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Lipid concentration and composition in xylem sap of woody angiosperms from a tropical savanna and a seasonal rainforest

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Plant Diversity 2024年第1期46卷 126-133页

作者： Ling-Bo Huang Xinyi Guan amy Ny Aina Aritsara Jun-Jie zhu Steven Jansen Kun-Fang Cao State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources Guangxi Key Laboratory of Forest Ecology and ConservationGuangxi UniversityDaxuedong Road 100NanningGuangxi 530004China Institute of Botany Ulm UniversityAlbert-Einstein-Allee 11Ulm89081Germany

Lipids may play an important role in preventing gas embolisms by coating nanobubbles in xylem *** studies on xylem sap lipids have been reported for temperate plants,and it remain unclear whether sap lipids have adaptational significance in tropical *** this study,we quantify the lipid composition of xylem sap for angiosperm species from a tropical savanna(seven species)and a seasonal rainforest(five species)using mass *** found that all twelve species studied contained lipids in their xylem sap,including galactolipids,phospholipids and triacylglycerol,with a total lipid concentration ranging from 0.09 to 0.26 nmol/*** was no difference in lipid concentration or composition between plants from the two sites,and the lipid concentration was negatively related to species’open vessel ***,savanna species showed little variation in lipid composition between the dry and the rainy *** results support the hypothesis that xylem sap lipids are derived from the cytoplasm of individual conduit cells,remain trapped inside individual conduits,and undergo few changes in composition over consecutive seasons.A xylem sap lipidomic data set,which includes 12 tropical tree species from this study and 11 temperate tree species from literature,revealed no phylogenetic signals in lipid composition for these *** study fills a knowledge gap in the lipid content of xylem sap in tropical trees and provides additional support for their common distribution in xylem sap of woody *** appears that xylem sap lipids have no adaptive significance.

关键词： Xylem sap Lipids Tropical savanna Tropical rainforest Vessels

复合加工技术及其在航空航天领域的应用——访北京机床研究所副总师盛伯浩先生

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航空制造技术 2009年第12期52卷 44-46页

作者：小颖《航空制造技术》编辑部

机床盛会CIMT2009结束了,但它展示给业内的新技术、新产品却影响深远,展会上各式复合加工机床纷纷亮相。那么此次展会反映了复合加工的哪些趋势?该技术在航空航天领域的应用情况如何?带着这些问题,本刊记者采访了北京机床研究所副总师... 详细信息

机床盛会CIMT2009结束了,但它展示给业内的新技术、新产品却影响深远,展会上各式复合加工机床纷纷亮相。那么此次展会反映了复合加工的哪些趋势?该技术在航空航天领域的应用情况如何?带着这些问题,本刊记者采访了北京机床研究所副总师盛伯浩先生。

关键词：北京机床研究所复合加工技术航天领域应用航空复合加工机床记者采访展会

特种加工精密制造——本刊总编辑刘柱对话北京市电加工研究所所长杨大勇先生

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航空制造技术 2011年第11期54卷 38-39页

作者：小颖

北京市电加工研究所专业从事精密数控电加工机床制造和精密运动控制技术开发,是一个集科研、开发、生产于一体的高新技术企业.凭借完全掌握产品的核心技术和优质的产品服务过程,北京市电加工研究所为客户提供系统的电加工成形制造业务... 详细信息

北京市电加工研究所专业从事精密数控电加工机床制造和精密运动控制技术开发,是一个集科研、开发、生产于一体的高新技术企业.凭借完全掌握产品的核心技术和优质的产品服务过程,北京市电加工研究所为客户提供系统的电加工成形制造业务解决方案.面对国内外竞争对手,经过十几年的发展历程,产品质量与核心技术不断提升,产品规格齐全,工艺服务完善.目前已经成为国内精密数控电火花成形机床的主要设备制造商.借CIMT 2011的机会,本刊专访了北京市电加工研究所所长杨大勇先生.

关键词：北京市电加工研究所所长领导人员电加工机床精密数控长杨精密模具超硬材料电火花成形加工航空动力金刚石拉丝模电火花成形机床电脉冲加工电火花加工刘柱大勇先生特种加工

科技创新走向世界——本刊总编辑刘柱与北京赛福斯特技术有限公司总经理栾国红先生对话

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航空制造技术 2009年第14期52卷 40-41页

作者：小颖《航空制造技术》编辑部

北京赛福斯特技术有限公司是中国区英国焊接研究所唯一直接授权的搅拌摩擦焊技术研发和推广中心，自成立以来，公司本着“合作、发展、创新、提高”的经营理念，致力于搅拌摩擦焊技术的研发和推广，依托中航工业北京航空制造工程研究所... 详细信息

北京赛福斯特技术有限公司是中国区英国焊接研究所唯一直接授权的搅拌摩擦焊技术研发和推广中心，自成立以来，公司本着“合作、发展、创新、提高”的经营理念，致力于搅拌摩擦焊技术的研发和推广，依托中航工业北京航空制造工程研究所多年从事特种焊接和大型数控设备开发的经验，公司已经在搅拌摩擦焊的机理、工艺开发、设备制造等领域取得了突破性的进展。近日，本刊专访了北京赛福斯特技术有限公司总经理栾国红先生。

关键词：北京赛福斯特技术有限公司科技创新总经理英国焊接研究所总编辑搅拌摩擦焊对话世界

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中航工业与GE成立综合航电合资企业

航空制造技术 2011年第4期54卷 66-67页

作者：小颖晓立

作为2011年1月胡锦涛主席访美时签署的系列协议中的重要内容之一,由中美两国政府领导见证,中航工业与美国通用电气(GE)公司于美国芝加哥当地时间2011年1月21日签署了共同组建航空电子合资公司合同;1月26日,双方在上海紫竹科学园区举行... 详细信息

作为2011年1月胡锦涛主席访美时签署的系列协议中的重要内容之一,由中美两国政府领导见证,中航工业与美国通用电气(GE)公司于美国芝加哥当地时间2011年1月21日签署了共同组建航空电子合资公司合同;1月26日,双方在上海紫竹科学园区举行了中航-通用电气民用航电系统有限责任公司揭牌仪式,中美两大航空集团"联姻"正式启动。为深入了解此次合作的意义,本刊记者采访了中航工业航电系统公司董事长总经理卢广山先生。

关键词：中航工业航电系统总经理董事长先生中国航空工业合资企业合资经营企业三资企业美国通用电气 GE 综合航电

Characterization of amyloid-β precursor protein intracellular domain-associated transcriptional complexes in SH-SY5Y neurocytes

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Neuroscience Bulletin 2012年第3期28卷 259-270页

作者： Wulin Yang amy Yong Chen Lau Shuizhong Luo Qian zhu Li Lu School of Biotechnology and Food Engineering Hefei University of TechnologyHefei 230009China Laboratory of Metabolic Medicine Singapore Bioimaging Consortium(SBIC)Agency for ScienceTechnology and Research(A*STAR)Singapore Department of Anatomy Shanxi Medical UniversityTaiyuan 030001China

Objective Alzheimer＇s disease （AD） is one of the major disorders worldwide. Recent research suggests that the amyloid-β precursor protein intracellular domain （AICD） is a potential contributor to AD development and progression. The small AICD is rapidly degraded after processing from the full-length protein. The present study aimed to apply a highly efficient biotinylation approach in vitro to study AICD-associated complexes in neurocytes. Methods By coexpressing Escherichia coli biotin ligase with biotinyl-tagged AICD in the SH-SY5Y neuronal cell line, the effects of AICD overexpression on cell proliferation and apoptosis were analyzed. Besides, AICD-associated nuclear transcriptional complexes were purified and then examined by mass spectrometry. Results Our data showed that AICD overexpression not only affected cell proliferation but also led to apoptosis in differentiated SH-SY5Y cells. Moreover, biotinylation allowed single-step purification of biotinylated AICD-associated complexes from total nuclear extract via high-affinity biotin-streptavidin binding. Following this by mass spectrometry, we identified physically associated proteins, some reported previously and other novel binding partners, CUX1 and SPT5. Conclusion Based on these results, a map of the AICD-associated nuclear interactome was depicted. Specifically, AICD can activate CUX1 transcriptional activity, which may be associated with AICD-dependent neuronal cell death. This work helps to understand the AICD-associated biological events in AD progression and provides novel insights into the development of AD.

关键词： Alzheimer's disease amyloid-β precursor protein AICD biotinylation apoptosis

FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation

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Signal Transduction and Targeted Therapy 2021年第6期6卷 1884-1894页

作者： Ruiqi zhu Li Li Bao Nguyen Jaesung Seo Min Wu Tessa Seale Mark Levis amy Duffield Yu Hu Donald Small Department of Oncology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Pathology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Pediatrics Johns Hopkins University School of MedicineBaltimoreMDUSA

Tyrosine kinase inhibitors(TKIs)targeting FLT3 have shown activity but when used alone have achieved limited success in clinical trials,suggesting the need for combination with other *** investigated the combination of FLT3 TKIs(Gilteritinib or Sorafenib),with Venetodax,a BCL-2 selective inhibitor(BCL-2i),on FLT3/ITD leukemia *** combination of a FLT3 TKI and a BCL-2i synergistically reduced cell proliferation and enhanced apoptosis/cell death in FLT3/ITD cell lines and primary AML *** also re-sensitized FLT3 TKI-resistant cells to Gilteritinib or Sorafenib treatment,mediated through MAPK pathway *** treatment alone dissociated BIM from MCL-1 but increased the binding of BIM to *** treatment enhanced the binding of BIM to MCL-1 but dissociated BIM from *** with the drugs together resulted in dissociation of BIM from both BCL-2 and MCL-1,with an increased binding of BIM to the cell death mediator BAX,leading to increased *** findings suggest that Venetoclax mitigates the unintended pro-survival effects of FLT3 TKI mainly through the dissociation of BIM and BCL-2 and also decreased BIM *** study provides evidence that the addition of BCL-2i enhances the effect of FLT3 TKI therapy in FLT3/ITD AML treatment.

关键词： FLT3 drugs alone treatment BIM

Occultocarpon,a new monotypic genus of Gnomoniaceae on Alnus nepalensis from China

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Fungal Diversity 2012年第1期52卷 99-105页

作者： Luis C.Mejía amy Y.Rossman Lisa A.Castlebury zhu L.Yang James F.White Jr USDA Agricultural Research ServiceSystematic Mycology&Microbiology LaboratoryB010A10300 Baltimore Ave.BeltsvilleMD 20705USA Department of Plant Biology and Pathology Rutgers UniversityNew BrunswickNJ 08901USA Key Laboratory of Biodiversity and Biogeography Kunming Institute of BotanyChinese Academy of SciencesKunming 650204(Yunnan ProvincePeople’s Republic of China Smithsonian Tropical Research Institute Apartado0843-03092BalboaAnconRepublic of Panama

Microfungi in the Gnomoniaceae(Diaporthales,Ascomycetes)comprise species commonly reported as pathogens and endophytes on trees and herbaceous hosts primarily from temperate forests of North America,Europe,and *** diversity of Gnomoniaceae in China is poorly known,although several plant families that occur there specifically the Betulaceae are considered important *** exploratory trip to Yunnan,China,resulted in the discovery of several members of the *** this paper a new monotypic genus,Occultocarpon and its species,***,are described and illustrated.A phylogeny based on three genes(LSU,rpb2,tef1-α)reveals that *** belongs to the Gnomoniaceae and forms a branch distinct from the currently known *** ailaoshanense is characterized by perithecia with thin,central to eccentric necks in groups embedded in a stroma and oblong elliptical-elongated,one-septate *** ailaoshanense occurs on the bark of branches of Alnus nepalensis(Betulaceae)in Yunnan,China.

关键词： Ascomycota Betulaceae DiaporthaleslGnomoniaceae Systematics Yunnan

lncRNA TUG1靶向调节miR-31-5p对急性胰腺炎小鼠炎症反应的影响

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中国免疫学杂志 2024年第5期40卷 1048-1054页

作者：林昌永王海波朱千三温州市中医院外科温州325000

目的:探讨长链非编码RNA牛磺酸上调基因1(lncRNA TUG1)在急性胰腺炎(AP)中的作用机制。方法:体外培养小鼠胰腺腺泡细胞系(MPC-83),用脂多糖(LPS,10μg/ml)和雨蛙素(Caerulein,100 nmol/L)处理3 h,建立AP模型。实验分为对照组(control组)... 详细信息

目的:探讨长链非编码RNA牛磺酸上调基因1(lncRNA TUG1)在急性胰腺炎(AP)中的作用机制。方法:体外培养小鼠胰腺腺泡细胞系(MPC-83),用脂多糖(LPS,10μg/ml)和雨蛙素(Caerulein,100 nmol/L)处理3 h,建立AP模型。实验分为对照组(control组)、AP组、AP+sh-NC组、AP+sh-TUG1组、AP+sh-TUG1+inhibitor-NC组、AP+sh-TUG1+miR-31-5p inhibitor组。实时荧光定量PCR(qRT-PCR)检测细胞中lncRNA TUG1和miR-31-5p表达水平;CCK-8法检测细胞活力;流式细胞术检测细胞凋亡;ELISA检测细胞上清液中IL-1β、肿瘤坏死因子α(TNF-α)水平;双荧光素酶报告基因实验验证lncRNA TUG1和miR-31-5p之间的靶向关系。构建AP小鼠模型,给予相应的干预后,qRT-PCR检测胰腺组织中lncRNA TUG1和miR-31-5p表达水平;试剂盒检测血清中炎症因子IL-1β、TNF-α含量和淀粉酶(amy)和脂肪酶(Lipase)活性;HE染色观察胰腺组织病理学变化;TUNEL检测胰腺组织中细胞凋亡。结果:在Caerulein和LPS共同处理的MPC-83细胞中lncRNA TUG1水平、细胞凋亡率、IL-1β和TNF-α水平升高,miR-31-5p水平、细胞活力降低(均P<0.05);敲低lncRNA TUG1可上调miR-31-5p,增加细胞活力,降低IL-1β和TNF-α水平,抑制细胞凋亡(均P<0.05);下调miR-31-5p表达可减弱敲低lncRNA TUG1对细胞炎症反应的抑制作用。miR-31-5p是lncRNA TUG1的直接靶标。在体内敲低lncRNA TUG1表达可上调AP小鼠胰腺组织中miR-31-5p表达,降低IL-1β、TNF-α水平,减少细胞凋亡,改善胰腺组织损伤。结论:敲低lncRNA TUG1可能通过上调miR-31-5p表达水平,抑制炎症反应,改善AP。

关键词：长链非编码RNA牛磺酸上调基因1 急性胰腺炎腺泡细胞炎症 miR-31-5p