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Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus

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World Journal of Diabetes 2018年第6期9卷 80-91页

作者： Vishal J Patel amit a joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain Department of Pharmacology and Toxicology Zydus Research CentreCadila Healthcare Limited

AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal *** Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia.

关键词： Coagonist Glucagon Renal dysfunction Glucagon-like peptide-1 Insulin sensitivity

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Cerebral tuberculoma:critical review of two cases

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Asian Pacific Journal of Tropical Medicine 2008年第4期1卷 67-71页

作者： amit Agrawal Sameer Singhal S.R.joharapurkar S.J.Vagha Bhushan Wani Department of Surgery Datta Meghe Institute of Medical SciencesSawangi(Meghe) Wardha India Department of Medicine Datta Meghe Institute of Medical SciencesSawangi(Meghe) Wardha India Datta Meghe Institute of Medical Sciences Datta Meghe Institute of Medical SciencesSawangi(Meghe)Wardha.India Department of Pathology Datta Meghe Institute of Medical SciencesSawangi(Meghe)Wardha India Department of Surgery Datta Meghe Institute of Medical SciencesSawangi(Meghe)Wardha India

Central nervous system tuberculosis can have protean *** review the clinical and radiological findings in two cases of cerebral tuberculoma in immuoncompetent *** two cases represent the spectrum of variations of clinical and radiological features of cerebral tuberculoma and highlight the controversies in the approach to diagnosis and management.

关键词： Cerebral tuberculoma Intracerebral mass Tuberculoma Tuberculosis

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Lichen planus and hepatitis c virus (HCV)-there is no association:A serological case control study

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海南医学院学报 2010年第2期16卷 154-156页

作者： Adarsh Lata Singh Sanjeev Chaudhary A.D.Salodkar S.R.joharapurkar Associate Professor in Dermatology Department of DermatologyDatta Meghe Institute of Medical SciencesSawangi(Meghe) Assistant Professor in Dermatology Department of DermatologyDatta Meghe Institute of Medical SciencesSawangi(Meghe) Department of Dermatology Datta Meghe Institute of Medical SciencesSawangi(Meghe) Director DMDPGME & R Datta Meghe Institute of Medical SciencesSawangi(Meghe)

Fifty patients(28 males and 22 females)with lichen planus were tested for anti HCV *** of them gave positive result in our case control *** were various studies conducted in different parts of the world that proved or... 详细信息

关键词：丙型肝炎治疗方法临床分析预防措施

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