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Nuclear factor κB represses the expression of latent membrane protein 1 in Epstein-Barr virus transformed cells

World Journal of Virology 2014年第4期3卷 22-29页

作者： Mingxia Cao Qianli Wang amy lingel Luwen Zhang School of Biological Sciences University of NebraskaLincolnNE 68588United States 238 Morrison Center School of Biological SciencesNebraska Center for VirologyUniversity of NebraskaLincolnNE 68583-0900United States

AIM: To investigate the role of nuclear factor κB(NF-κB) in the regulation of Epstein-Barr virus(EBV) latent membrane protein 1(LMP1) in EBV transformed cells. METHODS: LMP1 expression was examined in EBV transformed human B lymphocytes with modulation of NF-κB activity. RESULTS: EBV infection is associated with several human cancers. EBV LMP1 is required for efficient transformation of adult primary B cells in vitro, and is expressed in several pathogenic stages of EBVassociated cancers. Regulation of EBV LMP1 involves both viral and cellular factors. LMP1 activates NF-κB signaling pathway that is a part of the EBV transformation program. However, the relation between NF-κB and LMP1 expression is not well established yet. In this report, we found that blocking the NF-κB activity by Inhibitor of κB stimulated LMP1 expression, while the overexpression of NF-κB repressed LMP1 expression in EBV-transformed IB4 cells. In addition, LMP1 repressed its own promoter activities in reporter assays, and the repression was associated with the activation of NF-κB. Moreover, NF-κB alone is sufficient to repress LMP1 promoter activities. CONCLUSION: Our data suggest LMP1 may repress its own expression through NF-κB in EBV transformed cells and shed a light on LMP1 regulation during EBV transformation.

关键词： Nuclear factorκB Epstein-Barr virus Latent membrane protein 1 Latency Transformation

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