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Branched module-modified SN38 prodrug nanoassemblies for improved colorectal cancer therapy:Effectively balance efficacy and safety

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Nano Research 2025年第1期18卷 572-585页

作者： qing wang Shiyi Zuo Shufang Zheng Cuiyun Liu Yaqiao Li Jiayu Guo Danping wang Shuo wang Wenjing wang Bowen Zhang Minglong Huang Xianbao Shi Jin Sun Zhonggui He Bingjun Sun Department of Pharmaceutics Wuya College of InnovationShenyang Pharmaceutical UniversityShenyang 110016China Joint International Research Laboratory of Intelligent Drug Delivery Systems Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China School of Chemical Engineering The University of AdelaideAdelaideSA 5005Australia Department of Pharmacy The First Affiliated Hospital of Jinzhou Medical UniversityJinzhou 121001China

The clinical utility of irinotecan is restricted by individual variability in carboxylesterase *** administration of its active metabolite,7-ethyl-10-hydroxycamptothecin(SN38),presents an appealing alternative due to its potent anti-tumor ***,the undesirable properties of SN38,such as poor water solubility and nontarget toxicity,present significant hurdles to its clinical *** nanoassemblies based on modular design strategy show promise in overcoming these challenges by enhancing drug delivery and selective *** modular design,the modification module plays a crucial role in improving the self-assembly capability of *** current studies mainly focus on using straight aliphatic chains for prodrug design,branched aliphatic chains emerge as superior alternatives warranting further *** this study,we selected 2-heptylundecanol(BAlc18)as modification module to construct an SN38 *** exquisite design,SN38-SS-BAlc18 NPs integrated prominent properties in selfassembly capability,specific activation and biocompatibility,resolving the challenges of irinotecan and SN38,ultimately demonstrating excellent anti-tumor *** exploration enriched the design theory of prodrug nanoassemblies that can effectively balance safety and colorectal anti-tumor efficacy.

关键词： irinotecan SN38 prodrug nanoassemblies disulfide bonds branched aliphatic chains

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有限元分析不同内固定方式治疗肱骨近端骨折的力学差异

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中国组织工程研究 2025年第15期29卷 3101-3109页

作者：王磊王清张申申福建医科大学附属闽东医院福建省福安市355000 福建医科大学福建省福州市350108

背景:目前临床中治疗肱骨近端骨折的钢板内固定方式仍无绝对标准,但重建内侧肱骨距并有效抵抗肱骨头内翻移位是实现肱骨近端骨折坚强固定的要点。目的:利用有限元分析技术获得3种内固定方式作用于肱骨近端骨折的力学差异,对比何种内固... 详细信息

背景:目前临床中治疗肱骨近端骨折的钢板内固定方式仍无绝对标准,但重建内侧肱骨距并有效抵抗肱骨头内翻移位是实现肱骨近端骨折坚强固定的要点。目的:利用有限元分析技术获得3种内固定方式作用于肱骨近端骨折的力学差异,对比何种内固定方法可以提供更加稳定的固定支撑。方法:选择一名健康女性志愿者进行左肩关节的CT扫描,通过有限元分析软件构建肱骨近端骨折伴内侧柱支撑缺损模型。根据钢板内固定方式将模型划分为3组:A组仅在外侧应用Philos钢板固定;B组外侧应用Philos钢板联合内侧微型直行锁定加压板固定;C组外侧Philos钢板联合前内侧微型直行锁定加压板固定。在相同的固定支撑和约束条件下,采用ANSYS分析软件评估3组内固定模型的生物力学稳定性。结果与结论:①3组内固定模型的内固定物应力均未超过450 MPa;②不同载荷条件下,A组肱骨和内固定物的应力较高于B、C两组,而C组的肱骨和内固定物的应力均为最小值;③在屈曲载荷条件下,C组的相对位移对比A、B两组数值较小;④所有载荷条件下,B组的骨折端相对位移是最小的;在内收、外展以及轴向压缩的载荷条件下,B组的相对位移大约只有A组的一半;⑤C组与B组之间的相对位移并没有显著的差异,且C组的相对位移也均小于A组;⑥结果发现,相较于仅应用外侧Philos钢板,外侧Philos钢板与内侧微型直行锁定加压板的联合应用,以及外侧Philos钢板与前内侧微型直行锁定加压板的联合应用,均展现出显著的内固定系统稳定性,后两种组合在内固定系统稳定性上并未呈现出明显差异;综合考虑临床实践中的操作难易程度,外侧Philos钢板与前内侧微型直行锁定加压板的联合内固定方式治疗肱骨近端骨折可能更具优势。

关键词：肱骨近端骨折内侧柱重建 Philos钢板双钢板有限元分析

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经“O”点穿刺与传统单侧入路治疗L_(5)椎体骨质疏松性压缩性骨折

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中国组织工程研究 2025年第15期29卷 3165-3170页

作者：徐雨果黄家虎王清徐双王松西南医科大学附属医院骨科四川省泸州市646000 四川省科技城医院四川省绵阳市621000

背景:单侧穿刺入路经皮穿刺球囊扩张椎体后凸成形治疗骨质疏松性椎体压缩骨折优于双侧穿刺入路,由于L_(5)特殊解剖形态和位置特殊,传统单侧穿刺入路治疗L_(5)椎体骨质疏松性椎体压缩骨折适用性差,因此提出“O”点穿刺入路来解决该问题... 详细信息

背景:单侧穿刺入路经皮穿刺球囊扩张椎体后凸成形治疗骨质疏松性椎体压缩骨折优于双侧穿刺入路,由于L_(5)特殊解剖形态和位置特殊,传统单侧穿刺入路治疗L_(5)椎体骨质疏松性椎体压缩骨折适用性差,因此提出“O”点穿刺入路来解决该问题。目的:比较经横突基底部-椎弓根后上部-关节突外侧交点(“O”点)入路与传统单侧入路经皮穿刺球囊扩张椎体后凸成形治疗L_(5)椎体骨质疏松性压缩骨折的疗效差异。方法:回顾性分析西南医科大学附属医院2020年1月至2022年12月收治的54例L_(5)椎体骨质疏松性压缩骨折行经“O”点入路或传统经皮穿刺球囊扩张椎体后凸成形治疗的患者,根据手术方式分为2组,“O”点入路组(A组)29例,传统入路组(B组)25例。术前在X射线正位片测量A组“O”点与髂棘位置及穿刺角度;比较两组术前与术后第2天、末次随访的局部Cobb角、椎体前缘、中部高度及骨水泥分布情况;术前、术后第2天及末次随访采用疼痛目测类比评分、Oswestry功能障碍指数评估患者疼痛缓解情况与日常生活能力,记录手术相关并发症。结果与结论:①A组手术时间、术中透视次数均少于B组,差异有显著性意义(P0.05);⑤术后骨水泥分布,A组分布良好占97%(28/29),B组分布良好占88%(22/25),A组明显优于B组(P<0.05);⑥提示经“O”点穿刺入路与传统入路经皮穿刺球囊扩张椎体后凸成形治疗L_(5)椎体骨质疏松性压缩骨折疗效满意,但“O”点穿刺入路经皮穿刺球囊扩张椎体后凸成形治疗骨水泥分布更满意,还可避免高髂棘对L_(5)椎体穿刺入路的影响。

关键词：骨质疏松性压缩骨折经皮穿刺椎体后凸成形 “O”点 L_(5)椎体骨水泥

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Control Design for Transient Performance

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IEEE/CAA Journal of Automatica Sinica 2023年第1期10卷 3-7页

作者： qing-Guo wang Institute of Artificial Intelligence and Future Networks Beijing Normal University Guangdong Key Lab of AI and Multi-Modal Data Processing BNU-HKBU United International CollegeZhuhai 519087China

CONTROL systems are everywhere – chemical plants,energy systems, manufacturing, homes and buildings,automobiles and trains, medical devices, cellular telephones and internet, aircraft and spacecraft. Recent developments in these fields bring up the systems with the unprecedented scope, scale and complexity such as cyber-physical and human systems, and the required control task becomes more challenging than ever [1]。

关键词： telephone automobile everywhere

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Mixing and heat transfer of binary mixtures of monodispersed spherical particles with different densities and thermal diffusivities

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Particuology 2021年第5期19卷 118-130页

作者： qing wang Bowen Liu Engineering Research Centre of Oil Shale Comprehensive Utilization Ministry of EducationNortheast Electric Power UniversityJilin 132012China

Mixing and heat transfer among particles in rotating drums are widely applied in numerous industrial ***,mixing and heat transfer occur ***,the interrelationship between mixing and heat transfer must be investigated for industrial *** this study,the radial mixing and heat transfer of spherical granular materials(3 mm)with various properties in batch rotating drums are investigated numerically using the discrete element *** evolution of mixing and heat transfer characteristics with rotation speed is analyzed from the perspective of time and number of revolutions,*** results indicate that,depending on the physical parameters and thermal properties of particles,the mixing quality does not always accurately reflect the heat transfer *** binary granular beds of monodispersed spherical particles with different densities and thermal diffusivities,the main heat transfer mechanism is related to the ratio of the thermal conductivity of the particles to that of the fluid.

关键词： Rotating drums Discrete element method Mixing Heat conduction Heat radiation

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后路C_(2-3)固定结合顶棒置入与单纯后路C_(2-3)固定治疗不稳定Hangman骨折的比较

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中国组织工程研究 2025年第9期29卷 1848-1854页

作者：张浩王清张建李广州王高举西南医科大学附属医院骨科四川省泸州市646000

背景:Hangman骨折中Ⅱ、ⅡA、Ⅲ型常需手术治疗,手术方式选择存在较大争议,目前均存在术后复位不全及畸形愈合等不足;前期作者团队使用C_(2-3)拉力螺钉结合经口顶棒技术间歇性推顶C2椎体治疗不稳定Hangman骨折,取得了满意的临床疗效,但... 详细信息

背景:Hangman骨折中Ⅱ、ⅡA、Ⅲ型常需手术治疗,手术方式选择存在较大争议,目前均存在术后复位不全及畸形愈合等不足;前期作者团队使用C_(2-3)拉力螺钉结合经口顶棒技术间歇性推顶C2椎体治疗不稳定Hangman骨折,取得了满意的临床疗效,但前期研究样本少,且缺少对照组比较。目的:比较后路C_(2-3)固定结合经口顶棒技术和单纯后路C_(2-3)固定治疗不稳定Hangman骨折的临床疗效。方法:回顾性分析西南医科大学附属医院收治的行后路C_(2-3)固定手术治疗的55例不稳定Hangman骨折患者临床及影像学资料,根据手术方案分为2组,其中23例患者接受后路C_(2-3)固定结合经口顶棒技术治疗(A组),32例接受单纯后路C_(2-3)固定术(B组)。比较两组患者的手术时间、术中出血量、并发症、术前及末次随访时疼痛目测类比评分、颈椎功能障碍指数、美国脊髓损伤协会脊髓损伤分级和患者满意度(Odom’s分级);另外对比各观察时间点C_(2-3)移位和成角及其他影像学指标的变化。结果与结论:①两组患者手术时间、术中出血量和术后并发症发生情况比较差异无显著性意义(P>0.05);②两组患者末次随访颈痛目测类比评分和颈椎功能障碍指数较术前获得显著改善(P0.05);③两组术前C_(2-3)成角和位移差异无显著性意义(P>0.05);术后及末次随访时,两组患者C_(2-3)成角和位移均较术前明显减小,差异有显著性意义(P0.05);术后及末次随访时,A组C_(2-3)位移和成角较B组明显减小,差异有显著性意义(P<0.05);④末次随访时,A组患者均未发生残余畸形,B组发生残余畸形4例(13%,4/32);⑤因此,后路C_(2-3)固定结合经口顶棒技术可能有利于枢椎体复位和稳定,减少畸形愈合,获得更好的复位。

关键词： Hangman骨折顶棒技术后路拉力螺钉骨折复位内固定

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Mechanisms and strategies to overcome immunotherapy resistance in hepatobiliary malignancies

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Hepatobiliary & Pancreatic Diseases International 2022年第5期21卷 430-439页

作者： Jia Xiong qing-qing wang Institute of Immunology Zhejiang University School of MedicineHangzhou 310058China The Key Laboratory for Immunity and Inflammatory Diseases of Zhejiang Province Hangzhou 310058China

Unprecedented advances have been achieved in hepatobiliary cancer treatment with immune checkpoint blockade(ICB).However,the efflcacy of ICB in patients with hepatobiliary malignancies is still *** to immunotherapies is often orchestrated by complicated tumor-host-microenvironment interactions but could also occur after initial efflcacy,mostly when only partial responses are *** of cancer-resistance mechanisms will be beneficial to provide the rationale for the administration of personalized ***,we review the factors related to resistance to immune-targeted therapies in hepatobiliary malignancies and discuss the potential strategies for overcoming resistance and future directions of immunotherapy development.

关键词： Cancer immunotherapy Hepatobiliary malignancies Immune checkpoint blockade Drug resistance

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Methods for determining unimpeded aircraft taxiing time and evaluating airport taxiing performance

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Chinese Journal of Aeronautics 2017年第2期30卷 523-537页

作者： Yu Zhang qing wang Civil and Environmental Engineering University of South Florida College of Air Traffic Management Civil Aviation University of China College of Transportation Engineer Tongji University

The objective of this study is to improve the methods of determining unimpeded（nominal） taxiing time,which is the reference time used for estimating taxiing delay,a widely accepted performance indicator of airport surface *** reviewing existing methods used widely by different air navigation service providers（ANSP）,new methods relying on computer software and statistical tools,and econometrics regression models are *** models are highly recommended because they require less detailed data and can serve the needs of general performance analysis of airport surface *** proposed econometrics model outperforms existing ones by introducing more explanatory variables,especially taking aircraft passing and over-passing into the considering of queue length calculation and including runway configuration,ground delay program,and weather *** length of the aircraft queue in the taxiway system and the interaction between queues are major contributors to long taxi-out *** proposed method provides a consistent and more accurate method of calculating taxiing delay and it can be used for ATM-related performance analysis and international comparison.

关键词： Aircraft taxiing Airport performance Econometric regression modeling Queue length Simulation analysis Taxiway system

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Experiments on unsteady vortex flowfield of typical rotor airfoils under dynamic stall conditions

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Chinese Journal of Aeronautics 2016年第2期29卷 358-374页

作者： wang qing Zhao Qijun National Key Laboratory of Science and Technology on Rotorcraft Aeromechanics Nanjing University of Aeronautics and Astronautics

A new experiment for airfoil dynamic stall is conducted by employing the advanced par- ticle image velocimetry （PIV） technology in an open-return wind tunnel. The aim of this experimen- tal investigation is to demonstrate the influences of different motion parameters on the convection velocity, position and strength of leading edge vortex （LEV） of airfoil under different dynamic stall conditions. Two different typical rotor airfoils, OA209 and SC1095, are measured at different free stream velocities, oscillation frequencies, and angles of attack. It is demonstrated by the measured data that the airfoil with larger leading edge radius could notably decrease the strength of LEV. The angle of attack （AoA） of airfoil can obviously influence the dynamic stall characteristics of airfoil, and the LEV would be effectively inhibited by decreasing the mean pitch angle. In addition, the con- vection velocity of LEV is estimated in this measurement, and the results demonstrate that the influ- ence of airfoil shape on convection velocity of LEV is limited, but the convection velocity of LEV would be increased by enlarging the oscillation frequency. Meanwhile, the convection velocity of LEV is a time variant value, and this value would increase as the LEV convects to the trailing edge of airfoil.

关键词： Convection velocity Dynamic stall Leading edge vortex PIV Rotor airfoil

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BAHA:A Novel Approach to Automatic Bug Report Assignment with Topic Modeling and Heterogeneous Network Analysis

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Chinese Journal of Electronics 2016年第6期25卷 1011-1018页

作者： ZHANG Wen wang Song wang qing School of Economics and Management Beijing University of Chemical Technology Department of Electrical and Computer Engineering at University of Waterloo Laboratory of Internet Technologies Institute of SoftwareChinese Academy of Sciences

We propose an approach called Bug report assignment with topic modeling and heterogeneous network analysis(BAHA) to automatically assign bug reports to developers. Existing studies adopt social network analysis to characterize the collaboration of developers. The networks used in these studies are all homogenous. In real practice of bug resolution, different developers collaborate on different bug reports that makes the homogenous network unable to capture this information. We use heterogeneous network to describe the relations between reporters,bug reports and developers to characterize developers’ collaboration. Experiments on Eclipse JDT pro ject show that BAHA outperforms the state of art methods on automatic bug report assignment.

关键词： Bug report assignment Topic model Heterogeneous network Bug report tracking

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