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Pancreatic endometrial cyst mimics mucinous cystic neoplasm of the pancreas

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World Journal of Gastroenterology 2017年第6期23卷 1113-1118页

作者： Michael A Mederos Nicole Villafane Sadhna Dhingra Carlos Farinas amy mc elhany William E Fisher George Van Buren II Department of General Surgery Baylor College of Medicine Department of Pathology Baylor College of Medicine Department of Radiology Baylor College of Medicine

Pancreatic cysts include a variety of benign, premalignant, and malignant lesions. Endometrial cysts in the pancreas are exceedingly rare lesions that are difficult to diagnose pre-operatively. This report describes the findings in a 43-year-old patient with a recent episode of acute pancreatitis who presented with a large cyst in the tail of the pancreas. Imaging demonstrated a loculated pancreatic cyst, and cyst fluid aspiration revealed an elevated amylase and carcinoembryonic antigen. The patient experienced an interval worsening of abdominal pain, fatigue, diarrhea, and a 15-pound weight loss 3 mo after the initial episode of pancreatitis. With concern for a possible pre-malignant lesion, the patient underwent a laparoscopic distal pancreatectomy with splenectomy, which revealed a 16cm×12cm×4cm lesion. Final histopathology was consistent with an intra-pancreatic endometrial cyst. Here we discuss the overlapping imaging and laboratory features of pancreatic endometrial cysts and mucinous cystic neoplasms of the pancreas.

关键词： Pancreatic cyst Pancreatic endometrial cyst Endometriosis Mucinous cystic neoplasm of the pancreas Distal pancreatectomy

Protein digestive dynamics of meat and bone meals in broiler chickens

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Animal Nutrition 2020年第4期6卷 521-528页

作者： Shemil P.Macelline Leon R.mc Quade Bernie V.mclnerney amy F.Moss Peter H.Selle Sonia Y.Liu School of Life and Environmental Sciences Faculty of ScienceThe University of SydneySydneyNSW2006Australia Poultry Research Foundation The University of SydneyCamdenNSW2570Australia Australian Proteome Analysis Facility Macquarie UniversitySydneyNSW2109Australia School of Environmental and Rural Science University of New EnglandArmidaleNSW2351Australia

This study determined the variations in protein digestibilities and digestion rates in broiler chickens offered diets containing 7 different meat and bone meals(MBM).A total of 252 male Ross 308 broiler chickens were offered 7 atypical diets largely based on maize and MBM from 24 to 28 d *** experimental diet was offered to 6 replicates with 6 birds per replicate *** were collected in their entirety from 25 to 27 d post-hatch and on 28 d *** samples were collected from the proximal jejunum,distal jejunum,proximal ileum and distal *** digestibilities of protein were determined in each segment and apparent digestibilities of amino acids were measured in the distal *** were significant differences in apparent protein digestibility coefficients in the proximal jejunum(P=0.006),where broiler chickens offered the high ash beef meal(diet 7)generated the lowest protein digestibility in the proximal jejunum(0.318).Similarly,there were significant differences in apparent digestibility coefficients in the distal jejunum(P<0.001)and distal ileum(P<0.001)but not in the proximal *** pronounced differences were found in the disappearance rate of protein and there were significant differences in all 4 segments of the small intestine(P<0.001).Broiler chickens offered the high ash beef meal had the lowest protein disappearance rate(P<0.001).No difference was observed in the predicted protein digestion rate(P=0.486)but chickens offered the high ash beef meal had the lowest potential digestible protein(0.662,P=0.034)whereas the highest potential digestible protein(0.739)was detected in diet 5(containing a beef meal).This study contributed to the establishment of a preliminary database to include digestion rates of starch and protein into practical diet formulation.

关键词： Amino acid Digestibility Digestive dynamics Meat and bone meal Protein digestion rate

Juxtacrine interaction of macrophages and bone marrow stromal cells induce interleukin-6 signals and promote cell migration

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Bone Research 2015年第2期3卷 100-111页

作者： Jia Chang amy J Koh Hernan Roca Laurie K mcCauley Department of Periodontics and Oral Medicine University of Michigan School of Dentistry Department of Periodontology University of Florida College of Dentistry Department of Pathology University of Michigan Medical School

The bone marrow contains a heterogeneous milieu of cells, including macrophages, which are key cellular mediators for resolving infection and inflammation. Macrophages are most well known for their ability to phagocytose foreign bodies or apoptotic cells to maintain homeostasis; however, little is known about their function in the bone microenvironment. In the current study, we investigated the in vitro interaction of murine macrophages and bone marrow stromal cells （BMSCs）, with focus on the juxtacrine induction of IL-6 signaling and the resultant effect on BMSC migration and growth. The juxtacrine interaction of primary mouse macrophages and BMSCs activated IL-6 signaling in the co-cultures, which subsequently enhanced BMSC migration and increased BMSC numbers. BMSCs and macrophages harvested from IL-6 knockout mice revealed that IL-6 signaling was essential for enhancement of BMSC migration and increased BMSC numbers via juxtacrine interactions. BMSCs were the main contributor of IL-6 signaling~ and hence activation of the IL-6/ gp130/STAT3 pathway. Meanwhile, macrophage derived IL-6 remained important for the overall production of IL-6 protein in the co-cultures. Taken together, these findings show the function of macmphages as co-inducers of migration and growth of BMSCs, which could directly influence bone formation and turnover.

关键词： BMSCs IL bone STAT cell

2,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents

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Acta Pharmaceutica Sinica B 2017年第1期7卷 73-79页

作者： Erin Marie Kirwen Tarun Batra Chandrabose Karthikeyan Girdhar Singh Deora Vandana Rathore Chaitanya Mulakayala Naveen Mulakayala amy Catherine Nusbaum Joel Chen Haneen Amawi Kyle mc Intosh Sahabjada Neelam Shivnath Deepak Chowarsia Nisha Sharma Md Arshad Piyush Trivedi Amit KTiwari Department of Pharmacology and Experimental Therapeutics College of Pharmacy & Pharmaceutical SciencesUniversity of Toledo School of Pharmaceutical Sciences Rajiv Gandhi Technical University The University of Queensland School of Pharmacy Dr. Reddy’s Institute of Life Sciences University of Hyderabad Campus The University of Queensland School of Biomedical Sciences Department of Biosciences Sri Satya Sai Institute of Higher LearningAnantapur campus Clearsynth Labs Ltd. Research CentreIDA-Mallapur Molecular Endocrinology Lab Department of ZoologyUniversity of Lucknow University Institute of Pharmacy Chhatrapati Shahu Ji Maharaj University

In this study we examined the suitability of the 3H-imidazo[4,5-b]pyridine ring system in developing novel anticancer and anti-inflammatory agents incorporating a diaryl pharmacophore. Eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives retrieved from our in-house database were evaluated for their cytotoxic activity against nine cancer cell lines. The results indicated that the compounds showed moderate cytotoxic activity against mcF-7, MDA-MB-468, K562 and SaOS2 cells, with K562 being the most sensitive among the four cancer cell lines. The eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives were also evaluated for their COX-1 and COX-2 inhibitory activity in vitro. The results showed that compound 3f exhibited 2-fold selectivity with IC_(50) values of 9.2 and 21.8 mmol/L against COX-2 and COX-1, respectively. Molecular docking studies on the most active compound 3f revealed a binding mode similar to that of celecoxib in the active site of the COX-2 enzyme.

关键词： 3H-Imidazo[4,5-b]pyridine Cytotoxicity MTT assay COX inhibitors Docking studies

Stressful life events,psychosocial health and general health in preschool children before age 4

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World Journal of Pediatrics 2023年第3期19卷 243-250页

作者： Jie Luo amy van Grieken Shuang Zhou Yuan Fang Hein Raat Department of Public Health Erasmus MCDr.Molewaterplein 403015 GD RotterdamThe Netherlands Department of Maternal and Child Health School of Public HealthPeking UniversityBeijingChina

Background The impact of stressful life events(SLEs)in early childhood is often *** aimed to examine longitudinal associations between SLEs and psychosocial and general health in preschool *** Twelve SLEs occurring before the age of 24 months were assessed and categorized by frequency(no events,1-2 SLEs,and>2 SLEs)and overall tension(no events,low,and high)(n=1431).Psychosocial and general health were meas-ured three times at the age of 24,36 and 45 *** associations were examined by logistic regression models using generalized estimating equations to handle repeated *** Half(48.4%)of the families experienced SLEs,and 23.8%perceived high-tension SLEs before the children were aged 24 *** differences were observed in the association between SLEs and psychosocial *** to girls without SLEs,girls who experienced>2 SLEs[OR=3.31,95%confidence interval(CI)2.05-5.35]or high-tension SLEs(OR=3.01,95%CI 2.07-4.39)had higher odds of psychosocial problems from 24 to 45 *** odds ratios in boys were 2.10(95%CI 1.36-3.24)and 1.47(95%CI 1.06-2.03),***,only girls'risk of psychosocial problems increased after experiencing 1-2 SLEs(OR=2.15,95%CI 1.54-3.00)or low-tension SLEs(OR=1.90,95%CI 1.31-2.74).Regarding general health,children who experienced>2 SLEs(OR=1.96,95%CI 1.21-3.18)and high-tension SLEs(OR=1.60,95%CI 1.12-2.28)had higher odds of poor general health from 24 to 45 *** The findings emphasized that young children's psychosocial and general health can be impacted by experienc-ing SLEs in early *** and adequate support for families experiencing SLEs are needed to minimize the potential negative effect of SLEs on child health,particularly in girls.

关键词： Child health Preschool children Stressful life event

Creation of an optic nerve sheath diameter ultrasound model for Neuro ICU education

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Military Medical Research 2021年第1期8卷 116-120页

作者： Heidi M.Felix Kristin A.Rosenbush amy M.Lannen Robert A.Pooley Jason L.Siegel Benjamin L.Brown Melissa L.mc Mullan Christina I.Collins William D.Freeman J.Wayne and Delores Barr Weaver Simulation Center Mayo Clinic4500 San Pablo RoadJacksonvilleFL 32224USA Division of Medical Physics Mayo ClinicJacksonvilleFL 32224USA Department of Critical Care Medicine Mayo ClinicJacksonvilleFL 32224USA Department of Neurology Mayo ClinicJacksonvilleFL 32224USA Department of Neurologic Surgery Mayo ClinicJacksonvilleFL 32224USA Department of Radiology Mayo ClinicJacksonvilleFL 32224USA Department of Nursing Mayo ClinicJacksonvilleFL 32224USA

Background: Using ultrasound to measure optic nerve sheath diameter(ONSD) is an emerging bedside technique to noninvasively assess intracranial pressure(ICP) in patients with brain injury. This technique is unique among bedside ultrasonography and is often performed by providers who have no formal ultrasound training. We sought to create a low-cost, 3 D, reusable ONSD model to train neurology, neurosurgery, and critical care providers in measuring ***: We identified 253 articles, of which 15 were associated with models and 2 with simulation. One gelatin model was reported, upon which we based our initial design. We could not validate the visual findings of this model;however, after constructing multiple beta models, the design most representative of human eye anatomy was a globe made of ballistics gel and either a 3 mm, 5 mm, or 7 mm×50 mm 3 D-printed optic nerve inserted into a platform composed of ballistics gel, all of which sat inside a 3 D-printed skull. This model was used to teach ONSD measurements with ultrasound at a continuing medical education event prior to training on a live human ***: A simple 3 D ballistic ONSD model allows learners to practice proper hand placement and pressure, basic landmarks, and ONSD measurement prior to operating on a human eye. This model is replicable and sustainable given that the globe and platform are composed of ballistics gel.

关键词： Intracranial pressure Simulation Task trainer Ultrasound

Reversal of the diabetic bone signature with anabolic therapies in mice

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Bone Research 2023年第2期11卷 328-339页

作者： Silvia Marino Nisreen Akel Shenyang Li Meloney Cregor Meghan Jones Betiana Perez Gaston Troncoso Jomeeka Meeks Scott Stewart amy YSato Intawat Nookaew Teresita Bellido Department of Physiology and Cell Biology University of Arkansas for Medical SciencesLittle RockARUSA Central Arkansas Veterans Healthcare System John L.Mc Clellan Little RockLittle RockARUSA Department of Biostatistics University of Arkansas for Medical SciencesLittle RockARUSA Department of Biomedical Informatics University of Arkansas for Medical SciencesLittle RockARUSA Winthrop P.Rockefeller Cancer Institute University of Arkansas for Medical SciencesLittleRockARUSA

The mechanisms underlying the bone disease induced by diabetes are complex and not fully understood;and antiresorptive agents,the current standard of care,do not restore the weakened bone ***,we reveal the diabetic bone signature in mice at the tissue,cell,and transcriptome levels and demonstrate that three FDA-approved bone-anabolic agents correct *** decreased bone mineral density(BMD)and bone formation,damaged microarchitecture,increased porosity of cortical bone,and compromised bone ***(PTH),abaloparatide(ABL),and romosozumab/anti-sclerostin antibody(Scl-Ab)all restored BMD and corrected the deteriorated bone ***,PTH and more potently ABL induced similar responses at the tissue and gene signature levels,increasing both formation and resorption with positive balance towards bone *** contrast,Scl-Ab increased formation but decreased *** agents restored bone architecture,corrected cortical porosity,and improved mechanical properties of diabetic bone;and ABL and Scl-Ab increased toughness,a fracture resistance ***,all agents increased bone strength over the healthy controls even in the presence of severe *** findings demonstrate the therapeutic value of bone anabolic agents to treat diabetes-induced bone disease and suggest the need for revisiting the approaches for the treatment of bone fragility in diabetes.

关键词： signature porosity corrected

Use of sensory substitution devices as a model system for investigating cross-modal neuroplasticity in humans

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Neural Regeneration Research 2015年第11期10卷 1717-1719页

作者： amy C.Nau Matthew C.Murphy Kevin C.Chan UPmc Eye Center Ophthalmology and Visual Science Research Center Department of Ophthalmology School of Medicine University of Pittsburgh mc Gowan Institute for Regenerative Medicine University of Pittsburgh Louis J.Fox Center for Vision Restoration University of Pittsburgh Department of Bioengineering Swanson School of Engineering University of Pittsburgh mcGowan Institute for Regenerative Medicine University of Pittsburgh Center for the Neural Basis of Cognition University of Pittsburgh Carnegie Mellon University

Blindness provides an unparalleled opportunity to study plasticity of the nervous system in *** work in this area examined the often dramatic modifications to the visual cortex that result when visual input is completely absent from birth or very early in life（Kupers and Ptito,2014）.More recent studies explored what happens to the visual pathways in the context of acquired *** is particularly relevant as the majority of diseases that cause vision loss occur in the elderly.

关键词： Use of sensory substitution devices as a model system for investigating cross-modal neuroplasticity in humans BOLD

Functional roles of melanocortin-4 receptor in hippocampal synapse

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Functional roles of melanocortin-4 receptor in hippocampal s...