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Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

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Frontiers of Chemical Science and Engineering 2013年第1期7卷 116-122页

作者： Ranvijay KUMAR Kaushlendra sharma Birla Institute of Technology Pama 800014 India

Polymethacrylic acid （PMA） was synthesized on the backbone of psyllium （Psy） by a microwave assisted method to prepare polymeric grafted materials designated as （Psy-g-PMA）. Various grades of Psy-g-PMA were prepared by changing the degree of grafting from 35%- 58% and the materials were then made into tablets. Swelling and biodegradability studies of the tablets were carried out. Acetyl salicylic acid was incorporated in the various Psy-g-PMA samples and tablets were prepared to study the in vitro drug release in acidic （pH = 4）, neutral （pH = 7）, and basic （pH = 9） media. In the acidic medium, the swelling was more than 1300%. In addition, the biodegradable Psy-g-PMA had the highest drug release in the acidic medium. This may be attributed to Fickian diffusion since the drug and the medium in which it was released have the same acidic nature.

关键词： psyllium acetyl salicylic acid in-vitro drug release swelling biodegradation

Boundary conditions for porous solids saturated with viscous fluid

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Applied Mathematics and Mechanics(English Edition) 2009年第7期30卷 821-832页

作者： M.D.sharma Department of Mathematics Kurukshetra University

Boundary conditions are derived to represent the continuity requirements at the boundaries of a porous solid saturated with viscous fluid. They are derived from the physically grounded principles with a mathematical check on the conservation of energy. The poroelastic solid is a dissipative one for the presence of viscosity in the interstitial fluid. The dissipative stresses due to the viscosity of pore-fluid are well represented in the boundary conditions. The unequal particle motions of two constituents of porous aggre~ gate at a boundary between two solids are explained in terms of the drainage of pore-fluid leading to imperfect bonding. A mathematical model is derived for the partial connec- tion of surface pores at the porous-porous interface. At this interface, the loose-contact slipping and partial pore opening/connection may dissipate a part of strain energy. A numerical example shows that, at the interface between water and oil-saturated sandstone, the modified boundary conditions do affect the energies of the waves refracting into the isotropic porous medium.

关键词： porous solid dissipative boundary conditions

Multifunctional nanocomposites modulating the tumor microenvironment for enhanced cancer immunotherapy

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Bioactive Materials 2024年第1期31卷 440-462页

作者： Prashant sharma Mario Otto Department of Child Health University of Arizona College of Medicine-PhoenixABC1 Building425 N 5th StreetPhoenixAZ85004USA Center for Cancer and Blood Disorders(CCBD) Phoenix Children’s1919 E Thomas RdPhoenixAZ85016USA

Cancer immunotherapy has gained momentum for treating malignant tumors over the past *** blockade and chimeric antigen receptor cell therapy(CAR-T)have shown considerable potency against liquid and solid ***,the tumor microenvironment(TME)is highly immunosuppressive and hampers the effect of currently available cancer immunotherapies on overall treatment *** in the design and engineering of nanomaterials have opened new avenues to modulate the *** in the current nanocomposite technology can overcome immunosuppression and trigger robust immunotherapeutic responses by integrating synergistic functions of different *** will review recent advancements in nanomedical applications and discuss specifically designed nanocomposites modulating the TME for cancer *** addition,we provide information on the current landscape of clinical-stage nanocomposites for cancer immunotherapy.

关键词： Tumor microenvironment Nanocomposites Immunotherapeutic Cancer Immunosuppressive

Internal transcribed spacer guided multiplex PCR for species identification of Convolvulus prostratus and Evolvulus alsinoides

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Acta Pharmaceutica Sinica B 2016年第3期6卷 253-258页

作者： Sonal sharma Neeta Shrivastava B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre Sarkhej-Gandhinagar Highway Nirma University

Shankhpushpi is a reputed drug from an Indian system of medicine for treating mental disorders and enhancing memory. Two herbs, namely Convolvulus prostratus Forssk. and Evolvulus alsinoides(L.) L., are commonly known as Shankhpushpi. Ambiguous vernacular identity can affect the scientific validity of the Shankpushpi-based herbal drug therapy. In the present investigation, a novel and sensitive multiplex PCR method based on polymorphism in the internal transcribed spacer(ITS) region was developed to establish the molecular identity of C. prostratus and E. alsinoides. DNA was isolated and the ITS region was amplified, sequenced and assembled. Sequences were aligned to identify variable nucleotides in order to develop plant-specific primers. Primers were validated in singleplex reactions and eventually a multiplex assay was developed. This assay was tested for sensitivity and validated by amplifying DNA isolated from the simulated blended powdered plant material. Primers developed for C. prostratus resulted into a 200 bp amplicon and 596 bp for E. alsinoides. The assay was found to be sensitive enough for amplification of low quantities of DNA. The method can detect 10% of the mixing of plants with each other in blended material. This PCR assay can be used for rapid botanical identification of Shankhpushpi plant materials and will improve evidence-based herbal drug therapy.

关键词： PCR Internal transcribed spacers Shankhpushpi Botanical identification Adulteration Substitution Herbal drugs DNA barcoding

Behavior of ring footing resting on reinforced sand subjected to eccentric-inclined loading

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第2期10卷 347-357页

作者： Vaibhav sharma Arvind Kumar Dr.B.R.Ambedkar National Institute of Technology Jalandhar144011India

Ring footings are suitable for the structures like tall transmission towers, chimneys, silos and oil *** types of structures are susceptible to horizontal loads(wind load) in addition to their dead *** the literature, very little or no effort has been made to study the effect of ring footing resting on reinforced sand when subjected to eccentric, inclined and/or eccentric-inclined loadings. This paper aims to study the behavior of ring footing resting on loose sand and/or compacted randomly distributed fiberreinforced sand(RDFS) when subjected to eccentric(0 B, 0.05 B and 0.1 B, where B is the outer diameter of ring footing), inclined(0°,5°,10°, 15°,-5°,-10° and-15°)and eccentric-inclined loadings by using a finite element(FE) software PLAXIS 3 D. The behavior of ring footing is studied by using a dimensionless factor called reduction factor(RF). The numerical model used in the PLAXIS 3 D has been validated by conducting model plate load tests. Moreover, an empirical expression using regression analysis has been presented which will be helpful in plotting a load-settlement curve for the ring footing.

关键词： Soil reinforcement Ring footing Numerical method Randomly distributed fibers Load inclination Load eccentricity Model tests Reduction factor(RF)

Assessing the bird guild patterns in heterogeneous land use types around Jammu,Jammu and Kashmir,India

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Ecological Processes 2020年第1期9卷 564-578页

作者： Asha Sohil Neeraj sharma Institute of Mountain Environment University of JammuJammuIndia

Land-use sprawl in the Himalayas has caused the conversion of natural habitat into human-modified habitats,thus degrading ecosystem *** of birds to changing physical environment can be well understood by analyzing their habitat preferences,and foraging dynamics explored to a limited extent in the Himalayan region,as *** achieve a comprehensive understanding of avian guild structure,we used multivariate statistical techniques to classify bird species according to their similarities in foraging patterns and habitat *** based on habitat and diet affinities accounted for rich avian diversity with a total of 208 bird species(about 15%of country’s avifauna)recorded from six different sites during 1 year *** pair-group average cluster analysis performed on the families revealed ten feeding and fifteen habitat guilds among 63 bird families *** forests harbored more species followed by urban forests and agricultural *** and omnivorous outnumbered other feeding guilds in the study *** assemblages were richer in protected areas and semidisturbed landscapes and did not show significant variation between the *** of the study revealed that different functional groups of birds behaved differently,primarily induced by choice of *** site heterogeneity favored avifaunal persistence by providing favorable foraging,roosting,and nesting opportunities to *** of avian guilds indicated level of intactness and ecological integrity of ecosystems *** outcome thus sets the background for long-term analysis of bird-habitat relationship and their foraging *** study has the relevance for decision-makers to integrate avian guild structure as an essential ingredient in formulating conservation strategies.

关键词： Avian guild Food resource utilization Habitat preference Heterogeneous landscape Eutrophic wetland Protected area

HIGHER-ORDER NON-SYMMETRIC DUALITY FOR NONDIFFERENTIABLE MINIMAX FRACTIONAL PROGRAMS WITH SQUARE ROOT TERMS

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Acta Mathematica Scientia 2020年第1期40卷 127-140页

作者： SONALI Vikas sharma Navdeep KAILEY School of Mathematics Thapar Institute of Engineering and TechnologyPatialaIndia

In this paper,we emphasize on a nondifferentiable minimax fractional programming(NMFP)problem and obtain appropriate duality results for higher-order dual model under higher-order B-(p,r)-invex *** provide a nontrivial illustration of a function which belongs to the class of higher-order B-(p,r)-invex but not in the class of second-order B-(p,r)-invex functions already existing in *** example of finding a minimax solution of NMFP problem by using higher-order B-(p,r)-invex functions has also been *** known results are discussed as particular cases.

关键词： nonlinear programming higher-order duality fractional programming minimax programming B-(p,r)-invexity

Capture and fission analysis of various superheavy isotopes with ACN=258-280

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Communications in Theoretical Physics 2020年第2期72卷 65-74页

作者： Gurjit Kaur Manoj K sharma School of Physics and Materials Science Thapar Institute of Engineering and TechnologyPatiala—147004PunjabIndia

The capture and fission analysis of heavy ion induced fusion reactions leading to the formation of Z=107-111 superheavy nuclei has been carried *** have been made to analyze the synthesis traits,such as excitation functions,formation probabilities,barrier characteristics *** l-summed Wong model provides a decent description of available data on capture(σCap)and fusion-fission(σff)cross-sections and hence is exploited to make relevant predictions for future *** capture and fusion-fission excitation functions are predicted for the least explored region of superheavy nuclei(SHN)i.e.Z=*** role of massasymmetry(η),Coulomb factor(ZPZT)deformation and orientations,Businari-Gallone massasymmetry(αBG)fission barrier(Bf)etc is duly *** present study concludes that the mass-asymmetric reactions involving 24Mg,30Si,and 36S projectiles are preferred for the synthesis of unknown isotopes of Z=***,the doubly magic 48Ca-projectile also provides a competing alternative to produce neutron-rich isotopes of the abovementioned SHN.

关键词： Capture and fission cross-section compound nucleus formation probability quasi-fission

THE GENERALIZED HYPERSTABILITY OF GENERAL LINEAR EQUATION IN QUASI-2-BANACH SPACE

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Acta Mathematica Scientia 2022年第4期42卷 1357-1372页

作者： Ravinder Kumar sharma Sumit CHANDOK School of Mathematics Thapar Institute of Engineering and TechnologyPatiala-147004India

In this paper,we study the hyperstability for the general linear equation f(ax+by)=Af(x)+Bf(y)in the setting of complete quasi-2-Banach *** first extend the main fixed point result of Brzdek and Ciepliński(Acta Mathematica Scientia,2018,38 B(2):377-390)to quasi-2-Banach spaces by defining an equivalent quasi-2-Banach *** we use this result to generalize the main results on the hyperstability for the general linear equation in quasi-2-Banach *** results improve and generalize many results of literature.

关键词： Hyperstability quasi-2-Banach spaces fixed point general linear equation