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Aging Effect on Elapsed Time of Serrations in Al-Li Single Crystals

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Journal of Materials Science & Technology 1998年第4期14卷 353-356页

作者： Tian, bh Yan, MG Chen, CQ Beijing Inst Aeronaut Mat Beijing 100095 Peoples R China Beijing Univ Aeronaut & Astronaut Beijing 100083 Peoples R China

Elapsed time of serrations in AI-Li single crystals was investigated with two definitions: one is the time elapsed in one cycle of serrations, the other is the average elapsed time within a strain limit. Elapsed time of individual serration appears independent on stress drops during serrated flow. It primarily distributes within the limits of short elapsed time in peak aged condition compared with underaged and overaged conditions, corresponding to low level of the average elapsed time that appears indifferent to increasing strain. It seems that shearing behaviour of delta' particles could be responsible for the variations in elapsed time of serrations.

关键词： Aluminum alloys

RP-based Abrading Technique for Graphite EDM Electrode

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Journal of Materials Science & Technology 2002年第6期18卷 572-574页

作者： Tang, YP Zhou, HZ Hong, J Lu, bh Xian Jiaotong Univ Inst Adv Mfg Technol Xian 710049 Peoples R China

Traditional processes for machining mold cavities are lengthy and costly. EDM (electro-discharge machining) is the most commonly used technique to obtain complex mold cavities. However, some electrodes are difficult to fabricate because of the complexity. Applying RP (rapid prototyping) technology to fabricate an abrading tool which is used to abrade graphite EDM electrodes, the cost and cycle time can greatly be reduced. The paper describes the work being conducted in this area by the authors. This technique will find widespread application in rapid steel mold manufacturing.

关键词： Rapid prototyping EDM Electrode Abrading

A BOUNDARY ELEMENT METHOD FOR CALCULATING ELASTIC WAVES SCATTERED BY AXISYMMETRIC INCLUSION

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Acta Mechanica Solida Sinica 1998年第4期11卷 359-364页

作者： Liu, XG Zhong, WF Chen, bh Huazhong Univ Sci & Technol Dept Mech Wuhan 430074 Peoples R China

A Boundary Element Method(BEM) is;described to compute the scattering of elastic waves by an axisymmetric inclusion in an infinite elastic medium. The boundary loads applied to the inclusion is expanded in terms of Fourier series in an infinite space. The boundary integral equation is solved in the general direction of the axisymmetric inclusion by BEM The problem of the 3-D scattering of elastic waves is reduced to a 1-D one. According to the geometric features of the axisymmetric inclusion the ring shell elements are adopted in this method. A comparison is made with other BEM methods. The numerical results show this method can reduce the amount of calculation and enhance the speed of convergence.

关键词： inclusion wave scattering boundary element method

A new strategy for the stereospecific syntheses of C-furanosides

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Chinese Journal of Chemistry 1997年第2期15卷 178-187页

作者： Yang, bh Jiang, JQ Huang, XL Wu, HM State Key Laboratory of Bio-organic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China [*]State Key Laboratory of Bio-organic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China

This reaction provided an efficient method to synthesize C-furanoside derivatives in high yields and stereospecificity under mild conditions. The cyclization mechanism regarding benzyl group as a leaving group was dis... 详细信息

关键词： C-furanosides benzyl group stereospecific cyclization H-1-H-1 NOESY

Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis

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World Journal of Gastroenterology 2020年第45期26卷 7131-7152页

作者： Amit Kumar Ram Balasubramaniyan Vairappan bh Srinivas Liver Diseases Research Lab Department of BiochemistryJawaharlal Institute of Postgraduate Medical Education and Research(JIPMER)Dhanvantari NagarPuducherry 605006India Department of Pathology Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER)Dhanvantari NagarPuducherry 605006India

BACKGROUND Altered tight junction(TJ)proteins are correlated with carcinogenesis and tumor *** is a tetranotriterpenoid that has been shown to have antioxidant and anti-proliferative properties;however,its anticancer effects and molecular mechanism in hepatocellular carcinoma(HCC)remains *** To investigate the effect of nimbolide on TJ proteins,cell cycle progression,and hepatic inflammation in a mouse model of *** HCC was induced in male Swiss albino mice(CD-1 strain)by a single intraperitoneal injection of 100 mg/kg diethylnitrosamine(DEN)followed by 80 ppm N-nitrosomorpholine(NMOR)in drinking water for 28 *** 28 wk,nimbolide(6 mg/kg)was given orally for four consecutive weeks in DEN/NMOR induced HCC *** the end of the 32nd week,all the mice were sacrificed and blood and liver samples were collected for various *** examinations of hepatic nodules were *** histology and HCC tumor markers such as alpha-fetoprotein(AFP)and glypican-3 were *** of TJ proteins,cell proliferation,and cell cycle markers,inflammatory markers,and oxidative stress markers were *** silico analysis was performed to confirm the binding and modulatory effect of nimbolide on zonula occludens 1(ZO-1),nuclear factor of kappa light polypeptide gene enhancer in B-cells(NF-κB),and tumor necrosis factor alpha(TNF-α).RESULTS We found nimbolide treatment at a concentration of 6 mg/kg to HCC mice reduced hepatic tumor size by 52.08%and tumor volume(P<0.01),and delayed tumor growth in HCC mice with a concomitant reduction in tumor markers such as AFP levels(P<0.01)and glypican-3 expression(P<0.05).Furthermore,nimbolide treatment increased tight junction proteins such as ZO-1 and occludin expression(P<0.05,respectively)and reduced ZO-1 associated nucleic acid binding protein expression(P<0.001)in HCC mice *** treatment to HCC mice also inhibited cell proliferation and suppressed cell cycle progression

关键词： Hepatocellular carcinoma Nimbolide Tight junction Inflammation Oxidative stress Zonula occludens 1 associated nucleic acid binding protein

PREPARATION OF POLYURETHANE EMULSION

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Chinese Chemical Letters 1995年第7期6卷 625-626页

作者： Zhou, QY Song, MD Zhang, bh He, BL Nankai Univ Inst Polymer Chem Tianjin 300071 Peoples R China

A technique has been developed for preparing stable polyurethane emulsion which provides thermosetting film without the use of emulsifying agents. The reaction of an isocyanate terminated prepolymer with a stoichiometric excess of diethylenetriamine in the presence of ketones yields the polyurethane-amine). Then the free amino group is generated when the polymer is treated with epichlorohydrin and the reaction occurs between them, and a stable self-emulsifiable thermosetting urethane emulsion can be obtained. This paper also presents the effect of the curing temperature and time on the typical mechanical properties of the films from this urethane emulsion.

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FADD and TRADD expression and apoptosis in primary hepatocellular carcinoma

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World Journal of Gastroenterology 2000年第2期6卷 223-227页

作者： Sun bh Zhao XP Wang BJ Yang DL Hao LJ Tongji Med Univ Tongji Hosp Dept Clin Immunol Wuhan 430030 Hubei Province Peoples R China

AIM To investigate the clinical features ofFADD and TRADD expressions in primaryhepatocellular carcinoma(HCC)and todetermine their relationship with *** FADD and TRADD expressions weredetected by immunohistochemistry and hepaticapoptosis were determined by in situ end-labeling(ISEL).RESULTS Ten(25.6%)cases of HCC weredetected to express FADD *** positiverate in HCC is lower than that in non-cancerousadjacent liver tissues(62.5%)(P0.05).The expressionof TRADD is correlated with HCC differentiation, as only 22.2% of moderately to highlydifferentiated HCC showed positive TRADDprotein,while as high as 52.4% of poorlydifferentiated HCC had TRADD(P0.05).Hepatic apoptosis was not related toTRADD expression in HCC or non-cancerousadjacent liver *** Loss of FADD expression playsan important role in HCC carcinogenesis,andexpression of TRADD also contributes to *** cell apoptosis in HCC isassociated with FADD expres

关键词： FADD TRADD apoptosis carcinoma hepatocellular liver neoplasms

Enantioselective hydrolysis of naproxen ethyl ester catalyzed by polyclonal antibodies

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Chinese Science Bulletin 1997年第9期42卷 741-744页

作者： Hu, YJ Yang, bh Zhao, H Wu, YL Ji, YY Ye, M State Key Laboratory of Bicorganic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai China Shanghai Institute of Cell Biology Chinese Academy of Sciences Shanghai China

BASED on the hypothesis of Pauling on enzyme action that free energy difference between theground and transition state is reduced by the specific binding of active center of enzyme to theintermediate,a large number of... 详细信息

关键词： enantioselectivity hydrolysis of naproxen ethyl ester polyclonal antibody catalytic antibody.

Paleomagnetic study on volcanic rocks in Pulu, Xinjiang

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Chinese Science Bulletin 1997年第6期42卷 481-484页

作者： Meng, ZF Li, YG Deng, YS Fu, bh Sun, DJ Lanzhou Institute of Geology Chinese Academy of Sciences Lanzhou China Institute of Geology and Mineral Resources BGMR Xinjiang Urumqi China

MOST of the preexisting paleomagnetic studies on the Tarim Basin were conducted within its northern ànd northwestern margins with the exception that few people have paid their attention to starting paleomagnetism study along the southern and southwestern rims of the basin. Here we report our new results from volcanic rocks distributed in Pulu area

关键词： Tarim Pulu paleomagnetism Qinghai-Xizang Plateau.