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Optics-based metaheuristic approach to assess critical failure surfaces in both circular and non-circular failure modes for slope stability analysis

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Rock Mechanics Bulletin

Rock Mechanics Bulletin 2024年第1期3卷 37-54页

作者： Jayraj Singh amit kumar Verma Haider Banka Ravishankar kumar amit jaiswal Department of Computer Science&Engineering NIIT UniversityRajasthanIndia Department of Civil&Environment Engineering Indian Institute of TechnologyPatnaBihar801106India Department of Computer Science&Engineering Indian Institute of Technology(ISM)DhanbadJharkhand826004India Department of Mining Bharat Coking Coal LimitedDhanbadJharkhand826005India

In many construction projects,a proactive slope stability evaluation is a *** many deterministic or non-deterministic approaches have been commonly used,metaheuristic approaches have resulted in high precision and significant outcomes for slope stability analysis *** current work focuses on the reliable assessment of critical failure surfaces associated with the least factor of safety value in both homogeneous and non-homogeneous slopes using a new simplified meta-heuristic approach called optics-inspired optimization(OIO).The algorithm utilizes six different LEM methods as a fitness function for deriving the factor of *** analysis over three benchmark studies has been performed to demonstrate the algorithm's robustness and *** implementation found more robust results as compared to previous ***,the algorithm's statistical implication is conducted using the ANOVA test,which inferred better *** this interpretation,the approach claims to be suitable and efficient for slope stability analysis.

关键词： OIO-Algorithm Metaheuristic algorithms Slope stability analysis Critical failure surface LEM'S procedure

Therapeutic opportunities and challenges of induced pluripotent stem cells-derived motor neurons for treatment of amyotrophic lateral sclerosis and motor neuron disease

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Neural Regeneration Research 2017年第5期12卷 723-736页

作者： Manoj kumar jaiswal Molecular Imaging and Neuropathology Division New York State Psychiatry Institute Columbia University New York NY USA Department of Psychiatry Columbia University New York NY USA

Amyotrophic lateral sclerosis（ALS） and motor neuron diseases（MNDs） are progressive neurodegenerative diseases that affect nerve cells in the brain affecting upper and lower motor neurons（UMNs/LMNs）, brain stem and spinal cord. The clinical phenotype is characterized by loss of motor neurons（MNs）, muscular weakness and atrophy eventually leading to paralysis and death due to respiratory failure within 3–5 years after disease onset. No effective treatment or cure is currently available that halts or reverses ALS and MND except FDA approved drug riluzole that only modestly slows the progression of ALS in some patients. Recent advances in human derived induced pluripotent stem cells have made it possible for the first time to obtain substantial amounts of human cells to recapitulate in vitro “disease in dish” and test some of the underlying pathogenetic mechanisms involved in ALS and MNDs. In this review, I discussed the opportunities and challenges of induced pluropotent stem cells-derived motor neurons for treatment of ALS and MND patients with special emphasis on their implications in finding a cure for ALS and MNDs.

关键词： iPSCs stem cells human patients ALS mitochondria motor neuron disease disease modeling neurodegeneration gene editing transplantation drug screening

Randomized controlled trial of topical EMLA and vapocoolant spray for reducing pain during wDPT vaccination

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World Journal of Pediatrics 2017年第3期13卷 236-241页

作者： Navratan kumar Gupta amit Upadhyay Ajeet kumar Dwivedi Astha Agarwal Vijay jaiswal Abhishek Singh Department of Pediatrics LLRMMedical CollegeMeerut(UP)India

Background:Intramuscular vaccination is among the most common source of iatrogenic pain in *** sprays are rapid-acting alternative to topical *** provide transient anesthesia via evaporation induced skin cooling,and reduce pain due to vaccine injection in children and *** objective was to compare the synergistic analgesic effect of eutectic mixture of local anesthetics (EMLA) with breastfeeding (EB group) and vapocoolant spay with breastfeeding (VB group) to that of only breastfeeding (BO group) during whole cell diptheria,pertussis and tetanus (wDPT) ***:A double blind randomized controlled trial was done to include infants up to 3 months of age who came for their first wDPT *** primary outcome variable was the duration of cry after *** outcome variables were Modified Facial Coding Score,Neonatal Infant Pain Scale and latency of onset of ***:Of the 201 eligible participants,111 babies were excluded and remaining 90 babies were randomized into three groups of thirty *** groups did not differ significantly in baseline *** (interquartile range,IQR) of duration of cry was lesser [35.86 (21.07-107.75) seconds] in babies receiving EMLA cream with breast feeding (EB group) and in babies receiving vapocoolant spray with breast feeding (VB group) [32.58 (21.25-106.21) seconds] as compared to babies receiving only breast feeding (BO group) [67.5 (27.6-180) seconds] (P=-0.147).Difference in median (IQR) of latency of cry was not statistically *** Facial Coding Score and Neonatal Infant Pain Scale at 1 minute and 3 minutes was significantly lower in the EB and VB group,as compared to the BO group (P<0.05).Conclusions:Addition of topical EMLA application or vapocoolant spray to breastfeeding during wDPT vaccination does not reduce duration of cry in infants up to 3 months of ***,they are able to show reduction in pain score and further studi

关键词： diptheria,pertussis and tetanus vaccine eutectic mixture of local anesthetics Modified Facial Coding Score Neonatal Infant Pain Scale

Peripheral cemento-ossifying fibroma: A case report with review of literature

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World Journal of Clinical Cases 2013年第3期1卷 128-133页

作者： amit kumar Mishra Rahul Maru Shrikant Vishnuprasad Dhodapkar Gagan jaiswal Rajesh kumar Heena Punjabi Sri Aurobindo Institute of Dentistry and Post Graduate Institute Indore 452018India

Peripheral cemento-ossifying fibroma(PCOF) is a rare osteogenic neoplasm that ordinarily presents as an epulis-like growth. This is of a reactive rather than neoplastic nature and its pathogenesis is uncertain. PCOF predominantly affects adolescent and young adults with greatest prevalence around 28 years. We report here a rare clinical case of PCOF of the mandible, 1 cm mesiodistally and 1.5 cm occluso-gingivally in diameter, which caused difficulty in eating and speech, in a 42-year-old female patient. She was asymptomatic for 1 year and on follow-up for 6 mo post surgically showed gingival health and normal radioopacity of bone without any recurrence. Clinical, radiographic and histological characteristics are discussed and recommendations regarding differential diagnosis, treatment and follow up are provided. The controversial varied nomenclature and possible etiopathogenesis of PCOF are emphasized.

关键词： Peripheral cemento-ossifying fibroma Gingivectomy Granuloma

Molecular mechanism of noradrenaline during the stress-induced major depressive disorder

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Neural Regeneration Research 2018年第7期13卷 1159-1169页

作者： Kenjiro Seki Satomi Yoshida Manoj kumar jaiswal Department of Pharmacology School of Pharmaceutical ScienceOhu University Department of Psychiatry Icahn School of Medicine at Mount Sinai

Chronic stress-induced depression is a common hallmark of many psychiatric disorders with high morbidity ***-induced dysregulation of noradrenergic system has been implicated in the pathogenesis of *** of monoamine in the brain has been believed to be the main causative factor behind pathophysiology of major depressive disorder（MDD） and several antidepressants functions by increasing the monoamine level at the synapses in the ***,it is undetermined whether the noradrenergic receptor stimulation is critical for the therapeutic effect of *** to noradrenergic receptor stimulation,it has been suggested that the desensitization of β-adrenoceptor is involved in the therapeutic effect of *** addition,enhanced noradrenaline（NA） release is central response to stress and thought to be a risk factor for the development of ***,fast acting antidepressant suppresses the hyperactivation of noradrenergic neurons in locus coeruleus（LC）.However,it is unclear how they alter the firing activity of LC *** inconsistent reports about antidepressant effect of NA-reuptake inhibitors（NRIs） and enhanced release of NA as a stress response complicate our understanding about the pathophysiology of *** this review,we will discuss the role of NA in pathophysiology of stress and the mechanism of therapeutic effect of NA in *** will also discuss the possible contributions of each subtype of noradrenergic receptors on LC neurons,hypothalamic-pituitary-adrenal axis（HPA-axis） and brain derived neurotrophic factor-induced hippocampal neurogenesis during stress and therapeutic effect of NRIs in MDD.

关键词： major depression stress noradrenaline noradrenaline-reuptake inhibitors serotonin receptors hypothalamic-pituitary-adrenal axis locus coeruleus selective serotonin reuptake inhibitors serotonin noradrenaline-reuptake inhibitors

Estimation of drift limits for different seismic damage states of RC frame staging in elevated water tanks using Park and Ang damage index

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Earthquake Engineering and Engineering Vibration 2020年第1期19卷 161-177页

作者： Suraj O.Lakhade Ratnesh kumar O.R.jaiswal Department of Applied Mechanics Visvesvaraya National Institute of Technology

Damage to elevated water tanks in past earthquakes can be attributed to the poor performance of their supporting frame staging. In order to ascertain the performance of these elevated water tanks, it is crucial to categorize the damage in quantifiable damage states. Among various parameters to quantify the damage states, the top drift of frame staging can be conveniently correlated to the different damage levels. In literature, drift limits corresponding to different damage states of the frame staging of the elevated water tank are not available. In the present study, drift limits for RC frame staging in elevated water tanks corresponding to different seismic damage states have been proposed. Various damage states of the elevated water tank have been determined using the Park and Ang damage index. The Park and Ang damage index utilizes results of both pushover analysis and incremental dynamic analysis. Twelve models of elevated water tanks have been developed considering variation in staging height and tank capacity. Incremental dynamic analysis has been performed using the suite of twelve actual earthquake ground motions. Based on the regression analysis between damage indexes and drift, limiting drift values for each damage state are proposed.

关键词： elevated water tank frame staging damage states drift limit 3D modelling incremental dynamic analysis pushover analysis

Role of MgF2 addition on high energy ball milled kalsilite:Implementation as dental porcelain with low temperature frit

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Journal of Advanced Ceramics 2014年第4期3卷 332-338页

作者： Pattem Hemanth kumar Abhinav SRIVASTAVA Vijay kumar Nandini jaiswal Pradeep kumar Vinay kumar SINGH Department of Ceramic Engineering Indian Institute of Technology(BHU)VaranasiIndia Department of Chemical Engineering Indian Institute of Technology(BHU)VaranasiIndia

Porcelain fused to metal(PFM)has received great attention over the last few years due to its importance in the ***(K_(2)O·Al_(2)O_(3)·SiO_(2))is a high thermal expansion porcelain,suitable for bonding to ***,kalsilite is a metastable phase which gets converted into crystalline leucite upon *** the current work feasibility of developing stable kalsilite phase,dispersion of MgF2 in it as an additive and using mechanochemical synthesis are *** fine dental material has been formulated by mixing prepared kalsilite with low temperature frit(LTF)in different *** crystalline phases evolved in fired powders are characterized by powder X-ray diffraction(XRD)*** with different ratio of LTF has been cold pressed and heat treated to examine its coefficient of thermal expansion(CTE),flexural strength,apparent porosity(AP),bulk density(BD)and *** indicate that MgF_(2) addition and high milling duration help in kalsilite *** also plays an important role in this stabilization,and at 1100℃single phase kalsilite formation is *** outcomes demonstrate that it is easily possible to synthesize a stable single phase kalsilite with desirable properties.

关键词： kalsilite porcelain fused to metal(PFM) dental ceramic mechanochemical synthesis thermal expansion X-ray diffraction(XRD)

DIC Based Strain and Damage Analysis of Large Scale Steel to Composite Adhesive Joints Subjected to Tension and Compression Loading

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China Ocean Engineering 2023年第4期37卷 588-597页

作者： Pankaj R.jaiswal Rahul Iyer kumar Richard TRUMPER Wim DE WAELE Soete Laboratory Department of ElectromechanicalSystems and Metal Engineering(EMSME)Ghent UniversityGhent 9052Belgium BAE systems London SW1Y 5ADUnited Kingdom

This paper reports an experimental study of the mechanical response to tensile and compressive force of large scale steel to composite joints adhesively bonded with a thin layer of vinylester *** one specimen,the length of the reinforcing fibres in contact with the steel substrate has been reduced by saw cutting at both ends of the *** damaged specimen and four intact specimens were subjected to quasi-static tensile testing;six specimens were used for compression *** strain distribution at the composite surface and at the steel to hardwood connection of the specimen was monitored by digital image correlation(DIC).DIC allowed identifying the onset of damage in the tensile tested joints near the interface of the composite layer and the steel-hardwood *** tensile and compression tested specimens failed due to significant peel strain concentration at the composite near the connection of steel and *** average strength of a specimen tested in compression was about 66%higher than the average strength of a specimen tested in *** strain concentration zone in the damaged specimen was away from the introduced saw *** a result the damaged and intact tensile specimens showed the same failure strength and *** specimens failed by adhesive failure between the composite-hardwood interface.

关键词： vinylester resin multi-material joint strain damage digital image correlation.

Anti-cancer effects of sitagliptin,vildagliptin,and exendin-4 on triple-negative breast cancer cells via mitochondrial modulation

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BIOCELL 2022年第12期46卷 2645-2657页

作者： POOJA jaiswal VERSHA TRIPATHI ANSHUL ASSAIYA DHARMENDRA KASHYAP RAHUL DUBEY ANAMIKA SINGH JANESH kumar HEM CHANDRA JHA RAJESH SHARMA amit kumar DIXIT HAMENDRA SINGH PARMAR School of Biotechnology Devi Ahilya UniversityIndore452001India Laboratory of Membrane Protein Biology National Centre for Cell SciencePune411007India Department of Biosciences and Biomedical Engineering Indian Institute of TechnologyIndore452020India Department of Biotechnology IPS AcademyIndore452012India School of Pharmacy Devi Ahilya UniversityIndore452001India Central Council for Research in Ayurvedic Sciences Kolkata263645India

Triple-negative breast cancer(TNBC)cell line MDA-MB-231 is known for Warburg metabolism and defects in *** the other hand,dipeptidyl peptidase-IV(DPP-IV)inhibitors such as sitagliptin and vildagliptin and GLP-1 agonist exendin-4 are known to improve mitochondrial functions as well as biogenesis,but no study has evaluated the influence of these drugs on mitochondrial biogenesis on metastatic breast cancer cell *** have recently reported anticancer effects of 5-aminoimidazole-4-carboxamide riboside on MDA-MB-231 cells via activation of AMP-dependent kinase(AMPK),which activates the downstream transcription factors PGC-1α,PGC-1β,or FOXO1 for mitochondrial biogenesis;above-mentioned incretin-based therapies are also known to activate *** study evaluated the effects of sitagliptin,vildagliptin,and exendin-4 on MDA-MB-231 cells and the underlying changes in mitochondrial biogenesis,were *** with sitagliptin(100μM),vildagliptin(100μM),and exendin-4(10 nM)for 72 h to MDA-MB-231 cells led to a decrease in viability indicated by MTT assay,cell migration by scratch,and transwell migration assays,accompanied with marginal reduction in cell numbers along with the apoptotic appearance,the rate of apoptosis,and decreased lactate content in conditioned *** changes in the cancer phenotype were accompanied by an increase in the mitochondrial DNA to nuclear DNA ratio,increased MitoTracker green and red staining,and increased expression of transcription factors PGC-1α,NRF-1,NRF-2,TFAM,and ***-treatment of cells with these incretin-based drugs followed by 48 h treatment with 1μM doxorubicin increased doxorubicin sensitivity as observed by a decrease in viability by MTT ***,sitagliptin,vildagliptin,and exendin-4 exert their beneficial effects on TNBC cells via an increase in mitochondrial biogenesis that helps to switch Warburg metabolism into anti-Warburg *** response was in the order of:sitagliptin>vildagliptin>ex

关键词： Sitagliptin Vildagliptin Exendin-4 Apoptosis Migration Viability Chemo-sensitivity Mitochondrial biogenesis