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High-dose-rate intraluminal brachytherapy during preoperative chemoradiation for locally advanced rectal cancers

World Journal of Gastroenterology 2010年第35期16卷 4436-4442页

作者： Mutahir Ali Tunio Mansoor Rafi Altaf Hashmi Rehan Mohsin Abdul Qayyum Mujahid Hasan amjad sattar Muhammad Mubarak Department of Radiation Oncology Sindh Institute of Urology and Transplantation Department of Surgical Oncology Sindh Institute of Urology and Transplantation Department of Medical Oncology Sindh Institute of Urology and Transplantation Department of Gastroenterology Sindh Institute of Urology and Transplantation Department of Radiology Sindh Institute of Urology and Transplantation Department of Pathology Sindh Institute of Urology and Transplantation

AIM:To determine the feasibility and safety of high dose rate intraluminal brachytherapy(HDR-ILBT) boost during preoperative chemoradiation for rectal ***:Between 2008 and 2009,thirty-six patients with locally advanced rectal cancer(≥ T3 or N+),were treated initially with concurrent capecitabine(825 mg/m2 oral twice daily) and pelvic external beam radiotherapy(EBRT)(45 Gy in 25 fractions),then were randomized to group A;HDR-ILBT group(n = 17) to receive 5.5-7 Gy×2 to gross tumor volume(GTV) and group B;EBRT group(n = 19) to receive 5.4 Gy×3 fractions to GTV with *** patients underwent total mesorectal ***:Grade 3 acute toxicities were registered in 12 patients(70.6%) in group A and in 8(42.1%) in group *** pathologic response of T stage(ypT0) in group A was registered in 10 patients(58.8%) and in group B,3 patients(15.8%) had ypT0(P < 0.0001).Sphincter preservation was reported in 6/9 patients(66.7%) in group A and in 5/10 patients(50%) in group B(P < 0.01).Overall radiological response was 68.15% and 66.04% in Group A and B,*** a median follow up of 18 mo,late grade 1 and 2 sequelae were registered in 3 patients(17.6%) and 4 patients(21.1%) in the groups A and B,***:HDR-ILBT was found to be effective dose escalation technique in preoperative chemoradiation for rectal cancers,with higher response rates,downstaging and with manageable acute toxicities.

关键词： High dose rate Intraluminal brachytherapy boost Locally advanced rectal cancer Preoperative chemoradiation

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Sustainable bio-energy generation via the conversion of spent wash using dual chamber microbial fuel cell

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Waste Disposal and Sustainable Energy 2024年第2期6卷 219-231页

作者： Abdul sattar Jatoi Jawad Ahmed Afaque Ahmed Bhutto Muhammad Shuaib Shaikh Department of Chemical Engineering Dawood University of Engineering and Technology KarachiSindhPakistan Changzhou DUBO Polymer Co. Ltd.Changzhou 213002China Department of Basic Science and Related Studies The University of LarkanoSindhPakistan Department of Chemical Engineering Mehran University of Engineering and Technology JamshoroSindhPakistan

Microbial fuel cells(MFCs)are innovative devices that combine microbial processes with electrochemical reactions to convert organic matter in wastewater into electricity while simultaneously treating the *** such application is the treatment of spent wash,a highly polluting effluent generated from the distillery industry after crude mesh is separated into ethanol and spent *** wash,also known as distillery effluent or stillage,is a highly challenging wastewater treatment method due to its high chemical oxygen demand(COD),biological oxygen demand(BOD),and total dissolved solids(TDS).These characteristics make it a complex and polluting industrial effluent that requires specialized treatment processes to reduce its environmental impact ***,MFCs have shown promise in treating spent wash,as they can utilize the organic matter in wastewater as a fuel source for microbial growth as well as for electricity *** the treatment of spent wash,Saccharomyces cerevisiae *** used as a biocatalyst along with 340 mol/L potassium ferricyanide in the cathode chamber and 170 mol/L methylene blue in the anode as a *** tests were conducted by balancing a one-liter volume for power production from spent wash in MFC with the optimal conditions of 10%agarose,pH 8.5,300 mL/min of aeration in the cathode chamber,and 40%(in weight)substrate *** an ideal concentration,the maximum current and power density are roughly 53.41 mA/m^(2)and 72.22 mW/m^(2),*** each litre of processed spent wash,a maximum voltage of 850 mV(4.5 mA)was ***,91%of COD and BOD were removed from the effluent *** findings show that MFCs are capable of producing electricity and efficiently removing COD from wasted wash at the same time.

关键词： Microbial fuel cell Chemical oxygen demand Biological oxygen demand-Current density Power density Spent wash

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An asymmetrical multilevel inverter with minimum voltage stress and fewer components for photovoltaic renewable-energy system

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Clean Energy 2024年第1期8卷 1-22页

作者： Rabail Memon Mukhtiar Ahmed Mahar Abdul sattar Larik Syed Asif Ali shah Department of Electrical Engineering Mehran University of Engineering and TechnologyJamshoroPakistan

The enhanced power quality provided by multilevel inverters(MLIs)has made them more appropriate for medium-and high-power applications,including photovoltaic ***,a prevalent limitation involves the necessity for numerous switches and increased voltage stress across these switches,consequently increasing the overall system *** address these challenges,a new 17-level asymmetrical MLI with fewer components and low voltage stress is proposed for the photovoltaic *** innovative MLI configuration has four direct current(DC)sources and 10 *** on the trinary sequence,the proposed topology uses photovoltaics with boost converters and fuzzy logic controllers as its DC *** equations are used to calculate cru-cial parameters for this proposed design,including total standing voltage per unit(TSVPU),cost function per level(CF/L),component count per level(CC/L)and voltage stress across the *** comparison is conducted by considering switches,DC sources,TSVPU,CF/L,gate driver circuits and CC/L with other existing MLI *** analysis is carried out under various conditions,encompassing different levels of irradiance,variable loads and modulation *** reduce the total harmonic distortion of the suggested topology,the phase opposition disposition approach has been *** suggested framework is simulated in MATLAB®/Simulink®.The results indicate that the proposed topology achieves a well-distributed stress profile across the switches and has CC/L of 1.23,TSVPU of 5 and CF/L of 4.58 and 5.76 with weight coefficients of 0.5 and 1.5,*** values are not-ably superior to those of existing MLI *** results demonstrate that the proposed topology maintains a consistent output at varying irradiance levels with FLCs and exhibits robust performance under variable loads and diverse modulation ***,the total harmonic distortion achieved with phase opposition disposi

关键词： asymmetrical multilevel inverter photovoltaic system renewable energy component count per level cost function per level total standing voltage per unit phase opposition disposition technique

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Thermodynamic Performance Analysis of Geothermal Power Plant Based on Organic Rankine Cycle (ORC) Using Mixture of Pure Working Fluids

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Energy Engineering 2024年第8期121卷 2023-2038页

作者： Abdul sattar Laghari Mohammad Waqas Chandio Laveet Kumar Mamdouh El Haj Assad Department of Mechanical Engineering Mehran University of Engineering and TechnologyJamshoro76062Pakistan Department of Mechanical and Industrial Engineering College of EngineeringQatar UniversityDoha00000Qatar Sustainable&Renewable Energy Engineering Department University of SharjahSharjah00000United Arab Emirates

The selection of working fluid significantly impacts the geothermal ORC’s *** a mixture as a working fluid is a strategy to improve the output of geothermal *** the current study,modelling and thermodynamic analysis of ORC,using geothermal as a heat source,is carried out at fixed operating *** model is simulated in the Engineering Equation Solver(EES).An environment-friendly mixture of fluids,i.e.,R245fa/R600a,with a suitable mole fraction,is used as the operating *** mixture provided the most convenient results compared to the pure working fluid under fixed operating *** impact of varying the evaporator pressure on the performance parameters,including energy efficiency,exergy efficiency and net power output is *** system provided the optimal performance once the evaporator pressure reached the maximum *** efficiencies:Energy and Exergy,and Net Power output of the system are 16.62%,64.08%and 2199 kW for the basic cycle and 20.72%,67.76%and 2326 kW respectively for the regenerative cycle.

关键词： Organic rankine cycle internal heat exchanger moderate-temperature geothermal source mixture of the fluid exergy

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Agmatine ameliorates diabetes type 2-induced nephropathy in rats

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Asian Pacific Journal of Tropical Biomedicine 2024年第1期14卷 8-16页

作者： Fatemah O.Kamel Ohoud Shagroud Mai AAlim A.sattar Ahmad Gamal S Abd El-Aziz Abdulhadi S.Burzangi Duaa Bakhshwin Maha Jamal Shahid Karim Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Anatomy Faculty of MedicineKing Abdulaziz UniversityJeddah 21589Saudi Arabia

Objective:To assess the nephroprotective potential of agmatine in a rat model of streptozotocin-induced diabetic ***:A single dose of streptozotocin(40 mg/kg)coupled with a fructose diet induced diabetes in Wistar ***(40 and 80 mg/kg)was administered to rats for 12 *** body weight and fasting blood glucose were measured *** level,urine output,total protein,albumin,blood urea nitrogen,creatinine,and cystatin-C were also determined at the end of the ***,superoxide dismutase,glutathione,interleukin-1β,interleukin-6,and tumor necrosis factor-alpha were evaluated in kidney *** study was also performed using hematoxylin and eosin ***:Agmatine at both doses significantly increased final body weight,and lowered fasting blood glucose,urine output,insulin,total protein,albumin,blood urea nitrogen,creatinine,and cystatin-C levels compared with the diabetic group(P<0.05).Inflammatory markers and antioxidant effect were significantly improved in agmatine-treated ***,the histopathological changes in renal structure were ameliorated by agmatine ***:Agmatine alleviates diabetic nephropathy by improving renal functions and reducing inflammation and oxidative *** molecular mechanisms of its nephroprotective actions need to be investigated in future study.

关键词： Agmatine Type 2 diabetes Nephropathy Oxidative stress Nephroprotection

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The role of predictive and prognostic values of inflammatory markers in acute pancreatitis:a narrative review

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Journal of Pancreatology 2024年第1期7卷 72-85页

作者： Saira Rafaqat Aqsa sattar Farhan Anjum Mahrukh Gilani Sana Rafaqat Department of Zoology(Molecular Physiology) Lahore College for Women UniversityLahorePakistan Institute of Zoology University of the PunjabQuaid-i-Azam CampusLahorePakistan Department of Zoology Lahore College for Women UniversityLahorePakistan Department of Biotechnology(Human Genetics) Lahore College for Women UniversityLahorePakistan

Pancreatitis is an inflammatory condition affecting the pancreas and is classified into 2 types,acute and chronic,which can manifest in various *** review article summarizes the role of predictive and prognostic values of inflammatory markers in the pathogenesis of acute pancreatitis,mainly focused on preclinical and clinical *** includes serum amyloid A(SAA),monocyte chemotactic protein-1(MCP-1),erythrocyte sedimentation rate(ESR),interleukin-6(IL-6),C-reactive protein(CRP),IL-10,myeloperoxidase,pentraxin 3,and plasminogen activator inhibitor ***3 plays a crucial role in developing acute pancreatitis by triggering a receptor-interacting protein 3-dependent necroptosis pathway in acinar *** SAA3 could be a potential strategy for treating acute *** recruitment of monocytes/macrophages and the activation of the systemic MCP-1 signaling pathway play a role in the progression of pancreatitis,and blocking MCP-1 may have a suppressive effect on the development of pancreatic *** ESR can predict severe acute pancreatitis with slightly lower accuracy than *** ESR and CRP levels are combined at 24 hours,they predict severe acute pancreatitis ***-6 plays a crucial role in activating the Janus kinase/signal transducers and activators of the transcription pathway,exacerbating pancreatitis and contributing to the initiation and progression of pancreatic *** IL-10 plays a crucial role in controlling the regenerative phase and limiting the severity of fibrosis and glandular atrophy induced by repeated episodes of acute pancreatitis in *** predictive and diagnostic roles of these inflammatory factors in pancreatitis were introduced in detail in this review.

关键词： Acute pancreatitis Inflammatory markers Pathogenesis

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心血管疾病患者运动恐惧评估工具测量属性的系统评价

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International Journal of Nursing Sciences 2024年第1期11卷 57-65页

作者：贾盈盈崔念奇贾婷婷 Hammza Jabbar Abdl sattar Hamoudi 宋剑平 Nursing Department The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Nursing Department Zhejiang University School of MedicineHangzhouChina School of Nursing Kunming Medical UniversityKunmingChina General Surgery Cadre Ward Gansu Provincial People’s HospitalLanzhouChina Faculty of Clinical Medicine Zhejiang University School of MedicineHangzhouChina

目的系统评价心血管疾病患者运动恐惧评估工具的测量学特性及方法学质量,为医护人员选择高质量的评估工具提供参考。方法系统检索Embase、the Cochrane *** of Science、中国知网、万方数据库、中国生物医学文献数据库、CINAHL和维普数... 详细信息

目的系统评价心血管疾病患者运动恐惧评估工具的测量学特性及方法学质量,为医护人员选择高质量的评估工具提供参考。方法系统检索Embase、the Cochrane *** of Science、中国知网、万方数据库、中国生物医学文献数据库、CINAHL和维普数据库中有关心血管疾病患者运动恐惧量表测量属性的研究,检索时限为建库至2023年4月1日,并追溯纳人文献的参考文献以补充相关文献。两名研究员按照纳人排除标准,独立筛选文献、提取数据,并使用COSMIN偏倚风险检查表独立评估量表的方法学质量,使用COSMIN标准评估量表评价测量学特性,使用改良版定量系统评价证据分级评估证据等级。结果共纳人17项研究,对6个心血管疾病患者运动恐惧评估工具(包含不同语言版本)的心理测量学特性进行了评价,仅有2项研究报告的量表内容效度方法学质量为很好,其余研究报告的量表内容效度方法学质量为模糊。关于跨文化有效性/测量不变性、测量误差和反应性的信息较少。瑞典语版及中文版坦帕运动恐惧症量表(the Tampa Scale for Kinesiophobia Heart,TSK Heart)为A类推荐,其他工具为B类推荐。结论现有研究中报告的瑞典语版和中文版TSKHeart的方法学及测量学属性质量相对较高,可被推荐使用,其余量表的测量学特性有待进--步验证。

关键词：评估工具心血管疾病运动恐惧症病人系统评价

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葡萄花翅小卷蛾对不同波长单色光的选择性测定

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应用昆虫学报 2024年第2期61卷 423-428页

作者：阿不都拉·艾克拜尔阿地力·沙塔尔新疆农业大学林学与风景园林学院新疆林业科学院森林生态研究所

【目的】为制定葡萄花翅小卷蛾Lobesiabotrana灯光诱杀技术提供科学依据。【方法】从蛾类昆虫趋光性研究入手进行试验，对不同波段的单色光进行筛选，选出了葡萄花翅小卷蛾敏感波段。【结果】葡萄花翅小卷蛾对390 nm的单色光最敏感。从... 详细信息

【目的】为制定葡萄花翅小卷蛾Lobesiabotrana灯光诱杀技术提供科学依据。【方法】从蛾类昆虫趋光性研究入手进行试验，对不同波段的单色光进行筛选，选出了葡萄花翅小卷蛾敏感波段。【结果】葡萄花翅小卷蛾对390 nm的单色光最敏感。从初次和二次筛选结果来看，390 nm的单色光对葡萄花翅小卷蛾的诱捕量最大，420nm次之（P>0.05）。由诱虫灯和性信息素效果对比来看，灯光诱捕量显著大于性信息素诱捕量。390 nm诱虫灯诱捕量最大，为801头，平均诱捕量为12.14头，其次为420 nm，两者间无显著差异（P>0.05）。性引诱剂的诱捕总量为573头，平均诱捕量为12.14头，与上述两种诱虫灯均存在显著差异（P<0.05）。【结论】葡萄花翅小卷蛾对390 nm的单色光敏感性最强。

关键词：葡萄花翅小卷蛾单色光性信息素选择性测定

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Topomerization of 2-Halo-[9] Annulen Anion at the DFT Level

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Chinese Journal of Structural Chemistry 2011年第10期30卷 1509-1516页

作者： sattar Arshadi AHMADREZA Bekhradnia Department of Chemistry Payame Noor University Pharmaceutical Sciences Research Center Department of Medicinal ChemistryMazandaran University of Medical Sciences

Topomerization of [9] annulen anion （1） and its 2-fluoro-, 2-chloro- and 2- bromo-defivatives （2, 3 and 4, respectively） are studied at the HF/6-31G＊ and B3LYP/6-31 1＋＋G＊＊ levels of theory. The relative ease of topomerization is dependent on the charge distribution and planarity of the ground state and the transition state of 9-membered rings as well as the size and electronegativity of halogen substituent. Consequently, the endo-2-halo-[9] annulen anion topomers become unstable and easily convert to related exo-topomers. Hence, according to the DFT calcu- lations, the order of topomerization energy barrier for endo = exo topomerization is lendo 〉 2endo 〉 3endo.

关键词： topomerization substiuent effects 2-halo- annulen anion DFT

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Theoretical Study of Halogen Effect in Isomerization of 2-Halo-[9]-annulen Anion at the DFT Level

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Chinese Journal of Structural Chemistry 2011年第6期30卷 906-912页

作者： AHMADREZA Bekhradnia sattar Arshadi Pharmaceutical Sciences Research Center Department of Medicinal ChemistryMazandaran University of Medical Sciences Department of Chemistry Payame Noor UniversityBehshahr Unit

Cis-trans isomerization of [9]-annulenanion（1） and its 2-fluoro-,2-chloro-and 2-bromo-derivatives（2,3 and 4,respectively） were investigated at the HF/6-31G＊ and B3LYP/6-311＋＋G＊＊ levels of ***,cis,cis,cis structures appear more stable than their corresponding cis,cis,cis,*** relative height of energy barriers for cis-trans isomerization is：2cis 〉1cis 〉3cis〉 *** trend for the reverse trans-cis isomerization follows the electronegativity of the substituent at C-2（2trans 3trans 4trans 1trans）.

关键词： isomerization halogen effects -annulen anion DFT

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