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Examining the effects of voluntary avoidance behaviour and policy-mediated behaviour change on the dynamics of SARS-CoV-2:A mathematical model

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Infectious Disease Modelling 2024年第3期9卷 701-712页

作者： Gabrielle Brankston David N.Fisman Zvonimir Poljak Ashleigh R.Tuite amy L.Greer Department of Population Medicine University of GuelphCanada Dalla Lana School of Public Health University of TorontoCanada Centre for Immunization Readiness Public Health Agency of CanadaOttawaOntarioCanada

Background Throughout the SARS-CoV-2 pandemic,policymakers have had to navigate between recommending voluntary behaviour change and policy-driven behaviour change to mitigate the impact of the *** individuals will voluntarily engage in self-protective behaviour when there is an increasing infectious disease risk,the extent to which this occurs and its impact on an epidemic is not *** This paper describes a deterministic disease transmission model exploring the impact of individual avoidance behaviour and policy-mediated avoidance behaviour on epidemic outcomes during the second wave of SARS-CoV-2 infections in Ontario,Canada(September 1,2020 to February 28,2021).The model incorporates an information feedback function based on empirically derived behaviour data describing the degree to which avoidance behaviour changed in response to the number of new daily cases *** Voluntary avoidance behaviour alone was estimated to reduce the final attack rate by 23.1%,the total number of hospitalizations by 26.2%,and cumulative deaths by 27.5%over 6 months compared to a counterfactual scenario in which there were no interventions or avoidance behaviour.A provincial shutdown order issued on December 26,2020 was estimated to reduce the final attack rate by 66.7%,the total number of hospitalizations by 66.8%,and the total number of deaths by 67.2%compared to the counterfactual *** Given the dynamics of SARS-CoV-2 in a pre-vaccine era,individual avoidance behaviour in the absence of government action would have resulted in a moderate reduction in disease however,it would not have been sufficient to entirely mitigate transmission and the associated risk to the population in *** action during the second wave of the COVID-19 pandemic in Ontario reduced infections,protected hospital capacity,and saved lives.

关键词： Mathematical modelling COVID-19 SARS-CoV-2 Human behaviour

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阿力甜──性质优良的甜味剂

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中国食品添加剂 2000年第3期11卷 23-25页

作者：杨海燕张日生科特(中国)有限公司广州510730

本文阐述了新一代高甜度甜味剂阿力甜的甜味特性、溶解性以及稳定性．

关键词：阿力甜甜度甜味特性溶解性稳定性甜味剂

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IMpower210:A phase Ⅲ study of second-line atezolizumab vs. docetaxel in East Asian patients with non-small cell lung cancer

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Chinese Journal of Cancer Research 2024年第2期36卷 103-113页

作者： Yi-Long Wu Shun Lu Gongyan Chen Jianxing He Jifeng Feng Yiping Zhang Liyan Jiang Hongming Pan Jianhua Chang Jian Fang amy Cai Lilian Bu Jane Shi Jinjing Xia Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People's Hospital&Guangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China Shanghai Lung Cancer Center Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Respiration Harbin Cancer HospitalHarbin Medical UniversityHarbin 150081China Department of Thoracic Oncology and Surgery the First Affliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Medical Oncology Jiangsu Cancer HospitalNanjing 210009China Department of Medical Oncology Zhejiang Cancer HospitalHangzhou 330022China Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Medical Oncology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Medical Oncology Shenzhen HospitalCancer Hospital of Chinese Academy of Medical SciencesShenzhen 518116China Department of Thoracic Oncology Beijing Cancer HospitalBeijing 100142China Product Development Shanghai Roche Pharmaceutical LtdShanghai 201203China

Objective: IMpower210(NCT02813785) explored the efficacy and safety of single-agent atezolizumab *** as second-line treatment for advanced non-small cell lung cancer(NSCLC) in East Asian ***: Key eligibility criteria for this phase Ⅲ, open-label, randomized study included age ≥18 years;histologically documented advanced NSCLC per the Union for International Cancer Control/American Joint Committee on Cancer staging system(7th edition);Eastern Cooperative Oncology Group performance status of 0 or 1;and disease progression following platinum-based chemotherapy for advanced or metastatic NSCLC. Patients were randomized 2:1 to receive either atezolizumab(1,200 mg) or docetaxel(75 mg/m^(2)). The primary study endpoint was overall survival(OS) in the intention-to-treat(ITT) population with wild-type epidermal growth factor receptor expression(ITT EGFR-WT) and in the overall ITT ***: Median OS in the ITT EGFR-WT population(n=467) was 12.3 [95% confidence interval(95% CI),10.3-13.8] months in the atezolizumab arm(n=312) and 9.9(95% CI, 7.8-13.9) months in the docetaxel arm[n=155;stratified hazard ratio(HR), 0.82;95% CI, 0.66-1.03]. Median OS in the overall ITT population was 12.5(95% CI, 10.8-13.8) months with atezolizumab treatment and 11.1(95% CI, 8.4-14.2) months(n=377) with docetaxel treatment(n=188;stratified HR, 0.87;95% CI, 0.71-1.08). Grade 3/4 treatment-related adverse events(TRAEs) occurred in 18.4% of patients in the atezolizumab arm and 50.0% of patients in the docetaxel ***: IMpower210 did not meet its primary efficacy endpoint of OS in the ITT EGFR-WT or overall ITT populations. Atezolizumab was comparatively more tolerable than docetaxel, with a lower incidence of grade3/4 TRAEs.

关键词： Atezolizumab East Asia non-small cell lung cancer programmed death-ligand 1 inhibitors monoclonal antibody

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BLUE公寓楼

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城市环境设计 2016年第1期 178-183页

作者： Bernard Tschumi Kim Starr William Feuerman Adam Dayem Dominic Leong Alan Kusov Casey Crawmer Shai Gross Adam Marcus amy yang Adrien Durrmeyer

这座位于纽约下东区的中层公寓楼拥有32套单元,既有底部一卧和两卧的户型单元,也有中部连接一处大型退台的一层一户式单元,中上部是有着高挑空间的单元和一处大型退台,楼顶则是一套大型复式单元。基地有许多复杂的用地规定。基地地块的... 详细信息

这座位于纽约下东区的中层公寓楼拥有32套单元,既有底部一卧和两卧的户型单元,也有中部连接一处大型退台的一层一户式单元,中上部是有着高挑空间的单元和一处大型退台,楼顶则是一套大型复式单元。基地有许多复杂的用地规定。基地地块的规划用途是住宅,允许其上所建楼房被在邻近的固有商业建筑上

关键词：公寓楼住宅地块商业建筑 open BLUE 退台

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Hydraulic properties and drought response of a tropical bamboo (Cephalostachyum pergracile)

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Plant Diversity 2024年第3期46卷 406-415页

作者： Wanwalee Kongjarat Lu Han amy Ny Aina Aritsara Shu-Bin Zhang Gao-Juan Zhao Yong-Jiang Zhang Phisamai Maenpuen Ying-Mei Li Yi-Ke Zou Ming-Yi Li Xue-Nan Li Lian-Bin Tao Ya-Jun Chen CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYunnan 666303China University of the Chinese Academy of Sciences Beijing 100049China T-STAR Core Team Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYunnan 666303China School of Biology and Ecology University of MaineOronoMEUSA Climate Change Institute University of MaineOronoME 04469USA School of Biological and Chemical Science Pu’er UniversityXueyuan RoadYunnan 665000China Institute of Ecology and Geobotany School of Ecology and Environmental SciencesYunnan UniversityKunmingYunnan 650091China School of Ecology and Environment Southwest Forestry UniversityKunmingYunnan 650224China Yuanjiang Savanna Ecosystem Research Station Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesYuanjiangYunnan 653300China

Bamboo plants are an essential component of tropical ecosystems,yet their vulnerability to climate extremes,such as drought,is poorly understood due to limited knowledge of their hydraulic *** pergracile,a commonly used tropical bamboo species,exhibited a substantially higher mortality rate than other co-occurring bamboos during a severe drought event in 2019,but the underlying mechanisms remain *** study investigated the leaf and stem hydraulic traits related to drought responses,including leaf-stem embolism resistance(P50leaf;P50stem) estimated using optical and X-ray microtomography methods,leaf pressure-volume and water-releasing ***,we investigated the seasonal water potentials,native embolism level(PLC) and xylem water source using stable *** found that *** exhibited strong resistance to embolism,showing low P50leaf,P50stem,and turgor loss point,despite its rapid leaf water ***,its leaves displayed greater resistance to embolism than its stem,suggesting a lack of effective hydraulic vulnerability segmentation(HVS) to protect the stem from excessive xylem *** the dry season,approximately 49% of the water was absorbed from the upper 20-cm-deep soil ***,significant diurnal variation in leaf water potentials and an increase in midday PLC from 5.87±2.33% in the wet season to 12.87±4.09%in the dry season were *** summary,this study demonstrated that the rapid leaf water loss,high reliance on surface water,and a lack of effective HVS in *** accelerated water depletion and increased xylem embolism even in the typical dry season,which may explain its high mortality rate during extreme drought events in 2019.

关键词： Climate change Drought Hydraulic safety Hydraulic vulnerability segmentation Stable isotope Tree mortality

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肖全的西行漫记从成都出发

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商业周刊（中文版） 2024年第14期 38-40页

作者： amy 不详

从市井百态到文化名人,再到白云、雪山和菩提树,肖全从成都出发,走遍各地,通过镜头观看他者的同时,他也在追寻自己,身为一个土生土长的成都人,肖全却不会打麻将。“一个摄影师真的是应该非常勤奋,应该背着机器到处走。”如他所言,他全... 详细信息

从市井百态到文化名人,再到白云、雪山和菩提树,肖全从成都出发,走遍各地,通过镜头观看他者的同时,他也在追寻自己,身为一个土生土长的成都人,肖全却不会打麻将。“一个摄影师真的是应该非常勤奋,应该背着机器到处走。”如他所言,他全部的精力都投人了摄影,哪有时间打麻将。

关键词：打麻将菩提树西行漫记文化名人摄影师市井百态成都

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Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

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Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi Zhang Zhongwu Liu Michael Chopp Michael Millman Yanfeng Li Pasquale Cepparulo amy Kemper Chao Li Li Zhang Zheng Gang Zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

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Diversity and Structure of the Woody Stand in a Sudano-Sahelian Transition Zone in Senegal

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Open Journal of Ecology 2024年第1期14卷 1-16页

作者： Oumar Sarr Moustapha B. Sagna amy Bakhoum Sékouna Diatta Aliou Guissé UCAD/FST Laboratory of Ecology and Ecohydrology Dakar Senegal Tessekere Human Environment Observatory (Senegal) IRL 3189 “Environment Health Society” Dakar Senegal

The main objective of the study was to investigate the diversity of the woody stratum of the vegetation in intercommunity rangelands in the department of Koungheul based on an ecological inventory using vegetation surveys. The results indicate a rich flora of 70 species divided into 54 genera and 27 families where Ceasalpiniaceae and Rubiaceae are dominant (5 genera each). They are followed by Combretaceae and Euphorbiacea (4 genera each) and by Capparaceae, Fabaceae and Mimosaceae (3 genera for each family). But at the specific level, it is the Combretaceae which dominates with 10 species and Rubiaceae (7 species). It is more representative at the level of the rural community of Lour Esacale. The different values of vegetation parameters from one site to another indicate variability in community rangeland management practices. The woody stand, dominated by small Combretaceae, shows a relatively stable level of organization with an average equitability of about 45% for the two rural communities studied. Species such as Cordyla pinnata, Sclerocarya birrea, Adansonia digitata and Sterculia setigera contributed strongly to the basal and aerial cover of the overall stand. The regeneration of the stand is very good (about 85% on average) but it represents very few species, especially of the Combretaceae family. This shows a tendency to a progressive loss of species richness in the woody stratum.

关键词： Flora Woody Species Vegetation Surveys Regeneration Kaffrine Region

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Profile of Amoebic vs. Pyogenic Liver Abscess and Comparison of Demographical, Clinical, Radiological, and Laboratory Profiles of These Patients from Three Secondary Care Centers in Senegal

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Advances in Infectious Diseases 2024年第3期14卷 595-605页

作者： Agbogbenkou Tevi Dela-Dem Lawson Daouda Thioub Ndiaga Mbengue Ndeye amy Sarr Sylvie Audrey Diop Service des maladies Infectieuses et tropicales de lHpital de Tivaouane Tivaouane Sngal UFR des sciences de la sante de lUniversit Iba Der Thiam de This This Sngal

Background: Liver abscess (LA) is a suppurated collection in the hepatic parenchyma. In Africa, liver abscesses are most often of amoebic origin, but more recently, the rate of pyogenic liver abscesses (PLA) has increased. Objective: to assess the epidemiological characteristics, clinical features, biological radiological findings, and outcomes of patients with PLA and with amebic liver abscess (ALA) in order to determine the potential factors that may help improve diagnosis and treatment for LA in the context of secondary care centers with limited medical supports. Methods: Retrospective review of LA diagnosed and treated at three secondary care centers in Thiès over 11 years. Results: 61 patients, were included, 52.45% had ALA and 47.54% had PLA. Males were predominant (79.31% in PLA vs 65.63% in ALA, p = 0.2). The median age was 38 years for the PLA group vs 39 years for the ALA group (p = 0.4). In both groups, the most common symptom was right upper abdominal pain (81.97%), hepatomegaly (81.97%). The PLA group had a higher prevalence of fever (79.31% vs 46.88%, p = 0,009), chills (51.72% vs 18.75%, p = 0.007), right basi-thoracic pain (55.17% vs 28.13%, p = 0.032), and jaundice (55.17% vs 28%, p = 0.032). There was no difference in radiological features between PLA and ALA. Patients with PLA had a higher level of White blood cell (20.600 vs 15.400, p = 0.014). The most common bacteria identified in PLA were Escherichia coli (58.8%). All patients had received antibiotic therapy, which was combined with aspiration puncture (37.3%), transcutaneous drainage (43.3%), and surgery (9.0%). Seven patients had received antibiotic therapy alone and all had amoebic abscesses. Elsewhere, the occurrence of complications was higher in PLA cases (75.86% vs 37.5%, p = 0.003). The overall hospital mortality rate was 13.11%, higher in cases of PLA (24.14% vs 3.13%, p = 0.022). Conclusion: Clinical and biological features were more severe in PLA. But radiological features cannot be

关键词： Profile Liver Abscess Amoebic Pyogenic Senegal

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谷物和油料甲酸乙酯和硫化羰天然含量评估

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粮油食品科技 2024年

作者： Pushpendra KOLI Shalini MAHAWAR amy XIAO Yong-lin REN 李燕羽 ICAR印度草原与饲料研究所动植物关系部国家粮食和物资储备局科学研究院粮食储运研究所默多克大学环境和生命科学学院

甲酸乙酯和硫化羰是潜在的储藏物熏蒸剂，广泛存在于大气、植物和土壤中。它们在新收获的谷物和储存的小麦、大麦、燕麦和油菜籽中含量因商品、温度、含水量和储存期而异，其中甲酸乙酯含量为0.5～2.0 mg/kg，硫化羰含量为0.02～1.0 mg... 详细信息

甲酸乙酯和硫化羰是潜在的储藏物熏蒸剂，广泛存在于大气、植物和土壤中。它们在新收获的谷物和储存的小麦、大麦、燕麦和油菜籽中含量因商品、温度、含水量和储存期而异，其中甲酸乙酯含量为0.5～2.0 mg/kg，硫化羰含量为0.02～1.0 mg/kg。含量在前4～5个月呈上升趋势，然后下降，在温度高于20 ℃，谷物和油菜籽含水量分别大于9.5%和5%时变化最明显。这些本底含量研究对开发甲酸乙酯和硫化羰作为储藏物熏蒸剂时制定最大残留限量（MRL）和市场接受度值有重要参考价值。

关键词：甲酸乙酯硫化羰熏蒸剂熏蒸剂本底水平谷物油料

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