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Understanding risk of thrombosis with thrombocytopenia syndrome after ***2.S vaccination

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Frontiers of Medicine 2021年第6期15卷 938-941页

作者： Prathit a.kulkarni Vinay Prasad Infectious Diseases Section Department of MedicineBaylor College of MedicineHoustonTX77030USA Medical Care Line Michael E.DeBakey Veterans Affairs Medical CenterHoustonTX77030USA Department of Epidemiology and Biostatistics School of MedicineUniversity of California-San FranciscoSan FranciscoCA94143USA

On April 13,2021,the US Centers for Disease Control and Prevention(CDC)and the US Food and Drug Administration(FDA)recommended a pause in administration of the ***2.S(Johnson&Johnson[Janssen])coronavirus disease 2019(COVID-19)vaccine for all persons[1].At that time,approximately 6.8 million doses of vaccine had been administered around the United *** pause was prompted by 6 cases of cerebral venous sinus thrombosis(CVST)in combination with thrombocytopenia,a condition whose nomenclature is in flux but which we will refer to as thrombosis with thrombocytopenia syndrome(TTS),as used by CDC in describing the condition[2].All patients were women younger than 50 *** note,2 of 6 patients also had splanchnic and portal vein thrombosis.

关键词： thrombosis vaccine doses

Formononetin alleviates diabetic cardiomyopathy by inhibiting oxidative stress and upregulating SIRT1 in rats

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Asian Pacific Journal of Tropical Biomedicine 2020年第6期10卷 254-262页

作者： Manisha J.Oza Yogesh a.kulkarni Shobhaben Pratapbhai Patel School of Pharmacy&Technology Management SVKM's NMIMSV.L.Mehta RoadVile Parle(W)Mumbai 400056India SVKM's Dr.Bhanuben Nanavati College of Pharmacy Vile Parle(W)Mumbai 400056India

Objective:To evaluate the effect of formononetin on type 2 diabetic ***:Diabetes was induced by feeding high-fat diet for 2 weeks and administration of 35 mg/kg of streptozotocin in *** was administered at 10,20 and 40 mg/kg for 16 weeks once a *** glucose,lipid parameters,and cardiac markers in blood samples were *** weight and relative heart weight were *** parameters,oxidative stress parameters and silence information regulator 1(SIRT1)expression in cardiac tissue were *** changes in cardiac tissue were also ***:Formononetin significantly reduced the levels of glucose,triglycerides,cholesterol,low density lipoprotein,creatine kinaseMB,lactate dehydrogenase and aspartate *** addition,formononetin significantly improved hemodynamic parameters,alleviated oxidative stress and increased SIRT1 ***:The study indicates that formononetin can improve hyperglycemia and hyperlipemia,reduce oxidative stress and increase SIRT1 *** can be a potential therapeutic agent for diabetic cardiomyopathy.

关键词： Cardiomyopathy Formononetin Type 2 diabetes SIRT1 Creatinine kinase Cardiac hypertrophy

Improved performance of naringenin herbosomes over naringenin in streptozotocin- induced diabetic rats: In vitro and in vivo evaluation

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Asian Pacific Journal of Tropical Biomedicine 2021年第9期11卷 385-393页

作者： Ruthvika Joshi Ankit P.Laddha Yogesh a.kulkarni Sarika Wairkar Shobhaben Pratapbhai Patel School of Pharmacy&Technology Management SVKM's NMIMSV.L.Mehta RoadVile Parle(W)Mumbai.Maharashtra-400056India

Objective:To prepare naringenin herbosome and evaluate its antidiabetic ***:Herbosomes were prepared by the solvent evaporation *** vitro parameters like particle size,polydispersity index,zeta potential,and entrapment efficiency were estimated and in vitro diffusion study was *** in vivo studies were also performed in streptozotocin-induced diabetic male Sprague Dawley rats to evaluate blood glucose,total cholesterol,triglyceride,blood urea nitrogen,total protein,albumin level,aspartate aminotransferase,and alanine aminotransferase ***:The optimized herbosome batch showed a particle size of 564.4 nm,a polydispersity index of 0.412,and zeta potential of−39.3 *** percentage entrapment of this formulation was 84.04%,with complete drug release within 8 *** of diabetic rats with naringenin herbosomes for 28 d significantly reduced the elevated level of plasma glucose as compared to plain *** biochemical parameters,the treatment showed a significant decrease in total cholesterol,triglyceride,and blood urea nitrogen;while elevated levels of aspartate aminotransferase and alanine aminotransferase were returned to *** naringenin and herbosome formulation at high dose increased the total protein whereas albumin level significantly increased in naringenin herbosomes at the highest dose but not in the pure naringenin treatment ***:Naringenin herbosomes could improve the metabolic profile of diabetic rats,indicating enhanced antidiabetic activity of herbosome formulation.

关键词： Naringenin Herbosomes Blood glucose level Biochemical parameters Antidiabetic activity

Mortality from COVID-19 in patients with lung cancer

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 422-429页

作者： Amit a.kulkarni Grace Wilson Naomi Fujioka Manish R.Patel Division of Hematology Oncology and TransplantationDepartment of MedicineUniversity of MinnesotaMinneapolisMN55455USA University of Minnesota Medical School MinneapolisMN 55455USA

The World Health Organization declared coronavirus infectious disease-2019(COVID-19)linked to the severe acute respiratory syndrome(SARS-CoV-2),a global pandemic in March *** pandemic outbreak has led to the most unprecedented and catastrophic loss of human life in the recent *** of January 2021,there were more than 100 million cases of COVID-19 and more than two million deaths *** to the general population,patients with cancer are at a higher risk of poor outcomes from *** large cohort studies,mortality from COVID-19 in patients with cancer can be as high as 40%.In addition to clinical variables(older age,male sex,and co-morbidities)that are associated with mortality in general population,cancer patients are uniquely vulnerable to severe COVID-19 due to immunosuppression from cancer and its therapy,and disruption of routine clinical *** patients with cancer,the lung cancer population is at a higher risk of poor outcomes and mortality from COVID-19 for several *** instance,lung is the main target organ in COVID-19 that can lead to respiratory failure,patients with lung cancer have baseline poor lung function from chronic obstructive pulmonary disorder and *** addition,some of the lung cancer treatment side-effects like pneumonitis,may obscure the diagnosis of *** this article,we systematically review the most impactful cohort studies published to date in patients with cancer and *** describe the rates of mortality in patients with cancer and COVID-19 with a special focus on the lung cancer *** also summarize the factors associated with poor outcomes and mortality in patients with lung cancer and COVID-19.

关键词： Coronavirus COVID-19 lung cancer mortality

Opportunities and Challenges in Twisted Bilayer Graphene:A Review

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Nano-Micro Letters 2020年第10期12卷 16-35页

作者： amol Nimbalkar Hyunmin Kim Division of Biotechnology Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Republic of Korea

Two-dimensional(2D)materials exhibit enhanced physical,chemical,electronic,and optical properties when compared to those of bulk *** demands significant attention due to its superior physical and electronic characteristics among different types of 2D *** bilayer graphene is fabricated by the stacking of the two monolayers of *** twisted bilayer graphene(tBLG)superlattice is formed when these layers are twisted at a small *** presence of disorders and interlayer interactions in tBLG enhances several characteristics,including the optical and electrical *** studies on twisted bilayer graphene have been exciting and challenging thus far,especially after superconductivity was reported in tBLG at the magic *** article reviews the current progress in the fabrication techniques of twisted bilayer graphene and its twisting angle-dependent properties.

关键词： Graphene Twisted bilayer graphene Magic angle Superconductivity van Hove singularities

Standardized gum tapping techniques to maximize yield from high-value Indian tree,Sterculia urens

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Journal of Forestry Research 2017年第3期28卷 615-619页

作者： amol Vasishth Vipan Guleria Department of Forest Products&Utilization College of Horticulture&ForestryJhalrapatan-JhalawarRajasthan 326023India Regional Horticulture Research&Training Station Jachh DistrictKangraHimachal PradeshIndia

Industrial applications of natural gums have been expanding tremendously, so gum collection from trees provides an important livelihood for local dwellers in drought-prone Rajasthan and its surroundings states. Traditional gum tapping is crude and unscientific; deep incision, untimely extraction and high concentration of chemicals in gum have affected Sterculia urens species in its natural habitat. In studies 2 years on trees having diameter at breast height 〉40 cm from natural stands to maximize gum collection and standardize the tapping method （bore holes vs. V blazes）, tapping season, chemical and concentration, different tapping techniques were tes- ted. For tapping maximum gum was collected using bore hole. Ethephon was better as extraction chemical than sulphuric acid. Bore-hole tapping with a 5-cm hole and ethephon at 300 mg/mL yielded the most gum （135.20 g/ tree）. Ethephon at 300 mg/mL yielded the most gum. Ethephon induced gummosis without affecting the health of tree. Tapping seasons also significantly affected the gum yield; the most gum was obtained in April-June.

关键词： Bore-hole tapping Ethephon Natural gum Sterculia urens Tapping

Determining Potential Passive Islanding Detection Indicators for Single-point Single Inverter,Single-point Multi-inverter and Multi-point Multi-inverter Scenarios

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CSEE Journal of Power and Energy Systems 2022年第3期8卷 696-709页

作者： Nitin Kumar kulkarni Mohan Khedkar Department of Electrical Engineering Visvesvaraya National Institute of TechnologyNagpurIndia

Distributed Generation(DG)sources,predominantly renewable energy-based,such as solar photovoltaic and wind energy sources,have significantly penetrated into power system *** high penetration of DG sources may lead to the formation of unintentional islands,which is hazardous to both the equipment and personnel,if *** this paper,46 passive parameters are considered to find out which candidate(s)are promising for detecting sustained unintentional islands and avoid false DG *** 46 parameters are derived from point of common coupling(PCC)voltage,DG output current,frequency,power factor angle,active and reactive *** these parameters are tested on standard IEEE 13 and 34 bus distribution networks,integrated with inverter-interfaced DGs at different locations for different penetration levels in the MATLAB/SIMULINK *** parameters are tested for different islanding events(comprising of various local loads,such as conventional parallel RLC resonant load,R,RC,and RL loads)and for different non-islanding *** parameters are then ranked accordingly by a suitable averaging approach based performance ranking *** this analysis,the best candidates are obtained for detecting inverter DG islands at single-point(or single PCC)locations and multi-point(or multiple PCCs)*** best passive candidates are obtained for different island scenarios from which a set of promising islanding detection indicators are proposed.

关键词： Averaging approach inverter DG point of common coupling(PCC) passive parameters test system

Mine production index(MPI)-extension of OEE for bottleneck detection in mining

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International Journal of Mining Science and Technology 2016年第5期26卷 753-760页

作者： amol Arun Lanke Seyed Hadi Hoseinie Behzad Ghodrati Division of Operation and Maintenance Engineering Lule? University of Technology

Although mining production depends on various equipments, significant amount of production loss can be attributed a specific equipment or fleet. Bottleneck is defined not only by production loss but also by our satisfaction from the equipment. The user satisfaction could be measured as machine *** literatures on performance improvement and optimization of equipment operations assert importance of availability, utilization and production performance as key parameters. These three parameters are useful for evaluating effectiveness of equipment. Mine production index(MPI), which can represent the effect of these factors, has been applied for continuous operation in mining. MPI uses Fuzzy Delphi Analytical Hierarchy Process to determine importance of each three parameter for individual equipment. A case study in a Swedish open pit mine was done to evaluate the field application of *** results reveal that crusher is the bottleneck equipment in studied mine. As a methodical approach,an algorithm which uses MPI and detects bottleneck in continuous mining operation has been proposed.

关键词： Mine production index Bottleneck seeking FDAHP Production analysis

ntrinsically disordered proteins and prostate ancer： pouring new wine in an old bottle

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Asian Journal of Andrology 2016年第5期18卷 659-661页

作者： Prakash kulkarni ProteinBiophysics&StructuralBiologyLaboratory InstituteforBioscienceandBiotechnologyResearchUniversityofMarylandRockvilleMD20850USA

An inconvenient truth in urology is that .despite decades of intense research,prostate cancer （PCa） has remained one of the most prevalent cancers and leading cause of cancer-related deaths in men, particularly in t... 详细信息

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