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Iron supplementation during malaria infection in pregnancy and childhood:A review

Asian Pacific Journal of Tropical Medicine 2024年第1期17卷 12-20页

作者： Neha Surela amrendra Chaudhary Poonam Kataria Jyoti Das National Institute of Malaria Research Sector-8DwarkaNew Delhi-110077India

Malaria presents a significant global public health challenge,with severe malarial anaemia being a primary manifestation of the *** understanding of anaemia caused by malaria remains incomplete,making the treatment more *** is a crucial micronutrient essential for haemoglobin synthesis,oxygen delivery,and other vital metabolic functions in the *** is indispensable for the growth of human beings,as well as bacteria,protozoa,and viruses in vitro and in *** deficiency is among the most common nutritional deficiencies and can have detrimental effects during developmental stages of ***-induced iron deficiency occurs due to the hemolysis of erythrocytes and the suppression of erythropoiesis,leading to *** iron requirements is particularly critical during pivotal life stages such as pregnancy,infancy,and *** intake alone may not suffice to meet adequate iron requirements,thus highlighting the vital role of iron *** iron supplementation can alleviate iron deficiency,it can exacerbate malaria infection by providing additional iron for the ***,in the context of pregnancy and childhood,iron supplementation combined with malaria prevention and treatment has been shown to be beneficial in improving birth outcomes and ensuring proper growth and development,*** review aims to identify the role and impact of iron supplementation in malaria infection during the life stages of pregnancy and childhood.

关键词： Iron supplementation Malaria Pregnancy Childhood

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Revealing localization and regulation of GTPase PmRab7 in lymphoid cells of Penaeus monodon after WSSV infection

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Journal of Coastal Life Medicine 2016年第11期4卷 846-851页

作者： amrendra kumar Vaishnavi Ramasubbu Kiran D Rasal Saravanankumar Ayyappan Center for Advances Studies in Marine Biology Faculty of Marine SciencesAnnamalai UniversityParanipettaiTamilnadu 608502India ICAR-Central Institute of Freshwater Aquaculture Bhubaneswar 751002India

Objective:To identify white spot syndrome virus(WSSV)entry into the host-cells of the cultured shrimp Penaeus monodon,we have attempted to localize PmRab7(Ras-related in brain)which is playing a vital role in the WSSV ***:In this study,we have cloned PmRab7 and expressed in Escherichia coli,further purified rPmRab7 was used for antibody production,isolation of lysosomal sub-cellular fractions and western blot against lysosomal ***,high fold-change in PmRab7 regulation with increasing copy number of WSSV has been studied by using real-time ***:651 bp amplicon size gene was successfully amplified,ligated amplicon with pTZ T-tail vector confirmed by colony PCR and retriction enzyme digestion on agarose ***(pRSET-B)651 bp gene transformed successfully in Rosetta and after 6 h of induction expressed rPmRab7 was on SDS page,furthermore soluble fraction of rPmRab7(26 kDa)was purified by ni-NTA ***7 antibody was received by Merk ***.,and western blot analysis revealed that PmRab7 is present in the lysosomal sub-cellular *** number of WSSV was increased 5 fold in 24 h and 20 fold in 72 h of infection and subsequently transcrtipt of PmRab7 was Ct=1.0 to Ct=***:Presence of PmRab7 on lysosome clearly indicating PmRab7 participating in lysosomal maturation,other hand WSSV may follow the same route of *** internalization has directly linked with regulation of PmRab7.

关键词： Penaeus monodon White spot syndrome virus PmRab7 Gene regulation

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射血分数降低的心衰与射血分数保留的心衰临床特征分析

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华夏医学 2014年第6期27卷 31-35页

作者： amrendra kumar Bhadaishwar 莫新玲李全忠吴志伟何学恕桂林医学院附属医院心血管内科广西桂林541001

目的:通过总结射血分数降低的心衰(HFrEF)和射血分数保留的心衰(HFpEF)两种类型的心衰合并症及相关指标,探索其临床特征。方法:回顾性分析85例心衰患者的资料,根据Framingham标准确诊为心力衰竭,超声心动图检测LVEF为≥50%为HFpEF组,LVE... 详细信息

目的:通过总结射血分数降低的心衰(HFrEF)和射血分数保留的心衰(HFpEF)两种类型的心衰合并症及相关指标,探索其临床特征。方法:回顾性分析85例心衰患者的资料,根据Framingham标准确诊为心力衰竭,超声心动图检测LVEF为≥50%为HFpEF组,LVEF<50%为HFrEF组,对其临床特点进行分析。结果:85例患者中有51例是HFrEF患者,年龄(64.96±11.52)岁,其中男性34例(66.7%),女性17例(33.33%);34例是HFpEF患者,年龄(71.09±10.86)岁,其中男性14例(41.28%),女性20例(58.82%)。同组之间性别、年龄比较均有差异(P<0.05)。两组中EF值、LVD值、NTproBNP水平、合并心肌病、合并心律失常比较均有差异(P<0.05)。两组间不同性别患者NHYA分级Ⅱ级分布与Ⅲ、Ⅳ级分布均有不同。结论:HFpEF组年龄高于HFrEF组;两组间患者NHYA分级因性别不同,分布亦不同;HFrEF组中LVD值和NTproBNP水平较高;合并症对HFrEF组的总体影响较HFpEF组高。

关键词：射血分数降低的心衰射血分数保留的心衰心功能分级

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Atropine eye-drop-induced acute delirium:a case report

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General Psychiatry 2020年第3期33卷 197-198页

作者： Prashant Maravi Dheerendra kumar Mishra amrendra Singh Vijay Niranjan Department of Psychiatry Shyam Shah Medical CollegeRewaIndia Department of Psychiatry M.G.M.Medical CollegeIndoreIndia

Atropine is an anticholinergic drug which is used in both parental and topical *** eye-drops of atropine sulfate are used as mydriatic and *** atropine-induced delirium is well known but topical atropine eye-drop-induced delirium cases are very limited in *** this case report,an elderly man underwent cataract surgery and developed delirium after the use of 1%atropine sulfate eye-drops as *** case supports the notion that even atropine eye-drops can cause delirium in patients at therapeutic doses in elderly.

关键词： doses Atropine cataract

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Free fatty acid-induced miR-22 inhibits gluconeogenesis via SIRT-1-mediated PGC-1α expression in nonalcoholic fatty liver disease

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iLIVER 2023年第1期2卷 1-9页

作者： Ajay K.Yadav Teja Naveen Sata Daksh Verma amrendra K.Sah Amit K.Mishra Mrinalini Md.Musa Hossain Kishor Pant Senthil K.Venugopal Faculty of Life Sciences and Biotechnology South Asian UniversityAkbar BhawanChanakyapuriNew Delhi 110021India The Hormel Institute University of MinnesotaAustinMN55912 USA

Background and aims:Free fatty acids(FFAs)are one of the important regulators of the progression of nonalcoholic fatty liver *** FFAs are shown to modulate the metabolic status of the liver by modulating several cellular pathways in ***,we elucidated the role of miR-22 in modulating FFAs-mediated ***:Huh7 and WRL68 cells were transfected with nonspecific miRNA,miR-22 premiRs or anti-miR-22 oligos followed by incubation with palmitic acid,oleic acid,and linoleic acid(300μM each)for 48 and 72 h after *** expression of miR-22 was performed using real-time polymerase chain reaction and Western blots were performed for SIRT-1,PGC-1α,PEPCK,and *** groups of C57BL/6 mice(6 mice per group)were fed with standard diet,choline sufficient L-amino acid defined diet or choline-deficient L-amino acid defined(CDAA)diet for 6,18,32,or 54 *** content was measured in the *** of miR-22 and the protein expression of gluconeogenic enzymes were analyzed in the tissue ***:Incubation of miR-22-transfected cells with FFAs inhibited the expression of SIRT-1,PGC-1α,PEPCK,and glucose-6-phosphatase,while miR-22 expression was *** changes were reversed when the cells were transfected with anti-miR-22 ***-fed mice showed the significant increase in triglycerides content and miR-22 expression,while there was an inhibition of SIRT-1,PGC-1α,PEPCK,and glucose-6-phosphatase expression in CDAA-fed mice.

关键词： NASH Gluconeogenesis SIRT-1 CSAA CDAA microRNA-22

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