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Deoxyribonucleic acid methylation driven aberrations in pancreatic cancer-related pathways

World Journal of Gastrointestinal Oncology 2023年第9期15卷 1505-1519页

作者： Akash Bararia amlan das Sangeeta Mitra Sudeep Banerjee Aniruddha Chatterjee Nilabja Sikdar Human Genetics Unit Indian Statistical InstituteKolkata 700108India Department of Biochemistry Royal Global UniversityAssam 781035India Department of Biochemistry and Biophysics University of KalyaniWest Bengal 741235India Department of Gastrointestinal Surgery Tata Medical CenterKolkata 700160India Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9054New Zealand School of Health Sciences and Technology University of Petroleum and Energy StudiesDehradun 248007India

Pancreatic cancer(PanCa)presents a catastrophic disease with poor overall survival at advanced stages,with immediate requirement of new and effective treatment *** genetic mutations,epigenetic dysregulation of signaling pathway-associated enriched genes are considered as novel therapeutic *** beneath the deoxyribonucleic acid methylation and its utility in developing of epi-drugs in PanCa are under *** of epigenetic medicines with conventional cytotoxic treatments or targeted therapy are promising options to improving the dismal response and survival rate of PanCa *** studies have identified potentially valid pathways that support the prediction that future PanCa clinical trials will include vigorous testing of epigenomic *** thus promises to generate a significant amount of new knowledge of biological and medical *** review could identify various components of epigenetic mechanisms known to be involved in the initiation and development of pancreatic ductal adenocarcinoma and related precancerous lesions,and novel pharmacological strategies that target these components could potentially lead to *** aim to highlight the possibilities that exist and the potential therapeutic interventions.

关键词： Methylation driven pathways Pancreatic cancer methylation markers Signaling pathway targeted therapy PanCa enriched methylated pathway Pre-cancer methylated pathways

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Emerging role of non-invasive and liquid biopsy biomarkers in pancreatic cancer

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World Journal of Gastroenterology 2023年第15期29卷 2241-2260页

作者： Akash Bararia Prosenjeet Chakraborty Paromita Roy Bitan Kumar Chattopadhay amlan das Aniruddha Chatterjee Nilabja Sikdar Human Genetics Unit Indian Statistical InstituteKolkata 700108India Department of Molecular Biosciences SVYASA School of Yoga and NaturopathyBangalore 560105India Department of Pathology Tata Medical CenterKolkata 700160India Department of General Surgery IPGMER&SSKM HospitalKolkata 700020India Department of Biochemistry Royal Global UniversityAssam 781035India Department of Pathology Dunedin School of MedicineUniversity of OtagoDunedin 9061New Zealand School of Health Sciences and Technology University of Petroleum and Energy StudiesDehradun 248007India

A global increase in the incidence of pancreatic cancer(PanCa)presents a major concern and health *** traditional tissue-based diagnostic techniques provided a major way forward for molecular diagnostics;however,they face limitations based on diagnosis-associated difficulties and concerns surrounding tissue availability in the clinical *** disease development with asymptomatic behavior is a drawback in the case of existing diagnostic *** capability of cell free markers in discriminating PanCa from autoimmune pancreatitis and chronic pancreatitis along with other precancerous lesions can be a boon to ***-stage diagnosis of PanCa can be achieved only if these biomarkers specifically discriminate the non-carcinogenic disease stage from malignancy with respect to tumor *** this review,we comprehensively described the non-invasive disease detection approaches and why these approaches are gaining popularity for their early-stage diagnostic capability and associated clinical feasibility.

关键词： Non-invasive biomarkers Cell free biomarkers Proteomic biomarkers Liquid biopsy-based diagnostics Pancreatic cancer biomarkers

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Electrochemically functionalized graphene as an anti-corrosion reinforcement in Cu matrix composite thin films

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International Journal of Minerals,Metallurgy and Materials 2021年第9期28卷 1525-1533页

作者： Akhya kumar Behera amlan das Sanjeev das Archana Mallik Electrometallurgy and Corrosion Laboratory(Research) Department of Metallurgical and Materials EngineeringNational Institute of TechnologyRourkela 769008OdishaIndia Advanced Metal Casting Laboratory Department of Metallurgical and Materials EngineeringNational Institute of TechnologyRaipur 492010ChhatisgarhIndia

Cu-graphene(Gr)composite thin films were prepared by electrodeposition route using in-house synthesized Gr *** Gr sheets were synthesized by the electrochemical exfoliation route using 1 M HClO4 acid as *** Gr sheets were confirmed by X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),field-emission scanning electron microscopy(FESEM),and transmission electron microscopy(TEM).The(002)plane of Gr sheets was observed at 2θof 25.66°.The(002)plane confirmed the crystal structure of car-bon *** stretching vibration of C=C bond at a wavelength of 1577 cm^(−1) and other functional groups of carboxyl and epoxide groups were observed from *** confirmed the transparent structure of Gr *** prepared Gr sheets were used as reinforcement at con-centrations of 0.1 and 0.3 g/L with a copper matrix to synthesize the Cu-Gr *** prepared composite thin films were characterized by XRD,SEM,and energy-dispersion spectrometry(EDS)for morphological and analytical *** presence of Gr sheets in Cu-Gr com-posite was confirmed by EDS *** prepared Cu-Gr nanocomposite thin film showed higher corrosion resistance compared with pure copper thin films in 3.5wt%NaCl,as confirmed by Tafel *** impedance spectroscopy complimented the above results and showed that 0.3 g/L composite film achieved the highest film resistance.

关键词： graphene nanocomposite electrodeposition copper

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Ultrafast Laser Writing Deep inside Silicon with THz-Repetition-Rate Trains of Pulses

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Research 2020年第1期2020卷 1478-1488页

作者： Andong Wang amlan das David Grojo Aix-Marseille Univ. CNRSLP3 UMR 734113009 MarseilleFrance

Three-dimensional laser writing inside silicon remains today inaccessible with the shortest infrared light pulses unless complex schemes are used to circumvent screening propagation ***,we explore a new approach irradiating silicon with trains of femtosecond laser pulses at repetition rates up to 5.6 THz that is order of magnitude higher than any source used for laser processing so *** extremely high repetition rate is faster than laser energy dissipation from microvolume inside silicon,thus enabling unique capabilities for pulse-to-pulse accumulation of free carriers generated by nonlinear ionization,as well as progressive thermal bandgap closure before any diffusion process comes into *** space-resolved measurements of energy delivery inside silicon,we evidence changes in the interplay between detrimental nonlinearities and accumulation-based *** leads to a net increase on the level of space-time energy *** improvement is also supported by experiments demonstrating high performance for 3D laser writing inside *** comparison to repeated single pulses,irradiation with trains of only four-picosecond pulses with the same total energy leads to an apparent decrease of the energy threshold for modification and drastic improvements on the repeatability,uniformity,and symmetricity of the produced *** unique benefits of THz bursts can provide a new route to meet the challenge of 3D inscription inside narrow bandgap materials.

关键词： repetition Deep shortest

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印度四种蝗科农业害虫的取食量定量测定及据此推测的亲缘关系(英文)

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昆虫学报 2014年第8期57卷 869-878页

作者： amlan das Entomology Laboratory Department of Zoology University of Calcutta 35 Ballygunj Circular Road Kolkata 700019 West Bengal India

【目的】害虫的取食潜力反映了其生态学和经济学特性,这些知识有助于扩展其控制措施。能否将害虫物种按亲缘关系的远近进行分组,对它们在发育或成熟期的取食量进行定量排序？了解不同害虫种类的取食模式有助于这一问题的解答。【方法】... 详细信息

【目的】害虫的取食潜力反映了其生态学和经济学特性,这些知识有助于扩展其控制措施。能否将害虫物种按亲缘关系的远近进行分组,对它们在发育或成熟期的取食量进行定量排序？了解不同害虫种类的取食模式有助于这一问题的解答。【方法】对印度4种蝗科农业害虫——等岐蔗蝗Hieroglyphus banian（Fab.）,暗翅剑角蝗Acrida exaltata（Walk.）,中华板胸蝗Spathosternum prasiniferum prasiniferum（Walk.）和Oxya fuscovittata（Mars.）的取食量进行了定量测定,估测了4种害虫雌雄各若虫龄期及整个成虫期的每日取食量和总取食量。【结果】基于其多食性特征和存在多种食物来源的情况,所有测试中均只提供最为偏好的寄主植物。在研究的4种害虫中,观察到相同的取食率模式,取食率随着若虫龄期的增加而逐步增加。4种害虫的雌虫取食量均显著高于雄虫,且成虫期害虫的取食量显著高于幼期。各龄若虫和成虫的取食量与对应的若虫或成虫历期明显相关。就整个生活期的取食量和平均存活率而言,暗翅剑角蝗***和中华板胸蝗***的亲缘关系比其他两种昆虫略近。就整个生活期的取食量和平均存活率而言,单化性害虫（等岐蔗蝗***）和二化性害虫（暗翅剑角蝗***）比另外两种近缘的多化性害虫（中华板胸蝗***和***）的亲缘关系更近一些。【结论】寿命长的物种（每年可完成1~2个世代）在取食潜力方面比寿命短的物种（每年完成2代以上的世代）更具有可比性。通过对多个不同化性的害虫物种的研究,使我们在这方面能达到更全面的认识。

关键词：直翅目蝗虫取食量寿命存活寄主植物

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Effect of eccentric and inclined loading on the bearing capacity of strip footing placed on rock mass

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Journal of Mountain Science 2024年第1期21卷 292-312页

作者： Shuvankar das Debarghya CHAKRABORTY Department of Civil Engineering Indian Institute of Technology KharagpurWest Bengal-721302India

This paper deals with the bearing capacity determination of strip footing on a rock mass in hilly area by considering the influence of inclined and eccentric loading. Applying the generalized HoekBrown failure criterion, the failure behavior of the rock mass is modeled with the help of the power cone programming in the lower bound finite element limit analysis framework. Using bearing capacity factor(Ns), the change in bearing capacity of the strip footing due to the occurrence of eccentrically inclined loading is presented. The variations of the magnitude of Ns are obtained by examining the effects of the Hoek-Brown rock mass strength parameters(uniaxial compressive strength(sci), disturbance factor(D), rock parameter(mi), and Geological Strength Index(GSI)) in the presence of different magnitudes of eccentricity(e) and inclination angle(λ) with respect to the vertical plane, and presented as design charts. Both the inclined loading modes, i.e., inclination towards the center of strip footing(+λ) and inclination away from the center of strip footing(-λ), are adopted to perform the investigation. In addition, the correlation between the input parameters and the corresponding output is developed by utilizing the artificial neural network(ANN). Additionally, from sensitivity analysis, it is observed that inclination angle(λ) is the most sensitive parameter. For practicing engineers, the obtained design equation and design charts can be beneficial to understand the bearing capacity variation in the existence of eccentrically inclined loading in mountain areas.

关键词： Eccentric and inclined Power cone programming Rock mass Limit analysis Artificial neural network

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A Cocktail of Natural Compounds Holds Promise for New Immunotherapeutic Potential in Head and Neck Cancer

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Chinese Journal of Integrative Medicine 2024年第1期30卷 42-51页

作者： Sunil Kumar Asmita das Department of Biotechnology Delhi Technological UniversityDelhi(110042)India

Objective: To obtain detailed understanding on the gene regulation of natural compounds in altering prognosis of head and neck squamous cell carcinomas(HNSC). Methods: Gene expression data of HNSC samples and peripheral blood mononuclear cells(PBMCs) of HNSC patients were collected from Gene Expression Omnibus(GEO). Differential gene expression analysis of GEO datasets were achieved by the GEO2R tool. Common differentially expressed gerres(DEGs) were screened by comparing DEGs of HNSC with those of PBMCs. The combination was further analyzed for regulating pathways and biological processes that were affected. Results: Totally 110 DEGs were retrieved and identified to be involved in biological processes related to tumor regulation. Then 102 natural compounds were screened for a combination such that the expressions of all 110 commonly DEGs were altered. A combination of salidroside, ginsenoside Rd, oridonin, britanin, and scutellarein was chosen. A multifaceted, multi-dimensional tumor regression was showed by altering autophagy, apoptosis, inhibiting cell proliferation, angiogenesis, metastasis and inflammatory cytokines production. Conclusions: This study has helped develop a unique combination of natural compounds that will markedly reduce the propensity of development of drug resistance in tumors and immune evasion by tumors. The result is crucial to developing a combinatorial natural therapeutic cocktail with accentuated immunotherapeutic potential.

关键词： natural compounds chemopreventive gene expression head and neck cancer immunomodulator salidroside ginsenoside Rd oridonin britanin scutellarein

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Boulder-induced form roughness and skin shear stresses in a gravel-bed stream

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Journal of Mountain Science 2024年第1期21卷 346-360页

作者： das Ratul DATTA Akash Civil Engineering Department National Institute of Technology AgartalaAgartala-799046India

Boulder spacing in mountain rivers and near-wake flow zones within the boulder array is very useful for fish habitat and growth of aquatic *** present study aims to investigate how the boulder array and spacing influence the near-bed flow structures in a gravel-bed *** are staggered over a gravel-bed stream with three different inter-boulder spacing namely(a)large(b)medium and(c)small *** acoustic Doppler velocimeter was used for flow measurements in a rectangular channel and the results were compared with those acquired from numerical *** time-averaged velocity profiles at the near-wake flow zones of boulders experience maximum flow retardation which is an outcome of the boulder-induced form *** ratio of velocity differences associated to form and skin roughness and its positive magnitude reveals the dominance of form roughness closest to the *** roughness computed is 1.75 to 2 times higher than the skin roughness at the near-wake flow *** particular,the collective immobile boulders placed at different inter-boulder spacings developed high and low bed shear stresses closest to the *** low bed shear stresses characterised by a secondary peak developed at the trough location of the boulders is attributed to the skin shear ***,the spatial averaging of time-averaged flow quantities gives additional impetus to present an improved illustration of fluid shear *** formation of form-induced shear stress is estimated to be 17%to 23%of doubleaveraged Reynolds shear stress and partially compensates for the damping of time-averaged Reynolds shear stress in the interfacial *** quadrant analysis of spatial velocity fluctuations depicts that the form-induced shear stresses are dominant in the interfacial sub-layer and have no significance above the gravel-bed surface.

关键词： Array of boulders Near wake flow zones Velocity distributions Skin roughness Form induced shear stresses

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A machine learning approach for the prediction of pore pressure using well log data of Hikurangi Tuaheni Zone of IODP Expedition 372,New Zealand

Energy Geoscience

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Energy Geoscience 2024年第2期5卷 225-231页

作者： Goutami das Saumen Maiti Machine Learning and Geocomputing Laboratory Department of Applied GeophysicsIIT(ISM)Dhanbad826004JharkhandIndia

Pore pressure(PP)information plays an important role in analysing the geomechanical properties of the reservoir and hydrocarbon field *** prediction is an essential requirement to ensure safe drilling operations and it is a fundamental input for well design,and mud weight estimation for wellbore ***,the pore pressure trend prediction in complex geological provinces is challenging particularly at oceanic slope setting,where sedimentation rate is relatively high and PP can be driven by various complex *** overcome these difficulties,an advanced machine learning(ML)tool is implemented in combination with empirical *** empirical method for PP prediction is comprised of data pre-processing and model establishment ***'s method and Porosity method have been used for PP calculation of the well U1517A located at Tuaheni Landslide Complex of Hikurangi Subduction zone of IODP expedition ***-ray,sonic travel time,bulk density and sonic derived porosity are extracted from well log data for the theoretical framework *** normal compaction trend(NCT)curve analysis is used to check the optimum fitting of the low permeable zone *** statistical analysis is done using the histogram analysis and Pearson correlation coefficient matrix with PP data series to identify potential input combinations for ML-based predictive model *** dataset is prepared and divided into two parts:Training and *** PP data and well log of borehole U1517A is pre-processed to scale in between[-1,+1]to fit into the input range of the non-linear activation/transfer function of the decision tree regression *** Decision Tree Regression(DTR)algorithm is built and compared to the model performance to predict the PP and identify the overpressure zone in Hikurangi Tuaheni Zone of IODP Expedition 372.

关键词： Well log Pore pressure Machine learning(ML) IODP Hikurangi Tuaheni Zone IODP Expedition 372

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Krüppel-like factor 2(KLF2),a potential target for neuroregeneration

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Neural Regeneration Research 2024年第11期19卷 2327-2328页

作者： Surajit Hansda Prateeksha Prateeksha Hiranmoy das Department of Pharmaceutical Sciences Jerry H.Hodge School of PharmacyTexas Tech University Health Sciences CenterAmarilloTXUSA

Neurological disorders and injuries lead to the impairment or depletion of neurons in terms of quantity,structure,or function,resulting in the loss of cognitive,emotional,and physical abilities in human ***,in turn,accompanies the shortfall of valuable human resources and economic potential,causing a detriment to *** these challenges,therefore,becomes imperative not only from a humanitarian perspective but also as a means of preserving human capital and bolstering economic prosperity.

关键词： companies injuries potential

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