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Role of Vascular Endothelial Growth Factor-C during Stem Cell Therapy Using Autologous Bone marrow mononuclear Cells in Patients with Lower Limb Lymphedema

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Stem Cell Discovery 2023年第1期13卷 1-16页

作者： Ahmed m. Ismail Said m. Abdou amira Yousef Yousra Sameh m. Attia Ahmed Badran mohamed I. Adel el Eissawy Asmaa E. Bedeer Wesam m. Salama Ahmed O. Korany Vascular Surgery Department Faculty of Medicine Tanta University Tanta Egypt Clinical Pathology Department Faculty of Medicine Tanta University Tanta Egypt Pathology Department Faculty of Medicine Tanta University Tanta Egypt Faculty of Science Tanta University Tanta Egypt Vascular Surgery Department Alexandria University Alexandria Egypt

Introduction: Vascular endothelial growth factor-C (VEGF-C) is the primary lymphangiogenic factor that stimulates lymphangiogenesis by signaling via specific receptor, vascular endothelial growth factor receptor 3 (VEGFR3). This study was conducted to evaluate the change in the level of VEGF-C before and after autologous bone marrow mononuclear cell transplantation for treatment of Lower limb lymphedema. Patient and methods: Forty patients with lower limb lymphedema were divided into two groups. Group I included 20 patients with chronic lower limb lymphedema who underwent autologous bone marrow mononuclear cell transplantation. Group II included 20 patients with chronic lower limb lymphedema who were exposed only to compression therapy as a control group. VEGF-C level in the diseased limbs was measured in both groups at the beginning of the study then 3 and 6 months respectively. Results: Group I included 20 patients, 8 patients were male (40%) and 12 patients were females (60%) with mean age 29.5 ± 12.15 while group II included 20, 10 patients were male (50%) and 10 patients were females (50%) with mean age 39.5 ± 11.5. In group I, the specimens were taken at 3 and 6 months after transplantation showed a marked decrease in the VEGF-C level with statistically significant p value, 0.02 and 0.001 respectively. In group II the level of VEGF-C after compression therapy alone at 3 and 6 months interval showed fluctuation with statistically non-significant p value, 0.64 and 0.55 respectively. Conclusion: VEGF-C is essential for regulation of lymphangiogenesis. The level of VEGF-C was found elevated in patients with lymphedema and decrease after autologous mononuclear bone marrow cells, however these results were statically non-significant.

关键词： Lymphangiogenesis VEGF-C Bone marrow mononuclear Cells

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The Palestinian Terrestrial Vertebrate Fauna Preserved at the Biology Exhibitions of the Universities of the Gaza Strip

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Research in Ecology 2020年第4期2卷 9-21页

作者： Abdel Fattah N Abd Rabou Nour J musallam Eman J musallam Kamal E elkahlout Kamal J elnabris Tarek A el-Bashiti Ismail I Abdel Aziz Reham m Ishneiwra Eqbal S Radwan Hana S Saada Ashraf A shafei Nedal A Fayyad Saleh N mwafy Huda E Abu Amra Ramy A Abu Alajeen mohammed F Abu Owda Randa N Alfarra Haifaa A Hassouna Reem A Hassouna mohammed R Al-Agha mohammed A Abd Rabou Department of Biology and Biotechnology Islamic University of GazaGaza StripPalestine Department of English Islamic University of GazaGaza StripPalestine Department of Biology Al-Azhar UniversityGaza StripPalestine Department of Biology Al-Aqsa UniversityGaza StripPalestine Department of Geography Al-Aqsa UniversityGaza StripPalestine Department of Curricula and Teaching methods Islamic University of GazaGaza StripPalestine Department of Curricula and Teaching methods Ministry of EducationGaza StripPalestine Department of Pharmaceutical Sciences University of PalestineGaza StripPalestine Department of Environment and Earth Sciences Islamic University of GazaGaza StripPalestine Department of Information Technology University College of Applied SciencesGaza StripPalestine

The Gaza Strip(365 km^(2))of Palestine(27,000 km^(2))is home to a wealth of terrestrial vertebrate *** of these faunistic species find their ways to preservation at the local ***,the current study comes to document the Palestinian terrestrial vertebrate fauna acquired by the biology exhibitions(BEs)of Al-Azhar University,Islamic University of Gaza and Al-Aqsa University that are located at the Gaza City of the Gaza *** amphibians,reptiles,birds and mammals preserved at BEs of the universities in question were surveyed and scientifically classified during a three-month period extending from January to march,*** study showed that all BEs of local universities are underdeveloped,lacking attention and suffer from specimen scarcity and good *** BE at Al-Azhar University is the best in the arrangement and preservation of bird specimens.A total number of 200 specimens belonging to 54 terrestrial vertebrate fauna species,39 families and 17 orders was recorded at *** constituted 40.7%of the total species recorded,followed by birds(38.9%),mammals(14.8%)and amphibians(5.6%).The Islamic University of Gaza was considered the best in terms of the number of preserved species(39.8%),followed by Al-Azhar University(36.3%)and Al-Aqsa University(23.9%).The Common Toad(Bufo viridis)was the most preserved among the amphibian species *** was the biggest reptilian order,comprising 20 species(8 lizards and 12 snakes),with the Syrian Black Snake(Coluber jugularis asianus)was the *** Palestine Viper(Vipera palaestinae)is endemic to Palestine and most venomous and dangerous to human *** Great White Pelican(Pelecanus onocrotalus)was the largest Palestinian bird preserved at BE of Al-Azhar *** Egyptian mongoose(Herpestes ichneumon)and the Common Badger(meles meles)were the biggest mammalian specimens preserved,while the Palestine mole-rat(Spalax leucodon ehrenbergi)was the only Palestine endemic spe

关键词： Terrestrial vertebrate fauna Preservation Biology exhibitions Gaza universities Gaza Strip Palestine

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