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Insight into the relationship between non-linear mixed convection and thermal radiation:The case of Newtonian fluid flow due to non-linear stretching

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Propulsion and Power Research 2023年第1期12卷 153-165页

作者： amit kumar pandey Krishnendu Bhattacharyya Anil kumar Gautam Sohita Rajput Mani Shankar Mandal Ali J.Chamkha Dhananjay Yadav Department of Mathematics Institute of ScienceBanaras Hindu UniversityVaranasi-221005Uttar PradeshIndia Department of Mathematics Government General Degree CollegeKalnaeIBurdwan-713405West BengalIndia Faculty of Engineering Kuwait College of Science and TechnologyDoha DistrictKuwait Department of Mathematical and Physical Sciences University of NizwaOman

The current research focuses the light on the characterization of buoyancy-driven non-linear mixed convection and non-linear radiation in a Newtonian flow over a nonlinearly stretching vertical sheet,and this type of flow has useful applications in many industrial processes,such as the paper and pulp industry,polymer industry,electronic device cooling,solar collectors,gas turbine plants,and nuclear *** appropriate transformations,governing PDEs for non-linear mixed convection are reduced to higher-order non-linear ODEs and those are numerically *** with tabular presentations of computed results,the graphical representations are generated to elucidate the effects of involved parameters on convection transport properties and their *** demonstrates that flow velocity increases near the surface and decreases away from the surface as the non-linear convection parameter ***,increments in the thermal buoyancy,temperature ratio and non-linear radiation parameters result in the boost of *** temperature decreases as linear and non-linear buoyancy-related parameters(non-linear convection and thermal buoyancy parameters)are of higher *** contrast,the temperature rises with two non-linear thermal radiation-related parameters(thermal ratio and non-linear radiation parameters).For greater values of the non-linear stretching related parameter,a lower velocity and a higher temperature are *** non-linear convection,thermal buoyancy,thermal ratio and non-linear radiation parameters contribute toward the reduction of the magnitude of surface-drag force and growth of the surface cooling ***,with the non-linearity in surface stretching there are significant percentage hikes of surface-drag force magnitude and surface cooling rate.

关键词： Non-linear mixed convection Non-linear thermal radiation Non-linear stretching sheet Newtonian fluid

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A comprehensive review of rectangular duct solar air heaters featuring artificial roughness

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Clean Energy 2024年第5期8卷 186-217页

作者： Ravi Shankar Rajeev kumar Arun kumar pandey Deep Singh Thakur Department of Mechanical Engineering Rajkiya Engineering College BandaUttar Pradesh 210201India Department of Mechanical Engineering Institute of Engineering&TechnologyLucknowUttar Pradesh 226021India Department of Mechanical Engineering Bundelkhand Institute of Engineering&TechnologyJhansiUttar Pradesh 284128India

Solar air heaters(SAHs)are widely used solar thermal systems with applications in diverse ***,its effectiveness is re-strained by low convective heat transfer(HT)coefficients at the absorber plate,leading to inefficient HT,and the elevated temperature of the absorber plate causes significant heat losses,reducing thermal *** study addresses these challenges by introducing ribs or roughness on the absorber plate creating turbulence in the airflow,resulting in significant *** research inves-tigates various rib configurations,the influence of rib parameters,performance methods,and arrangements to evaluate their HT and friction *** these rib configurations,a comparative analysis is done on various factors such as the Nusselt number ratio,thermal enhancement factor,friction factor ratio,and thermal efficiency to optimize distinct roughness parameters and rib ar-rangement *** study also provides valuable recommendations from existing literature,offering insights into the effective design,prospects,and implementation of SAH systems.

关键词： solar air heater artificial roughness low heat transfer heating solar energy

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Optimization of variables and assessment of in-vitro and in-vivo antihyperlipidemic activity of Eudragit RS nanoparticles containing simvastatin

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Particuology 2024年第7期90卷 189-198页

作者： Bina Gidwani Vishal Jain Veenu Joshi Ravindra kumar pandey Shiv Shankar Shukla Amber Vyas Columbia Institute of Pharmacy Raipur(C.G.)India University Institute of Pharmacy Pt Ravishankar Shukla UniversityRaipur(C.G.)India Center for Basic Science and Research Pt Ravishankar Shukla UniversityRaipur(C.G.)India

Simvastatin, a BCS class II drug, is associated with poor aqueous solubility, first-pass metabolism and short half-life. In the present work, nanoparticles were prepared and evaluated. Optimization of formulation and process parameters was done through the use of independent and dependent variables. Preliminary studies were done to determine suitable range of the concentration of Eudragit polymer (10%–30%) and the ratio of drug to polymer (1:1 to 1:5) for the formation of nanoparticles by emulsification and a solvent evaporation technique. Results revealed that the mean size of nanoparticles was affected by stirring speed from 5000 RPM, 8000 RPM, and 12000 RPM. The results of increase in association efficiency and percent yield with increase in amount of drug from 100 mg, 150 mg, and 200 mg in selected range were observed. In-vitro release studies showed that two formulations possess highest initial burst and slow sustained drug release. There was 2.93-fold decrease in total cholesterol and 3.27-fold increases in triglyceride level during in-vivo study.

关键词： Simvastatin Eudragit RS 100 Nanoparticles Hyperlipidemia

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Climatic and Environmental Impacts of Dust over the Tibetan Plateau: An Overview

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Journal of Environmental Protection 2024年第9期15卷 907-920页

作者： Ashok kumar Pokharel Shree pandey Collaborative Innovation Center for Western Ecological Safety Lanzhou University Lanzhou China College of Pastoral Agriculture Science and Technology Lanzhou University Lanzhou China

The Tibetan Plateau (TP), located at a height of nearly 4000 m above sea level, has a unique setting that effects the environment of the whole of northern hemisphere. It acts as the “water reservoir” of Asia as several important rivers originate from this region. Therefore, even slight alternations in the TP’s hydrological cycle may have profound ecological and social impacts. However, it is experiencing a significant increase in accumulation of dust from local and global sources. The impact of dust on the region’s climate has become an active area of research. Further, the study of sources of dust arriving at the TP is also critical. Accumulation of dust is impacting temperature, snow cover, glaciers, water resources, biodiversity and soil desertification. This manuscript tries to provide a comprehensive summary of the impact of dust on weather, climate, and environmental components of the TP. The impact of dust on clouds, radiative energy, precipitation, atmospheric circulation, snow and ice cover, soil, air quality, and river water quality of the TP are discussed. It further discusses the steps immediately needed to mitigate the devastating impact of dust on the fragile ecosystem of the TP.

关键词： Tibetan Plateau Dust Clouds Precipitation Radiative Forcing Snow

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Biological,pathological,and multifaceted therapeutic functions of exosomes to target cancer

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Oncology Research 2024年第1期32卷 73-94页

作者： VIGNESH BALAJI E DIVYA RAMESH MANISHA CHUNGAN SHAJU AKSHARA kumar SAMYAK pandey RAKSHA NAYAK V.ALKA SRISHTI MUNJAL AMIR SALIMI K.SREEDHARA RANGANATH PAI SHANKAR M.BAKKANNAVAR Department of Pharmacology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Forensic Medicine and Toxicology Kasturba Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India School of Health and Community Services Durham CollegeOshawaOntarioL1G2G5Canada Department of Pharmaceutical Regulatory Affairs and Management Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Clinical Psychology Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Speech and Hearing Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India

Exosomes,small tiny vesicle contains a large number of intracellular particles that employ to cause various diseases and prevent several pathological events as well in the human *** is considered a“double-edged sword”,and depending on its biological source,the action of exosomes varies under physiological ***,the isolation and characterization of the exosomes should be performed accurately and the methodology also will vary depending on the exosome ***,the uptake of exosomes from the recipients’cells is a vital and initial step for all the physiological *** are different mechanisms present in the exosomes’cellular uptake to deliver their cargo to acceptor *** the exosomal uptake takes place,it releases the intracellular particles that leads to activate the physiological *** though exosomes have lavish functions,there are some challenges associated with every step of their preparation to bring potential therapeutic ***,overcoming the pitfalls would give a desired quantity of exosomes with high purity.

关键词： Exosomes Physiology Cancer Therapeutics Challenges

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Predictors of cerebrospinal fluid GeneXpert MTB/RIF positivity in patients with tuberculous meningitis:A prospective cohort study

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Asian Pacific Journal of Tropical Medicine 2024年第10期17卷 465-472页

作者： Priyanka Gupta Neeraj kumar Ravindra kumar Garg Hardeep Singh Malhotra Imran Rizvi Rajesh Verma Praveen kumar Sharma Ravi Uniyal Shweta pandey amita Jain Parul Jain Department of Neurology King George’s Medical UniversityLucknowIndia Department of Microbiology King George’s Medical UniversityLucknowIndia

Objective:To identify the clinical,laboratory,and radiological markers that could predict a positive GeneXpert result in patients suspected of tuberculous ***:In this prospective,observational study,patients with tuberculous meningitis were systematically *** clinical,laboratory[including cerebrospinal fluid(CSF)microscopy,culture,and GeneXpert],and neuroimaging factors were *** participants were administered anti-tuberculous treatment and corticosteroids.A six-month follow-up was done to evaluate the ***:Of the 116 patients studied,54(46.6%)tested positive for GeneXpert,while 62(53.4%)were *** cranial nerve involvement(OR 3.71,95%CI 1.052-13.09,P=0.04)and the presence of basal exudates on neuroimaging(OR 5.22,95%CI 2.03-13.42,P=0.001)emerged as independent predictive factors for a positive GeneXpert result.A positive CSF GeneXpert result(P=0.002)and drug resistance(P=0.004)were significantly linked to adverse ***,a high score on the Medical Research Council stageⅢ(OR 5.64,95%CI 1.18-26.87,P=0.03)and elevated CSF cell counts(OR 1.002,95%CI 1.00-1.001,P=0.03)were identified as independent predictors of poor ***:Third cranial nerve involvement and the presence of basal exudates were significant indicators of a positive GeneXpert *** stageⅢdisability and elevated CSF cell counts predicted poor outcomes.

关键词： Tuberculous meningitis Mycobacterium tuberculosis Cerebrospinal fluid Ziehl-Neelsen staining GeneXpert

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Remote Sensing approach to evaluate anthropogenic influences on Forest Cover of Palamau Tiger Reserve,Eastern India

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Ecological Processes 2020年第1期9卷 185-195页

作者： Binita kumari Arvind Chandra pandey amit kumar Department of Geoinformatics Central University of JharkhandRanchiJharkhand 835205India

Background:Tropical forests have been experiencing remarkable rates of transformation over the past century as they are getting degraded or decimated to a great extent by anthropogenic *** study aims at investigating the long-term forest cover transformation in Palamau Tiger Reserve(PTR),Jharkhand,India,using Landsat TM,ETM+,and OLI satellite images during *** forest cover was delineated utilizing various keys of visual interpretation ***:The forest cover was primarily decreased in the north-eastern and north-western parts in *** order to identify the anthropogenic disturbance in the forest reserve,human settlement density was mapped using highresolution Google Earth *** results showed a positive correlation between human population density and settlement *** major affected sites with an outer buffer of 2 km were demarcated in order to deduce the anthropogenic influences in major non-forested sites in *** was observed that the forest change was maximum at site 3(Ranidah,area 61.06 km^(2),−6.47%change)followed by site 2(Saidup,area 124.38 km^(2),−7.65%change),where settlement units were also high(2638 and 2621 settlement units,respectively).At site 1(Barkheta,area 81.59 km^(2)),−1.99%change was observed,and at site 4(Samadh Tola,area 9.15 km^(2)),1.03% change was observed having moderate settlement units(2422 and 1892 settlement units,respectively).Areas with the low level of human settlements(1038 settlement units)observed the least change,i.e.,at site 5(Netarhat,area 48.52 km^(2)),0.58%change was observed mainly during the ***:The forest cover exhibited an overall decrease of 14.55 km^(2)(−1.34%change)with episodic variation during 1975-2015 in PTR,Eastern India.A significant forest disturbance occurred primarily in the north-eastern and north-western parts of PTR along the forest fringe due to the high population and settlement *** study highlighted the potential use of freely availa

关键词： Population density Settlement density Remote sensing and GIS Palamau Tiger Reserve

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Performance validation of High Mountain Asia 8-meter Digital Elevation Model using ICESat-2 geolocated photons

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Journal of Mountain Science 2024年第8期21卷 2562-2578页

作者： Giribabu DANDABATHULA Subham ROY Omkar Shashikant GHATAGE Vaibhav Balaso KOLASE Shwetambari SATPUTE Koushik GHOSH Sahibnoor KAUR Satyanarayana PONDARI Apurba kumar BERA Sushil kumar SRIVASTAV Regional Remote Sensing Centre-West National Remote Sensing CentreIndian Space Research OrganisationJodhpur 342005India Department of Geography School of Earth SciencesBharathidasan UniversityTiruchirappalli 620024India Centre for Climate Change and Water Research Suresh Gyan Vihar UniversityJaipur 302017India Department of Geography Panjab UniversityChandigarh 160014India National Remote Sensing Centre Indian Space Research OrganisationHyderabad 500037India Regional Centres National Remote Sensing CentreIndian Space Research OrganisationNew Delhi 110049India

High Mountain Asia(HMA),recognized as a third pole,needs regular and intense studies as it is susceptible to climate *** accurate and high-resolution Digital Elevation Model(DEM)for this region enables us to analyze it in a 3D environment and understand its intricate role as the Water Tower of *** science teams of NASA realized an 8-m DEM using satellite stereo imagery for HMA,termed HMA 8-m *** this research,we assessed the vertical accuracy of HMA 8-m DEM using reference elevations from ICESat-2 geolocated photons at three test sites of varied topography and land *** were made from statistical quantifiers and elevation *** the world’s highest mountain,Mount Everest,and its surroundings,Root Mean Squared Error(RMSE)and Mean Absolute Error(MAE)resulted in 1.94 m and 1.66 m,respectively;however,a uniform positive bias observed in the elevation profiles indicates the seasonal snow cover change will dent the accurate estimation of the elevation in this sort of test *** second test site containing gentle slopes with forest patches has exhibited the Digital Surface Model(DSM)features with RMSE and MAE of 0.58 m and 0.52 m,*** third test site,situated in the Zanda County of the Qinghai-Tibet,is a relatively flat terrain bed,mostly bare earth with sudden river cuts,and has minimal errors with RMSE and MAE of 0.32 m and 0.29 m,respectively,and with a negligible ***,in one more test site,the feasibility of detecting the glacial lakes was tested,which resulted in exhibiting a flat surface over the surface of the lakes,indicating the potential of HMA 8-m DEM for deriving the hydrological *** results accrued in this investigation confirm that the HMA 8-m DEM has the best vertical accuracy and should be of high use for analyzing natural hazards and monitoring glacier surfaces.

关键词： High Mountain Asia Digital Elevation Model ICESat-2 geolocated photons Accuracy assessment

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Effects of urea,metal ions and surfactants on the binding of baicalein with bovine serum albumin

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Journal of Pharmaceutical Analysis 2016年第4期6卷 256-267页

作者： Atanu Singha Roy amit kumar Dinda Nitin kumar pandey Swagata Dasgupta Department of Chemistry Indian Institute of Technology

The interaction of baicalein with bovine serum albumin（BSA） was investigated with the help of spectroscopic and molecular docking *** binding affinity of baicalein towards BSA was estimated to be in order of 10~5 M^（-1） from fluorescence quenching *** ΔH°（-5.66 ＋ 0.14 kJ/mol） and positive（ΔS°）（＋ 79.96 ＋ 0.65J/mol K） indicate the presence of electrostatic interactions along with the hydrophobic forces that result in a positive ΔS°.The hydrophobic association of baicalein with BSA diminishes in the presence of sodium dodecyl sulfate（SDS） due to probable hydrophobic association of baicalein with SDS,resulting in a negative ΔS°（-40.65 ＋ 0.87 J/mol K）.Matrix-assisted laser desorption ionization/time of flight（MALDI-TOF） experiments indicate a 1：1 complexation between baicalein and *** unfolding and refolding phenomena of BSA were investigated in the absence and presence of baicalein using steady-state and fluorescence lifetime *** was observed that the presence of urea ruptured the non-covalent interaction between baicalein and *** presence of metal ions（Ag~＋,Mg^（2＋）,Ni^（2＋）,Mn^（2＋）,Co^（2＋） and Zn^（2＋）） increased the binding affinity of ligand towards *** changes in conformational aspects of BSA after ligand binding were also investigated using circular dichroism（CD） and Fourier transform infrared（FT-IR） spectroscopic *** selectivity studies following molecular docking analyses indicated the binding of baicalein to site 1（subdomain MA） of BSA.

关键词： Bovine serum albumin(BSA) Baicalein Binding constant Fluorescence spectroscopy Molecular docking

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Corrigendum to'Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics'[Genes&Diseases 10(2023)1367-1401]

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Genes & Diseases 2024年第4期11卷 426-427页

作者： Uttpal Anand Abhijit Dey Arvind K.Singh Chandel Rupa Sanyal Amarnath Mishra Devendra kumar pandey Valentina De Falco Arun Upadhyay Ramesh Kandimalla Anupama Chaudhary Jaspreet Kaur Dhanjal Saikat Dewanjee Jayalakshmi Vallamkondu Jose M.Perez de la Lastra Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Department of Botany Bhairab Ganguly College(affliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples FedericoⅡNaples 80131Italy Department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarhAjmerRajasthan 305817India CSiR-indian Institute of Chemical Technology HyderabadTelangana 500007India Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Department of Computational Biology Indraprastha Institute of Information Technology Delhi(ⅢT-D)Okhla Industrial EstatePhaseⅢNew Delhi 110020India Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of Macromolecules Research Group Instituto de Productos Naturales y AgrobiologiaIPNA-CSICSan Cristobal de La Laguna 38206TenerifeSpain

In the published article,there was an error in the affiliation information about the first author Uttpal Anand[a].Instead of"Department of Life Sciences,Ben-Gurion University of the Negev,Beer-Sheva 84105,Israel",it should be"CytoGene Research&Development LLP,K-51,UPSIDA Industrial Area,Kursi Road(Lucknow),***,225001,Uttar Pradesh,India".The authors would like to apologize for any inconvenience caused and state that this does not change the scientific conclusions of thearticle inanyway.

关键词： Cancer Cor targeted

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