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International Journal of Ophthalmology(English edition) 2022年第10期15卷 1714-1716页

作者： Sanchay Gupta amy yuan Marika Chachanidze David A.Solá-Del Valle Harvard Medical School BostonMA 02115USA Glaucoma Service Massachusetts Eye and Ear InfirmaryBostonMA 02114USA

Dear Editor,We report the case of severe mixed-mechanism glaucoma observed in a monocular Axenfeld-Rieger syndrome(ARS) patient who was successfully managed with an ahmed glaucoma implant(AGI) followed by a novel technique described as augmented Micro Pulse transscleral cyclophotocoagulation(MP-TSCPC)[1]. ARS encompasses a heterogeneous spectrum of diseases involving anterior segment dysgenesis and systemic developmental anomalies[2].

关键词： glaucoma patient implant

Stressful life events,psychosocial health and general health in preschool children before age 4

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World Journal of Pediatrics 2023年第3期19卷 243-250页

作者： Jie Luo amy van Grieken Shuang Zhou yuan Fang Hein Raat Department of Public Health Erasmus MCDr.Molewaterplein 403015 GD RotterdamThe Netherlands Department of Maternal and Child Health School of Public HealthPeking UniversityBeijingChina

Background The impact of stressful life events(SLEs)in early childhood is often *** aimed to examine longitudinal associations between SLEs and psychosocial and general health in preschool *** Twelve SLEs occurring before the age of 24 months were assessed and categorized by frequency(no events,1-2 SLEs,and>2 SLEs)and overall tension(no events,low,and high)(n=1431).Psychosocial and general health were meas-ured three times at the age of 24,36 and 45 *** associations were examined by logistic regression models using generalized estimating equations to handle repeated *** Half(48.4%)of the families experienced SLEs,and 23.8%perceived high-tension SLEs before the children were aged 24 *** differences were observed in the association between SLEs and psychosocial *** to girls without SLEs,girls who experienced>2 SLEs[OR=3.31,95%confidence interval(CI)2.05-5.35]or high-tension SLEs(OR=3.01,95%CI 2.07-4.39)had higher odds of psychosocial problems from 24 to 45 *** odds ratios in boys were 2.10(95%CI 1.36-3.24)and 1.47(95%CI 1.06-2.03),***,only girls'risk of psychosocial problems increased after experiencing 1-2 SLEs(OR=2.15,95%CI 1.54-3.00)or low-tension SLEs(OR=1.90,95%CI 1.31-2.74).Regarding general health,children who experienced>2 SLEs(OR=1.96,95%CI 1.21-3.18)and high-tension SLEs(OR=1.60,95%CI 1.12-2.28)had higher odds of poor general health from 24 to 45 *** The findings emphasized that young children's psychosocial and general health can be impacted by experienc-ing SLEs in early *** and adequate support for families experiencing SLEs are needed to minimize the potential negative effect of SLEs on child health,particularly in girls.

关键词： Child health Preschool children Stressful life event

Length-based separation of Bacillus subtilis bacterial populations by viscoelastic microfluidics

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Microsystems & Nanoengineering 2022年第1期8卷 149-159页

作者： Ping Liu Hangrui Liu Lucie Semenec Dan yuan Sheng Yan amy K.Cain Ming Li Suqian University Suqian 223800China School of Engineering Macquarie UniversitySydneyNSW 2109Australia Department of Physics and Astronomy Macquarie UniversitySydneyNSW 2109Australia ARC Centre of Excellence in Synthetic Biology Department of Molecular ScienceMacquarie UniversitySydneyNSW 2109Australia Centre for Regional and Rural Futures Deakin UniversityGeelongVIC 3216Australia Institute for Advanced Study Shenzhen UniversityShenzhen 518060China Biomolecular Discovery Research Centre Macquarie UniversitySydneyNSW 2109Australia

In this study,we demonstrated the label-free continuous separation and enrichment of Bacillus subtilis populations based on length using viscoelastic ***,a gram-positive,rod-shaped bacterium,has been widely used as a model organism and an industrial *** can be arranged in different morphological forms,such as single rods,chains,and clumps,which reflect differences in cell types,phases of growth,genetic variation,and changing environmental *** ability to prepare *** populations with a uniform length is important for basic biological studies and efficient industrial ***,we systematically investigated how flow rate ratio,poly(ethylene oxide)(PEO)concentration,and channel length affected the length-based separation of *** *** lateral positions of *** cells with varying morphologies in a straight rectangular microchannel were found to be dependent on cell length under the co-flow of viscoelastic and Newtonian ***,we evaluated the ability of the viscoelastic microfluidic device to separate the two groups of *** cells by length(i.e.,1-5μm and>5μm)in terms of extraction purity(EP),extraction yield(EY),and enrichment factor(EF)and confirmed that the device could separate heterogeneous populations of bacteria using elasto-inertial effects.

关键词： viscoelastic separation straight

amygdalin ameliorates apoptosis and imbalance of osteogenic/lipogenic homeostasis caused by NOX4/ROS/p38MAPK signaling activation to treat glucocorticoid-associated necrosis of the femoral head

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Food Science and Human Wellness 2024年

作者： Huihui Xu Kai'ao Zou Haipeng Huang Qinghe Zeng Xu Wang Ping'er Wang Wenhua yuan Luwei Xiao Jiali Chen Peijian Tong Hongting Jin he First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine) The First College of Clinical Medicine Zhejiang Chinese Medical University Institute of Orthopaedics and Traumatology of Zhejiang Province

The study aimed to explore the efficacy and potential mechanisms of a naturally aromatic cyanogenic compound-amygdalin (amy) in treating glucocorticoid (GC)-associated necrosis of the femoral head (GANFH). We demonstrated that GC exacerbates the oxidative stress (OS) microenvironment via promoting nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) expression in human， rat， and mesenchymal stem cells (MSCs) samples， thus generating excessive ROS， leading to increased apoptosis and unbalanced osteolipogenic differentiation. Furthermore， computational docking results revealed that amy could bind specifically to the predicted binding sites of NOX4. Additionally， amy ameliorated the OS microenvironment of MSCs via decreasing NOX4 expression and inhibiting NOX4/ROS/p38MAPK signaling， thereby reversing the GC-induced apoptosis and imbalanced osteolipogenic differentiation， and ultimately alleviating GANFH. In summary， we demonstrated for the first time that amy attenuated apoptosis and maintained osteolipogenic differentiation balance in MSCs via specifically targeting NOX4， inhibiting NOX4/ROS/p38MAPK signaling， thereby treating GANFH.

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Small extracellular vesicles in cancer

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Bioactive Materials 2021年第11期6卷 3705-3743页

作者： Komal Abhange amy Makler Yi Wen Natasha Ramnauth Wenjun Mao Waseem Asghar yuan Wan The Pq Laboratory of Micro/Nano BiomeDx Department of Biomedical EngineeringBinghamton University-SUNYBinghamtonNY 13902USA Micro1nd Nanotechnology in Medicine Department of Biological SciencesFlorida Atlantic UniversityBoca RatonFL 33431USA Department of Cardiothoracic Surgery The Affiliated Wuxi People’s Hospital of Nanjing Medical UniversityWuxiJiangsu 214023China

Extracellular vesicles(EV)are lipid-bilayer enclosed vesicles in submicron size that are released from cells.A variety of molecules,including proteins,DNA fragments,RNAs,lipids,and metabolites can be selectively encapsulated into EVs and delivered to nearby and distant recipient *** tumors,through such intercellular communication,EVs can regulate initiation,growth,metastasis and invasion of *** studies have found that EVs exhibit specific expression patterns which mimic the parental cell,providing a fingerprint for early cancer diagnosis and prognosis as well as monitoring responses to ***,various EV isolation and detection technologies have been developed for research and diagnostic ***,natural and engineered EVs have also been used as drug delivery nanocarriers,cancer vaccines,cell surface modulators,therapeutic agents and therapeutic ***,EVs are under intense investigation as they hold promise for pathophysiological and translational *** comprehensive review examines the latest EV research trends over the last five years,encompassing their roles in cancer pathophysiology,diagnostics and *** review aims to examine the full spectrum of tumor-EV studies and provide a comprehensive foundation to enhance the *** topics which are discussed and scrutinized in this review encompass isolation techniques and how these issues need to be overcome for EV-based diagnostics,EVs and their roles in cancer biology,biomarkers for diagnosis and monitoring,EVs as vaccines,therapeutic targets,and EVs as drug delivery *** will also examine the challenges involved in EV research and promote a framework for catalyzing scientific discovery and innovation for tumor-EV-focused research.

关键词： diagnosis overcome vesicles

Borderless, Not Lawless

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Beijing Review 2022年第48期65卷 32-33页

作者： yuan yuan 不详

It was a movie-worthy drama that played out in real life. On the night of March 15, online celebrity Wuwu made her usual appearance on Douyin, China’s version of Tik Tok. As a livestreamer with a loyal following, she... 详细信息

关键词： mostly appearance less

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早期IL-12p70、CAR、PCT联合检测对急性胰腺炎病情严重程度的预测价值

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医学信息 2024年第1期37卷 115-119页

作者：罗辉黄高明尹纯林孙远松王召华颜锡洋安徽医科大学第二附属医院急诊外科

目的探讨早期白介素12p70(IL-12p70)、C反应蛋白与血清白蛋白比值（CAR）、降钙素原（PCT）联合检测与急性胰腺炎（AP）患者病情严重度的相关性及对非轻症胰腺炎的早期预测效能。方法选取我院急诊外科2021年11月-2022年5月收治的102... 详细信息

目的探讨早期白介素12p70(IL-12p70)、C反应蛋白与血清白蛋白比值（CAR）、降钙素原（PCT）联合检测与急性胰腺炎（AP）患者病情严重度的相关性及对非轻症胰腺炎的早期预测效能。方法选取我院急诊外科2021年11月-2022年5月收治的102例AP患者的临床资料进行回顾性分析，依照修订后的亚特兰大分类将其分为轻症组（48例）和非轻症组（54例），比较两组入院时IL-12p70、CAR、PCT水平，通过受试者工作曲线（ROC）及相关性分析探究上述指标早期联合检测对AP病情严重程度的预测效能。结果两组性别、发病原因、年龄、血压、BMI、S-amy、Ca2+、WBC比较，差异无统计学意义（P>0.05）；非轻症组入院时的IL-12p70、CAR、PCT水平均高于轻症组（P<0.05）;ROC曲线显示，IL-12p70、CAR、PCT早期预测非轻症AP发生的曲线下面积分别为0.866、0.762、0.927，三者并行检测可以将检测的灵敏度提升到0.996，特异度达0.998。相关性分析显示，早期IL-12p70、CAR、PCT三项指标与改良CT严重指数评分（MCTSI）呈正相关（r=0.603、0.420、0.669）。结论早期检测IL-12p70、CAR、PCT在AP患者病情严重程度的预测中均有一定的临床价值，且三种方法联合使用具有更好的预测效果。

关键词：急性胰腺炎白介素12p70 C反应蛋白与血清白蛋白比值降钙素原

The role of tropomodulin1 in the migration inhibition of macrophage induced by oxLDL

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The role of tropomodulin1 in the migration inhibition of mac...

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第十一届全国生物力学学术会议暨第十三届全国生物流变学学...

作者： Weijuan Yao Fang Ding yuan Wu Xifu Wang Lide Xie L.amy Sung Hemorheology Center Department of Physiology and PathophysiologyPeking University Health Science Center Chengde Medical College Emergency Department Beijing Anzhen HospitalCapital Medical University Department of Bioengineering University of California

Objective:The migration inhibition of macrophage is the core event in the development of *** the mechanisms remain *** low density lipoprotein(oxLDL)is one of the main factors that inhibit macrophage *** cytoskeletal proteins determine the deformability and migration of the ***1(Tmod1)is a cytoskeleton protein that caps the pointed end of actin filaments and plays an im-

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China's Tibet 2013年第5期24卷 34-41页

作者： amy

At first,Liu yuan gave me the impression that she must be a"health nut"because at the dining table,she drank neither wine nor other beverages,just *** started her meal with vegetables and finished it with meat.I asked her what she had studied and,as expected,she answered’medicine’.I continued by asking her how to refuse a toast...and she gave me the simple response:"insist".As we returned to Songpan from Hongyuan and Ruoergai,Lv Qiang,Director of the New Lotus

关键词：成都理工大学中国传统医学博士学位薄层色谱法科研基金药用植物内容识别川贝母

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Influence of starch sources and dietary protein levels on intestinal functionality and intestinal mucosal amino acids catabolism in broiler chickens

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Journal of Animal Science and Biotechnology 2019年第3期10卷 658-672页

作者： Dafei Yin Peter H.Selle amy F.Moss Youli Wang Xiaoyu Dong Zhibin Xiao Yuming Guo Jianmin yuan State key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193People’s Republic of China Poultry Research Foundation The University of SydneyWerombi RoadCamdenNSW 2570Australia

Background: There is growing interest in carbohydrate and protein nutrition to enhance the efficiency of animal ***-crude protein diets depress environmental pollution and feeding cost,but the challenge to their adoption is maintaining digestive function and growth performance of *** present study was conducted to evaluate the influence of different dietary starch sources and protein levels on intestinal functionality and mucosal amino acid ***: Six dietary treatments,based on maize and soybean meal,were offered to 360 AA+male chicks from 6 to 35 d post-hatch as a 3 × 2 factorial *** waxy rice or amylose was added to a conventional maize-soy diet to provide three sources of starch with different digestion rates and relatively high and low dietary protein *** performance,parameters of intestinal functionality and concentrations of free amino acid in the portal circulation were ***: In the grower phase,starch source influenced(P amylose supported significantly higher weight gains than waxy *** increase of ileal ATP concentrations and Na^+/K^+-ATPase activity were found in amylose ***,amylose decreased BrdU positive cell numbers and down-regulated m RNA expression for *** activity in the ileum was higher(P amylose,***: Amino acid catabolism in the gut mucosa is subject to nutritional *** that amino acids can be spared from catabolism in the gut mucosa by supplementation of amylose,it follow

关键词： Amino acids Broiler chickens Enterocytes Glucose Starch

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