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Treatment-Plan Comparison of Three Advanced Radiation Treatment Modalities for Fractionated Stereotactic Radiotherapy to the Head and Neck

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International j.urnal of Medical Physics, Clinical Engineering and Radiation Oncology 2019年第2期8卷 106-120页

作者： He Wang j.mes N. Yang Xiaodong Zhang j.ng Li Steven j. Frank Zhongxiang Zhao Dershan Luo Xiaorong Zhu Congj.n Wang Samuel Tung Adam S. Garden David I. Rosenthal Clifton David Fuller Gary Brandon Gunn amol j. ghia j.y P. Reddy Shaan M. Raza Franco De Monte Mark S. Chambers Paul D. Brown Shirley Su j.ck Phan Department of Radiation Physics The University of Texas MD Anderson Cancer Center Houston TX USA Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA Department of Neurosurgery The University of Texas MD Anderson Cancer Center Houston TX USA Department of Oncologic Dentistry Prosthodontics Thoracic/Head &Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX USA Department of Radiation Oncology The Mayo Clinic Rochester MN USA

Purpose: Fractionated stereotactic radiosurgery (FSRS) can be given with at least three modalities: Gamma Knife, with the noninvasive frameless extend system (GKE);linear accelerator-based volumetric modulated arc therapy (VMAT);and intensity-modulated proton therapy (IMPT). We extracted treatment plans for patients who had received FSRS with GKE for recurrent skull base or intracranial tumors, created corresponding plans for VMAT and IMPT, and compared the quality of the three sets of plans. Methods and materials: Plans were extracted for 9 patients with recurrent malignant skull-base tumors (n = 6) or large intracranial tumors (n = 3) who had received FSRS with GKE (median dose 24 Gy in 3 fractions) in 2013 through 2015. Plans for VMAT were generated with a TrueBeam STx LINAC machine using 6-MV photons, and plans for IMPT were generated with multi-field optimization. The optimized VMAT and IMPT plans were normalized to achieve the best possible target coverage while meeting the same dose-volume constraints on organs at risk (OARs) as the GKE plans. Plans were evaluated on the basis of target coverage, conformity index, homogeneity index, gradient index, and treatment efficiency. Results: The median target volume was 10.2 cm3 (range 1.9 - 33.8 cm3). The VMAT and IMPT plans met all OAR constraints, and target coverage and conformity were comparable among all plans. VMAT and IMPT plans showed significantly better target uniformity and treatment delivery efficiency (P P Conclusion: FSRS for skull base and large intracranial lesions delivered by VMAT and IMPT can achieve comparable target coverage, conformity, and sparing of critical structure as the GKE while providing superior target uniformity and treatment delivery efficiency. The GKE had superior high-dose gradients outside the target and thus better protected surrounding normal structures.

关键词： Gamma Knife Extend System Stereotactic Radiosurgery Volumetric Modulated Arc Therapy Intensity-Modulated Proton Therapy Spot Scanning Proton Therapy

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Settling and spreading behaviour of particle clusters in quiescent liquids in confined vessels

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Particuology 2023年第12期83卷 91-100页

作者： Sayan Pal amol A.Kulkarni Chemical Engineering&Process Development Division CSIR-National Chemical LaboratoryPune411008India Academy of Scientific and Innovative Research(AcSIR) Ghaziabad 201002India University College London Torrington PlaceLondonWC1E 7JEUK

Here we report experiments on particle cluster settling at high Reynolds number in quiescent liquid contained in a *** particles were observed to spread at the vessel bottom surface in a near-circular annular shape after settling irrespective of the shape of the vessel cross-section and particle shape,size,and *** of different parameters such as mass,type and aspect ratio of the particles,height,and viscosity of liquid was investigated on spreading *** of the hemispherical bottom cap of the cluster that bounces upon hitting the vessel bottom surface was found to be responsible for the final circular annular shape of the settled *** leakage from the cluster was seen in the form of a *** the liquid having viscosity beyond 100 cP,cluster breakage was observed that resulted in hindered settling and asymmetric shapes of finally settled *** observations are useful to understand the overall area over which settling and spreading of such clusters can be observed.

关键词： Particle cluster Temporal evolution Settling Spreading

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Mine production index(MPI)-extension of OEE for bottleneck detection in mining

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International j.urnal of Mining Science and Technology 2016年第5期26卷 753-760页

作者： amol Arun Lanke Seyed Hadi Hoseinie Behzad Ghodrati Division of Operation and Maintenance Engineering Lule? University of Technology

Although mining production depends on various equipments, significant amount of production loss can be attributed a specific equipment or fleet. Bottleneck is defined not only by production loss but also by our satisfaction from the equipment. The user satisfaction could be measured as machine *** literatures on performance improvement and optimization of equipment operations assert importance of availability, utilization and production performance as key parameters. These three parameters are useful for evaluating effectiveness of equipment. Mine production index(MPI), which can represent the effect of these factors, has been applied for continuous operation in mining. MPI uses Fuzzy Delphi Analytical Hierarchy Process to determine importance of each three parameter for individual equipment. A case study in a Swedish open pit mine was done to evaluate the field application of *** results reveal that crusher is the bottleneck equipment in studied mine. As a methodical approach,an algorithm which uses MPI and detects bottleneck in continuous mining operation has been proposed.

关键词： Mine production index Bottleneck seeking FDAHP Production analysis

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Physics-constrained graph modeling for building thermal dynamics

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Energy and AI 2024年第2期16卷 150-157页

作者： Ziyao Yang amol D.Gaidhane j.n Drgoňa Vikas Chandan Mahantesh M.Halappanavar Frank Liu Yu Cao School of Electrical Computer and Energy EngineeringArizona State UniversityTempeAZ 85287USA Pacific Northwest National Laboratory RichlandWA 99354USA Oak Ridge National Laboratory Oak RidgeTN 37830USA

In this paper,we propose a graph model embedded with compact physical equations for modeling the thermal dynamics of *** principles of heat flow across various components in the building,such as walls and doors,fit the message-passing strategy used by Graph Neural networks(GNNs).The proposed method is to represent the multi-zone building as a graph,in which only zones are considered as nodes,and any heat flow between zones is modeled as an edge based on prior knowledge of the building ***,the thermal dynamics of these components are described by compact models in the *** are further employed to train model parameters from collected *** model training,our proposed method enforces physical constraints(e.g.,zone sizes and connections)on model parameters and propagates the penalty in the loss function of *** constraints are essential to ensure model robustness and *** evaluate the effectiveness of the proposed modeling approach on a realistic dataset with multiple *** results demonstrate a satisfactory accuracy in the prediction of multi-zone ***,we illustrate that the new model can reliably learn hidden physical parameters with incomplete data.

关键词： Physics-constrained learning Graph Neural Networks Compact model Building thermal dynamics

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Synthesis of bis(indolyl) methanes using aluminiumoxide(acidic) in dry media

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Chinese Chemical Letters 2010年第1期21卷 39-42页

作者： Sandip A.Sadaphal amol H.Kategaonkar Vilas B.Labade Murlidhar S.Shingare Organic Research Laboratory Department of ChemistryDr.Babasaheb Ambedkar Marathwada UniversityAurangabadMS 431001 India

Heterogeneous catalyst aluminium oxide(acidic) is found to be an effective catalyst for the solvent-free condensation reaction of indole with aldehydes in microwave irradiation with shorter reaction time and higher yi... 详细信息

关键词： Aluminium oxide(acidic) Indole Aldehydes Bis(indolyl) methanes Microwave irradiation Dry media

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Polyethylene glycol(PEG) mediated expeditious synthetic route to 1,3-oxazine derivatives

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Chinese Chemical Letters 2011年第8期22卷 915-918页

作者： Pravin V.Shinde amol H.Kategaonkar Bapurao B.Shingate Murlidhar S.Shingare Department of Chemistry Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431004MaharashtraIndia

Various 1,3-oxazine derivatives were synthesized in high yields,within shorter reaction times using PEG-400 as a safer medium/ *** synthetic route is exceedingly easy and avoids the use of acid/base catalysts.

关键词： Ecofriendly synthetic protocol Green chemistry 1 3-Oxazines Polyethylene glycol(PEG)

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Environment friendly hydrothermal synthesis of carbon–Co3O4 nanorods composite as an efficient catalyst for oxygen evolution reaction

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j.urnal of Energy Chemistry 2017年第4期26卷 695-702页

作者： amol R.j.dhav Harshad A.Bandal Ashif H.Tamboli Hern Kim Department of Energy Science and Technology Smart Living Innovation Technology CenterMyongji UniversityYonginGyeonggi-do 17058Republic of Korea

The design of cost-effective, highly active catalysts for hydrogen energy production is a vital element in the societal pursuit of sustainable energy. Water electrolysis is one of the most convenient processes to produce high purity hydrogen. Cobalt-based catalysts are well-known electrocatalysts for oxygen evolution reaction（OER）. In this article, all these merits indicate that the present cobalt nanocomposite is a promising electrocatalyst for OER. C–CoO-nanorods catalyst with nanorod structure was synthesized by hydrothermal treatment of CoCl·6HO/dextrose/urea mixture at 180 °C for 18 h and then calcined at400 °C for 3.5 h. The role of dextrose percentage in solution to achieve the uniform coating of carbon on the surface of CoO-nanorods has been demonstrated. The prepared materials were characterized by X-ray diffraction（XRD）, X-ray photoelectron spectrum（XPS）, field emission scanning electron microscopy（FE-SEM）, high-resolution transmission electron microscopy（HR-TEM）, and Brunauer–Emmett–Teller instrument（BET）. Due to its unique morphology, the C–CoO-nanorods catalyst exhibited better activity than CoO-microplates catalyst for OER in 1 M KOH aqueous solution. The results showed a highly efficient, scalable, and low-cost method for developing highly active and stable OER electrocatalysts in alkaline solution.

关键词： Oxygen evolution reaction Overpotential Tafel slope Synergistic effect

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A catalyst- and solvent-free multicomponent synthesis of 7-azagramine analogues via a Mannich type reaction

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Chinese Chemical Letters 2016年第1期27卷 99-103页

作者： Sakharam B.Dongare Hemant V.Chavan Pravin S.Bhale Yoginath B.Mule amol S.Kotmale Babasaheb P.Bandgar School of Chemical Sciences Solapur University Department of Chemistry A.S.P.College

A catalyst- and solvent-free protocol for the synthesis of 7-azagramine analogues is described via a three-component Mannich type reaction between 7-azaindole, aromatic aldehydes and heterocyclic amines in acceptable to excellent yields. Structures of the compounds were confirmed satisfactorily by ~1H NMR, IR, mass, TOCSY, HSQC and HMBC spectral analyses.

关键词： Bioisosters 7-Azaindole Mannich reaction Multicomponent reaction

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单克隆B淋巴细胞增多症和“原位”淋巴瘤

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临床与实验病理学杂志 2016年第1期32卷 68-79页

作者：刘芳(译) 周小鸽(审校) Karube K Scarfò L Campo E ghia P 中山大学附属佛山医院病理科佛山528000 首都医科大学附属北京友谊医院病理科北京100050 不详

最新研究发现“单克隆B细胞群”并不能诊断为淋巴系统恶性肿瘤,其促使人们探索淋巴瘤的发生机制、B细胞前体转化成真正淋巴组织增殖性疾病的致病因子。单克隆B淋巴细胞扩增,最初在不同健康个体的外周血中发现,因此定义为单克隆B淋巴细... 详细信息

最新研究发现“单克隆B细胞群”并不能诊断为淋巴系统恶性肿瘤,其促使人们探索淋巴瘤的发生机制、B细胞前体转化成真正淋巴组织增殖性疾病的致病因子。单克隆B淋巴细胞扩增,最初在不同健康个体的外周血中发现,因此定义为单克隆B淋巴细胞增多症（monoclonalB-celllym-phocytosis,MBL）,同时分析显示许多患者与慢性淋巴细胞性白血病（chroniclymphocyticleukemia,CLL）具有相似的免疫表型。依据B细胞数量的不同,临床相关性也不同：高数量MBL被认为是肿瘤前期状态,且每年以1%-2%的比率进展成CLL;而低数量的MBL可存在多年。目前,临床上尚未显示与真正白血病相关。非CLL-样的MBL代表一小部分病例,其临床及生物学意义仍不清楚。原位滤泡淋巴瘤（follicularlymphoma,FL）和套细胞淋巴瘤（mantlecelllym-phoma,MCL）是以非典型淋巴样细胞的定位为特点,分别具有生发中心t（14;18）（q32;q21）或套区t（11;14）（q13;q32）易位,且有正常细胞对应体存在。生发中心或套区为这些携带致癌基因的细胞提供恰当的微环境,促进其生存或增殖。然而这些病变进展成真正淋巴瘤的机率较低,也许需要其他基因改变的蓄积。因此,这些淋巴组织增殖的患者应受到更多的关注。

关键词：单克隆B淋巴细胞增多症慢性淋巴细胞性白血病 t(14 18)(q32 q21)或 t(11 14)(q13 q32)原位淋巴瘤滤泡性淋巴瘤套细胞淋巴瘤

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Knowledge‐based deep learning system for classifying Alzheimer's disease for multi‐task learning

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 805-820页

作者： amol Dattatray Dhaygude Gaurav Kumar Ameta Ihtiram Raza Khan Pavitar Parkash Singh Renato R.Maaliw III Natrayan Lakshmaiya Mohammad Shabaz Muhammad Attique Khan Hany S.Hussein Hammam Alshazly Department of Data Science University of WashingtonSeattleWashingtonUSA Department of Computer Science&Engineering Parul Institute of TechnologyParul UniversityVadodaraGujaratIndia Department of Computer Science Jamia HamdardDelhiIndia Department of Management Lovely Professional UniversityPhagwaraIndia 5 College of Engineering Southern Luzon State UniversityLucbanQuezonPhilippines Department of Mechanical Engineering Saveetha School of EngineeringSIMATSChennaiTamil NaduIndia Model Institute of Engineering and Technology JammuJ&KIndia Department of Computer Science HITEC UniversityTaxilaPakistan Department of Computer Science and Mathematics Lebanese American UniversityBeirutLebanon Electrical Engineering Department College of EngineeringKing Khalid UniversityAbhaSaudi Arabia Electrical Engineering Department Aswan UniversityAswanEgypt Faculty of Computers and Information South Valley UniversityQenaEgypt

Deep learning has recently become a viable approach for classifying Alzheimer's disease(AD)in medical ***,existing models struggle to efficiently extract features from medical images and may squander additional information resources for illness *** address these issues,a deep three‐dimensional convolutional neural network incorporating multi‐task learning and attention mechanisms is *** upgraded primary C3D network is utilised to create rougher low‐level feature *** introduces a new convolution block that focuses on the structural aspects of the magnetORCID:ic resonance imaging image and another block that extracts attention weights unique to certain pixel positions in the feature map and multiplies them with the feature map ***,several fully connected layers are used to achieve multi‐task learning,generating three outputs,including the primary classification *** other two outputs employ backpropagation during training to improve the primary classification *** findings show that the authors’proposed method outperforms current approaches for classifying AD,achieving enhanced classification accuracy and other in-dicators on the Alzheimer's disease Neuroimaging Initiative *** authors demonstrate promise for future disease classification studies.

关键词： classification deep learning

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