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世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 30-31页

作者： amouretti m. Gaudin A.-F. 张诗峰 Hpital du Haut Lévêque Service de Gastroentérologie5avenue Magellan33604 Pessac

Aim.-To assess the im.act of irritable bowel syndrom.(IBS)on patient-reported health-related quality of life(HRQOL).m.thods-Two HRQOL instrum.nts were adm.nistered by telephone interviews to a sam.le of 253 IBS French patients recruited from.the general *** was diagnosed according to the m.nning,Rom. I and Rom. II *** with organic diseases were excluded from.the study.A generic instrum.nt,the Short Form.36(SF-36),and an IBS disease-specific instrum.nt,the IBSQOL,were ***-Patients with IBS had statistically significant(P m.ins com.ared with the general French ***(N = 192)reported significantly(P m.n(N = 61)for all dom.ins except energy on the SF-36 and the sleep on the *** deteriorated with tim. since onset of IBS sym.tom. for som. dom.ins such as *** both instrum.nts,a positive correlation was observed between low scores and intensity of pain and *** patients with a predom.nance of diarrhea(N = 72)exhibited significantly greater im.airm.nt of HRQOL in the em.tional dom.in than IBS persons with constipation predom.nance(N = 65)(P≤0.05).Conclusion-IBS has a significant im.act on HRQOL of *** addition,specific characteristics such as gender,sym.tom.severity and tim. since onset of sym.tom. are predictive of m.re im.aired health-related quality of life.

关键词：健康相关生活质量肠易激综合征 IBS患者 HRQOL SF-36 量表评估普通人群 Rom.

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胃食管反流病特异性生活质量问卷:RQS表的效应确定

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世界核心医学期刊文摘（胃肠病学分册） 2006年第2期2卷 32-32页

作者： amouretti m. Nalet B. Robaszkiewicz m. C. De La Loge 王志宇 27 rue de la Villette 69003 Lyon France

Introduction-Being an easy-to-use (eight item.) quality of life questionnaire specific to GERD, the Reflux- Qual Short form.(RQS ) was developed for use in everyday practice. The purpose of this study was to assess the psychom.tric properties of the RQS . m.thods and m.terials -The reliability of the RQS-was m.asured by the Cronbachs alpha coefficient and its clinical validity by com.aring the RQS score for increasing clinical severity groups. The RQS discrim.native power was com.ared with that of the SF- 12. Sensitivity to change over tim. was m.asured by calculating effect- sizes. Results-The reliability and validity of the questionnaire were assessed on a sam.le of 1195 patients. Its psychom.tric properties were very satisfactory: Cronbach alpha = 0.84;RQS score significantly reduced for the worst- affected patients; the discrim.native power was up to 5 tim.s higher when com.ared with the SF- 12. Sensitivity to change over tim., evaluated with 362 patients, showed highly significant differences between groups with different levels of clinical progression (P = 0.0001). Conclusion- The RQS is a quality of life m.asurem.nt instrum.nt specific to GERD which is short, reliable, valid, and sensitive to within and between- subject differences.

关键词：胃食管反流 RQS 生活质量问卷特异性有效性评估心理测验识别力样本人群本项 α系数

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