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Atypical presentation of a hepatic artery pseudoaneurysm:A case report and review of the literature

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World Journal of Hepatology 2016年第18期8卷 779-784页

作者： Casey m Luckhurst Chelsey Perez amy L Collinsworth Jose G Trevino Department of Surgery Colleges of MedicineUniversity of Florida Health Science Center Department of Surgery Colleges of MedicineUniversity of FloridaHealth Science Center Department of Pathology Colleges of MedicineUniversity of Florida Health Science Center

Classically, hepatic artery pseudoaneurysms(HAPs) arise secondary to trauma or iatrogenic causes. With an increasing prevalence of laparoscopic procedures of the hepatobiliary system the risk of inadvertent injury to arterial vessels is increased. Pseudoaneurysm formation post injury can lead to serious consequences of rupture and subsequent hemorrhage, therefore intervention in all identified visceral pseudoaneurysms has been advocated. A variety of interventional methods have been proposed, with surgical management becoming the last step intervention when minimally invasive therapies have failed. The authors present a case of a HAP in a 56-year-old female presenting with jaundice and pruritis suggestive of a Klatskin's tumor. This presentation of HAP in a patient without any significant past medical or surgical intervention is atypical when considering that the majority of HAP cases present secondary to iatrogenic causes or trauma. multiple minimally invasive approaches were employed in an attempt to alleviate the symptomology which included jaundice and associated inflammatory changes. Ultimately, a right hepatic trisegmentectomy was required to adequately relieve the mass effect on biliary outflow obstruction and definitively address the HAP. The presentation of a HAP masquerading as a malignancy with jaundice and pruritis, rather than the classic symptoms of abdominalpain, anemia, and melena, is unique. This presentation is only further complicated by the absent history of either trauma or instrumentation. It is important to be aware of HAPs as a potential cause of jaundice in addition to the more commonly thought of etiologies. Furthermore, given the morbidity and mortality associated with pseudoaneurysm rupture, intervention in identifiable cases, either by minimally invasive or surgical interventions, is recommended.

关键词： Klatskin tumor Cholangitis Hepatic artery pseudoaneurysm Biliary obstruction Trisegmentectomy

Specific bone region localization of osteolytic versus osteoblastic lesions in a patient-derived xenograft model of bone metastatic prostate cancer

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Asian Journal of Urology 2016年第4期3卷 229-239页

作者： Takeshi Hirata Seung Chol Park michelle T.muldong Christina N.Wu Tomonori Yamaguchi amy Strasner Omer Raheem Hiromi Kumon Robert L.Sah Nicholas A.Cacalano Catriona H.m.Jamieson Christopher J.Kane Koichi masuda Anna A.Kulidjian Christina A.m.Jamieson Department of Urology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayamaJapan Department of Urology Wonkwang University School of Medicine and HospitalIksanSouth Korea moores Cancer Center University of CaliforniaSan DiegoLa JollaCAUSA Department of Urology University of CaliforniaSan DiegoLa JollaCAUSA Department of Surgery University of CaliforniaSan DiegoLa JollaCAUSA Department of medicine University of CaliforniaSan DiegoLa JollaCAUSA Department of Orthopaedic Surgery School of MedicineUniversity of CaliforniaSan DiegoLa JollaCAUSA Department of Bioengineering University of CaliforniaSan DiegoLa JollaCAUSA Department of Radiation Oncology University of California at Los AngelesLos AngelesCAUSA

Objective:Bone metastasis occurs in up to 90%of men with advanced prostate cancer and leads to fractures,severe pain and *** metastases induce a spectrum of types of bone lesions which can respond differently to therapy even within individual prostate cancer ***,the special environment of the bone makes the disease more complicated and incurable.A model in which bone lesions are reproducibly induced that mirrors the complexity seen in patients would be invaluable for pre-clinical testing of novel *** microstructural changes in the femurs of mice implanted with PCSD1,a new patient-derived xenograft from a surgical prostate cancer bone metastasis specimen,were ***:Quantitative micro-computed tomography(micro-CT)and histological analyses were performed to evaluate the effects of direct injection of PCSD1 cells or media alone(Control)into the right femurs of Rag2/gc/male ***:Bone lesions formed only in femurs of mice injected with PCSD1 *** volume(BV)was significantly decreased at the proximal and distal ends of the femurs(pmeter(pmur ***:PCSD1 cells reproducibly induced bone loss leading to osteolytic lesions at the ends of the femur,and,in contrast,induced aberrant bone formation leading to osteoblastic lesions along the femur ***,the interaction of PCSD1 cells with different bone region-specific microenvironments specified the type of bone *** approach can be used to determine if different bone regions support more therapy resistant tumor growth,thus,requiring novel treatments.

关键词： Bone metastatic prostate cancer Patient-derived xenograft microenvironment microstructural CT Osteolytic lesions Osteoblastic lesions

患有典型毛细支气管炎的婴儿应避免胸部X线检查

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英国医学杂志中文版 2022年第11期25卷 677-681页

作者： Jeremy N Friedman Tessa Davis Aarani Somaskanthan amy ma 韩彤妍(译) Paediatrics Hospital for Sick ChildrenTorontoOntario M3B 3E8Canada Paediatric Emergency Department Royal London HospitalLondonUK Sydney Children's Hospital Network Australia Family Advisory Forum Montreal Children's HospitalMontrealQuebecCanada 北京大学第三医院

毛细支气管炎是一种病毒性下呼吸道感染,主要发生在冬季,通常由呼吸道合胞病毒(respiratory syncytial virus,RSV)引起。其主要发生于婴儿期,但可发生在2岁以下幼儿,是这一年龄组住院治疗的最常见原因。90%的儿童在2岁以内感染RSV,高达... 详细信息

毛细支气管炎是一种病毒性下呼吸道感染,主要发生在冬季,通常由呼吸道合胞病毒(respiratory syncytial virus,RSV)引起。其主要发生于婴儿期,但可发生在2岁以下幼儿,是这一年龄组住院治疗的最常见原因。90%的儿童在2岁以内感染RSV,高达40%的患儿会在感染初始阶段经历毛细支气管炎^(1)。

关键词：毛细支气管炎下呼吸道感染呼吸道合胞病毒胸部X线检查婴儿期住院治疗 RSV 病毒性

Cell based therapy aides in infection and inflammation resolution in the murine model of cystic fibrosis lung disease

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Stem Cell Discovery 2013年第2期3卷 139-153页

作者： Tracey L. Bonfield Donald Lennon Santosh K. Ghosh amy m. Dimarino Aaron Weinberg Arnold I. Caplan Department of Pediatric Pulmonology Case Western Reserve University Cleveland USA

Cystic fibrosis (CF) is a genetically inherited disease which is characterized by excessive inflammation and inability to resolve infection with pathogens such as Pseudomonas aeruginosa. Treatment options have improved with correctors and potentiators, but a cure remains elusive. Human mesenchymal stem cells (hmSCs) have the potential to be both anti-inflammatory and anti-microbial, which makes them ideal candidates for exploration as an innovative new therapeutic for CF. Using a sublethal CF mouse model of chronic Pseudomonas aeruginosa infection, we show that hmSCs and wild type bone marrow derived macrophages (Bmm) have the capacity to attenuate inflammation while at the same time improving the ability to resolve infection. Animals infected with bacteria and treated with hmSCs and Bmm had less weight lost, decreased pro-inflammatory cytokines, decreased severity of gross lung pathology as well as clinical score. Importantly, even though the inflammation was decreased in vivo, both Bmm and hmSC treatment resulted in significant decrease in lung bacterial load. The improvement in the CF model was consistent with hmSC induced anti-inflammatory and anti-microbial activity which may involve the cathelicidin LL-37. These studies suggest that both healthy mSCs and Bmm may provide important new direction toward cell based therapies in CF.

关键词： Inflammation mesenchymal Stem Cells Antimicrobial Activity

PNAS:科学家或成功实现利用基因疗法来治疗阿尔兹海默氏症

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现代生物医学进展 2017年第4期17卷 I0001-I0002页

作者： Loukia Katsouri[a] Yau m. Lim[a] Katrin Blondrath[a] Ioanna Eleftheriadou[b] Laura Lombardero[a] amy m. Birch[a] Nazanin mirzaei[a] Elaine E. Irvine[c] Nicholas D. mazarakis[b], magdalena Sastre[a], [a]Division of Brain Sciences Imperial College London London W12 0NN United Kingdom [b]Gene Therapy Division of Brain Sciences Imperial College London London W12 0NN United Kingdom [c]Institute for Clinical Sciences Medical Research Council Clinical Sciences Centre London W12 0NN United Kingdom

日前,来自帝国理工学院的研究人员通过利用病毒将特殊的基因片段运输到小鼠大脑中，从而成功抑制小鼠患阿尔兹海默氏症，相关研究刊登于国际杂志PNAS上，该研究或为后期开发治疗诸如阿尔兹海默氏症等神经性疾病的新型疗法提供思路。

关键词：基因疗法治疗利用科学家神经性疾病基因片段研究人员后期开发

Beyond the Pediatric end-stage liver disease system: Solutions for infants with biliary atresia requiring liver transplant

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World Journal of Gastroenterology 2014年第32期20卷 11062-11068页

作者： mary Elizabeth m Tessier Sanjiv Harpavat Ross W Shepherd Girish S Hiremath mary L Brandt amy Fisher John A Goss Department of Pediatrics Baylor College of Medicine and Texas Children’s Hospital Department of Pediatrics Baylor College of Medicine and Texas Children’s Hospital Houston Department of Surgery Baylor College of Medicine and Texas Children’s HospitalHouston

Biliary atresia(BA), a chronic progressive cholestatic disease of infants, is the leading cause for liver transplant in children, especially in patients under two years of age. BA can be successfully treated with the Kasai portoenterostomy; however most patients still require a liver transplant, with up to one half of BA children needing a transplant by age two. In the current pediatric end-stage liver disease system, children with BA face the risk of not receiving a liver in a safe and timely manner. In this review, we discuss a number of possible solutions to help these children. We focus on two general approaches:(1) preventing/delaying need for transplantation, by optimizing the success of the Kasai operation; and(2) expediting transplantation when needed, by performing techniques other than the standard deceased-donor, whole, ABO-matched organ transplant.

关键词： Biliary atresia Liver transplantation Pediatric li

Quantitative trait loci associated with soybean seed weight and composition under different phosphorus levels

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Journal of Integrative Plant Biology 2018年第3期60卷 232-241页

作者： Gokhan Hacisalihoglu amy L.Burton Jeffery L.Gustin Selim Eker Safiye Asikli Elif Hakli Heybet Levent Ozturk Ismail Cakmak Atilla Yazici Kent O.Burkey James Orf A.mark Settles Department of Biological Sciences Florida A&M UniversityTallahasseeFL 32307USA United States Department of Agriculture Agricultural Research ServicePlant Science Research UnitRaleighNC 27607USA Horticultural Science Department University of FloridaGainesvilleFL 32611USA Department of Soil Science&Plant Nutrition Cukurova University01330 AdanaTurkey Faculty of Engineering&Natural Sciences Sabanci University34956 IstanbulTurkey Department of Agronomy&Plant Genetics University of MinnesotaSt.PaulMN 55108USA

Seed size and composition are important traits in food crops and can be affected by nutrient availability in the soil. Phosphorus （P） is a non-renewable, essential macronutrient, and P deficiency limits soybean （G1ycine max） yield and quality. To investigate the associations of seed traits in low- and high-P environ- ments, soybean recombinant inbred lines （RILs） from a cross of cultivars Fiskeby III and mandarin （Ottawa） were grown under contrasting P availability environments. Traits including individual seed weight, seed number, and intact mature pod weight were significantly affected by soil P levels and showed transgressive segregation among the RILs. Surprisingly, P treatments did not affect seed composition or weight, suggesting that soybeanmaintains sufficient P in seeds even in Iow-P soil. Quantitative trait loci （QTLs） were detected for seed weight, intact pods, seed volume, and seed protein, with five significant QTLs identified in Iow-P environments and one significant QTL found in the optimaI-P environment. Broad-sense heritability estimates were 0.78 （individual seed weight）, *** （seed protein）, 0.34 （seed oil）, and 0.98 （seed number）. The QTLs identified under low P point to genetic regions that may be useful to improve soybean performance under limiting P conditions.

关键词： Qian Qian China National Rice Research Institute China

硫胺素与甘草酸二铵治疗慢性乙型肝炎的临床疗效分析

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临床肝胆病杂志 2003年第4期19卷 226-227页

作者：李永新高庆伟 Diana m Luan amy E. Wallace 王英兰大连市第六人民医院辽宁大连116001 Dartmouth medical School

观察硫胺素与甘草酸二铵治疗慢性乙型肝炎的临床疗效。在美国加州及大连分别对慢性乙型肝炎患者应用硫胺素和甘草酸二铵。甘草酸二铵组与甘草酸二铵 +硫胺素组肝功复常率两组间有显著差异 ;硫铵素组与上述两组比较肝功复常率明显降低 ,... 详细信息

观察硫胺素与甘草酸二铵治疗慢性乙型肝炎的临床疗效。在美国加州及大连分别对慢性乙型肝炎患者应用硫胺素和甘草酸二铵。甘草酸二铵组与甘草酸二铵 +硫胺素组肝功复常率两组间有显著差异 ;硫铵素组与上述两组比较肝功复常率明显降低 ,差异显著。硫铵素组连续用药 4 8周后 ,肝功复常率、血清HBVDNA、HBeAg阴转率与治疗第八周结束时各治疗组比较有显著差异。硫铵素可降低乙肝病毒含量 ,稳定肝脏内环境。

关键词：硫胺素甘草酸二铵治疗慢性乙型肝炎疗效分析

ICU小组长交接班基本信息文档设计：一项小组研究

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中国护理管理 2018年第2期18卷 288-288页

作者： amy J. Spooner Leanne m. Aitken Amanda Corley Wendy Chaboyer 查尔斯王子医院危重病房重症护理研究小组澳大利亚布理斯本 NHmRC护理研究中心、昆士兰menzies卫生学校格利菲斯大学格利菲斯大学护理学院亚历山大王子医院危重病房伦敦城市大学医学院

背景:尽管对有系统结构的交接班文档(用于引导有效交接班)的需求在不断增加,针对ICU交接班的交班指导工具却是有限的。目的 :此项研究的目的在于帮助ICU小组长收集患者的主要病情项目,更有效地进行班次之间的交接。方法 :研究设在澳洲... 详细信息

背景:尽管对有系统结构的交接班文档(用于引导有效交接班)的需求在不断增加,针对ICU交接班的交班指导工具却是有限的。目的 :此项研究的目的在于帮助ICU小组长收集患者的主要病情项目,更有效地进行班次之间的交接。方法 :研究设在澳洲的一个有21张床位的危重病房内/外科ICU。参加人员为参与交接班的高资历护士。参与小组采用名义群体法(Nominal Group Technique,NGT)选择并且排序需要收集患者主要病情资料的重要性。接班的护士从前一班护士组长的交班内容中选择哪些项目应该包含在基本病情资料中。选择结果以出现频率和百分率作总结。结果 :参与研究的三个小组由17位高资历护士组成。参与人员一致同意ISBAR(识别-基本情况-背景-检查分柝-建议)是指导临床交接班的一项有效的应用工具。经筛选应该包含在基本资料组成的项目(至少65%同意)包括识别(姓名、年龄、ICU住院天数)、基本情况(诊断、手术名称)、现状背景(主要病症)、主要病症的治疗措施、建议(下一班对患者的治疗和观察计划及跟进措施)。总的来说,检查项目中选出的67项中有30项(45%)被认为应该包含为基本资料的组成部分,具体到对身体特定系统的观察和治疗。其他和ISBAR没有关联的项目,例如ICU收住入院、工作人员和技术能力配置、手术病例等,以及患者病情(感染状态、感染部位、濒死计划)都作为重要考虑因素。其他增加的项目并应包含在交接班的内容仅在与患者病情有关时讨论。结论:研究结果表明,使用专为ICU设计的ISBAR能够帮助ICU小组长有效收集患者病情资料,更有效地进行交接班,并保证患者的安全和治疗计划得以实施。

关键词：临床交接班重症监护室基本资料重症护理