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Phytochemical and biological studies of Butia capitata *** cultivated in Egypt

Asian Pacific Journal of Tropical Biomedicine 2014年第6期4卷 456-462页

作者： Nagwa Mohamed Ammar Mohammed Said Hefnawy Sahar Youssef Al-Okbi Doha Abdou Mohamed Nabil Khamis el-Sayed amira ahmed el-anssary Tom Mabry Pharmacognosy Department National Research Centre Pharmacognosy Department Faculty of PharmacyCairo University Food Sciences and Nutrition Department National Research Centre Tanning Materials and Protein Chemistry National Research Centre Molecular Cell and Developmental Biology The School of Biological ScienceBotany DepartmentTaxas State University

Objective:To study the antioxidant and anti-inflammatory activity of Butia capitata(***)leaf extracts along with phytochemical analysis of the proposed bioactive ***:Different successive extracts of *** *** were prepared with selective organic solvents and screened for their anti-inflammatory activities in tested animals and invitro antioxidant *** extensive phytochemical investigation of the bioactive extracts through paper chromatography,thin layer chromatography,column chromatography,gasliquid chromatography(GLC),high pressure liquid chromatography and spectral ***,ultraviolet,hydrogen and carbon nuclear magnetic resonance,electron ionization-mass spectrometry,heteronuclear multiple bond correlation and heteronuclear multiple quantum correlation were carried out Results:Results showed that different extracts possess promising antioxidant effect and significant anti-inflammatory activity with variable *** results of the phytochemical investigation of the bioactive extracts revealed the presence of volatile substances,lipoidal matter,α-tocopherol,free sugars,polysaccharides and flavonoidal ***:*** leaf extracts were shown to possess variable antioxidant effect,the most promising was methanol extract Both polar and non polar extracts were proved to have anti-inflammatory activity,the non polar extract was superior in this respect The bioactivity of the extracts was ascribed to the presence of flavonoids,sterols andα-tocopherol.

关键词： Butia capitata leaves antioxidant effect anti-inflammatory activity bioactive constituents rats.

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Summary of the current guidelines for managing iatrogenic colorectal perforations and the evolving role of endoluminal vacuum therapy

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World Journal of Clinical Cases 2025年第6期13卷 1-8页

作者： ahmed Tawheed Ibrahim Halil Bahcecioglu Mehmet Yalniz Mubin Ozercan Ali Cagri Oral Mohamed el-Kassas Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt Department of Gastroenterology Firat UniversityElazig 23119Türkiye Liver Disease Research Center College of MedicineKing Saud UniversityRiyadh 7805Saudi Arabia

Colonoscopy represents a safe procedure that is widely used in medical practice either to diagnose or treat various gastrointestinal *** the last few years,the incidence rate of perforations in colonoscopic procedures has increased,especially in therapeutic *** recent advancements in endoscopic techniques and gastrointestinal tumoral resection procedures such as endoscopic mucosal resection,endoscopic full-thickness resection,and endoscopic submucosal dissection(ESD)could be a risk factor for this increased *** incidence rate of mortality of serious colonoscopic perforations is 7.1%.The management plan for these perforations starts with conservative treatment in mild cases,endoscopic closure,and surgical management in severe ***,endoluminal vacuum therapy was found to be effective in the management of colorectal perforations and this has been reported in multiple case *** editorial provides an overview of the current guidelines for the management of iatrogenic colorectal *** insights are from the perspectives of endoscopists and *** also present a management algorithm based on the guidelines of the European Society of Gastrointestinal Endoscopy,the American Gastroenterological Association,and the World Society of Emergency *** also discussed in brief the use of endoluminal vacuum therapy in colorectal perforations.

关键词： Colon Rectum Iatrogenic colonic perforation Colonoscopy Guidelines Endovacuum Endolumical vacuum therapy Endoscopic management

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A Transfer Learning-Enabled Optimized Extreme Deep Learning Paradigm for Diagnosis of COVID-19

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Computers, Materials & Continua 2022年第1期70卷 1381-1399页

作者： ahmed Reda Sherif Barakat amira Rezk Department of Information System Faculty of Computer and Information ScienceMansoura UniversityMansouraEgypt

Many respiratory infections around the world have been caused by ***-19 is one of the most serious coronaviruses due to its rapid spread between people and the lowest survival *** is a high need for computer-assisted diagnostics(CAD)in the area of artificial intelligence to help doctors and radiologists identify COVID-19 patients in cloud *** learning(ML)has been used to examine chest X-ray *** this paper,a new transfer learning-based optimized extreme deep learning paradigm is proposed to identify the chest X-ray picture into three classes,a pneumonia patient,a COVID-19 patient,or a normal ***,three different pre-trainedConvolutionalNeuralNetwork(CNN)models(resnet18,resnet25,densenet201)are employed for deep feature ***,each feature vector is passed through the binary Butterfly optimization algorithm(bBOA)to reduce the redundant features and extract the most representative ones,and enhance the performance of the CNN *** selective features are then passed to an improved Extreme learning machine(elM)using a BOA to classify the chest X-ray *** proposed paradigm achieves a 99.48%accuracy in detecting covid-19 cases.

关键词： Butterfly optimization algorithm(BOA) covid-19 chest X-ray images convolutional neural network(CNN) extreme learning machine(elM) feature selection

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Three-dimensional printing of biomaterials for bonetissue engineering: a review

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Frontiers of Materials Science 2023年第2期17卷 1-43页

作者： ahmed el-Fiqi Glass Research Department Advanced Materials Technology and Mineral Resources Research InstituteNational Research CentreCairo 12622Egypt

Processing biomaterials into porous scaffolds for bone tissueengineering is a critical and a key step in defining and controlling their physicochemical,mechanical,and biological *** such as polymers are commonlyprocessed into porous scaffolds using conventional processing techniques,e.g.,***,these traditional techniques have shown unavoidable limitations andseveral *** instance,tissue-engineered porous scaffolds with a complexthree-dimensional(3D)geometric architecture mimicking the complexity of theextracellular matrix of native tissues and with the ability to fit into irregular tissue defectscannot be produced using the conventional processing techniques.3D printing hasrecently emerged as an advanced processing technology that enables the processing ofbiomaterials into 3D porous scaffolds with highly complex architectures and tunableshapes to precisely fit into irregular and complex tissue defects.3D printing providescomputer-based layer-by-layer additive manufacturing processes of highly precise andcomplex 3D structures with well-defined porosity and controlled mechanical propertiesin a highly reproducible ***,3D printing technology provides anaccurate patient-specific tissue defect model and enables the fabrication of a patientspecifictissue-engineered porous scaffold with pre-customized properties.

关键词： 3D printing biomaterial ink printability 3D printing technique 3D printed scaffold bone tissue engineering

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Sol-gel synthesis,properties and protein loading/delivery capacity of hollow bioactive glass nanospheres with large hollow cavity and mesoporous shell

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Frontiers of Materials Science 2022年第3期16卷 145-157页

作者： ahmed el-FIQI Glass Research Department National Research CentreCairo 12622Egypt

Hollow nanospheres exhibit unique properties and find a wide interest in several potential applications such as drug ***,novel hollow bioactive glass nanospheres(HBGn)with large hollow cavity and large mesopores in their outer shells were synthesized by a simple and facile one-pot ultrasound assisted sol-gel method using PEG as the core ***,the produced HBGn exhibited large hollow cavity with ~43 nm in diameter and mesoporous shell of ~37 nm in thickness and 7 nm pore size along with nanosphere size around 117 *** confirmed the presence of Si and Ca elements at the surface of the HBGn outer ***,HBGn showed high protein loading capacity(~570 mg of Cyto c per 1 g of HBGn)in addition to controlled protein release over 5 *** also demonstrated a good in vitro capability of releasing calcium(Ca^(2+):170 ppm)and silicate(SiO_(4)^(4-):78 ppm)ions in an aqueous medium over 2 weeks under physiological-like *** in vitro growth of bone-like hydroxyapatite nanocrystals was exhibited by HBGn during the soaking in SBF.A possible underlying mechanism involving the formation of spherical aggregates(coils)of PEG was proposed for the formation process of HBGn.

关键词： bioactive glass hollow nanosphere hollow cavity mesoporous shell soft-template ultrasound assisted sol-gel synthesis therapeutic protein delivery

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LEO satellite clock analysis and prediction for positioning applications

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Geo-Spatial Information Science 2022年第1期25卷 14-33页

作者： Kan Wang ahmed el-Mowafy School of Earth and Planetary Sciences Curtin UniversityPerthAustralia

The positioning service aided by low Earth orbit(LEO)mega-constellations has become a hot topic in recent *** achieve precise positioning,accuracy of the LEO clocks is important for single-receiver *** bridge the gap between the applicable time of the clock products and the time of positioning,the precise LEO clocks need to be predicted over a certain period depending on the sampling interval of the clock *** study discusses the prediction errors for periods from 10 s to 1 h for two typical LEO clock types,*** ultra-stable oscillator(USO)and the oven-controlled crystal oscillator(OCXO).The prediction is based on GNSS-determined precise clock estimates,where the clock stability is related to the GNSS estimation errors,the behaviors of the oscillators themselves,the systematic effects related to the environment and the relativistic effects,and the stability of the time *** on real data analysis,LEO clocks of the two different types are simulated under different conditions,and a prediction model considering the systematic effects is *** to a simple polynomial fitting model usually applied,the proposed model can significantly reduce the prediction errors,*** about 40%-70%in simulations and about 5%-30%for real data containing different miss-modeled *** both clock types,short-term prediction of 1 min would result in a root mean square error(RMSE)of a few centimeters when using a very stable time *** RMSE amounts to about 0.1 m,when a typical real-time time reference of the national center for space studies(CNES)real-time clocks was *** long-term prediction of 1 h,the RMSE could range from below 1 m to a few meters for the USOs,depending on the complexity of the miss-modeled *** OCXOs,the 1 h prediction could lead to larger errors with an RMSE of about 10 m.

关键词： LEO clock prediction USO OCXO relativistic effects

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Magnetoresistive properties of Ni-doped La_(0.7)Sr_(0.3)MnO_3 manganites

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Rare Metals 2016年第7期35卷 551-558页

作者： ahmed Mohamed ahmed Abd el-Moez ahmed Mohamed Medhat Abdelrady Abdellateef Hassan ahmed Abd el-Ghanny Physics Department Faculty of ScienceSohag University

Lao.7Sr0.3Mnl_xNixO3 （x = 0, 0.025, 0.050 and 0.075） ceramics were prepared by the conventional solid-state reaction method. The partial substitution of Mn by Ni2＋ leads to a decrease in cell volume as well as a structural transition from the rhombohedral to the orthorhombic structure. Ni2＋ doping increases the electrical resistivity, decreases the semiconductor-metal transition temperature （Tms） and relatively enhances the room temperature magnetoresistance （MR）, especially in x = 0.025 and around Tins. With respect to conduction mechanism, the small polaron hopping （SPH） and the variable range hopping （VRH） models were used to ex- amine conduction in the semiconducting region.

关键词： Manganites X-ray diffraction Structure electrical resistivity Magnetoresistance

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Laboratory diagnosis of schistosomiasis mansoni: Current status and future trends

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Asian Pacific Journal of Tropical Medicine 2019年第6期12卷 243-249页

作者： amira Taman Samar N.el-Beshbishi Department of Medical Parasitology Faculty of Medicine Mansoura University

Schistosomiasis is a neglected tropical disease that affects about 290 million patients worldwide. Children aged between 5 and 14 years represent 45.8% of the affected patients, in addition, schistosomiasis has been reported in Schistosoma-free areas, mostly because of tourism and immigration from endemic countries. Intestinal schistosomiasis caused by Schistosoma mansoni is mainly diagnosed via direct stool examination for egg detection. Immunological methods are favoured for disease monitoring and preliminary checking for communities in areas with low infection rates, and for patients with light and chronic infections where parasitological tests are negative. PCR-based diagnostic techniques are more sensitive, but expensive. Tegument proteins and miRNAs are promising markers for diagnosis of schistosomiasis. Here we review the diagnostic methods for schistosomiasis mansoni aiming to reach a standardized technique for diagnosis of early infection to help better control of the disease.

关键词： Schistosoma mansoni elISA miRNA Tegument Polymerase chain reaction

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Axonal degeneration of the ulnar nerve secondary to carpal tunnel syndrome: fact or fiction?

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Neural Regeneration Research 2013年第15期8卷 1418-1422页

作者： Radwa Mahmoud Azmy amira ahmed Labib Saly Hassan elkholy Department of Special Medicine Faculty of Medicine Cairo University

The distribution of sensory symptoms in carpal tunnel syndrome is strongly dependent on the degree of electrophysiological dysfunction of the median nerve. The association between carpal tunnel syndrome and ulnar nerve entrapment is still unclear. In this study, we measured ulnar nerve function in 82 patients with carpal tunnel syndrome. The patients were divided into group I with minimal carpal tunnel syndrome （n = 35） and group II with mild to moderate carpal tunnel syndrome （n = 47） according to electrophysiological data. Sixty-one age- and sex-matched subjects without carpal tunnel syndrome were used as a control group. There were no significant differences in ulnar sensory nerve peak latencies or conduction velocities from the 4th and 5th fingers between patients with carpal tunnel syndrome and the control group. The ulnar sensory nerve action potential amplitudes from the 4th and 5th fingers were lower in patients with carpal tunnel syndrome than in the control group. The ratios of the ulnar sensory nerve action potential amplitudes from the 4th and 5th fingers were almost the same in patients with carpal tunnel syndrome as in the control group. These findings indicate that in patients with minimal to moderate carpal tunnel syndrome, there is some electrophysiological evidence of traction on the adjacent ulnar nerve fibers. The findings do not indicate axonal degeneration of the ulnar nerve.

关键词： neural regeneration peripheral nerve injury carpal tunnel syndrome median nerve extra-mediansymptoms motor conduction sensory conduction ulnar nerve ulnar amplitude ratio neuroregeneration

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Hepatoprotective Effect of Camel Thorn Polyphenols in Concanavalin A-Induced Hepatitis in Mice

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Chinese Journal of Integrative Medicine 2024年第12期30卷 1090-1100页

作者： Nageh ahmed el-Mahdy Thanaa ahmed el-Masry ahmed Mahmoud el-Tarahony .Fatemah AAlherz Enass Youssef Osman Department of Pharmacology and Toxicology Faculty of PharmacyTanta UniversityTanta 31527Egypt Department of Pharmaceutical Sciences College of PharmacyPrincess Nourah Bint Abdulrahman UniversityP.O.Box 84428Riyadh 11671Saudi Arabia

Objective:To explore the prophylactic and therapeutic effects of Alhagi maurorum ethanolic extract(AME)in concanavalin A(Con A)-induced hepatitis(CIH)as well as possible underlying ***:Polyphenols in AME were characterized using high performance liquid chromatography(HPLC).Swiss albino mice were divided into 4 *** group received intravenous phosphate-buffered saline(PBS);Con A group received 40 mg/kg intravenous Con *** group administered 300 mg/(kg·d)AME orally for 5 days before Con A *** group received intravenous Con A then administered300 mg/kg AME at 30 min and 3 h after Con A *** 24 h of Con A injection,hepatic injury,oxidative stress,and inflammatory mediators were *** examination and markers of apoptosis,inflammation,and CD4^(+)cell infiltration were also ***:HPLC analysis revealed that AME contains abundant polyphenols with pharmacological constituents,such as ellagic acid,gallic acid,ferulic acid,methylgallate,and *** alleviated Con A-induced hepatic injury,as manifested by a significant reduction in alanine aminotransferase,aspartate aminotransferase and alkaline phosphatase(Pels of proinflammatory cytokines(tumor necrosis factor-α,interferon-γ,and interleukin-6)and c-Jun N-terminal kinase(JNK)activity were reduced(Peliorated necrotic and inflammatory lesions induced by Con A(Pell hepatic infiltration(Peliorative effects in CIH mice

关键词： concanavalin A-induced hepatitis Alhagi maurorum ethanolic extract hepatoprotective effect

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