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Prevalence and features of colorectal lesions among Hispanics: A hospital-based study

World Journal of Gastroenterology 2015年第46期21卷 13095-13100页

作者： Hassan Ashktorab Adeyinka O Laiyemo Edward Lee Marcia Cruz-Correa amita ghuman Mehdi Nouraie Hassan Brim Gastroenterology Division and Cancer Center Pathology DepartmentHoward University College of Medicine

AIM: To evaluate the prevalence and characteristics of colorectal adenoma and carcinoma in an inner city Hispanic ***: We reviewed the reports of 1628 Hispanic patients who underwent colonoscopy at Howard University from 2000 to 2010. Advanced adenoma was defined as adenoma ≥ 1 cm in size,adenomas with villous histology,high grade dysplasia and/or invasive cancer. Statistical analysis was performed using χ2 statistics and ***: The median age of the patients was 54 years,64.2% were females. Polyps were observed in 489(30.0%) of patients. Adenoma prevalence was 16.8%(n = 273),advanced adenoma 2.4%(n = 39),and colorectal cancer 0.4%(n = 7). Hyperplastic polyps were seen in 6.6% of the cohort(n = 107). Adenomas predominantly exhibited a proximal colonic distribution(53.7%,n = 144); while hyperplastic polyps were mostly located in the distal colon(70%,n = 75). Among 11.7%(n = 191) patients who underwent screening colonoscopy,the prevalence of colorectal lesions was 21.4% adenoma,2.6% advanced adenoma; and 8.3% hyperplastic ***: Our data showed low colorectal cancer prevalence among Hispanics in the Washington DC area. However,the pre-neoplastic pattern of colonic lesions in Hispanics likely points toward a shift in this population that needs to be monitored closely through large epidemiological studies.

关键词： Colon Rectum Adenoma Carcinoma Hispanics

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Biomaterial applications in neural therapy and repair

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Chinese Neurosurgical Journal 2017年第1期3卷 27-34页

作者： Harmanvir ghuman Department of Bioengineering University of Pittsburgh Pittsburgh PA USAMcGowan Institute for Regenerative Medicine University of PittsburghPittsburgh PA USA

The use of biomaterials,such as hydrogels,as a scaffold to deliver cells and drugs is becoming increasingly common to treat neurological conditions,including *** a limited intrinsic ability to regenerate after injury,innovative tissue engineering strategies have shown the potential of biomaterials in facilitating neural tissue regeneration and functional *** biomaterials can not only promote the survival and integration of transplanted cells in the existing circuitry,but also support controlled site specific delivery of therapeutic *** review aims to provide the reader an understanding of the brain tissue microenvironment after injury,biomaterial criteria that support tissue repair,commonly used natural and synthetic biomaterials,benefits of incorporating cells and neurotrophic factors,as well as the potential of endogenous neurogenesis in repairing the injured brain.

关键词： Biomaterial Hydrogel Microparticles Stroke Cell therapy Drug delivery Brain ECM Neurogenesis Tissue engineering Biocompatibility

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SVEAT score outperforms HEART score in patients admitted to a chest pain observation unit

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World Journal of Cardiology 2022年第8期14卷 454-461页

作者： Daniel Antwi-Amoabeng Chanwit Roongsritong Moutaz Taha Bryce David Beutler Munadel Awad Ahmed Hanfy Jasmine ghuman Nicholas T Manasewitsch Sahajpreet Singh Claire Quang Nageshwara Gullapalli Department of Internal Medicine Reno School of MedicineUniversity of NevadaRenoNV 89502United States Institute for Heart and Vascular Health Renown Regional Medical CenterRenoNV 89502United States

BACKGROUND Timely and accurate identification of subgroup at risk for major adverse cardiovascular events among patients presenting with acute chest pain remains a *** available risk stratification scores are ***,a new scoring system called the Symptoms,history of Vascular disease,Electrocardiography,Age,and Troponin(SVEAT)score has been shown to outperform the History,Electrocardiography,Age,Risk factors and Troponin(HEART)score,one of the most used risk scores in the United *** To assess the potential usefulness of the SVEAT score as a risk stratification tool by comparing its performance to HEART score in chest pain patients with low suspicion for acute coronary syndrome and admitted for overnight *** We retrospectively reviewed medical records of 330 consecutive patients admitted to our clinical decision unit for acute chest pain between January 1st to April 17th,*** avoid potential biases,investigators assigned to calculate the SVEAT,and HEART scores were blinded to the results of 30-d combined endpoint of death,acute myocardial infarction or confirmed coronary artery disease requiring revascularization or medical therapy[30-d major adverse cardiovascular event(MACE)].An area under receiving-operator characteristic curve(AUC)for each score was then calculated.C-statistic and logistic model were used to compare RESULTS A 30-d MACE was observed in 11 patients(3.33%of the subjects).The AUC of SVEAT score(0.8876,95%CI:0.82-0.96)was significantly higher than the AUC of HEART score(0.7962,95%CI:0.71-0.88),P=*** logistic model,SVEAT score with cut-off of 4 or less significantly predicts 30-d MACE(odd ratio 1.52,95%CI:1.19-1.95,P=0.001)but not the HEART score(odd ratio 1.29,95%CI:0.78-2.14,P=0.32).CONCLUSION The SVEAT score is superior to the HEART score as a risk stratification tool for acute chest pain in low to intermediate risk patients.

关键词： Acute chest pain Risk stratification tool Symptoms,history of Vascular disease,Electrocardiography,Age,and Troponin score History,Electrocardiography,Age,Risk factors and Troponin score

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Cardiac adverse events of immune checkpoint inhibitors in oncology patients:A systematic review and meta-analysis

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World Journal of Cardiology 2020年第11期12卷 584-598页

作者： Nso Nso Daniel Antwi-Amoabeng Bryce D Beutler Mark B Ulanja Jasmine ghuman Ahmed Hanfy Joyce Nimo-Boampong Sirri Atanga Rajkumar Doshi Sostanie Enoru Nageshwara Gullapalli Department of Medicine Icahn School of Medicine at Mount SinaiQueensNY 10029United States Department of Internal Medicine University of NevadaReno School of MedicineRenoNV 89502United States Department of Radiology University of Southern CaliforniaKeck School of MedicineLos AngelesCA 90033United States Department of Internal Medicine Warren Alpert Medical School of Brown UniversityProvidenceRI 02903United States Department of Medicine United Health Services Wilson Medical CenterJohnson CityNY 13790United States Department of Cardiovascular Disease SUNY Downstate Health Science UniversityBrooklynNY 11203United States

BACKGROUND Immune checkpoint inhibitors(ICIs)are novel therapeutic agents used for various types of *** have revolutionized cancer treatment and improved clinical outcomes among cancer ***,immune-related adverse effects of ICI therapy are *** immune-related adverse events(irAEs)are rare but potentially life-threatening *** To estimate the incidence of cardiovascular irAEs among patients undergoing ICI therapy for various *** We conducted this systematic review and meta-analysis by searching PubMed,Cochrane CENTRAL,Web of Science,and SCOPUS databases for relevant interventional trials reporting cardiovascular *** performed a single-arm meta-analysis using OpenMeta[Analyst]software of the following outcomes:Myocarditis,pericardial effusion,heart failure,cardiomyopathy,atrial fibrillation,myocardial infarction,and cardiac *** assessed the heterogeneity using the I2 test and managed to solve it with Cochrane’s leave-one-out *** risk of bias was performed with the Cochrane’s risk of bias *** A total of 26 studies were *** incidence of irAEs follows:Myocarditis:0.5%[95%confidence interval(CI):0.1%-0.9%];Pericardial effusion:0.5%(95%CI:0.1%-1.0%);Heart failure:0.3%(95%CI:0.0%-0.5%);Cardiomyopathy:0.3%(95%CI:-0.1%-0.6%);atrial fibrillation:4.6%(95%CI:1.0%-14.1%);Myocardial infarction:0.4%(95%CI:0.0%-0.7%);and Cardiac arrest:0.4%(95%CI:0.1%-0.8%).CONCLUSION The most common cardiovascular irAEs were atrial fibrillation,myocarditis,and pericardial *** rare,data from post market surveillance will provide estimates of the long-term prevalence and prognosis in patients with ICIassociated cardiovascular complications.

关键词： Atrial fibrillation Cancer Immune checkpoint inhibitors Immunotherapy Cardiovascular adverse events Pericardial effusion

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