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Insight into the relationship between non-linear mixed convection and thermal radiation:The case of Newtonian fluid flow due to non-linear stretching

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Propulsion and Power Research 2023年第1期12卷 153-165页

作者： amit kumar pandey Krishnendu Bhattacharyya Anil kumar Gautam Sohita Rajput Mani Shankar Mandal Ali J.Chamkha Dhananjay Yadav Department of Mathematics Institute of ScienceBanaras Hindu UniversityVaranasi-221005Uttar PradeshIndia Department of Mathematics Government General Degree CollegeKalnaeIBurdwan-713405West BengalIndia Faculty of Engineering Kuwait College of Science and TechnologyDoha DistrictKuwait Department of Mathematical and Physical Sciences University of NizwaOman

The current research focuses the light on the characterization of buoyancy-driven non-linear mixed convection and non-linear radiation in a Newtonian flow over a nonlinearly stretching vertical sheet,and this type of flow has useful applications in many industrial processes,such as the paper and pulp industry,polymer industry,electronic device cooling,solar collectors,gas turbine plants,and nuclear *** appropriate transformations,governing PDEs for non-linear mixed convection are reduced to higher-order non-linear ODEs and those are numerically *** with tabular presentations of computed results,the graphical representations are generated to elucidate the effects of involved parameters on convection transport properties and their *** demonstrates that flow velocity increases near the surface and decreases away from the surface as the non-linear convection parameter ***,increments in the thermal buoyancy,temperature ratio and non-linear radiation parameters result in the boost of *** temperature decreases as linear and non-linear buoyancy-related parameters(non-linear convection and thermal buoyancy parameters)are of higher *** contrast,the temperature rises with two non-linear thermal radiation-related parameters(thermal ratio and non-linear radiation parameters).For greater values of the non-linear stretching related parameter,a lower velocity and a higher temperature are *** non-linear convection,thermal buoyancy,thermal ratio and non-linear radiation parameters contribute toward the reduction of the magnitude of surface-drag force and growth of the surface cooling ***,with the non-linearity in surface stretching there are significant percentage hikes of surface-drag force magnitude and surface cooling rate.

关键词： Non-linear mixed convection Non-linear thermal radiation Non-linear stretching sheet Newtonian fluid

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Optimization of variables and assessment of in-vitro and in-vivo antihyperlipidemic activity of Eudragit RS nanoparticles containing simvastatin

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Particuology 2024年第7期90卷 189-198页

作者： Bina Gidwani Vishal Jain Veenu Joshi Ravindra kumar pandey Shiv Shankar Shukla Amber Vyas Columbia Institute of Pharmacy Raipur(C.G.)India University Institute of Pharmacy Pt Ravishankar Shukla UniversityRaipur(C.G.)India Center for Basic Science and Research Pt Ravishankar Shukla UniversityRaipur(C.G.)India

Simvastatin, a BCS class II drug, is associated with poor aqueous solubility, first-pass metabolism and short half-life. In the present work, nanoparticles were prepared and evaluated. Optimization of formulation and process parameters was done through the use of independent and dependent variables. Preliminary studies were done to determine suitable range of the concentration of Eudragit polymer (10%–30%) and the ratio of drug to polymer (1:1 to 1:5) for the formation of nanoparticles by emulsification and a solvent evaporation technique. Results revealed that the mean size of nanoparticles was affected by stirring speed from 5000 RPM, 8000 RPM, and 12000 RPM. The results of increase in association efficiency and percent yield with increase in amount of drug from 100 mg, 150 mg, and 200 mg in selected range were observed. In-vitro release studies showed that two formulations possess highest initial burst and slow sustained drug release. There was 2.93-fold decrease in total cholesterol and 3.27-fold increases in triglyceride level during in-vivo study.

关键词： Simvastatin Eudragit RS 100 Nanoparticles Hyperlipidemia

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Biological,pathological,and multifaceted therapeutic functions of exosomes to target cancer

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Oncology Research 2024年第1期32卷 73-94页

作者： VIGNESH BALAJI E DIVYA RAMESH MANISHA CHUNGAN SHAJU AKSHARA kumar SAMYAK pandey RAKSHA NAYAK V.ALKA SRISHTI MUNJAL AMIR SALIMI K.SREEDHARA RANGANATH PAI SHANKAR M.BAKKANNAVAR Department of Pharmacology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Forensic Medicine and Toxicology Kasturba Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India School of Health and Community Services Durham CollegeOshawaOntarioL1G2G5Canada Department of Pharmaceutical Regulatory Affairs and Management Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Clinical Psychology Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Speech and Hearing Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India

Exosomes,small tiny vesicle contains a large number of intracellular particles that employ to cause various diseases and prevent several pathological events as well in the human *** is considered a“double-edged sword”,and depending on its biological source,the action of exosomes varies under physiological ***,the isolation and characterization of the exosomes should be performed accurately and the methodology also will vary depending on the exosome ***,the uptake of exosomes from the recipients’cells is a vital and initial step for all the physiological *** are different mechanisms present in the exosomes’cellular uptake to deliver their cargo to acceptor *** the exosomal uptake takes place,it releases the intracellular particles that leads to activate the physiological *** though exosomes have lavish functions,there are some challenges associated with every step of their preparation to bring potential therapeutic ***,overcoming the pitfalls would give a desired quantity of exosomes with high purity.

关键词： Exosomes Physiology Cancer Therapeutics Challenges

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Performance validation of High Mountain Asia 8-meter Digital Elevation Model using ICESat-2 geolocated photons

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Journal of Mountain Science 2024年第8期21卷 2562-2578页

作者： Giribabu DANDABATHULA Subham ROY Omkar Shashikant GHATAGE Vaibhav Balaso KOLASE Shwetambari SATPUTE Koushik GHOSH Sahibnoor KAUR Satyanarayana PONDARI Apurba kumar BERA Sushil kumar SRIVASTAV Regional Remote Sensing Centre-West National Remote Sensing CentreIndian Space Research OrganisationJodhpur 342005India Department of Geography School of Earth SciencesBharathidasan UniversityTiruchirappalli 620024India Centre for Climate Change and Water Research Suresh Gyan Vihar UniversityJaipur 302017India Department of Geography Panjab UniversityChandigarh 160014India National Remote Sensing Centre Indian Space Research OrganisationHyderabad 500037India Regional Centres National Remote Sensing CentreIndian Space Research OrganisationNew Delhi 110049India

High Mountain Asia(HMA),recognized as a third pole,needs regular and intense studies as it is susceptible to climate *** accurate and high-resolution Digital Elevation Model(DEM)for this region enables us to analyze it in a 3D environment and understand its intricate role as the Water Tower of *** science teams of NASA realized an 8-m DEM using satellite stereo imagery for HMA,termed HMA 8-m *** this research,we assessed the vertical accuracy of HMA 8-m DEM using reference elevations from ICESat-2 geolocated photons at three test sites of varied topography and land *** were made from statistical quantifiers and elevation *** the world’s highest mountain,Mount Everest,and its surroundings,Root Mean Squared Error(RMSE)and Mean Absolute Error(MAE)resulted in 1.94 m and 1.66 m,respectively;however,a uniform positive bias observed in the elevation profiles indicates the seasonal snow cover change will dent the accurate estimation of the elevation in this sort of test *** second test site containing gentle slopes with forest patches has exhibited the Digital Surface Model(DSM)features with RMSE and MAE of 0.58 m and 0.52 m,*** third test site,situated in the Zanda County of the Qinghai-Tibet,is a relatively flat terrain bed,mostly bare earth with sudden river cuts,and has minimal errors with RMSE and MAE of 0.32 m and 0.29 m,respectively,and with a negligible ***,in one more test site,the feasibility of detecting the glacial lakes was tested,which resulted in exhibiting a flat surface over the surface of the lakes,indicating the potential of HMA 8-m DEM for deriving the hydrological *** results accrued in this investigation confirm that the HMA 8-m DEM has the best vertical accuracy and should be of high use for analyzing natural hazards and monitoring glacier surfaces.

关键词： High Mountain Asia Digital Elevation Model ICESat-2 geolocated photons Accuracy assessment

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Corrigendum to'Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics'[Genes&Diseases 10(2023)1367-1401]

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Genes & Diseases 2024年第4期11卷 426-427页

作者： Uttpal Anand Abhijit Dey Arvind K.Singh Chandel Rupa Sanyal Amarnath Mishra Devendra kumar pandey Valentina De Falco Arun Upadhyay Ramesh Kandimalla Anupama Chaudhary Jaspreet Kaur Dhanjal Saikat Dewanjee Jayalakshmi Vallamkondu Jose M.Perez de la Lastra Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Department of Botany Bhairab Ganguly College(affliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples FedericoⅡNaples 80131Italy Department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarhAjmerRajasthan 305817India CSiR-indian Institute of Chemical Technology HyderabadTelangana 500007India Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Department of Computational Biology Indraprastha Institute of Information Technology Delhi(ⅢT-D)Okhla Industrial EstatePhaseⅢNew Delhi 110020India Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of Macromolecules Research Group Instituto de Productos Naturales y AgrobiologiaIPNA-CSICSan Cristobal de La Laguna 38206TenerifeSpain

In the published article,there was an error in the affiliation information about the first author Uttpal Anand[a].Instead of"Department of Life Sciences,Ben-Gurion University of the Negev,Beer-Sheva 84105,Israel",it should be"CytoGene Research&Development LLP,K-51,UPSIDA Industrial Area,Kursi Road(Lucknow),***,225001,Uttar Pradesh,India".The authors would like to apologize for any inconvenience caused and state that this does not change the scientific conclusions of thearticle inanyway.

关键词： Cancer Cor targeted

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Current therapeutic modalities and chemopreventive role of natural products in liver cancer:Progress and promise

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World Journal of Hepatology 2023年第1期15卷 1-18页

作者： amit kumar Singh Shiv Vardan Singh Ramesh kumar Shashank kumar Sabyasachi Senapati Abhay K pandey Department of Botany Government Naveen Girls CollegeBalod(Hemchand Yadav University)DurgChattisgarhIndia Department of Biochemistry University of AllahabadPrayagraj 211002Uttar PradeshIndia Department of Biochemistry School of Basic and Applied SciencesCentral University of PunjabBathinda 151401PunjabIndia Department of Human Genetics and Molecular Medicine Central University of PunjabBathinda 151401PunjabIndia

Liver cancer is a severe concern for public health officials since the clinical cases are increasing each year,with an estimated 5-year survival rate of 30%–35%after *** carcinoma(HCC)constitutes a significant subtype of liver cancer(approximate75%)and is considered primary liver *** for liver cancer mainly depends on the stage of its progression,where surgery including,hepatectomy and liver transplantation,and ablation and radiotherapy are the prime *** advanced liver cancer,various drugs and immunotherapy are used as first-line treatment,whereas second-line treatment includes chemotherapeutic drugs from natural and synthetic *** and lenvatinib are first-line therapies,while regorafenib and ramucirumab are secondline *** metabolic and signaling pathways such as Notch,JAK/STAT,Hippo,TGF-β,and Wnt have played a critical role during HCC *** has also been implicated in liver ***-induced toxicity is a key obstacle in the treatment of liver cancer,necessitating the development of effective and safe medications,with natural compounds such as resveratrol,curcumin,diallyl sulfide,and others emerging as promising anticancer *** review highlights the current status of liver cancer research,signaling pathways,therapeutic targets,current treatment strategies and the chemopreventive role of various natural products in managing liver cancer.

关键词： Liver cancer Hepatocellular carcinoma Signaling pathways Therapeutic targets Natural products Chemopreventive

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Recent development in upconversion nanoparticles and their application in optogenetics:A review

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Journal of Rare Earths 2022年第6期40卷 847-861,I0001页

作者： Madhumita Patel Maninder Meenu Jitender kumar pandey Pawan kumar Rajkumar Patel Department of Chemistry and Nano Science Ewha Womans UniversitySeodaemun-guSeoul120-750South Korea College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058China School of Basic and Applied Sciences Adamas UniversityKolkata700126India Institut National de la Recherche Scientifique-Centreénergie Materiaux Télecommunications(INRS-EMT) VarennesQCCanada Department of Chemistry and Biochemistry University of Oklahoma101 Stephenson ParkwayNormanOK73019United States Energy&Environmental Science and Engineering(EESE) Integrated Science and Engineering Division(ISED)Underwood International CollegeYonsei University85 Songdogwahak-roYeonsu-guIncheon21983South Korea

Ion channels present in the plasma membrane are responsible for integration and propagation of electric signals,which transmit information in nerve *** of these ion channels leads to many neurological ***,optogenetic technology has gained a lot of attention for the manipulation of neuronal *** is a neuromodulation approach that has been developed to control neuronal functions and activities using *** lanthanide-doped upconversion nanoparticles(UCNPs)absorb low energy photons in near-infrared(NIR) window and emit high energy photons in the visible spectrum region via nonlinear *** the last few decades,UCNPs have gained great attention in various bio-medical applications such as bio-imaging,drug delivery and *** near-infrared illumination is considered more suitable for optogenetics application,due to its lower degree of light attenuation and higher tissue penetration compared to visible ***,UCNPs have been considered as the new promising candidates for optogenetics *** nanoparticlemediated optogenetic systems provide a great opportunity to manipulate the ion channel in deep ***,we summarize the upconversion photoluminescence in lanthanide doped nanomaterials and its mechanisms and several approaches adopted to tune emission color or enhance upconversion *** advances of lanthanide-doped UCNPs design strategy and their mechanism are ***,we discuss the neural circuitry modulation using upconversion nanoparticles mediated ***,the future perspectives towards optogenetics are also included.

关键词： Lanthanide Upconversion Optogenetics Nanoparticles Neuronal modulation Rare earths

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Mechanism and recent updates on insulin-related disorders

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世界临床病例杂志 2023年第25期11卷 5840-5856页

作者： Shashank kumar Sabyasachi Senapati Neetu Bhattacharya amit Bhattacharya Shashank kumar Maurya Hadiya Husain Jasvinder Singh Bhatti Abhay kumar pandey Department of Biochemistry Central University of PunjabBathinda 151401PunjabIndia Department of Human Genetics and Molecular Medicine Central University of PunjabBathinda 151401PunjabIndia Department of Zoology Dyal Singh CollegeUniversity of DelhiNew Delhi 110003India Department of Zoology Ramjas CollegeUniversity of DelhiNew Delhi 110007India Department of Zoology University of DelhiNew Delhi 110007India Department of Zoology University of LucknowLucknow 226007India Department of Biochemistry University of AllahabadAllahabad(Prayagraj)211002India

Insulin,a small protein with 51 amino acids synthesized by pancreatic β-cells,is crucial to sustain glucose homeostasis at biochemical and molecular *** metabolic dysfunctions are related to insulin-mediated altered glucose *** of the significant pathophysiological conditions linked to the insulin associated disorder is diabetes mellitus(DM)(type 1,type 2,and gestational).Insulin resistance(IR)is one of the major underlying causes of metabolic disorders despite its association with several physiological *** syndrome(MS)is another pathophysiological condition that is associated with IR,hypertension,and ***,several other pathophysiological disorders/diseases are associated with the insulin malfunctioning,which include polycystic ovary syndrome,neuronal disorders,and *** are an uncommon type of pancreatic β-cell-derived neuroendocrine tumor that makes up 2% of all pancreatic *** revealed that different biochemical events,molecular signaling pathways,microRNAs,and microbiota act as connecting links between insulin disorder and associated pathophysiology such as DM,insuloma,neurological disorder,MS,and *** this review,we focus on the insulin-related disorders and the underlying mechanisms associated with the pathophysiology.

关键词： Insulin disorder Diabetes Metabolic syndrome Neurological disorder Obesity Cancer

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A robust deep structured prediction model for petroleum reservoir characterization using pressure transient test data

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Petroleum Research 2022年第2期7卷 204-219页

作者： Rakesh kumar pandey Anil kumar Ajay Mandal Department of Petroleum and Energy Studies School of Engineering and TechnologyDIT UniversityDehradun248009India Data Science Research Group School of ComputingDIT UniversityDehradun248009India Department of Petroleum Engineering Indian Institute of Technology(Indian School of Mines)Dhanbad826004India

A robust deep learning model consisting of long short-term memory and fully connected neural net-works has been proposed to automatically interpret homogeneous petroleum reservoirs having infinite,no flow,and constant pressure outer boundary *** pressure change data recorded during the well test operation along with its derivative is input into the model to perform the classification for identifying the reservoir model and,further,regression to estimate output *** noise was added to analytical models while generating the synthetic training *** hyperparameters were regulated to perform model optimization,resulting in a batch size of 64,Adam optimization algorithm,learning rate of 0.01,and 80:10:10 data split ratio as the best choices of *** perfor-mance accuracy also increased with an increase in the number of samples during *** classification and regression metrics have been used to evaluate the performance of the *** paper also demonstrates the prediction performance of the optimized model using simulated and actual oil well pressure drawdown test *** proposed model achieved minimum and maximum relative errors of 0.0019 and 0.0308,respectively,in estimating output for the simulated test cases and relative error of 0.0319 for the real test case.

关键词： Well test Reservoir characterization Automatic interpretation Prediction model Hyperparameter tuning Performance indicator

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A graphical user interface(GUI)for model-based radiation-induced acoustic computed tomography

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Journal of Innovative Optical Health Sciences 2023年第1期16卷 39-53页

作者： Michelle Simon Prabodh kumar pandey Leshan Sun Liangzhong Xiang Department of Biomedical Engineering Samueli School of Engineering University of California IrvineCA 92617USA Department of Radiological Sciences School of Medicine University of California IrvineCA 92697USA Beckman Laser Institute&Medical Clinic University of California Irvine CA 92612USA

Radiation-induced acoustic computed tomography(RACT)is an evolving biomedical imaging modality that aims to reconstruct the radiation energy deposition in *** backprojection(BP)reconstructions carry noisy and limited-view ***-based algorithms have been demonstrated to overcome the drawbacks of ***,model-based algorithms are relatively more complex to develop and computationally ***,while a plethora of novel algorithms has been developed over the past decade,most of these algorithms are either not accessible,readily available,or hard to implement for researchers who are not well versed in *** developed a user-friendly MATLAB-based graphical user interface(GUI;RACT2D)that facilitates back-projection and model-based image reconstructions for twodimensional RACT *** included numerical and experimental X-ray-induced acoustic datasets to demonstrate the capabilities of the *** developed algorithms support parallel computing for evaluating reconstructions using the cores of the computer,thus further accelerating the reconstruction *** also share the MATLAB-based codes for evaluating RACT reconstructions,which users with MATLAB programming expertise can further modify to suit their *** shared GUI and codes can be of interest to researchers across the globe and assist them in e±cient evaluation of improved RACT reconstructions.

关键词： Radiation-induced acoustic computed tomography(RACT) image reconstruction graphical user interface(GUI) photoacoustic tomography

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