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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 47-60页

作者： Raghunath Hazra amrita kar.santanu kar.mahapatra Department of Paramedical and Allied Health Sciences Biodiversity and Environmental Studies Research CentreMidnapore City CollegeKuturiyaBhadutalaPaschim Medinipur-721129West BengalIndia

Visceral leishmaniasis(VL)is a neglected tropical disease,and this review has summarized the current treatment scenario and its *** also highlights alternative approaches used by research groups in India and around the world to develop cutting-edge and potent anti-leishmanial *** though numerous medications could be utilized to treat VL,the limitations of current treatments including their toxicity,cost,route of administration,and duration of doses,have contributed to the emergence of *** therapy might be a better option due to its shorter duration,easier route of administration,and ability to extend the lifespan of individual ***,there is a risk of not delivering both the drugs to the target site together,which can be overcome by the liposomal entrapment of those drugs and at a time knock an opportunity to reduce the dosage of amphotericin B if the combination drug provides a synergistic effect with ***,this review presents a novel strategy to fight against VL by introducing dual drug-loaded liposomes.

关键词： Visceral leishmaniasis Liposomal anti-leishmanial drug Dual drug liposome

Aqueous extract of Ocimum gratissimum Linn and ascorbic acid ameliorate nicotine-induced cellular damage in murine peritoneal macrophage

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Asian Pacific Journal of Tropical Medicine 2010年第10期3卷 775-782页

作者： santanu kar.mahapatra Subhankari Prasad Chakraborty Somenath Roy Immunology and Microbiology Laboratory Department of Human Physiology with Community HealthVidyasagar UniversityMidnapore -721 102West BengalIndia

Objective:To test the in vitro protective role of aqueous extract of Ocimum gratissimum Linn. (***) and ascorbic acid against nicotine-induced murine peritoneal macrophage. Methods:Peritoneal macrophages from mice were treated with nicotine(10 mM),nicotine (10 mM) with aqueous extract of ***(1 to 25μg/mL),and nicotine(10 mM) with ascorbic acid(0.01 mM) for 12 h in cell culture media,while the control group was treated with culture *** of free radical generation,lipid peroxidation,protein carbonyls,oxidized glutathione levels and DNA damage were observed and ***:Phytochemical analysis of aqueous extract has shown high amount of phenolics and flavonoids compound present in *** significantly increased free radical generation,lipid peroxidation,protein carbonyls,oxidized glutathione levels and DNA damage were observed in nicotine-treated group as compared to the control group:those were significantly reduced in aqueous extract of O. gratissimum and ascorbic acid supplemented ***,significantly reduced antioxidant status in nicotine exposed murine peritoneal macrophage was effectively ameliorated by these two *** the different concentration of aqueous extract of ***,the maximum protective effect was observed at 10μg/mL which does not produce any significant change in the normal ***:These findings suggest the potential use and beneficial role of *** as a modulator of nicotine-induced cellular damage in murine peritoneal macrophage.

关键词： Ocimum gratissimum Linn Nicotine Peritoneal macrophage Free radical DNA fragmentation

Macrophage polarization or repolarization in tuberculosis

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Asian Pacific Journal of Tropical Medicine 2024年第10期17卷 435-444页

作者： Arijeet Samanta Sangita Maity Raghunath Hazra Adithyan Jayaraman santanu kar.mahapatra Department of Paramedical and Allied Health Sciences Biodiversity and Environmental Studies Research CentreMidnapore City CollegeKuturiyaBhadutalaPaschim Medinipur 721129West BengalIndia

Tuberculosis caused by Mycobacterium(M.)tuberculosis remains a global public health *** the last few decades,anti-tubercular research mainly focused on mechanisms of identifying by which activated macrophages can slaughter or the proliferation of *** bacilli prevented in a cell-dependent *** this regard,for disease resolution,inflammatory cytokines are very ***,we demonstrate how macrophages act as the first line of defense against the *** have revealed a dual role in *** infection played by *** is worth mentioning that the macrophages are the crucial immune effector and antigen-presenting cells that play the anti-tubercular response,which is the habitat of ***,hence,followed by progressing the disease protecting *** dual role can be correlated with the different macrophage polarization statuses,namely,M1 and ***,we have stated how the several polarization conditions of macrophages are directly linked to the immune responses during host and *** pathogen *** have proposed that macrophage polarization and repolarization are of paramount significance for the anti-tubercular immune response that may involve a sterile cure of the *** article summarizes the immune response to ***,the polarization states of macrophages during *** and the repolarization of macrophages by some agents during some diseases including ***,which may be an important factor in the World Health Organization's target to cure tuberculosis by 2035.

关键词： Tuberculosis Macrophage polarization Effector responses Antitubercular immune response

Biochemical characters and antibiotic susceptibility of Staphylococcus aureus isolates

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Asian Pacific Journal of Tropical Biomedicine 2011年第3期1卷 212-216页

作者： Subhankari Prasad Chakraborty santanu kar.mahapatra Somenath Roy Immunology and Microbiology Laboratory Department of Human Physiology with Community HealthVidyasagar University

Objective:To observe the biochemical characters and antibiotic susceptibility of isolated Staphylococcia aureus(***) strains against some conventional and traditional antibiotics. Methods:Thirty post operative pathogenic isolated *** strains were used in this study. Bacterial culture was done in Mueller-Hinton broth at 37 ℃.Characters of these strains were determined by traditional biochemical tests such as hydrolysis test of gelatin,urea,galactose, starch and protein,and fermentation of lactose and *** susceptibility were carried out by minimum inhibilory concentration test,minium bactericidal concentration test,disc agar diffusion test and brain heart infusion oxacillin screening ***:Prom this study,it was observed that 100%*** isolates showed positive results in gelatin,urea and galactose hydrolysis test.50%isolates were positive in starch hydrolysis test,35%in protein hydrolysis test. 100%isolates in lactose fermenting test,but no isolate was positive in sucrose fermenting test. Antibiotic susceptibility testing suggested that 20%of isolates were resistant to kanamycin and 46.67%were resistant to ***:These findings show that all these isolates have gelatin,urea,galactose hydrolysis and lactose fermenting activity.20%of these isolates were resistant to kanamvcin and 46.67%were resistant to oxacillin.

关键词： Staphylococcus aureus Oxacillin Antibiotic susceptibility Minimum inhibitory concentration Disc agar diffusion Pathogen Biochemical character Bacterial culture

Antioxidative effect of folate-modified chitosan nanoparticles

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Asian Pacific Journal of Tropical Biomedicine 2011年第1期1卷 29-38页

作者： Subhankari Prasad Chakraborty santanu kar.mahapatra Sumanta Kumar Sahu Panchanan Pramanik Somenath Roy Immunology and Microbiology Laboratory Department of Human Physiology with Community HealthVidyasagar University Nanomaterials Laboratory Department of ChemistryIndian Institute of Technology

Objective:To evaluate the potency of carboxymethyl chitosan-2,2' ethylenedioxy bisethylamine-folate(CMC-EDBE-FA) on tissue injury,antioxidant status and glutathione system in tissue mitochondria and serum against nicotine-induced oxidative stress in ***: CMC-EDBE-FA was prepared on basis of carboxymethyl chitosan tagged with folic acid by covalently linkage through 2,2' ethylenedioxy *** were divided into four groups,i.e.,control,nicotine(1 mg/kg bw/day),CMC-EDBE-FA(1 mg/kg bw/day) and nicotine(1 mg/kg bw/day) and CMC-EDBE-FA(1 mg/kg bw/day) for 7 *** of lipid peroxidation, oxidized glutathione level,antioxidant enzyme status and DNA damage were observed and ***:The significantly increase of lipid peroxidation,oxidized glutathione levels and DNA damage was observed in nicotine treated group as compared with control group;those were significantly reduced in CMC-EDBE-FA supplemented ***,significantly reduced antioxidant status in nicotine treated group was effectively ameliorated by the supplementation of *** CMC-EDBE-FA treated groups showed no significant change as compared with control group;rather than it repairs the tissue damage of nicotine treated ***:These findings suggest that CMC-EDBE-FA is non-toxic and ameliorates nicotine-induced toxicity.

关键词： Carboxymethyl chitosan Nicotine Glutathione Antioxidants Deoxyribonucleic acid fragmentation Antioxidative effect Folate Lipid peroxidation Oxidized

Nitric oxide mediated Staphylococcus aureus pathogenesis and protective role of nanoconjugated vancomycin

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Asian Pacific Journal of Tropical Biomedicine 2011年第2期1卷 102-109页

作者： Subhankari Prasad Chakraborty santanu kar.mahapatra Sumanta Kumar Sahu Sourav Chattopadhyay Panchanan Pramanik Somenath Roy Immunology and Microbiology laboratory Department of Human Physiology with Community HealthVidyasagar University Nanomaterials Laboratory Department of ChemistryIndian Institute of Technology

Objective:To investigate the relation between fruit seeds,plants residuals and appendicitis. Methods:Among cases that underwent appendectomy,the appendicitis cases having fruit seeds and undigested plant residuals in their etiology were examined ***, histopathological features,age,sex,and parameters of morbidity and mortality were used. Results:Fruit seed was found in one case(0.05%) with presence of pus in appendix lumen, undigested plant residuals in 7 cases(0.35%).It was determined that there were appendix inflammation in 2 of the plant residuals cases,while there were obstruction and lymphoid hyperplasia in the appendix lumen of 5 *** mortality was ***:The ratio of acute appendicitis caused by plants is minimal among all appendectomised patients, but avoidence of eating undigested fruit seeds and chewing plants well may help to prevent appendicitis.

关键词： Staphylococcus aureus Lymphocyte Nanoconjugated vancomycin Antioxidant enzymes TNF-α IL-10 Infection Anti-inflammatory Antioxidative effect Bacteremia Oxidative stress Nitric oxide Inflammatory parameter Pathogenesis