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囊性纤维化患者中过敏性支气管肺曲霉病的危险因素及烟曲霉菌的致敏作用

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世界核心医学期刊文摘（儿科学分册） 2006年第2期2卷 19-20页

作者： ritz N. ammann r.a. Casaulta Aebischer C. M.H. Schoeni 朱新菊 Department of Paediatrics University of Berne 3010 Berne Switzerland

An incr.a.ing incidence of allergic bronchopulmonary aspergillosis (ABPA) as a complication in patients with cystic fibrosis (CF) is reported. The objective of this retrospective case-control study was to assess potential risk factors for.a.PA and for.a.pergillus fumigatus sensitisation (AFS). In a group of 160 CF patients, 11 (7% ) fulfilled the diagnostic criter.a.for.a.PA and 20 (13% ) had evidence of AFS. They were compared to 62 control CF patients (25 for.a.PA and 37 for.a.S group) without evidence of ABPA or.a.S using extended matching for sex, age and weight. AFS patients had received significantly higher cumulative doses of inhaled corticosteroids than their respective controls (Or 8.0; 95% CI 1.74-63). Bronchial colonisation with Stenotropho monasmaltophilia was strongly and independently associated with ABPA (Or 20; 95% CI 2.8-infinity). A longer duration of Pseudomonas aeruginosa colonisation was independently associated with AFS (Or per year 1.50; 95% CI 1.12-infinity). Conclusion: Cystic fibrosis patients with allergic bronchopulmonary aspergillosis have a more frequent isolation of S. maltophilia in their sputum than their controls. Longer duration of colonisation with P. aeruginosa is a risk factor for.a.pergillus fumigatus sensitisation. Higher cumulative doses of inhaled corticosteroids are associated with Aspergillus fumigatus sensitisation and their role as a risk factor needs to be clarified.

关键词：潜在危险因素囊性纤维化支气管内肺曲霉病致敏作用烟曲霉菌过敏性患者嗜麦芽黄单胞菌病例对照研究

伏立康唑不能治疗1例免疫缺陷儿童的播散性接合菌病

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世界核心医学期刊文摘（儿科学分册） 2005年第9期1卷 41-41页

作者： ritz N. ammann r.a. Aebischer C.C. C. Aebi 王经纬 Department of Paediatrics University of Bern Inselspital 3010 Bern Switzerland

Voriconazole is incr.a.ingly used as a first-line agent for empirical antifungal therapy of prolonged febrile neutropenia in paediatric cancer patients. We describe the case of a 9-yearold patient with stage IV Burkitt lymphoma, who developed pulmonary and splenic zygomycosis while receiving voriconazole for persistent febrile neutropenia. The causative agent, Absidia corymbifera,was identified by br.a.-range fungalPCr in a lung biopsy sample. The patient was successfully tr.a.ed with a combination of partial resection of the left upper lobe and antifungal therapy with high-dose liposomal amphotericin B followed by oral itraconazole as demonstrated by resolving pulmonary infiltrates on ser.a. high resolution CT scans. Conclusion: This case emphasises that the lack of in vitro activity of voriconazole against zygomycetes is clinically relevant. Failure of voriconazole in suspected fungal infection should be investigated for the possibility of zygomycosis. Br.a.-range polymerase chain r.a.tion may be able to identify the causative or.a.ism when cultures remain sterile.

关键词：接合菌病伏立康唑免疫缺陷播散性两性霉素真菌感染伯基特淋巴瘤持续性发热左上肺叶发热性

Arsenic Speciation Analysis by Ion Chromatography - A Critical review of Principles and Applications

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American Jour.a. of Analytical Chemistry 2011年第1期2卷 27-45页

作者： Adr.a. A. ammann 不详

Multiple acute and chronic toxicity of arsenic species and its mobilisation from geological deposits into ground and drinking water resources is one of the gr.a.est thr.a.s to human health. Arsenic speciation analy-sis, mostly done by liquid chromatography, is a challenging task which requires an intense high quality work with respect to extraction, preser.a.ion, separation, detection and validation. A growing number of As-spe-cies and low regulatory limits (10 μg/L) may require more than one speciation method preferably performed by species specific procedures and detectors. Beside As-fractionation for special application there are many selective speciation methods based on high perfor.a.ce separation techniques like capillary electrophoreses, gas and liquid chromatography. Both, fractionation and speciation methods are reviewed. However, the focus is on scopes and limits of ion chromatographic separations, the most frequently used methods. Based on IC-principles the methods applied are critically discussed and recommendations given which should result in more robust and reliable As-speciation.

关键词： review Arsenic Speciation Ion Chromatography

Late biliary complications in human alveolar echinococcosis are associated with high mor.a.ity

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World Jour.a. of Gastroenterology 2014年第19期20卷 5881-5888页

作者： Pascal Frei Benjamin Misselwitz Meher K Prakash Alain M Schoepfer Bettina M Prinz Vavricka Beat Müllhaupt Michael Fried Kuno Lehmann rudolf W ammann Stephan r Vavricka Division of Gastroenterology and Hepatology University Hospital Zurich8091 ZurichSwitzerland Division of Gastroenterology and Hepatology Centre Hospitalier Universitaire Vaudois1011 LausanneSwitzerland Swiss Hepato-Pancr.a.ico-Biliary and Transplantation Center Department of SurgeryUniversity Hospital Zurich8091 ZurichSwitzerland Division of Gastroenterology and Hepatology Stadtspital Triemli8063 ZurichSwitzerland

AIM: To evaluate the incidence of late biliary complications in non-resectable alveolar echinococcosis (AE) under long-term chemotherapy with benzimidazoles.

关键词： Alveolar echinococcosis Biliary strictures Biliary cirrhosis Cholangitis Cholestatic liver disease Chronic liver disease Complications Echinococcal cysts Prognosis

Bioniechanical Exploration of Bone Tissue

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Bioniechanical Exploration of Bone Tissue

rSS-Based Indoor Localization System with Single Base Station

第十五届国际药理学大会

作者： Patrick ammann Division of Bone Diseases Department of Rehabilitation and Geriatrics University Hospital of Geneva Geneva Switzerland.

＜正＞ Bone mechanical properties represent the most impor.a.t end point in preclinical study of osteoporosis since bone fragility is a key element of fracture risk. Bone strength can be measured at different skeletal sites taking into account the relative contribution of cancellous and cortical tissue. Axial compression of vertebrae or metaphysis and bending test of long bones provide infor.a.ion on maximal load, stiffness and energy. Bone strength is determined by bone geometry （diameter, thickness）, trabecular micr.a.chitecture and intrinsic properties of bony tissue （mater.a. quality）. recently, nanoindentation has been proved to be a reliable method to assess the intrinsic mechanical properties of single bone structural units like hardness, modulus and working energy. Investigation of these determinants is of major impor.a.ce since new antiosteoporotic drugs potentially influence all these determinants, including intrinsic bone tissue quality. Similar investigations are also feasible using human bone biopsy. Careful investigation of biomechanics and all its determinants should be considered to fully understand the mechanisms of action of antiosteoporotic drugs.

关键词： Biomechanics bone osteoporosis safety

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Computers, Mater.a.s & Continua 2022年第3期70卷 5437-5452页

作者： Samir Salem Al-Bawri Mohammad Tariqul Islam Mandeep Jit Singh Mohd Faizal Jamlos Adam Narbudowicz Max J.ammann Dominique M.M.P.Schreurs Space Science Centre Climate Change InstituteUniversiti Kebangsaan MalaysiaBangi43600Malaysia Department of Electrical Electronic and Systems EngineeringFaculty of Engineering and Built EnvironmentUniversiti Kebangsaan MalaysiaUKMBangi43600SelangorMalaysia Faculty of Mechanical Engineering Universiti Malaysia PahangPekan26600PahangMalaysia Antenna and High Frequency research Centre School of Electrical&Electronic EngineeringDublin Institute of TechnologyDublin 8Ireland Department of Electrical Engineering Division ESAT-TELEMICKU LeuvenBelgium

The paper proposes an Indoor Localization System(ILS)which uses only one fixed Base Station(BS)with simple non-reconfigurable *** proposed algorithm measures received Signal Strength(rSS)and maps it to the location in the room by estimating signal strength of a direct line of sight(LOS)signal and signal of the first order reflection from the *** algorithm is evaluated through both simulations and empirical measurements in a furnished open space office,sampling 21 different locations in the *** is demonstrated the system can identify user’s r.a.-time location with a maximum estimation error below 0.7 m for 80%confidence Cumulative Distribution Function(CDF)user level,demonstrating the ability to accurately estimate the receiver’s location within the *** system is intended as a cost-efficient indoor localization technique,offering simplicity and easy integration with existing wireless communication *** comparable single base station localization techniques,the proposed system does not require beam scanning,offering stable communication capacity while performing the localization process.

关键词： Indoor localization localization techniques received signal strength

Theplant cytosolic m^(6)A r.a.methylome stabilizes photosynthesis in the cold

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Plant Communications 2023年第6期4卷 70-84页

作者： Alexandre Magno Vicente Nikolay Manavski Paul Torben rohn Lisa-Marie Schmid Antoni Garcia-Molina Dario Leister Charlotte Seydel Leo Bellin Torsten Möhlmann Gregor ammann Stefanie Kaiser Jörg Meurer Plant Molecular Biology Faculty of BiologyLudwig-Maximilians-University MunichGroßhaderner Street 2-482152 Planegg-MartinsriedGermany Plant Development Faculty of BiologyLudwig-Maximilians-University MunichGroßhaderner Street 2-482152 Planegg-MartinsriedGermany Plant Physiology Faculty of BiologyUniversity of KaiserslauternErwin-Schröodinger-Street767663 KaiserslauternGermany Phar.a.eutical Chemistry Goethe University FrankfurtMax-von-Laue-Str.960438 Frankfurt am MainGermany Present address:Loewe Biochemica GmbH Möuhlweg 2a82054 SauerlachGermany Present address:Center for research in Agricultural Genomics 08193

The sessile lifestyle of plants requires an immediate response to environmental stressors that affect photosynthesis,growth,and crop ***,we showed that three abiotic pertur.a.ions—heat,cold,and high light—triggered considerable changes in the expression signatures of 42 epitranscriptomic factors(writers,erasers,and r.a.ers)with putative chloroplast-associated functions that formed clusters of commonly expressed genes in *** expression changes under.a.l conditions were reversible upon deacclimation,identifying epitranscriptomic players as modulators in acclimation *** dysfunctions,particularly those induced by the oxidative stress-inducing norflurazon in a largely GENOME UNCOUPLED-independent manner,triggered retrograde signals to remodel chloroplastassociated epitranscriptomic expression patterns.N6-methyladenosine(m^(6)A)is known as the most prevalent r.a.modification and impacts numerous developmental and physiological functions in living *** cold tr.a.ment,expression of components of the primary nuclear m^(6)A methyltransferase complex was upregulated,accompanied by a significant incr.a.e in cellular m^(6)A mr.a.*** the cold,the presence of FIP37,a core component of the writer complex,played an impor.a.t role in positive regulation of thylakoid structure,photosynthetic functions,and accumulation of photosystemⅠ,the Cytb6f complex,cyclic electron transport proteins,and Cur.a.ure Thylakoid1 but not that of photosystemⅡcomponents and the chloroplast ATP *** of FIP37 affected abundance,polysomal loading,and translation of cytosolic transcripts related to photosynthesis in the cold,suggesting m^(6)Adependent translational regulation of chloroplast *** summary,we identified multifaceted roles of the cellular m^(6)A r.a.methylome in coping with cold;these were predominantly associated with chloroplasts and served to stabilize photosynthesis.

关键词： m^(6)A r.a.methylation cold acclimation stress response Arabidopsis thaliana photosynthesis chloroplast

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软件测试基础

生物和免疫调节因子治疗儿童获得性免疫缺陷综合征

作者： (美)阿曼 (美)奥法特

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国外医学（儿科学分册） 1991年第5期18卷 260-262页

作者： ammann AJ 陶惠荣程秋兰

70年代末和80年代初,单克隆抗体的产生,敏感的免疫测定方法,重组DNA技术和特异性生物检测方法,体内生物化学的活性的评价,出现了许多科学上的进展。更多的生物因子可用于临床,并最终证实它对人类疾病的有益疗效。临床评价生物因子的步... 详细信息

70年代末和80年代初,单克隆抗体的产生,敏感的免疫测定方法,重组DNA技术和特异性生物检测方法,体内生物化学的活性的评价,出现了许多科学上的进展。更多的生物因子可用于临床,并最终证实它对人类疾病的有益疗效。临床评价生物因子的步骤在体内的一种新的生物因子试验需要在体外生物活性中加以证实。早期研究肿瘤坏死因子(TNF)于动物中证实在体外具抗肿瘤活性,也提示TNF对心肌动力学上有显著效应,并在内毒素休克中起作用。

关键词：生物因子免疫调节因子艾滋病