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Optics-based metaheuristic approach to assess critical failure surfaces in both circular and non-circular failure modes for slope stability analysis

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Rock Mechanics Bulletin

Rock Mechanics Bulletin 2024年第1期3卷 37-54页

作者： Jayraj Singh amit Kumar verma Haider Banka Ravishankar kumar amit Jaiswal Department of Computer Science&Engineering NIIT UniversityRajasthanIndia Department of Civil&Environment Engineering Indian Institute of TechnologyPatnaBihar801106India Department of Computer Science&Engineering Indian Institute of Technology(ISM)DhanbadJharkhand826004India Department of Mining Bharat Coking Coal LimitedDhanbadJharkhand826005India

In many construction projects,a proactive slope stability evaluation is a *** many deterministic or non-deterministic approaches have been commonly used,metaheuristic approaches have resulted in high precision and significant outcomes for slope stability analysis *** current work focuses on the reliable assessment of critical failure surfaces associated with the least factor of safety value in both homogeneous and non-homogeneous slopes using a new simplified meta-heuristic approach called optics-inspired optimization(OIO).The algorithm utilizes six different LEM methods as a fitness function for deriving the factor of *** analysis over three benchmark studies has been performed to demonstrate the algorithm's robustness and *** implementation found more robust results as compared to previous ***,the algorithm's statistical implication is conducted using the ANOVA test,which inferred better *** this interpretation,the approach claims to be suitable and efficient for slope stability analysis.

关键词： OIO-Algorithm Metaheuristic algorithms Slope stability analysis Critical failure surface LEM'S procedure

Novel targeting approaches and signaling pathways of colorectal cancer: An insight

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World Journal of Gastroenterology 2018年第39期24卷 4428-4435页

作者： Ankita Tiwari Shivani Saraf amit verma Pritish Kumar Panda Sanjay K Jain Pharmaceutics Research Projects Laboratory Department of Pharmaceutical SciencesDr. Hari Singh Gour Central University

Colorectal cancer(CRC) is the third most common cancer of mortality in the world. Chemotherapy based treatment leads to innumerable side effects as it delivers the anticancer drug to both normal cells besides cancer cells. Sonic Hedgehog(SHH), Wnt wingless-type mouse mammary tumor virus/β-catenin, transforming growth factor-β/SMAD, epidermal growth factor receptor and Notch are the main signaling pathways involved in the progression of CRC. Targeted therapies necessitate information regarding the particular aberrant pathways. Advancements in gene therapies have resulted in the recognition of novel therapeutic targets related with these signal-transduction cascades. CRC is a stepwise process where mutations occur over the time and activation of oncogenes and deactivation of tissue suppressor genes takes place. Genetic changes which are responsible for the induction of carcinogenesis include loss of heterozygosity in tumor suppressor genes such as adenomatous polyposis coli, mutation or deletion of genes like p53 and K-ras. Therefore, many gene-therapy approaches like gene correction, virusdirected enzyme-prodrug therapy, immunogenetic manipulation and virotherapy are currently being explored. Development of novel strategies for the safe and effective delivery of drugs to the cancerous site is the need of the hour. This editorial accentuates different novel strategies with emphasis on gene therapy and immunotherapy for the management of CRC.

关键词： Colorectal cancer Immunotherapy Gene therapy Signaling Targeted therapy

Secure Rotation Invariant Face Detection System for Authentication

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Computers, Materials & Continua 2022年第1期70卷 1955-1974页

作者： amit verma Mohammed Baljon Shailendra Mishra Iqbaldeep Kaur Ritika Saini Sharad Saxena Sanjay Kumar Sharma Department of Computer Science&Engineering Chandigarh Group of CollegesMohali140317India Department of Computer Engineering College of Computer&Information ScienceMajmaah University11952Saudi Arabia Department of Computer Science and Engineering Thapar Institute of Engineering&TechnologyPatiala147004India Department of Computer Centre&Campus Network Facility Science Complex PO Central UniversityGachibowliHyderabad500046TelanganaIndia

Biometric applications widely use the face as a component for recognition and automatic *** rotation is a variable component and makes face detection a complex and challenging task with varied angles and *** problem has been investigated,and a novice algorithm,namely RIFDS(Rotation Invariant Face Detection System),has been *** objective of the paper is to implement a robust method for face detection taken at various *** to achieve better results than known algorithms for face *** RIFDS Polar Harmonic Transforms(PHT)technique is combined with Multi-Block Local Binary Pattern(MBLBP)in a hybrid *** MBLBP is used to extract texture patterns from the digital image,and the PHT is used to manage invariant rotation *** this manner,RIFDS can detect human faces at different rotations and with different facial *** RIFDS performance is validated on different face databases like LFW,ORL,CMU,MIT-CBCL,JAFFF Face Databases,and Lena *** results show that the RIFDS algorithm can detect faces at varying angles and at different image resolutions and with an accuracy of 99.9%.The RIFDS algorithm outperforms previous methods like Viola-Jones,Multi-blockLocal Binary Pattern(MBLBP),and Polar HarmonicTransforms(PHTs).The RIFDS approach has a further scope with a genetic algorithm to detect faces(approximation)even from shadows.

关键词： Pose variations face detection frontal faces facial expressions emotions

Monoclonal antibody and its use in the diagnosis of livestock diseases

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Advances in Bioscience and Biotechnology 2013年第4期4卷 50-62页

作者： Rajib Deb Sandip Chakraborty Belamaranahlly Veeregowda amit Kumar verma Ruchi Tiwari Kuldeep Dhama Animal Resource Development Department Pt. Nehru Complex Agartala India Department of Veterinary Epidemiology and Preventive Medicine Uttar Pradesh Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishvidhyalaya Ewam Go-Anusandhan Sansthan (DUVASU) Mathura India Department of Veterinary Microbiology and Immunology Uttar Pradesh Pandit Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishvidhyalaya Ewam Go-Anusandhan Sansthan (DUVASU) Mathura India Division of Pathology Indian Veterinary Research Institute Bareilly India Scientist Division of Animal Genetics & Breeding Project Directorate on Cattle (ICAR) Meerut India Veterinary College Bengaluru India

Since the discovery of hybridoma cells by Kohler and Milstein, the uses of monoclonal antibody (mAb), the protein produced by such cells are in vogue. Such antibodies with single isotype have higher specificity, and the serological tests employed in show higher reproducibility compared to those with use of polyclonal antisera. There are several procedures of mAb production which vary considerably but the principle remains the same which states that antigens introduced into animals generally result in the stimulation of lymphocytes, some of which produce antibody of only one type, although the isotype may change. The developments in the field of cell culture and transfection technology have lead to the production of improved qualities of mAbs. In general, monoclonal antibodies are important reagents used in biomedical research, such as, in the field of diagnostics and therapeutics as well as targeted drug delivery systems. They have got importance not only for infectious diseases caused by microbes and parasites, but also for cancer, metabolic and hormonal disorders, in the diagnosis of lymphoid and myeloid malignancies and tissue typing, enzyme linked immunosorbent assay (ELISA) (especially blocking ELISA), radio immunoassay (RIA), serotyping of pathogens and their immunological intervention with passive antibody, anti-idiotype inhibition or magic bullet therapy with cytotoxic agents coupled with antimouse specific antibody. The application of mAbs in diagnosis of various livestock diseases is an important area of concern as these diseases are a major and increasingly important factor reducing livestock productivity in various parts of the world. In this context, the application of mAbs for diagnosis of important bacterial diseases viz., Anthrax, Brucellosis, Paratuberculosis, Leptospirosis, Listeriosis, Clostridial infections and Mycoplasmosis (CBPP), fungal diseases viz., Zygomycosis, Cryptococcosis, Histoplasmosis and Paracoccidiodomycosis, viral diseases viz., F

关键词： Antibody Cell Engineering Diagnosis Livestock Microbes Monoclonal Parasites

Survival mechanisms of <i>Mycobacterium avium</i>subspecies <i>paratuberculosis</i>within host species and in the environment—A review

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Natural Science 2013年第6期5卷 710-723页

作者： Shoor Vir Singh Ajay Vir Singh Avnish Kumar Pravin Kumar Singh Rajib Deb amit Kumar verma amit Kumar Ruchi Tiwari Sandip Chakraborty Kuldeep Dhama Animal Genetics and Breeding Project Directorate on Cattle Indian Council of Agricultural Research Meerut India Animal Resource Development Department Pt. Nehru Complex Agartala India Department of Microbiology & Immunology Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU) Mathura India Department of Veterinary Epidemiology & Preventive Medicine Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vi- gyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU) Mathura India Division of Pathology Indian Veterinary Research Institute (IVRI) Bareilly India Microbiology Laboratory Animal Health Division Central Institute for Research on Goats (CIRG) Mathura India National JALMA Institute for Leprosy and Other Mycobacterial Diseases (NJIL and OMD) Agra India

Mycobacterium avium subsp. paratuberculosis causes chronic inflammation of the intestine known as Johne’s disease (JD) in domestic and wild ruminants including primates. MAP has also been associated with inflammatory bowel disease (IBD) so called Crohn’s disease (CD) of human beings, which is incurable even after surgery. By virtue of the pasteurization resistant power, high endemicity of the infection in animals continues to be the permanent source of infection to human population. High bio-burden of MAP in wide range of biotic (animal hosts including human beings) and abiotic environment in each and every country where it has been investigated, serves a reminder about the survival abilities of the MAP in diverse range of environmental conditions. Ability of the MAP to evade immune system of the host and the temporal events during infection of the macro-phages, is an area of major concern and research activities as the pattern of distribution are quiet different from those of other pathogenic intracellular organisms. Moreover, the organism can survive over a wide range of environmental conditions such as high and low environmental temperatures, pasteurization, low pH, and high salt concentration etc. This superior survival efficiency from environmental degradation and dormancy within host allows the pathogen to be available for causing disease and pathogenicity in animals and human beings, when conditions are favorable. Perusal of literature reveal that, despite the availability of whole genome sequence of MAP, a very little is known about the replication, persistence and survival mechanisms of this pathogen. Therefore, this review tries to address the survival mechanisms of Mycobacterium avium subspecies paratuberculosis in the different host species and adverse environmental conditions in order to allow designing of more rational diagnostic and control procedures.

关键词： Paratuberculosis Johne’s Disease Reservoir Disease Survival MAP Animal

Missed ulnar nerve injury and closed forearm fracture in a child

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Chinese Journal of Traumatology 2013年第4期16卷 246-248页

作者： Batra amit Devgan Ashish verma Vinit Singh Raj Batra Shivan Magu Narender Singla Rohit Gogna ParitoshGupta Navdeep Department of Orthopedics PGIMS Rohtak HaryanaIndia

Ulnar nerve injury in closed fracture of lbrearnl in children is uncommon. Commonly, neurapraxia is the reason for this palsy but other severe injuries or nerve entrapment has been reported in some cases. The impor- tance of diagnosis concerning the types of the nerve injury lies in the fact that they have totally different management. We present a case of ulnar nerve deficit in a child following a closed fracture of the forearm bones. It is imperative to diagnose exact cause of palsy as it forms the basis for treatment. MR1 scan can help diagnosis and accordingly guide the management. Simple nelwe contusion should be treated conservatively, and exploration with fixation of the fracture should be done in lacerations and entrapments of the nerve. Surgery is not the treatment of choice in cases that could be managed conserwltively.

关键词： Ulnar nerve Peripheral nerve injuries Forearm injuries Child

Influence of rooftop telecommunication tower on set back-step back building resting on different ground slopes

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Earthquake Engineering and Engineering Vibration 2019年第2期18卷 351-362页

作者： amit Thakur Deepankar Kumar Ashish Surender Kumar verma Civil Engineering Department Kurukshetra University Civil Engineering Department Maharaja Agrasen Institute of Technology Maharaja Agrasen University Civil Engineering Department Punjab Engineering College (Deemed to be University)

In the hilly region due to scarcity of the plain area, buildings like set back-step back are more often used and also as a big surge in the telecommunication industries, rooftop tower adaptation is very common story nowadays. In the present study an analogy has been drawn to find out the influence of the rooftop telecommunication tower on the setback-step back building resting on ground at 20° and 30° slopes. A dynamic analysis has been performed and compared on the 4 legged angled section telecommunication tower which is located on the roof top of set back-step back building by varying positions of tower with the existing host structure built up on ground slope of 20° and 30° in both directions(X and Y).

关键词： rooftop telecommunication tower set back-step back building response spectrum analysis steel, RC frame, earthquake SAP2000

Influence of tool rotation speeds on mechanical and morphological properties of friction stir processed nano hybrid composite of MWCNT-Graphene-AZ31 magnesium

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Journal of Magnesium and Alloys 2019年第3期7卷 487-500页

作者： Sanjay Sharma amit Handa Sahib Sartaj Singh Deepak verma I.K.Gujral punjab technical university kapurthalaIndia punjabi university patialaindia graphic era hill university dehradunindia

The ever-increasing demand for light weighted hard materials for transportation industries encouraged researchers to develop composites with excellent mechanical properties which can transform it into more economical and *** the metals with carbonaceous nanomaterials are progressively in focus due to their excellent capability to inculcate and tailor the properties of *** the present research,a hybrid nanocomposite of MWCNT-Graphene-AZ31 Mg alloy has been developed by using variable tool rotation speeds with friction stir processing(FSP).Optimized reinforcement ratio of 1.6%*** and 0.3%*** graphene have been used with variable tool rotation speeds,whereas other processing parameters are kept *** developed specimens were investigated using standard testing equipment for evaluating and comparing the mechanical properties on the basis of the microstructure of the processing regions and their morphological analysis,according to the ASTM *** obtained results revealed an improvement of 19.72%in microhardness and 77.5% of compressive strength in comparison with the base metal AZ 31 Magnesium alloy,with a tool rotational speed of *** values of tensile stress and percentage area reduction were recorded as less than that of the base metal matrix,but an increasing trend has been observed in the values of both with the improvement on rotational speeds of the *** effectual strengthening mechanisms are analyzed on the bases of SEM images and observed that discussed and found that grain refinement strengthening is the major contributor to the strength of the nanocomposite.

关键词： MMCs(Metal Matrix composites) Friction stir processing(FSP) Multi-walled carbon nanotubes(MWCCT) Graphene Nano Particular Stir Zone(SZ) Thermo-mechanically affected zone(TMAZ) Heat Affected Zone(HAZ)

Evaluation of slope stability through rock mass classification and kinematic analysis of some major slopes along NH-1A from Ramban to Banihal, North Western Himalayas

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 167-182页

作者： amit Jaiswal A.K.verma T.N.Singh Department of Civil and Environmental Engineering Indian Institute of Technology PatnaPatna801106India

The network of Himalayan roadways and highways connects some remote regions of valleys or hill slopes,which is vital for India’s socio-economic *** to natural and artificial factors,frequency of slope instabilities along the networks has been increasing over last few *** of stability of natural and artificial slopes due to construction of these connecting road networks is significant in safely executing these roads throughout the *** rock mass classification methods are generally used to assess the strength and deformability of rock *** study assesses slope stability along the NH-1A of Ramban district of North Western *** structurally and non-structurally controlled rock mass classification systems have been applied to assess the stability conditions of 14 *** evaluating the stability of these slopes,kinematic analysis was performed along with geological strength index(GSI),rock mass rating(RMR),continuous slope mass rating(CoSMR),slope mass rating(SMR),and Q-slope in the present *** SMR gives three slopes as completely unstable while CoSMR suggests four slopes as completely *** stability of all slopes was also analyzed using a design chart under dynamic and static conditions by slope stability rating(SSR)for the factor of safety(FoS)of 1.2 and 1 respectively.Q-slope with probability of failure(PoF)1%gives two slopes as stable *** slope angle has been determined based on the Q-slope safe angle equation and SSR design chart based on the *** value ranges given by different empirical classifications were RMR(37-74),GSI(27.3-58.5),SMR(11-59),and CoSMR(3.39-74.56).Good relationship was found among RMR&SSR and RMR&GSI with correlation coefficient(R 2)value of 0.815 and 0.6866,***,a comparative stability of all these slopes based on the above classification has been performed to identify the most critical slope along this road.

关键词： Rock mass classification Kinematic analysis Slope stability Himalayan road Static and dynamic conditions