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Laboratory investigation on damping characteristics of homogeneous and stratified soil-ash system

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第10期15卷 2757-2777页

作者： amit kumar ram Supriya Mohanty Department of Civil Engineering Indian Institute of Technology(BHU)VaranasiVaranasi221005India

In this study,the damping responses of uniform soil,equi-proportional fly ash,and local soil as a single unit were *** large-strain cyclic triaxial tests were performed for the specimen compacted at the desired density(95%e99%of maximum dry density).The compacted specimens were tested under the loading frequency of 0.3e1 Hz with medium confinement of 70e100 ***,the unsymmetrical behavior of the hysteresis loop was analyzed using three different damping estimation approaches,*** hysteresis loop(SHL),asymmetric hysteresis loop(ASHL),and the modified American Society for Testing and Materials(ASTM)*** outcome of the study shows for fly ash,local soil,and layered soil-ash,the ASHL technique has the highest damping value,followed by ASTM and then the SHL *** specimens prepared under high density and subjected to high confinement show low damping ***,the specimens tested at high frequency exhibits high damping ***,the damping value of fly ash determined using the SHL and ASHL methods has a similar profile and reaches a maximum at 1%shear strain value before *** composite stratified deposit exhibits more dependency on relative compaction,confining pressure,and less on loading *** on the results,it is highly recommended to use the ASHL approach,especially under large strain conditions irrespective of soil *** maximum damping ratio of stratified deposits is always in between the damping ratio of local soil and fly *** damping ratio of stratified soil and local soil is slightly larger than that of the other soils,although the damping ratio of fly ash is equivalent to that of the sand and clayey *** results may be helpful in the accurate determination of the damping properties of the layered soil-ash system that is required in the seismic response analysis.

关键词： Homogeneous soil Stratified soil-ash system Damping behavior Cyclic triaxial test Asymmetric hysteresis loop Model fitting

Role of zonula occludens in gastrointestinal and liver cancers

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World Journal of Clinical Cases 2022年第12期10卷 3647-3661页

作者： amit kumar ram Balasubramaniyan Vairappan Liver Diseases Research Lab Department of BiochemistryJawaharlal Institute of Postgraduate Medical Education and ResearchPondicherry 605006India

A growing body of evidence suggests that tight junction(TJ)proteins play a crucial role in the pathogenesis of various diseases,including gastrointestinal(GI)cancer and hepatocellular carcinoma(HCC).TJ proteins primarily maintain the epithelial and endothelial cells intact together through integral proteins however,recent reports suggest that they also regulate gene expression necessary for cell proliferation,angiogenesis,and metastasis through adapter proteins such as zonula occludens(ZO).ZO proteins are membrane-associated cytosolic scaffolding proteins that modulate cell proliferation by interacting with several transcription *** ZO proteins in GI cancer and HCC are correlated with tumor development and poor *** has searched for using the keyword ZO and gastric cancer,ZO and cancer,and ZO and HCC for the last ten years to *** review summarized the role of ZO proteins in cell proliferation and their expression in GI cancer and ***,therapeutic interventions targeting ZO in GI and liver cancers are reviewed.

关键词： Tight junction Zonula occludens-1 Zonula occludens-1 associated nucleic acid binding protein Hepatocellular carcinoma Colon cancer Gastric cancer

Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis

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World Journal of Gastroenterology 2020年第45期26卷 7131-7152页

作者： amit kumar ram Balasubramaniyan Vairappan BH Srinivas Liver Diseases Research Lab Department of BiochemistryJawaharlal Institute of Postgraduate Medical Education and Research(JIPMER)Dhanvantari NagarPuducherry 605006India Department of Pathology Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER)Dhanvantari NagarPuducherry 605006India

BACKGROUND Altered tight junction(TJ)proteins are correlated with carcinogenesis and tumor *** is a tetranotriterpenoid that has been shown to have antioxidant and anti-proliferative properties;however,its anticancer effects and molecular mechanism in hepatocellular carcinoma(HCC)remains *** To investigate the effect of nimbolide on TJ proteins,cell cycle progression,and hepatic inflammation in a mouse model of *** HCC was induced in male Swiss albino mice(CD-1 strain)by a single intraperitoneal injection of 100 mg/kg diethylnitrosamine(DEN)followed by 80 ppm N-nitrosomorpholine(NMOR)in drinking water for 28 *** 28 wk,nimbolide(6 mg/kg)was given orally for four consecutive weeks in DEN/NMOR induced HCC *** the end of the 32nd week,all the mice were sacrificed and blood and liver samples were collected for various *** examinations of hepatic nodules were *** histology and HCC tumor markers such as alpha-fetoprotein(AFP)and glypican-3 were *** of TJ proteins,cell proliferation,and cell cycle markers,inflammatory markers,and oxidative stress markers were *** silico analysis was performed to confirm the binding and modulatory effect of nimbolide on zonula occludens 1(ZO-1),nuclear factor of kappa light polypeptide gene enhancer in B-cells(NF-κB),and tumor necrosis factor alpha(TNF-α).RESULTS We found nimbolide treatment at a concentration of 6 mg/kg to HCC mice reduced hepatic tumor size by 52.08%and tumor volume(P<0.01),and delayed tumor growth in HCC mice with a concomitant reduction in tumor markers such as AFP levels(P<0.01)and glypican-3 expression(P<0.05).Furthermore,nimbolide treatment increased tight junction proteins such as ZO-1 and occludin expression(P<0.05,respectively)and reduced ZO-1 associated nucleic acid binding protein expression(P<0.001)in HCC mice *** treatment to HCC mice also inhibited cell proliferation and suppressed cell cycle progression

关键词： Hepatocellular carcinoma Nimbolide Tight junction Inflammation Oxidative stress Zonula occludens 1 associated nucleic acid binding protein

Performance of Marine Power Plant Given Generator, Main and Distribution Switchboard Failures

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Journal of Marine Science and Application 2015年第4期14卷 450-458页

作者： amit kumar Mangey ram Department of Mathematics Graphic Era University Dehradun 248002 lndia

Power generation is one of the most essential functions of any plant for continuous functioning without any interruption. A marine power plant （MPP） is the same section. In the present paper, the authors have tried to find the various reliability characteristics of an MPR A marine power plant which is a composition of two generators and in which one of them is located at the stern and another at the bow, both associated to the main switchboard （MSB）. The distribution switchboards （DSB） receive power from the MSB through cables and their respective junctions. Given that arrangement, a working based transition state diagram has been generated. With the help of the Markov process, a number of intro-differential equations are formed and solved by Laplace transform. Various reliability characteristics are calculated and discussed with the help of graphs.

关键词： marine Markov process switchboards (DSB) engineering marine main switchboards sensitivity analysis rel power plant (MPP) (MSB) distribution iability theory

Smart tailoring of molecular catalysts:Mounting approach to oxygen reduction reaction

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Journal of Materials Science & Technology 2024年第1期168卷 169-184页

作者： Anuj kumar Mohd Ubaidullah Guoxin Zhang Jasvinder Kaur Saira Ajmal Mudassir Hasan Krishna kumar Yadav Hafiz M.Adeel Sharif ram K.Gupta Ghulam Yasin Nano-Technology Research Laboratory Department of ChemistryGLA UniversityMathuraUttar Pradesh 281406India Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdaoShandong 266590China Institute for Advanced Study Shenzhen UniversityShenzhenGuangdong 518060China Department of Chemistry Kansas Polymer Research CenterPittsburg State UniversityPittsburgKS 66762United States Faculty of Science and Technology Madhyanchal Professional UniversityRatibadBhopal 462044India Environmental and Atmospheric Sciences Research Group Scientific Research CenterAl-Ayen UniversityThi-QarNasiriyah 64001Iraq Department of Chemical Engineering King Khalid University Saudi Arabia Department of Chemistry School of SciencesIFTM UniversityMoradabadUttar Pradesh 244102India Research Center for Eco-Environmental Engineering Dongguan University of TechnologyDongguan 523808China School of Environment and Civil Engineering Dongguan University of TechnologyDongguanGuangdong 523808China

Efficient electrocatalytic rupture of energy-rich molecules(H_(2)and O_(2))is a green approach for gener-ating clean energy for modern *** this context,porphyry-type molecular electrocatalysts act intelligently toward oxygen reduction reaction(ORR),a fundamental process in fuel cells,due to their redox-rich chemistry,which involves core metal ions and macrocyclic *** concerned scientific community has tried many times to correlate the ORR intermediates with their formation kinetics and simplify the associated multi H+/e-stages during the ORR process,constructing several volcano plots be-tween catalytic Tafel data,turnover frequencies,and overpotentials for many *** the fact that many review articles on molecular electrocatalysts for ORR have been published,understanding the strategic implications and molecular catalyst intelligence towards homogenous ORR has been poorly *** review examined the relationships between volcano plots of current *** parameters and the Sabatier principle in order to explain the intelligence of molecular electrocatalysts and approaches for their creation,as well as the difficulties and potential prospects of molecular *** facts distinguish this review from previously published articles and will pique the scien-tific community’s interest in avoiding trial-and-error procedures for catalyst creation while also allowing for more exact evaluations of the molecular catalyst’s performance.

关键词： Electrocatalysis Molecular catalysts Oxygen reduction reaction Sabatier principle

Prediction of bearing capacity of pile foundation using deep learning approaches

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Frontiers of Structural and Civil Engineering 2024年第6期18卷 870-886页

作者： Manish kumar Divesh Ranjan kumar Jitendra KHATTI Pijush SAMUI Kamaldeep Singh GROVER Department of Civil Engineering SRM Institute of Science and Technology Tiruchirappalli CampusTrichy 621105India Department of Civil Engineering National Institute of Technology PatnaBihar 800005India Department of Civil Engineering Faculty of EngineeringThammasat School of EngineeringThammasat UniversityBangkok10200Thailand Department of Civil Engineering Rajasthan Technical UniversityKota 324010India

The accurate prediction of bearing capacity is crucial in ensuring the structural integrity and safety of pile *** research compares the Deep Neural Networks(DNN),Convolutional Neural Networks(CNN),Recurrent Neural Networks(RNN),Long Short-Term Memory(LSTM),and Bidirectional LSTM(BiLSTM)algorithms utilizing a data set of 257 dynamic pile load tests for the first ***,this research illustrates the multicollinearity effect on DNN,CNN,RNN,LSTM,and BiLSTM models’performance and accuracy for the first time.A comprehensive comparative analysis is conducted,employing various statistical performance parameters,rank analysis,and error matrix to evaluate the performance of these *** performance is further validated using external validation,and visual interpretation is provided using the regression error characteristics(REC)curve and Taylor *** from the comparative analysis reveal that the DNN(Coefficient of determination(R^(2))_(training(TR))=0.97,root mean squared error(RMSE)_(TR)=0.0413;R^(2)_(testing(TS))=0.9,RMSE_(TS)=0.08)followed by BiLSTM(R^(2)_(TR)=0.91,RMSE_(TR)=0.782;R^(2)_(TS)=0.89,RMSE_(TS)=0.0862)model demonstrates the highest performance *** is noted that the BiLSTM model is better than LSTM because the BiLSTM model,which increases the amount of information for the network,is a sequence processing model made up of two LSTMs,one of which takes the input in a forward manner,and the other in a backward *** prediction of pile-bearing capacity is strongly influenced by ram weight(having a considerable multicollinearity level),and the effect of the considerable multicollinearity level has been determined for the model based on the recurrent neural network *** this study,the recurrent neural network model has the least performance and accuracy in predicting the pile-bearing capacity.

关键词： deep learning algorithms high-strain dynamic pile test bearing capacity of the pile

Autologous peripheral blood-derived orthobiologics:Different types and their effectiveness in managing knee osteoarthritis

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World Journal of Orthopedics 2024年第5期15卷 400-403页

作者： Ashim Gupta Vijay kumar Jain Department of Orthopaedics and Regenerative Medicine Future BiologicsLawrencevilleGA 30043United States Department of Orthopaedics South Texas Orthopaedic Research Institute(STORI Inc.)LaredoTX 78045United States Department of Regenerative Medicine BioIntegrateLawrencevilleGA 30043United States Department of Orthopaedics and Regenerative Medicine Regenerative OrthopaedicsNoida 201301India Department of Orthopaedics Atal Bihari Vajpayee Institute of Medical SciencesDr.Ram Manohar Lohia HospitalDelhi 110001New DelhiIndia

Knees are the most commonly impacted weight-bearing joints in osteoarthritis(OA),affecting millions of people *** increasing life spans and obesity rates,the incidence of knee OA will further increase,leading to a significant increase in the economic *** treatment modalities utilized to manage knee OA have *** the last decade,the role of various autologous peripheral blood-derived orthobiologics(APBOs)for the treatment of knee OA has been extensively *** editorial provided an overview and focused on defining and shedding light on the current state of evidence based on the most recent published clinical studies concerning the use of APBO for the management of knee *** numerous studies have demonstrated promising results for these preparations,a notable gap exists in the comparative analysis of these diverse *** absence of head-to-head studies poses a considerable challenge for physicians/surgeons in determining the optimal preparation for managing knee OA and achieving sustained longterm ***,more adequately powered,multicenter,prospective,doubleblind,randomized controlled trials with longer follow-ups are needed to establish the long-term efficacy and to aid physicians/surgeons in determining the optimal APBO for the management of knee OA.

关键词： Knee osteoarthritis Platelet-rich plasma Platelet lysate Autologous conditioned serum Gold-induced cytokine Plasma rich in growth factors Growth factor concentrate Autologous protein solution Platelet-rich fibrin Hyperacute serum

Effect of weight-adjusted antimicrobial antibiotic prophylaxis on postoperative dosage and surgical site infection incidence in total joint arthroplasty

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World Journal of Orthopedics 2024年第4期15卷 318-320页

Surgical site infections(SSI)following total joint arthroplasty pose a significant concern for both providers and patients across the ***,administration of antimicrobial antibiotic prophylaxis is used throughout the world to reduce the incidence of ***,the correct dosage and frequency of administration remains *** this editorial,we emphasized the determination of the effect of administration of weight-adjusted antimicrobial antibiotic prophylaxis regime on the incidence of SSI and postoperative dosage reduction compared to the conventionally used regime during total joint *** results demonstrated similar efficacy between both regimes with respect to the incidence of *** addition,weight-adjustment led to reduced postoperative dosage and has the potential to reduce chances of achieving lower therapeutic concentration,drug resistance,drug toxicity,and costs.

关键词： Antibiotics Antimicrobial prophylaxis Weight-adjusted Surgical site infections Total joint arthroplasty Knee arthroplasty Hip arthroplasty

Depillaring of total thickness of a thick coal seam in single lift using cable bolts：A case study

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International Journal of Mining Science and Technology 2016年第2期26卷 223-233页

作者： kumar Rakesh Mishra Arvind kumar Singh Arun kumar Singh amit kumar ram Sahendr Singh Rajendr Central Institute of Mining and Fuel Research (under CSIR) Dhanbad 826015 India Indian School of Mines Dhanbad 826004 India

Explaining fundamentals of application of cable bolting for a thick seam depillaring,this paper summarizes the results of field studies conducted during adoption of this approach in more than fifteen panels of Madhusudanpur 7 pit and incline *** 7.0 m thick Kajora top coal seam of this mine is developed on pillars along the floor horizon to an average height of 3.0 m,leaving a coal band of around 4.0 m along the *** of procured core samples showed that roof strata are easily caveable with a caveability index value of around 2000 *** caveable overlying strata and shallow depth of cover alleviated most of the expected strata mechanics problems of the thick seam ***,extraction of total thickness at shallow cover caused differential-subsidence and cracks on the *** manifestations were immediately tackled to avoid creation of a breathing path for spontaneous heating in the extracted area.

关键词： Cable bolting Thick seam depillaring Extraction height Pillar stability Caveability index