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Diamant in the Rough

大视野 2008年第3期 34-37页

作者： amy fabris-shi

After going walkabout over the past decade, Sydney’s hotel scene is back on the up Sydney is known for being relaxed-but its hotel sector was so laidback that it had slipped into a decade-long *** tide began to turn at last in 2007,when the city welcomed its first boutique hotel in ten years. The Diamant is not only Sydney’s first new-

关键词： hotel Sydney scene sector relaxed visitors Hotel i

IMpower210:A phase Ⅲ study of second-line atezolizumab vs. docetaxel in East Asian patients with non-small cell lung cancer

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Chinese Journal of Cancer Research 2024年第2期36卷 103-113页

作者： Yi-Long Wu Shun Lu Gongyan Chen Jianxing He Jifeng Feng Yiping Zhang Liyan Jiang Hongming Pan Jianhua Chang Jian Fang amy Cai Lilian Bu Jane shi Jinjing Xia Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People's Hospital&Guangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China Shanghai Lung Cancer Center Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Respiration Harbin Cancer HospitalHarbin Medical UniversityHarbin 150081China Department of Thoracic Oncology and Surgery the First Affliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Medical Oncology Jiangsu Cancer HospitalNanjing 210009China Department of Medical Oncology Zhejiang Cancer HospitalHangzhou 330022China Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Medical Oncology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Medical Oncology Shenzhen HospitalCancer Hospital of Chinese Academy of Medical SciencesShenzhen 518116China Department of Thoracic Oncology Beijing Cancer HospitalBeijing 100142China Product Development Shanghai Roche Pharmaceutical LtdShanghai 201203China

Objective: IMpower210(NCT02813785) explored the efficacy and safety of single-agent atezolizumab *** as second-line treatment for advanced non-small cell lung cancer(NSCLC) in East Asian ***: Key eligibility criteria for this phase Ⅲ, open-label, randomized study included age ≥18 years;histologically documented advanced NSCLC per the Union for International Cancer Control/American Joint Committee on Cancer staging system(7th edition);Eastern Cooperative Oncology Group performance status of 0 or 1;and disease progression following platinum-based chemotherapy for advanced or metastatic NSCLC. Patients were randomized 2:1 to receive either atezolizumab(1,200 mg) or docetaxel(75 mg/m^(2)). The primary study endpoint was overall survival(OS) in the intention-to-treat(ITT) population with wild-type epidermal growth factor receptor expression(ITT EGFR-WT) and in the overall ITT ***: Median OS in the ITT EGFR-WT population(n=467) was 12.3 [95% confidence interval(95% CI),10.3-13.8] months in the atezolizumab arm(n=312) and 9.9(95% CI, 7.8-13.9) months in the docetaxel arm[n=155;stratified hazard ratio(HR), 0.82;95% CI, 0.66-1.03]. Median OS in the overall ITT population was 12.5(95% CI, 10.8-13.8) months with atezolizumab treatment and 11.1(95% CI, 8.4-14.2) months(n=377) with docetaxel treatment(n=188;stratified HR, 0.87;95% CI, 0.71-1.08). Grade 3/4 treatment-related adverse events(TRAEs) occurred in 18.4% of patients in the atezolizumab arm and 50.0% of patients in the docetaxel ***: IMpower210 did not meet its primary efficacy endpoint of OS in the ITT EGFR-WT or overall ITT populations. Atezolizumab was comparatively more tolerable than docetaxel, with a lower incidence of grade3/4 TRAEs.

关键词： Atezolizumab East Asia non-small cell lung cancer programmed death-ligand 1 inhibitors monoclonal antibody

Caspase-1 activation and mature interleukin-1β release are uncoupled events in monocytes

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World Journal of Biological Chemistry 2013年第2期4卷 30-34页

作者： amy J Galliher-Beckley Li-Qiong Lan Shelly Aono Lei Wang Jishu shi Department of Anatomy and Physiology College of Veterinary MedicineKansas State University College of Life Sciences Sichuan University Department of Anatomy Physiologyand PharmacologyCollege of Veterinary MedicineAuburn University

AIM:To investigate whether caspase-1 activation/intracellular processing of pro-interleukin-1β(pro-IL-1β) and extracellular release of mature IL-1β from activated monocytes are separable ***:All experiments were performed on fresh or overnight cultured human peripheral blood monocytes(PBMCs) that were isolated from healthy *** were activated by lipopolysaccharide(LPS) stimulation before being treated with Adenosine triphosphate(ATP,1 mmol/L),human α-defensin-5(HD-5,50 μg/mL),and/or nigericin(Nig,30 μmol/L).For each experiment,the culture supernatants were collected separately from the *** lysates and supernatants were both subject to immunoprecipitation with anti-IL1β antibodies followed by western blot analysis with anti-caspase-1 and anti-IL-1β ***:We found that pro-IL-1β was processed to mature IL-1β in LPS-activated fresh and overnight cultured human monocytes in response to ATP *** the presence of HD-5,this release of IL-1β,but not the processing of pro-IL-1β to IL-1β,was completely ***,in the presence of HD-5,the release of IL-1β,but not the processing of IL-1β,was significantly inhibited from LPS-activated monocytes stimulated with ***,we treated LPS-activated monocytes with ATP and Nig and collected the *** found that both ATP and Nig stimulation could activate and release cleaved caspase-1 from the ***,and contrary to IL-1β processing and release,caspase-1 cleavage and release was not blocked by *** images are representative of three independent ***:These data suggest that caspase-1 activation/processing of pro-IL-1β by caspase-1 and the release of mature IL-1β from human monocytes are distinct and separable events.

关键词： Caspase-1 Human defensin Monocytes Interleukin-1β processing and release Inflammasome

Montanide<sup>TM</sup>Gel01 ST Adjuvant Enhances PRRS Modified Live Vaccine Efficacy by Regulating Porcine Humoral and Cellular Immune Responses

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World Journal of Vaccines 2013年第1期3卷 1-9页

作者： Xiangdong Li amy Galliher-Beckley Jerome C. Nietfeld Kay S. Faaberg Jishu shi Department of Anatomy and Physiology College of Veterinary Medicine Kansas State University Manhattan USA Department of Diagnostic Medicine and Pathobiology College of Veterinary Medicine Kansas State University Manhattan USA Virus and Prion Research Unit National Animal Disease Center United States Department of Agriculture Ames USA

Porcine reproductive and respiratory syndrome (PRRS) is a devastating disease caused by the PRRS virus. The MontanideTM class of flexible polymeric adjuvants has recently been shown to enhance protective immunity against PRRSV infection in piglets when used in combination with PRRS modified live vaccines (MLV). In this study, we explored the efficacy and immunological mechanisms of protection of MontanideTM Gel01 ST (Gel01) adjuvanted modified live PRRSV vaccine in pigs challenged with two genetically distinct strains of PRRSV. Gel01-MLV reduced lymph node pathology scores in pigs challenged with VR-2332 (parental strain of MLV vaccine) but not that in pigs challenged with MN184A (heterologous strain), when compared to that in pigs vaccinated with un-adjuvanted MLV. Pigs vaccinated with Gel01-MLV had higher levels of PRRS-specific antibodies, as measured by IDEXX ELISA and virus neutralizing antibodies, after vaccination and VR-2332 challenge. In addition, pigs vaccinated with Gel01-MLV had decreased levels of IFN-γ, IL-10, and T-regulatory lymphocytes in the blood as compared to that in pigs vaccinated with MLV alone. Interestingly, we found that addition of Gel01 did not change the profile of other T lymphocyte populations after PRRSV challenge. These results demonstrate that the MLV adjuvanted with Gel01 provides enhanced protection against homologous PRRSV infection, possibly by regulating the production of PRRSV-specific antibodies and cytokines involved in the development of T-regulatory cells. Thus, Gel01 ST is a promising adjuvant that can be formulated with PRRSV MLV vaccines to reduce disease severity and tissue damage caused by PRRSV infection in pigs.

关键词： PRRSV MontanideTM Gel01 ST IFN-γ Adjuvant IL-10 Immune Response Vaccine

Dose Reduction to the Scalp with Hippocampal Sparing Is Achievable with Intensity Modulated Radiotherapy

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2014年第3期3卷 176-182页

作者： Matthew Witek Yelena Vahknenko Joshua Siglin amy Harrison Ying Xiao Haison Lui David Andrews Wenyin shi Department of Neurosurgery Thomas Jefferson University Hospital Philadelphia USA Department of Radiation Oncology Thomas Jefferson University Hospital Philadelphia USA

We evaluated the feasibility of combined hippocampal- and scalp-sparing intensity-modulated radiotherapy (IMRT) plans. This study included 7 patients who received conventional palliative whole brain radiation treatment (WBRT) for brain metastasis. The brain, hippocampus, and scalp were contoured and replanned with intensity modulated radiation therapy. The prescription dose was 30 Gray (Gy) in 10 fractions with hippocampus and normal structure constraints per the Radiation Therapy Oncology Group (RTOG) 0933 protocol. Further planning was done to minimize the scalp dose while maintaining the dose constraints for the hippocampus. Dose volume histograms were obtained from conventional opposed lateral fields, IMRT and compared. Planning target volume (PTV) coverage for all plans fell within the RTOG 0933 critical structure acceptable variation category. When compared to traditional opposed lateral fields, the IMRT plan with combined hippocampal- and scalp-sparing constraints was able to significantly reduce the max and mean scalp dose as well as the percentage of scalp receiving 10 and 20 Gy by 46% and 35%, respectively, while maintaining acceptable RTOG 0933 hippocampal dose variations. We conclude that acceptable PTV coverage and sparing of the scalp and hippocampus can be accomplished using a 9-field non-coplanar IMRT plan. Prospective study is warranted to understand the impact on radiation-induced alopecia.

关键词： Hippocampal Scalp Sparing WBRT IMRT

Identification and optimization of a potent and highly selective D3 dopamine receptor agonist

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中国药理学与毒理学杂志 2017年第10期31卷 950-951页

作者： amy E MORITZ R Benjamin FREE Warren WEINER Muzna BACHANI Trevor DOYLE Noel SOUTHALL Marc FERRER Jonathan A JAVITCH Joseph STEINER Ara ABRamyAN Lei shi Jeffrey AUBé Kevin FRANKOWSKI David R SIBLEY Molecular Neuropharmacology Section National Institute of Neurological Disorders and StrokeNational Institutes of Health Bethesda MD 20814 University of North Carolina Chapel Hill NC27599 Neurotherapeutic Development Unit National Institute of Neurological Disorders and StrokeNational Institutes of Health Bethesda MD 20814 National Center for Advancing Translational Sciences Rockville MD 20892 Columbia University New York NY 10032 Computational Chemistry and Molecular Biophysics Unit Molecular Targets and Medications Discovery Branch National Institute on Drug Abuse National Institutes of Health Baltimore MD 21224

OBJECTIVE Dopamine receptors(DRs) are involved in the development and treatment of many neuropsychiatric *** available dopaminergic drugs modulate both DRD2 and DRD3,leading to side effects and uncertainty as to the roles each DR subtype plays *** lab employed high throughput screening paradigms to discover highly selective modulators for the *** The NIH Molecular Libraries Program 400,000 + small molecule library was screened using the Discove Rx Path Hunter?β-arrestin assay for compounds that activate the DRD3 without effects on the *** and counter-screens assessed selectivity and mechanisms of *** identified 62 potential agonists,and chose the most promising to perform a structure-activity relationship(SAR) study to increase potency while maintaining *** lead compound identified through this process,ML417,was also characterized using bioluminescence resonance energy transfer(BRET)-based β-arrestin recruitment and G-protein activation assays as well as p-ERK *** neuroprotective properties of this compound were assessed using a SHSY5 Y neuronal cell *** ML417 displays potent,DRD3-selective agonist activity in multiple functional *** and functional GPCR screens(>165 receptors) show ML417 has limited cross-reactivity with other ***417 also displays superior(compared to the reference compound pramipexole),dose-dependent protection against a decrease in neurite length induced by 10 μmol·L^(-1) of the neurotoxin,6-hydroxydopamine,in the SHSY5 Y cell *** We have discovered and characterized ML417,a potent and highly selective DRD3 *** compound will be useful as a research tool,and may prove useful as a therapeutic drug lead.

关键词： Dopamine receptor high throughput screening subtype selectivity neuroprotection

血清amy、Hcy、D-D水平对急性胰腺炎患者预后的预测价值探究

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四川生理科学杂志 2024年第9期46卷 2067-2069页

作者：刘洋李亚设石芳芳漯河市郾城区中医院检验科河南漯河462300

目的:分析血清淀粉酶(amylase,amy)、同型半胱氨酸(Homocysteine,Hcy)、D-二聚体(D-dimer,D-D)水平及联合检测对急性胰腺炎(Acutepancreatitis,AP)患者预后的预测价值。方法:选取2020年5月-2023年6月期间本院收治的AP患者为研究对象。... 详细信息

目的:分析血清淀粉酶(amylase,amy)、同型半胱氨酸(Homocysteine,Hcy)、D-二聚体(D-dimer,D-D)水平及联合检测对急性胰腺炎(Acutepancreatitis,AP)患者预后的预测价值。方法:选取2020年5月-2023年6月期间本院收治的AP患者为研究对象。根据患者治疗后的预后情况,将患者分为预后良好组(43例)及预后不良组(19例)。收集并对比两组的一般资料及血清amy、Hcy、D-D水平。logistic回归模型分析影响AP患者预后的影响因素。分析血清各指标水平联合检测对AP预后的预测效能。结果:预后不良组入院时急性生理功能和慢性健康状况评分系统Ⅱ(Acute physiological function and Chronic health status score SystemⅡscore,APACHEⅡ)评分及血清Hcy、amy、D-D水平均显著高于预后良好组(Pamy、D-D及APACHEⅡ评分均为患者发生预后不良的危险因素(Pamy、Hcy、D-D水平联合预测患者发生预后不良的曲线下面积(AUC)为0.879。结论:血清amy、Hcy、D-D水平与AP患者预后密切相关,三者联合检测在患者预后评估中具有重要价值。

关键词：血清淀粉酶同型半胱氨酸 D-二聚体急性胰腺炎预后

中亚热带喀斯特常绿落叶阔叶混交林典型树种的木质部解剖与功能特征分析

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植物生态学报 2021年第4期45卷 394-403页

作者：倪鸣源 ARITSARA amy Ny Aina 王永强黄冬柳项伟万春燕朱师丹广西大学亚热带农业生物资源保护与利用国家重点实验室南宁530004 广西大学林学院广西森林生态与保育重点实验室南宁530004

树木木质部主要由导管、纤维和薄壁组织组成,分别具有运输、支撑和贮存的生理功能。由于木质部空间限制,一种组织比例的增加会导致其他组织比例的降低,因而可能表现出权衡关系。分析木质部组织比例和权衡关系有助于了解植物的生理生态... 详细信息

树木木质部主要由导管、纤维和薄壁组织组成,分别具有运输、支撑和贮存的生理功能。由于木质部空间限制,一种组织比例的增加会导致其他组织比例的降低,因而可能表现出权衡关系。分析木质部组织比例和权衡关系有助于了解植物的生理生态适应性。该研究选择中亚热带喀斯特常绿落叶阔叶混交林21种典型树种(10种落叶树种, 11种常绿树种),测定枝条木质部各组织比例,计算水力相关指标并分析性状之间的相关性。结果表明:(1)与全球木质部解剖数据对比分析,喀斯特树种木质部趋向具有较高比例的薄壁组织;(2)喀斯特树种导管组织比例与薄壁和纤维组织比例之间没有显著的相关性,但是薄壁和纤维组织比例之间有显著的权衡关系;(3)常绿和落叶树种的木质部水力运输安全性(导管壁加固系数)和效率性(理论导水率)均具有显著的权衡关系,但是这两个类群线性回归的截距存在显著差异,即在相同的理论导水率条件下,落叶树种比常绿树种具有较高的导管壁加固系数(安全性),可能与常绿树种具有更多的轴向薄壁组织有关。喀斯特树种木质部解剖特征表明薄壁组织的贮存功能对喀斯特树种(尤其是常绿树种)的干旱适应具有重要作用。

关键词：导管组织薄壁组织纤维组织导管壁加固系数理论导水率权衡

The Comparison and Analysis of Sino-American Family Educational Ways—from the Case of American Chinese “Tiger Mother” Family Educational Way

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校园英语 2015年第34期 8-10页

作者： shi Lei Xi’an University of Technology

amy Lynn Chua is a daughter of Chinese immigrants, a lifetime professor of Law school of Yale university, she became popular and controversial since she published her child-rearing memoir《Battle Hymn of the Tiger Mother》, in which amy Chua wrote down how to teach her two daughters in a harsh and strict way, especially a discussion about Chinese and American family educational ways. This paper use this case as an example to compare differences between Chinese and American family educational ways and try to analyze reasons.

关键词： Comparison Analysis Sino-American family educational ways Tiger mother