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Molecular exposition of broad‑spectrum antibacterial efficacy by p‑coumaric acid from an edible mushroom Termitomyces heimii:in vitro and in silico approach

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Systems Microbiology and Biomanufacturing 2023年第4期3卷 750-764页

作者： Krishanu Singha amrita banerjee Arijit Jana Poushali Bandyopadhyay Smarajit Maiti Bikas Ranjan Pati Pradeep Kumar Das Mohapatra Department of Microbiology Vidyasagar UniversityMidnaporeWest Bengal 721102India Department of Biotechnology Oriental Institute of Science and TechnologyMidnaporeWest Bengal 721102India Department of Chemical Engineering IIT RoorkeeUttarakhand 247667India Department of Microbiology Raiganj UniversityRaiganjWest Bengal 733134India

P-Coumaric acid was previously reported to contain antioxidant,antidiabetic,anti-inflammatory,antiplatelet,antiulcer and anticancer *** with these,the present work has been conducted to study the antibacterial activity of p-coumaric *** could be used to control broad-spectrum microbiome-based inflammation or in cancer *** analysis of methanolic extract from the mushroom Termitomyces heimii has exhibited a rich fraction of p-coumaric acid(p-CA),which in the pure form showed significant bactericidal *** predict the molecular interactions associated with the bactericidal mechanism of p-CA,the transmembrane protein sequences of Staphylococcus aureus and Escherichia coli were retrieved from the IMG–JGI database,screened and then aligned using Clustal X2 and PHYLIP 3.69 *** common sequences were subjected to tertiary structure prediction using Phyre2 server,followed by quality assessment through the Ramachandran ***,the 3D molecular structure of p-CA was downloaded from PubChem and docked with the selected tertiary structures using Patchdock and showed higher affinity towards 12 common transmembrane protein structures,amongst which CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyl transferase(PgsA)exhibited best dock-ing with p-CA on the basis of ACE value(–249 kcal/mol).This fact revealed that p-CA can block the normal functioning of membrane-bound enzyme PgsA,consequently leading to the interruption in the synthesis and recycling of an essential membrane component phosphatidylglycerol(PG),resulting in membrane disruption followed by cell ***,for the first time we reported the molecular insights and fundamental biochemical events underlying the bactericidal action by p-CA,to explore new perspective to combat multidrug-resistant bacteria.

关键词： p-Coumaric acid Bactericidal Docking ACE value PgsA Lysis

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Recombinase Polymerase Amplification Based Rapid Detection of Aroma Gene in Rice

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Rice science 2023年第2期30卷 96-99,I0010-I0013页

作者： amrita banerjee S.BHARTI J.KUMAR P.SAR PRIYAMEDHA N.P.MANDAL S.SARKAR Somnath ROY Central Rainfed Upland Rice Research Station Indian Council of Agricultural Research(ICAR)-National Rice Research InstituteHazaribagJharkhand 825301India Department of Biotechnology Vinoba Bhave UniversityHazaribagJharkhand 825301India Crop Improvement Division ICAR-National Rice Research InstituteCuttackOdisha 753006India

Recombinase polymerase amplification(RPA) has been emerged as an alternative to PCR due to its high specificity and sensitivity in diagnostics of animal and plant pathogens. In this study, an RPA protocol was develope... 详细信息

关键词： specificity Rec emerged

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Sensing Behaviour of Some Nanocomposite Systems

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Soft Nanoscience Letters 2013年第4期3卷 12-15页

作者： Dipankar Chakravorty Bhola Nath Pal Shilpi banerjee amrita Mandal Sreemanta Mitra Dhriti Ranjan Saha Department of Physics University of Calcutta Kolkata India. MLS Prof. Unit Indian Association for the Cultivation of Science Jadavpur Kolkata India MLS Prof. Unit Indian Association for the Cultivation of Science Jadavpur Kolkata India

Silver nanoparticles of diameters 3.4 to 13.2 nm grown at the interfaces between silicate glass and some oxide crystallites exhibited about six orders of magnitude reduction in resistivity for a relative humidity change from 25% to 80%. Sn-SnO2 nano core-shell structure prepared within a gel-derived silica glass film by electrodeposition technique followed by heat treatment showed large change in resistivity as a function of humidity. The resistivity also changed due to gas flow of CO2, C2H5OH and NO2, respectively. The latter arose because of reduction/oxidation of Sn4+/Sn2+ species present at the shell layer of the nanostructures. Nickel nanosheets of thickness ~0.6 nm grown within the interlayer spaces of Na-4 mica crystallites showed a change of dielectric permittivity (5%) for an applied magnetic field of 1.2 Tesla. An inhomogeneous model was used to explain this behavior. Two dimensional CuO phase was grown within the channels of diameter ~5 nm of mesoporous SiO2 structure. A magnetodielectric (MD) parameter M.D. of 4.4% was obtained in this case. BaTiO3 nanoparticles of diameter ~25 nm having pores with diameter 10 nm showed multiferroic behavior which arose due to the presence of oxygen vacancies as a result of large surface area present. An M.D. parameter of 11% was found. Similarly mesoporous LiNbO3 of 10 nm diameter showed an M.D. parameter of ~4.5% at a magnetic field 1 Tesla. A giant magnetocapacitance effect with a value of 44% at 1.5 T was observed in nickel zinc ferrite (NZF) impregnated mesoporous silica. A magnetocapacitance of 51% at magnetic field 1.7 T was found in the case of nanocomposites comprising of iron ion containing silica based nanoglass and mesoporous silica. In the last two examples the behavior was explained on the basis of Catalan model of space-charge polarization with extracted values of magnetoresistance of the NZF and nanoglass phases being 58%.

关键词： Nanocomposites Na-4 Mica Mesoporous Silica BaTiO3+LiNbO3 Magneto Dielectric Effect

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