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Nocardiopsistins A-C:New angucyclines with anti-MRSA activity isolated from a marine sponge-derived Nocardiopsis ***-J378

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Synthetic and Systems Biotechnology 2018年第4期3卷 246-251页

作者： Dongbo Xu Keshav K.Nepal Jing Chen Dedra Harmody Haining zhu Peter J.McCarthy amy E.Wright Guojun Wang Harbor Branch Oceanographic Institute Florida Atlantic University5600 US 1 NorthFort PierceFL34946United States Department of Molecular and Cellular Biochemistry University of Kentucky741 South LimestoneLexingtonKY40536United States

Marine natural products have become an increasingly important source of new drug leads during recent *** an attempt to identify novel anti-microbial natural products by bioprospecting deep-sea Actinobacteria,three new angucyclines,nocardiopsistins A-C,were isolated from Nocardiopsis *** ***,the supplementation of the rare earth salt Lanthanum chloride(LaCl3)during fermentation of HB-J378 significantly increased the yield of these *** structures of nocardiopsistins A-C were identified by 1D and 2D NMR and HR-MS *** A-C have activity against MRSA(methicillin-resistant Staphylococcus aureus)with MICs of 3.12–12.5μg/mL;the potency of nocardiopsistin B is similar to that of the positive control,*** analysis of the draft genome of HB-J378 identified a set of three core genes in a biosynthetic gene cluster that encode a typical aromatic or type II polyketide synthase(PKS)system,including ketoacyl:ACP synthaseα-subunit(KSα),β-subunit(KSβ)and acyl carrier protein(ACP).The production of nocardiopsistins A-C was abolished when the three genes were knocked out,indicating their indispensable role in the production of nocardiopsistins.

关键词： Nocardiopsis Nocardiopsistins Angucycline Anti-MRSA Actinobacteria LaCl_(3)

Systematic Errors Induced by the Elliptical Power-law model in Galaxy–Galaxy Strong Lens Modeling

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Research in Astronomy and Astrophysics 2022年第2期22卷 143-172页

作者： Xiaoyue Cao Ran Li J.W.Nightingale Richard Massey Andrew Robertson Carlos SFrenk Aristeidis Amvrosiadis Nicola CAmorisco Qiuhan He amy Etherington Shaun Cole Kai zhu National Astronomical Observatories Chinese Academy of Sciences20A Datun RoadChaoyang DistrictBeijing 100012China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Institute for Computational Cosmology Physics DepartmentDurham UniversitySouth RoadDurhamDH13LEUnited Kingdom

The elliptical power-law model of the mass in a galaxy is widely used in strong gravitational lensing ***,the distribution of mass in real galaxies is more *** quantify the biases due to this model mismatch by simulating and then analyzing mock Hubble Space Telescope imaging of lenses with mass distributions inferred from SDSS-Ma NGA stellar dynamics *** find accurate recovery of source galaxy morphology,except for a slight tendency to infer sources to be more compact than their true *** Einstein radius of the lens is also robustly recovered with 0.1%accuracy,as is the global density slope,with 2.5%relative systematic error,compared to the 3.4%intrinsic ***,asymmetry in real lenses also leads to a spurious fitted"external shear"with typical strengthγext=***,time delays inferred from lens modeling without measurements of stellar dynamics are typically underestimated by~5%.Using such measurements from a sub-sample of 37 lenses would bias measurements of the Hubble constant H0 by~9%.Although this work is based on a particular set of Ma NGA galaxies,and the specific value of the detected biases may change for another set of strong lenses,our results strongly suggest the next generation cosmography needs to use more complex lens mass models.

关键词： galaxies:structure galaxies:halos gravitational lensing:strong

从杏仁核-中缝背核探索雷公藤红素干预小鼠肥胖-抑郁共病的中枢炎症机制

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中国中药杂志 2024年第14期49卷 3828-3836页

作者：张双盼姚雪敏朱春燕林娜安徽中医药大学药学院安徽合肥230012 中国中医科学院中药研究所北京100700

在明确雷公藤红素(CEL)干预肥胖-抑郁共病小鼠杏仁核(amy)及中缝背核(DRN)mRNA表达异同基础上,进一步揭示CEL干预肥胖-抑郁共病中枢炎症的药效靶标群。C57BL/6J小鼠随机分为正常(Chow)组,肥胖-抑郁共病(COM)组,CEL低、中、高剂量(CEL-L... 详细信息

在明确雷公藤红素(CEL)干预肥胖-抑郁共病小鼠杏仁核(amy)及中缝背核(DRN)mRNA表达异同基础上,进一步揭示CEL干预肥胖-抑郁共病中枢炎症的药效靶标群。C57BL/6J小鼠随机分为正常(Chow)组,肥胖-抑郁共病(COM)组,CEL低、中、高剂量(CEL-L、CEL-M、CEL-H,0.5、1.0、2.0 mg·kg^(-1))组。Chow组给予普通饲料,其余组给予高脂饲料结合潮湿垫料慢性应激。饲养10周后灌胃给药3周,然后取Chow组、COM组和CEL-H组小鼠的amy及DRN进行转录组分析,并将2个核团的目标差异基因以Venn图取交集。将交集基因导入STRING,进行蛋白-蛋白相互作用(PPI)分析,以DAVID进行基因本体论(GO)功能富集分析,明确CEL调控amy、DRN的核心靶点。在独立样本中,通过qPCR对上述交集基因进行验证。结果显示,CEL调控amy及DRN的共有基因为趋化因子家族Ccl2、Ccl5、Ccl7、Cxcl10、Cxcr6和Hsp70家族Hspa1a、Hspa1b及Myd88、Il2ra、Irf7、Slc17a8、Drd2、Parp9、Nampt。GO分析显示,前五位节点Ccl2、Cxcl10、Myd88、Ccl5、Irf7均参与免疫-炎症调控(Pamy中,与Chow组相比,COM组趋化因子家族、Hsp70、Myd88、Il2ra、Irf7、Slc17a8、Parp9、Nampt表达显著上调,Drd2有降低的趋势;与COM组相比,CEL-H组上述病理变化显著改善。在DRN中,与Chow组相比,COM组趋化因子家族、Hsp70、Myd88、Il2ra、Irf7、Parp9、Nampt表达显著下调,Slc17a8表达显著上调;与COM组相比,CEL-H组Cxcr6、Irf7、Drd2表达显著上调,Slc17a8表达显著下调。在amy及DRN中,CEL对Irf7的表达抑制及激活均呈现剂量依赖性(R2分别为0.7098、0.9172)。上述研究结果显示,CEL可通过调控相同靶标蛋白的双向表达,干预肥胖-抑郁共病小鼠amy的免疫激活及DRN的免疫抑制状态,从而有效改善神经炎症。

关键词：肥胖抑郁共病杏仁核中缝背核雷公藤红素 RNA-seq

PDGFRαreporter activity identifies periosteal progenitor cells critical for bone formation and fracture repair

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Bone Research 2022年第1期10卷 122-136页

作者： Jiajia Xu Yiyun Wang zhu Li Ye Tian Zhao Li amy Lu Ching-Yun Hsu Stefano Negri Cammy Tang Robert J.Tower Carol Morris Aaron W.James Departments of Pathology Johns Hopkins UniversityBaltimoreMD 21205USA Departments of Orthopedics Johns Hopkins UniversityBaltimoreMD 21205USA Department of Oral and Maxillofacial Surgery School of StomatologyChina Medical UniversityShenyangLiaoningPR China

The outer coverings of the skeleton,which is also known as the periosteum,are arranged in concentric layers and act as a reservoir for tissue-specific bone *** cellular heterogeneity within this tissue depot is being increasingly ***,inducible PDGFRαreporter animals were found to mark a population of cells within the periosteum that act as a stem cell reservoir for periosteal appositional bone formation and fracture *** these processes,PDGFRαreporter^(+)progenitors give rise to Nestin+periosteal cells before becoming osteoblasts and *** diphtheria toxin-mediated ablation of PDGFRαreporter^(+)cells led to deficits in cortical bone formation during homeostasis and a diminutive hard callus during fracture *** ossicle transplantation,both mouse PDGFRαreporter^(+)periosteal cells and human Pdgfrα+periosteal progenitors expand,ossify,and recruit marrow to a greater extent than their counterpart periosteal cells,whereas PDGFRαreporter^(−)periosteal cells exhibit a predisposition to chondrogenesis in *** RNA sequencing identified enrichment of the secreted factors Fermt3 and Ptpn6 within PDGFRαreporter^(+)periosteal cells,which partly underlie the osteoblastogenic features of this cell population.

关键词： progenitor fracture reservoir

保定地区髋部骨折患者院内感染情况及危险因素分析

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华南预防医学 2024年第1期50卷 35-38,44页

作者：田梦田雪涛朱丽娜朱玲保定市第二中心医院河北保定072750 河北大学附属医院陆军第82集团军医院

目的探讨分析髋部骨折患者院内感染发生情况以及其危险因素。方法选择2020年1月至2023年1月保定市3家综合性医院的骨科住院手术治疗的髋部骨折患者为研究对象,收集患者疾病相关信息,并对其院内感染情况进行跟踪随访,采集疑似感染者生物... 详细信息

目的探讨分析髋部骨折患者院内感染发生情况以及其危险因素。方法选择2020年1月至2023年1月保定市3家综合性医院的骨科住院手术治疗的髋部骨折患者为研究对象,收集患者疾病相关信息,并对其院内感染情况进行跟踪随访,采集疑似感染者生物样本用于病原菌培养及鉴定,采用描述分析法分析院内感染发生情况,并采用单、多因素分析方法对院内感染的危险因素进行分析。结果本研究共纳入1012例患者,发生院内感染87例,院内感染发生率为8.60%,其中泌尿系统感染42例,肺部感染26例,手术切口感染10例,其他感染9例。87例院内感染患者的样本中培养出病原菌98株,其中革兰阳性菌30株(30.61%),革兰阴性菌67株(68.37%),真菌1株(1.02%)。多因素logistic回归分析结果显示年龄(OR=1.581)、基础疾病(OR=1.442)、手术时间(OR=1.689)、术后卧床时间(OR=1.730)、术后住院时间(OR=1.530)、侵入性操作(OR=1.659)、术中异体输血(OR=1.436)、季节(OR=1.637)是髋部骨折患者院内感染的危险因素。结论髋部骨折患者的院内感染发生率较高,且病原菌主要为革兰阴性菌,年龄、基础疾病、手术时间、术后卧床时间、术后住院时间、侵入性操作、术中异体输血、季节是髋部骨折患者院内感染的危险因素。

关键词：髋部骨折院内感染病原菌危险因素

Ambient synthesis, characterization, and electrochemical activity of LiFePO4 nanomaterials derived from iron phosphate intermediates

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Nano Research 2015年第8期8卷 2573-2594页

作者： Jonathan M. Patete Megan E. Scofield Vyacheslav Volkov Christopher Koenigsmann Yiman Zhang amy C. Marschilok Xiaoya Wang Jianming Bai Jinkyu Han Lei Wang Feng Wang Yimei zhu Jason A. Graetz Stanislaus S. Wong Department of Chemistry State University of New York at Stony Brook Stony Brook NY 77794-3400 USA Condensed Matter Physics and Materials Sciences Department Building 480 Brookhaven National Laboratory Upton NY 11973 USA Department of Materials Science and Engineering State University of New York at Stony Brook Stony Brook NY 11794-2275 USA Sustainable Energy Technologies Department Building 815 Brookhaven National Laboratory Upton NY 11973 USA National Synchrotron Light Source II Building 741 Brookhaven National Laboratory Upton NY 11973 USA

LiFePO4 materials have become increasingly popular as a cathode material due to the many benefits they possess including thermal stability, durability, low cost, and long life span. Nevertheless, to broaden the general appeal of this material for practical electrochemical applications, it would be useful to develop a relatively mild, reasonably simple synthesis method of this cathode material. Herein, we describe a generalizable, 2-step methodology of sustainably synthesizing LiFePO4 by incorporating a template-based, ambient, surfactantless, seedless, U-tube protocol in order to generate size and morphologically tailored, crystalline, phase-pure nanowires. The purity, composition, crystallinity, and intrinsic quality of these wires were systematically assessed using transmission electron microscopy （TEM）, high-resolution TEM （HRTEM）, scanning electron microscopy （SEM）, X-ray diffraction （XRD）, selected area electron diffraction （SAED）, energy dispersive analysis of X-rays （EDAX）, and high-resolution synchrotron XRD. From these techniques, we were able to determine that there is an absence of any obvious defects present in our wires, supporting the viability of our synthetic approach. Electrochemical analysis was also employed to assess their electrochemical activity. Although our nanowires do not contain any noticeable impurities, we attribute their less than optimal electrochemical rigor to differences in the chemical bonding between our LiFePO4 nanowires and their bulk-like counterparts. Specifically, we demonstrate for the first time experimentally that the Fe-O3 chemical bond plays an important role in determining the overall conductivity of the material, an assertion which is further supported by recent ＂first-principles＂ calculations. Nonetheless, our ambient, solution-based synthesis technique is capable of generating highly crystalline and phase-pure energy-storage-relevant nanowires that can be tailored so as to fabricate different sized materials of repro

关键词： ambient synthesis template synthesis cathode material lithium iron phosphate nanostructures

Biochar and zero-valent iron sand filtration simultaneously removes contaminants of emerging concern and Escherichia coli from wastewater effluent

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Biochar 2023年第1期5卷 710-722页

作者： Linyan zhu Suhana Chattopadhyay Oluwasegun Elijah Akanbi Steven Lobo Suraj Panthi Leena Malayil Hillary A.Craddock Sarah M.Allard Manan Sharma Kalmia E.Kniel Emmanuel F.Mongodin Pei C.Chiu Amir Sapkota amy R.Sapkota Maryland Institute for Applied Environmental Health University of Maryland School of Public HealthCollege ParkMDUSA Department of Civil and Environmental Engineering University of DelawareNewarkDEUSA Department of Pediatrics University of California San DiegoSan DiegoCAUSA United States Department of Agriculture Agriculture Research ServiceNortheast AreaBeltsville Agriculture Research CenterEnvironmental Microbiology and Food Safety LaboratoryBeltsvilleMDUSA Department of Animal and Food Science University of DelawareNewarkDEUSA Institute for Genome Sciences and Department of Microbiology and Immunology University of Maryland School of MedicineBaltimoreMDUSA Department of Epidemiology and Biostatistics School of Public HealthUniversity of MarylandCollege ParkMDUSA Present Address:Division of Lung Diseases National Institutes of Health(NIH)National HeartLung and Blood Institute(NHLBI)BethesdaMDUSA

Advanced treated municipal wastewater is an important alternative water source for agricultural ***,the possible persistence of chemical and microbiological contaminants in these waters raise potential safety concerns with regard to reusing treated wastewater for food crop *** low-cost and environmentally-friendly filter media,biochar(BC)and zero-valent iron(ZVI),have attracted great interest in terms of treating reused ***,we evaluated the efficacy of BC-,nanosilver-amended biochar-(Ag-BC)and ZVI-sand filters,in reducing contaminants of emerging concern(CECs),Escherichia coli(***)and total bacterial diversity from wastewater *** experiments were conducted with control quartz sand and sand columns containing BC,Ag-BC,ZVI,BC with ZVI,or Ag-BC with *** filtration,Ag-BC,ZVI,BC with ZVI and Ag-BC with ZVI demonstrated more than 90%(>1 log)removal of *** from wastewater samples,while BC,Ag-BC,BC with ZVI and Ag-BC with ZVI also demonstrated efficient removal of tested *** bacterial diversity was also observed after filtration;however,differences were marginally *** addition,significantly(p<0.05)higher bacterial diversity was observed in wastewater samples collected during warmer versus colder *** of silver ions occurred from Ag-BC columns;however,this was prevented through the addition of *** conclusion,our data suggest that the BC with ZVI and Ag-BC with ZVI sand filters,which demonstrated more than 99%removal of both CECs and *** without silver ion release,may be effective,low-cost options for decentralized treatment of reused wastewater.

关键词： Biochar Zero-valent iron Wastewater reuse Contaminants of emerging concern Recycled water E.coli

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原发性皮肤淀粉样变治疗进展

中国麻风皮肤病杂志 2024年第10期40卷 744-748页

作者：白璐张丽君朱才勇中国人民解放军陆军第八十集团军医院皮肤病科山东潍坊261031

原发性皮肤淀粉样变(PCA)引起的瘙痒难以忍受,目前对治疗的总体反应不佳,严重影响了患者的生活质量。近年来发现系统使用度普利尤单抗、乌帕替尼、巴瑞替尼、阿布昔替尼,局部使用氨甲环酸、加巴喷丁、二甲基亚砜溶液及火针疗法、点阵二... 详细信息

原发性皮肤淀粉样变(PCA)引起的瘙痒难以忍受,目前对治疗的总体反应不佳,严重影响了患者的生活质量。近年来发现系统使用度普利尤单抗、乌帕替尼、巴瑞替尼、阿布昔替尼,局部使用氨甲环酸、加巴喷丁、二甲基亚砜溶液及火针疗法、点阵二氧化碳激光等取得了显著的治疗效果。本文对PCA的治疗进展进行综述,为临床提供参考。

关键词：原发性皮肤淀粉样变度普利尤单抗乌帕替尼氨甲环酸

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敌草快中毒早期危险因素筛选及对预后的预测

中华急诊医学杂志 2024年第3期33卷 286-290页

作者：张晓凡谷玉雷朱志强裴辉谢佳丰郑州大学第一附属医院急诊ICU 郑州450000

目的分析敌草快中毒患者早期血清肌酐等水平的变化特点,筛选早期危险因素并评估其对预后的判断价值。方法选取2020年1月至2022年6月郑州大学第一附属医院收治的敌草快中毒患者进行回顾性分析,收集患者的基本资料及入院第1天(D1)、第3天(... 详细信息

目的分析敌草快中毒患者早期血清肌酐等水平的变化特点,筛选早期危险因素并评估其对预后的判断价值。方法选取2020年1月至2022年6月郑州大学第一附属医院收治的敌草快中毒患者进行回顾性分析,收集患者的基本资料及入院第1天(D1)、第3天(D3)和第5天(D5)的血清指标及血气分析。根据中毒后28 d预后分为生存组和死亡组。分析两组之间的临床特征差异,采用多元logistic回归方程筛选变量,并通过绘制受试者工作特征曲线(ROC曲线)评价其对患者预后的预测价值。结果经过筛查共纳入88例患者,其中生存组40例,死亡组48例。死亡组的中毒剂量显著高于生存组[100(40.00,120.00)mL vs.50.00(20.00,90.00)mL,P=0.003]。中毒剂量越多,病死率越高,口服>200 mL者共4例,均死亡。与生存组相比,死亡组患者的丙氨酸转氨酶(alanine aminotransfease,ALT)(D3、D5),肌酐(CR)(D3、D5),血淀粉酶(amylase,amy)(D5)明显升高,氧分压(PaO_(2))(D5)明显降低(均Pamy(D5)为中毒后死亡的独立危险因素,PaO_(2)(D5)为独立保护因素。绘制ROC曲线并进行分析,可以得出CR(D3)、amy(D5)、PaO_(2)(D5)预测敌草快中毒后死亡的ROC曲线下面积分别为0.814、0.741、0.702。其中,CR(D3)预测中毒死亡的ROC曲线下面积最大。结论敌草快中毒患者,口服剂量越大,病死率越高。入院后CR(D3)、amy(D5)、PaO_(2)(D5)为敌草快中毒预后的独立影响因素,尤其CR(D3)预测中毒后死亡的效能更高,在临床上可作为评估病情严重程度及预后的重要指标。

关键词：敌草快中毒血肌酐危险因素预后