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Anti-Anaemic Activity and Potential Toxicity of Extracts of Four Tinctorial Plants Used in the Treatment of Anemia in Benin: Gossypium barbadense, Sorghum bicolor, Hibiscus sabdariffa and Justicia secunda

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American Journal of Plant Sciences 2022年第12期13卷 1460-1477页

作者： Louis Fagbohoun Gbènagnon C. Nonvidé Aziz Sina Orou Alban Houngbèmè amoussatou sakirigui Felix Gunin Joachim Djimon Gbénou Kaba Research Laboratory in Chemistry and Applications (LaKReCA) National University of Sciences Technologies Engineering and Mathematics Abomey Benin Laboratory of Biologie and Molecular Typing in Microbiology Department of Biochemistry and Cell Biology Univessity of Abomey-Calavi Abomey-Calavi Benin Laboratory of Pharmacognosy and Essential Oils Department of Chemistry University of Abomey-Calavi Abomey-Calavi Benin

Justicia secunda, Sorghum bicolor, Gossypiun barbadense and Hibiscus sabdariffa are dye plants traditionally used in Benin for the treatment of anemia. This work is part of the therapeutic valorization of dyes from these plants. Its objective is to characterize their composition in chemical groups and evaluate their harmlessness and their anti-anaemic property in laboratory rats. Anemia was induced in Wistar rats by phenylhydrazine hydrochloride followed by treatment by gavage with hydroethanolic extracts of the plants studied. Phytochemical screening of these extracts made it possible to characterize the major chemical groups, in particular alkaloids, polyphenols including tannins, flavonoids and leucoanthocyanins, as well as reducing compounds and saponosides in the plants studied. Cytotoxic analysis of these extracts on Artemia salina shrimp larvae revealed globally high LC50 values of between 3.14 and 4.64 mg/mL, which testify a priori to the harmlessness of these extracts. The administration of the hydroethanolic extract of each plant to anaemic rats at doses of 2000 mg/kg/d promoted, after 15 days, an increase in hemoglobin levels, the number of red blood cells and hematocrit, going to more than 90% recovery of the hematological parameters involved. The highest rate, 99.06% being that of the species Justicia secunda followed closely by Sorghum bicolor (96.80%) compared to 93.93% obtained by treatment with the Ranferon-12 positive control used. Indeed, these results confirm the therapeutic indication of these plants in the resorption of anemia in traditional medicine.

关键词： Anemia Resorption Tinctorial Plants Phytochemistry Benin

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ANTIMICROBIAL ACTIVITY OF CYMBOPOGON CITRATUS ESSENTIAL OIL AND CITRAL THIOSEMICARBAZONE AGAINST MYCOBACTERIUM TUBERCULOSIS

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World Journal of Traditional Chinese Medicine 2015年第4期1卷 103-104页

作者： Habib Toukourou amoussatou sakirigui Georges C.Accrombessi Joёlle Quetin-Leclercq Jacques H.Poupaert Fernand A.Gbaguidi Medicinal Organic Chemistry Laboratory Benin Center of Ecological Drug Discovery School of pharmacy/ UAC Laboratoire de Chimie Organique Physique et de Synthese UAC Pharmacognosy Louvain Drug Research Institute UCL Medicinal Chemistry Louvain Drug Research InstituteUCL Laboratoire de Chimie Organique Physique et de Synthese

Introduction:Tuberculosis,caused by Mycobacterium tuberculosis became more prevalent due to drug *** citratus,a crop from the African flora contains an essential oil rich in carbonyl *** of carbonyl compounds with thi... 详细信息

关键词： GC ANTIMICROBIAL ACTIVITY OF CYMBOPOGON CITRATUS ESSENTIAL OIL AND CITRAL THIOSEMICARBAZONE AGAINST MYCOBACTERIUM TUBERCULOSIS

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