 16 healthy volunteers with 32 eyes,matched in terms of age and sex with the patients,were recruited as control *** macular retina’s superficial retinal layer(SRL)and deep retinal layer(DRL)were examined and scanned using OcTA in each individual *** densities of retinal microvascular(mIR),macrovascular(mAR),and total microvascular(TmI)were calculated and *** in retinal vascular density in the macular region were analyzed using three different segmentation methods:central annuli segmentation method(c1-c6),hemispheric segmentation method[uperior right(SR),superior left(SL),inferior left(IL),and inferior right(IR)],and Early Treatment Diabetic Retinopathy Study(ETDRS)methods[superior(S),inferior(I),left(L),and right(R)].The data were analyzed using Version 9.0 of GraphPad prism and Pearson ***:The OcTA data demonstrated a statistically significant difference(Pmacular retinal microvessel density between the two ***,in the SRL and DRL analyses,the ILD group exhibited significantly lower surface density of mIR and TmI compared to the Hcs group(Pmore,using the hemispheric segmentation method,the ILD group showed notable reductions in SL,SR,and IL in the superficial retina(Pmarked decreases in SL and IR in the deep retina(Pmilarly,when employing the ETDRS method,the ILD group displayed substantial drops in superficial retinal S and I(Pctions in deep retinal L,I,and R(Pcentral annuli segmentation m

关键词： connective tissue disease‑related interstitial lung disease optical coherence tomography angiography microvessel density ocular surface retina

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马鞍山长江公铁大桥2100 mPa高强度钢绞线斜拉索及锚具研制

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桥梁建设 2024年第1期54卷 1-7页

作者：张强李冰郝玉柱周琦中铁大桥勘测设计院集团有限公司湖北武汉430056 宁安铁路公司(合肥枢纽指挥部) 安徽合肥230001 威胜利工程有限公司安徽合肥230001 河间市宝泽龙金属材料有限公司河北河间062450

巢马铁路马鞍山长江公铁大桥副汊航道桥为(58+168+392+168+58)m双塔三索面钢桁梁斜拉桥,斜拉索设计采用抗拉强度2100 mPa、抗疲劳应力幅280 mPa的∅15.2 mm低松弛PE镀锌钢绞线拉索。为保证高强度钢绞线斜拉索的力学及锚固性能,根据其技... 详细信息

巢马铁路马鞍山长江公铁大桥副汊航道桥为(58+168+392+168+58)m双塔三索面钢桁梁斜拉桥,斜拉索设计采用抗拉强度2100 mPa、抗疲劳应力幅280 mPa的∅15.2 mm低松弛PE镀锌钢绞线拉索。为保证高强度钢绞线斜拉索的力学及锚固性能,根据其技术指标要求,在1860 mPa钢绞线基础上,研制2100 mPa钢绞线及配套锚具。通过提高钢绞线原材料盘条中c、Si、mn元素含量及改进钢丝拉拔工艺,选择直径14.0 mm的PQS92Si-HT盘条为2100 mPa钢绞线原材料。为提高钢绞线的锚固性能,夹片选择20crmnTi钢,夹片长度52 mm、牙高0.45 mm、锥角6°10′、表面粗糙度R a3.2以上且表面硬度不低于56 HRc。根据2100 mPa钢绞线锚具的载荷变化和现行锚具锚板的材料性能,锚板选择40cr钢,并进行调质处理。对研制的2100 mPa钢绞线及配套锚具进行单孔锚及斜拉索锚具组件疲劳试验及疲劳后静载试验。结果表明:研制的2100 mPa钢绞线及其锚具组件均满足规范要求,可应用于马鞍山长江公铁大桥副汊航道桥。

关键词：公路铁路两用桥斜拉桥斜拉索钢绞线锚具夹片疲劳试验静载试验

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Impact of baseline body mass index on the long-term prognosis of advanced hepatocellular carcinoma treated with immunotherapy

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World Journal of Gastroenterology 2024年第37期30卷 4132-4148页

作者： Yu-qin Wang Di Pan Zhi-Yuan Yao Yu-qi Li Peng-Fei Qu Run-Bang Wang qing-Hao Gu Jie Jiang Zheng-Xiang Han Hao-Nan Liu Department of General Surgery The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina The First college of clinical medicine Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Oncology Suining County People’s HospitalXuzhou 221000Jiangsu ProvinceChina

BAcKGROUND Primary liver cancer is the sixth most common cancer worldwide,with hepato-cellular carcinoma(Hcc)being the most prevalent *** the current availability of multiple immune or immune combination treatment options,the prognosis is still poor,so how to identify a more suitable population is extremely *** To evaluate the clinical effectiveness of combining lenvatinib with camrelizumab for patients with hepatitis B virus(HBV)-related Hcc in Barcelona clinic Liver cancer(BcLc)stages B/c,considering various body mass index(BmI)in diffe-rent *** Retrospective data were collected from 126 Hcc patients treated with lenvatinib plus *** were divided into two groups based on BmI:The non-overweight group(BmIm2,n=51)and the overweight/obese group(BmI≥25 kg/m2,n=75).Short-term prognosis was evaluated using mREcIST criteria,with subgroup analyses for non-overweight(BmI:18.5-24.9 kg/m2),overweight(BmI:25-30 kg/m2),and obese(BmI≥30 kg/m2)patients.A cox proportional hazards regression analysis identified independent prognostic factors for overall survival(OS),leading to the development of a column-line graph *** subgroup analyses for non-overweight(BmI:18.5-24.9 kg/m2),overweight(BmI:25-30 kg/m2),and obese(BmI≥30 kg/m2)patients.A cox proportional hazards regression analysis identified independent prognostic factors for overall survival(OS),leading to the development of a column-line graph *** median progression-free survival was significantly longer in the obese/overweight group compared to the non-overweight ***,the median OS was significantly prolonged in the obese/overweight group than in the non-overweight *** objective remission rate and disease control rate for the two groups of patients were,respectively,objective remission rate(5.88%vs 28.00%)and disease control rate(39.22%vs 62.67%).Fatigue was more prevalent in the obese/overweight group,while other adverse effects showed n

关键词： Hepatocellular carcinoma camrelizumab Lenvatinib Efficacy Safety

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Inflammation-Targeting Fullerene Nanoparticles Dually Inhibit macrophage and Osteoclast Differentiation for mitigating Rheumatoid Arthritis

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ccS chemistry 2024年第9期6卷 2275-2288页

作者： Lei Liu Xue Li Zhanfeng Wu Libin Yang Jiawei Huo Shaojian Tang Xinran cao Yuan Xu Xiaodan Liao Hedong qi Jie Li Jingchao Liu Jianxin Tian Rui Wen chunru Wang chunli Bai Key Laboratory of molecular Nanostructure and Nanotechnology Beijing National Laboratory for Molecular SciencesCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190 University of chinese Academy of Sciences Beijing 100049 School of Pharmacy Weifang Medical UniversityWeifang 261053

In rheumatoid arthritis(RA),the presence of substantial inflammatory macrophages and osteoclasts in joints is known to contribute to the progression of articular inflammation and bone ***,we develop a sialic acid-modified tetra malonic acid derivative of c70 fullerene(STmF).STmF possesses inflammation-targeting capability that can effectively impede the differentiation of macrophages and osteoclasts,offering a potential treatment strategy for *** acts as a mimic of sialyl Lewis x,enabling it to specifically bind with E-selectin,which is overexpressed on inflamed endothelial *** selective binding results in a targeted distribution of STmF to inflamed joints,addressing articular *** uptake by macrophages,STmF demonstrates the ability to effectively eliminate intracellular reactive oxygen species and deactivate the downstream events,thereby suppressing their differentiation into m1-phenotype and *** our experiments using collagen-induced arthritis mouse models,STmF significantly improves paw swelling and redness,mitigates articular inflammation with reduced m1 macrophages,lessens osteoclasts,and repairs bone erosion with neglectable side *** findings suggest that STmF has potential as a therapeutic agent for RA,leveraging inflammation-targeting fullerene nanomaterials.

关键词： fullerene targeting inflammation rheumatoid arthritis sialic acid macrophages osteoclasts

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The siphonic energy transfer between hot solar wind and cold martian ionosphere through open magnetic flux rope

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Fundamental Research 2024年第4期4卷 882-889页

作者： Xiaojun Xu Lou-chuang Lee qi Xu qing chang Jing Wang ming Wang Shaosui Xu christian mosti charles J.Farrugia Xing Wang Yudong Ye Zilu Zhou Lei Luo Peishan He Shaoguan cheng State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China cNSA macao center for Space Exploration and Science Macao 999078China Institute of Earth Science Academia SinicaTaipei 115029China Institute of Space Science and Applied Technology Harbin Institute of TechnologyShenzhen 518000China Planetary Environmental and Astrobiological Research Laboratory(PEARL) School of Atmospheric SciencesSun Yat-sen UniversityZhuhai 519000China Nanjing University of Information Science and Technology Nanjing 210000China Space ScienceLaboratory Universityof CaliforniaBerkeleyCA94320USA Space Research Institute Austrian Academy of SciencesGraz 8010Austria University of New Hampshire NH 03824USA

A mechanism for energy transfer from the solar wind to the martian ionosphere through open magnetic flux rope is proposed based on the observations by mars Atmosphere and Volatile EvolutioN(mAVEN).The satellite was located in the dayside magnetosheath at an altitude of about 70o km above the northern *** between the hot solar wind protons and the cold heavy ions/neutrals in the subsolar region can cool the protons and heat the heavy *** a result,the magnetosheath protons are siphoned into the ionosphere due to the thermal pressure gradient of protons and the heated heavy ions escape along the open magnetic field *** direct collisions in the lower-altitude region were not detected,this physical process is demonstrated by mAVEN measurements of enhanced proton density,decreased proton temperature and oppositely directed motions of hot and cool protons within the flux rope,which are very different from the observational features of the flux transfer events near the Earth's *** mechanism could universally exist in many contexts where a collisionless plasma region is connected to a collisional plasma *** reconstructing the magnetic geometry and the cross-section of the flux rope using the Grad-Shafranov technique,the ion loss rates are quantitatively estimated to be on the order of 1023 s-l,which is much higher than previously estimated.

关键词： mars Flux rope Solarwind Ionosphere Ion loss

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