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Asian Journal of Andrology 2016年第2期18卷 186-193,J0003页

作者： Chak-Lam Cho Sandro C Esteves Ashok agarwal Division of Urology Department of Surgery Kwong Wah Hospital 25 Waterloo Road Yau Ma Tei Hong Kong ANDROFERT Center for Male Reproduction Av. Dr. Heitor Penteado 1464 campinas SP 13075-460 Brazil American Center for Reproductive Medicine 10681 Carnegie Avenue X-11 Cleveland OH 44195 USA.

Varicocele has been associated with reduced male reproductive potential. With the advances in biomolecular techniques, it has been possible to better understand the mechanisms involved in testicular damage provoked by varicocele. Current evidence suggests the central role of reactive oxygen species （ROS） and the resultant oxidative stress （OS） in the pathogenesis of varicocele-associated male subfertility although the mechanisms have not yet been fully described and it is likely to be multifactorial. Excessive ROS is associated with sperm DNA fragmentation, which may mediate the clinical manifestation of poor sperm function and fertilization outcome related to varicocele. Testing of ROS/OS and DNA fragmentation has the potential to provide additional diagnostic and prognostic information compared to conventional semen analysis and may guide therapeutic management strategies in individual patient.

关键词： antioxidants infertility male reproduction oxidative stress sperm DNA damage sperm DNA fragmentation varicocele varicocelectomy

Proteomic analysis reveals dysregulated cell sign aling in ejaculated spermatozoa from in fertile men

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Asian Journal of Andrology 2019年第2期21卷 121-130页

作者： Luna Samanta Rakesh Sharma Zhihong Cui Ashok agarwal American Center for Reproductive Medicine Cleveland ClinicClevelandOH 44195USA Department of Zoology School of Life SciencesRavenshaw UniversityCuttackOdisha 753003India Institute of Toxicology The Third Military Medical UniversityChongqing 400038China

Dysfunctional sperm maturation is the primary reason for the poor sperm motility and morphology in infertile *** from infertile men were fractioned on three-layer density gradient(80%,60%,and 40%).Fraction 1(Fl)refers to the least mature stage having the lowest den sity,whereas the fraction 4(F4)in eludes the most dense and morphologically mature motile *** 2(F2)and fraction 3(F3)represent the intermediate *** were extracted and separated by dimensional *** were digested with trypsin and analyzed on a LTQ-Orbitrap Elite hybrid mass spectrometer *** annotations of proteins were obtained using bioinformatics tools and pathway databases.A total of 1585 proteins were detected in the four fractions of spermatozoa.A dysregulated protein turnover and protein folding may lead to accumulation of defective proteins or proteins that otherwise would have been eliminated during the process of maturation,resulting in the impairment of sperm fun *** nt chaper one expressi on may be a major con tributing factor to the defective sperm *** n receptor was predicted as a transcription regulator in one of the networks and the affected pathways were chaperone-mediated stress response,proteosomal pathway,and sperm *** down regulation of key pathways and protei ns which compromises the fertilizi ng potential of spermatozoa may provide in sight into the mecha nisms that lead to male infertility.

关键词： androgen receptor chaperone immature sperm infertile men proteasome spermatozoa

A Hierarchical Reconfiguration Strategy for Bus-Based Multiprocessors

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Journal of Computer Science & Technology 1990年第2期5卷 175-186页

作者： Ashish Pancholy Fidel Muradali Vinod K.agarwal VLSI Design Laboratory Department of ElectricalEngineeringMcGill University

A method of providing redundancy to a class of bus-based multiprocessor arrays is *** reconfiguration is hierarchical,providing global spare replacement at the array level and local reconfiguration within the spare **... 详细信息

关键词： A Hierarchical Reconfiguration Strategy for Bus-Based Multiprocessors PE

Electrospinning of ABS nanofibers and their high filtration performance

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Advanced Fiber Materials 2020年第1期2卷 34-43页

作者： Shaohua Jiang Holger Schmalz Seema agarwal Andreas Greiner Macromolecular Chemistry Bavarian Polymer InstituteUniversity of BayreuthUniversitätsstraße 3095440 BayreuthGermany Bavarian Polymer Institute(BPI) University of BayreuthUniversitätsstraße 3095440 BayreuthGermany Present Address:College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037China

Acrylonitrile-butadiene-styrene(ABS)is a commercial polymer for widely industrial applications due to its good mechanical and physical ***,there are only countable reports regarding its fibers from *** investigation on its optimized electrospinning parameters is ***,ABS fibers with different fiber diameters were produced by *** electrospinning conditions,including the solvents,solution concentrations and amounts of different salt additives,have been comprehensively *** morphologies of electrospun ABS fibers are studied by scanning electron microscopy and Raman *** fiber diameters and coating densities are applied for filtration applications,which showed excellent filtration *** filtration efficiency of up to 99%,low pressure drop of<30 Pa,and high filtration quality factor of up to 0.477 are achieved from the electrospun ABS fibers coated on microfibrous polypropylene *** addition,the electrospun ABS fibers also shows good thermal stability and other applications such as oil/water separation.

关键词： Acrylonitrile-butadiene-styrene fiber Electrospinning Filtration Oil-water separation

Magnetic and magnetotransport behavior of overdoped nanocrystalline Nd_(1-x)Sr_xMnO_3 (0.50≤x≤0.63)

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Journal of Rare Earths 2011年第7期29卷 654-659页

作者： Neelam Maikhuri Vasudha agarwal Anurag Gaur H.K.Singh Department of Physics National Institute of Technology Kurukshetra-136119 India National Physical Laboratory New Delhi-110012 India

The nanocrystalline samples of Nd1-xSrxMnO3 （NSMO）（x=0.5, 0.55, 0.60, 0.63） were synthesized by sol-gel based polymeric pre-cursor route. Structural, magnetic and magnetotransport properties were studied systematically. It was found that in the composition range （x=0.50-0.63）, Nd1-xSrxMnO3 showed paramagnetic to ferromagnetic （PM-FM） transition in the vicinity of TC～270 K but the FM phase was weakened as the Sr concentration increased. The appearance of weak ferromagnetism was explained in terms of the core-shell model. More-over, for x=0.63 sample, a second transition is observed below TC at T=185 K, which is possibly due to the appearance of A-AFM/ C-AFM or a mixture of both the phases. Resistivity vs temperature （ρ-T） curve showed that the resistivity of all the samples was much larger than the sin-gle crystals of corresponding compositions due to large contribution of the grain boundaries in the present nanocrystalline samples. In all samples, extrinsic kind of MR behavior dominated because of nanocrystalline nature of the samples, which was nearly of the same order （～10%） in all samples. However, the intrinsic kind of MR behavior was also significant in x=0.50 sample, because of the strongest FM feature in this sample.

关键词： manganites magnetoresistance spin polarized tunnelling rare earths

An evaluation of the emission profile for two-wheelers at a traffic junction

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Particuology 2015年第1期13卷 112-119页

作者： Avinash Kumar agarwal Prakhar Bothra Tarun Gupta Pravesh Chandra Shukla Engine Research Laboratory Department of Mechanical EngineeringIndian Institute of Technology Kanpur Department of Civil Engineering Indian Institute of Technology Kanpur

Two-wheeler vehicles are an important mode of transportation in developing countries. However, the emissions from two-wheeler vehicles are significant. Urban two-wheeler vehicles with gasoline-fueled engines produce NOx and particulate matter emissions that affect urban air quality. During traffic light stops and programmed stops, for instance, pollutants are emitted and are dangerous to human health. In this experimental study, two-wheeler vehicles with different makes, technologies and engine capacities were tested for exhaust emissions including gravimetric and online measurements at different engine speeds and a no load condition at a simulated traffic junction. Gravimetric measurements were performed by collecting the particulate mass （at two engine speeds： 1500 and 2500 rpm） from a diluted engine-out exhaust on quartz filter paper. Next, these collected particulates were used to determine the presence of metals, as well as the benzene soluble organic fraction （BSOF）. The total particulate mass, BSOF and trace elements were slightly higher at a higher engine speed （2500 rpm）. Online measurements were performed by sampling the engine exhaust （at four engine speeds： 1500, 2000, 2500, and 3000rpm） and using online instruments to determine the particle number and size distribution, the particle-bound polyaromatic hydrocarbons （PAHs）, the gaseous emissions and the smoke opacity. Engines with higher cubic capacity emitted a higher concentration of nano-particles. The particle-bound PAH concentration increased as the engine speed increased, but this concentration was notably low for the highest engine speed tested （3000 rpm）. The regulated gaseous emissions increased as the engine speed increased for all vehicles.

关键词： Benzene soluble organic fraction (BSOF) Particle number and size distribution Trace elements Polyaromatic hydrocarbons (PAHs) Regulated gaseous emissions

Emission profiling of diesel and gasoline cars at a city traffic junction

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Particuology 2015年第1期13卷 186-193页

作者： Avinash Kumar agarwal Tarun Gupta Prakhar Bothra Pravesh Chandra Shukla Engine Research Laboratory Department of Mechanical EngineeringIndian Institute of Technology Kanpur Department of Civil Engineering Indian Institute of Technology Kanpur

In congested urban roads, cars must stop at intersections because of city traffic lights. As a result, pedestri- ans and traffic police personnel are exposed to pollutants emanating from the tailpipe of various vehicles at such city trafficjunctions. In this study, various gasoline- and diesel-fueled cars complying with differ- ent emission standards were tested for their emissions in simulated city traffic junction conditions. The engine exhaust from these cars was subjected to physicochemical characterization at different engine speeds under no-load conditions. These engine conditions were chosen because the cars idle at differ- ent engine speeds at a city traffic junction. Gravimetric and real-time measurements were performed for the tailpipe exhaust sampled from these vehicles. Exhaust particles were collected on 47 mm diameter quartz filter papers and subjected to gravimetric analysis for determining the total particulate mass （TPM） and trace metals while the engines were operated at two different engine idling speeds, 1500 rpm （representing low idling） and 2500 rpm （representing high idling）. At similar engine operating condi- tions, TPM and trace metals were lower for the exhaust from gasoline engines compared to the exhaust from diesel engines. Real-time measurements were performed for particle-bound poly-aromatic hydro- carbons （PAHs）, particle number and size distribution, regulated gaseous emissions and smoke opacity of the exhaust at four different engine speeds, 1500, 2000, 2500, and 3000 rpm. Particle-bound PAHs showed a decreasing trend for the vehicles that complied with stricter vehicular emission standards. Higher particle peak number concentrations were observed for diesel exhausts compared to the results for gasoline exhaust. Regulated gaseous emissions were also comoared.

关键词： Traffic junctions Traffic stop emissions Particle number emission Particle mass emissions Diesel and gasoline fueled cars

Critical evaluation of two models of flow cytometers for the assessment of sperm DNA fragmentation:an appeal for performance verification

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Asian Journal of Andrology 2019年第5期21卷 438-444页

作者： Rakesh Sharma Sajal Gupta Ralf Henkel Ashok agarwal American Center for Reproductive Medicine Cleveland ClinicClevelandOH 44195USA Department of Medical Bioscience University of the Western CapeBellville 7535South Africa

Lack of standardized,reproducible protocols and referencO values is among the challenges faced when using new or upgraded versions of instruments in reproductive laboratories and flow *** deoxynucleotidyl transferase dUTP nick end labeling(TUNEL)assay combined with flow cytometry routinely used for diagnostic measurement of sperm DNA fragmentation(SDF)is a unique *** change in the setting of the standard instrument,including upgrades of hardware or software,can lead to different results and may affect clinicians'decision for ***,we compared TUNEL results of SDF obtained from a standard(C6)flow cytometer with a newer version of the same instrument(C6 Plus)and examined the cutoff,sensitivity,and specificity without calibration(adjustment)and after *** sperm preparation and matched acquisition settings were used to examine the performance of two flow *** strength of agreement of the results between the two observers was also *** adjustment of the settings,overall concordance became high and the two cytometers showed 100%positive and negative predictive value with 100%area under the *** overall correlation coefficient observed between C6 and C6 Plus was highly significant(P99%.The in terobserver agreeme nt on C6 flow cytometer for the two observers was 0.801±0.062 and 0.746±0.044 for C6 *** demonstrated a strong agreement between the samples tested on the two flow cytometers after calibration and established the robustness of both instruments.

关键词： DNA fragmentation flow cytometer oxidative stress sperm TUNEL assay

Xanthogranulomatous cholecystitis:a premalignant condition?

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Hepatobiliary & Pancreatic Diseases International 2011年第2期10卷 179-184页

作者： Mila Ghosh Puja Sakhuja Anil K agarwal Department of Gastrointestinal Surgery GB Pant Hospita and Maulana Azad Medical College Department of Pathology GB Pant Hospita and Maulana Azad Medical College

BACKGROUND:Xanthogranulomatous cholecystitis(XGC)is an uncommon variant of chronic cholecystitis,characterized by marked thickening of the gallbladder wall and dense local *** often mimics a gallbladder carcinoma(GBC), and may coexist with GBC,leading to a diagnostic dilemma. Furthermore,the premalignant nature of this entity is not *** study was undertaken to assess the p53,PCNA and beta-catenin expression in XGC in comparison to GBC and chronic inflammation. METHODS:Sections from paraffin-embedded blocks of surgically resected specimens of GBC(69 cases),XGC(65), chronic cholecystitis(18)and control gallbladder(10)were stained with the monoclonal antibodies to p53 and PCNA, and a polyclonal antibody to beta-catenin.p53 expression was scored as the percentage of nuclei *** expression was scored as the product of the percentage of nuclei stained and the intensity of the staining(1-3).A cut-off value of 80 for this score was taken as a positive result. Beta-catenin expression was scored as type of expression-membranous,cytoplasmic or nuclear staining. RESULTS:p53 mutation was positive in 52%of GBC cases and 3%of XGC,but was not expressed in chronic cholecystitis and control gallbladders.p53 expression was lower in XGC than in GBC(P<0.0001).PCNA expression was seen in 65%of GBC cases and 11%of XGC,but not in chronic cholecystitis and control *** expression was higher in GBC than XGC(P=0.0001),but there was no significant difference between the XGC,chronic cholecystitis and control gallbladder ***-catenin expression was positive in the GBC,XGC, chronic cholecystitis and control gallbladder *** the expression pattern in XGC,chronic cholecystitis and control gallbladders was homogenously membranous,whereas in GBC the membranous expression pattern was altered to cytoplasmic and ***:The expression of p53,PCNA and beta-catenin in XGC was significantly different from GBC and similar to chronic cholecystitis,

关键词： xanthogranulomatous cholecystitis gallbladder cancer p53 PCNA beta-catenin

Camelina sativa,a short gestation oilseed crop with biofuel potential:Opportunities for Indian scenario

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Oil Crop Science 2021年第3期6卷 114-121页

作者： Ankur agarwal Om Prakash Madhu Bala Defence Institute of Bio-Energy Research Defence R&D OrganizationGoraparaoP.O.ArjunpurHaldwaniUttarakhand263139India

Camelina is an oilseed crop which is being commercially produced globally as feedstock for *** a non-edible oil bearing low input crop owing to its low fertilizer and water requirement,fits well for biofuel *** India,targets for biofuel blending has been set by New Biofuel Policy-2018 and to meet these targets efforts are being made to harness the potential of available feedstock in the *** these feedstock,contribution of short gestation oilseed bearing crop has been very *** has been introduced in India during 2009–10 as experimental crop by DIBER,*** then various efforts have made to standardize the production technology of this crop under various agro-climatic regions of the country,crop improvement,oil quality analysis and development of high energy *** has various advantages to offer for Indian biofuel *** paper reviews the potential of this crop for Indian Biofuel scenario.

关键词： Camelina False flax Production Agro-technology Crop improvement Economics