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Preparation, characterization and in vivo evaluation of alginate-coated chitosan and trimethylchitosan nanoparticles loaded with PR8 influenza virus for nasal immunization

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Asian Journal of Pharmaceutical Sciences 2019年第2期14卷 216-221页

作者： Jafar Mosafer amir-hossein sabbaghi Ali Badiee Solmaz Dehghan Mohsen Tafaghodi Research Center of Advanced Technologies in Medicine Torbat Heydariyeh University of Medical Sciences School of Pharmacy Mashhad University of Medical Sciences Student Research Committee Mashhad University of Medical Sciences Nanotechnology Research Center Pharmaceutical Technology Institute Mashhad University of Medical Sciences

For efficient mucosal vaccine delivery, nanoparticulate antigens are better taken by microfold cells in the nasal associated lymphoid tissue and also dendritic cells. Nanoparticles based on polymers such as chitosan(CHT) and its water soluble derivative, trimethylchitosan(TMC), could be successfully used as carrier/adjuvant for this purpose. Sodium alginate, a negatively charged biopolymer, could modify the immunostimulatory properties of CHT and TMC NPs and increase their stability. Sodium alginate(ALG)-coated chitosan(CHT)and trimethylchitosan(TMC) nanoparticles(NPs) loaded with inactivated PR8 influenza virus were successfully prepared by direct coating of the virus with CHT or TMC polymers to evaluate their immunoadjuvant potential after nasal immunization. After nasal immunizations in BALB/c mice, PR8-CHT formulation elicited higher IgG2 a and Ig G1 antibody titers compared with PR8-TMC. ALG coating of this formulation(PR8-CHT-ALG) significantly decreased the antibody titers and a less immune response was induced than PR8-TMC-ALG formulation. PR8-TMC-ALG formulation showed significantly higher Ig G2 a/Ig G1 ratio, as criteria for Th1-type immune response, compared with PR8-CHT-ALG and PR8 virus alone. Altogether, the PR8-TMC-ALG formulation could be considered as an efficient intranasal antigen delivery system for nasal vaccines.

关键词： Chitosan Trimethyl chitosan Alginate PR8 influenza virus Nasal immunization

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Energy-based numerical models for assessment of soil liquefaction

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Geoscience Frontiers 2012年第4期3卷 541-555页

作者： amir hossein Alavi amir hossein Gandomi School of Civil Engineering lran University of Science and TechnologyTehranIran College of Civil Engineering Tafresh UniversityTafreshlran

This study presents promising variants of genetic programming （GP）, namely linear genetic programming （LGP） and multi expression programming （MEP） to evaluate the liquefaction resistance of san- dy soils. Generalized LGP and MEP-based relationships were developed between the strain energy density required to trigger liquefaction （capacity energy） and the factors affecting the liquefaction characteristics of sands. The correlations were established based on well established and widely dispersed experimental results obtained from the literature. To verify the applicability of the derived models, they were employed to estimate the capacity energy values of parts of the test results that were not included in the analysis. The external validation of the models was verified using statistical criteria recommended by researchers. Sensitivity and parametric analyses were performed for further verification of the correlations. The results indicate that the proposed correlations are effectively capable of capturing the liquefaction resistance of a number of sandy soils. The developed correlations provide a significantly better prediction performance than the models found in the literature. Furthermore, the best LGP and MEP models perform superior than the optimal traditional GP model. The verification phases confirm the efficiency of the derived correlations for their general application to the assessment of the strain energy at the onset of liquefaction.

关键词： Soil liquefaction Capacity energy Linear genetic programming Multi expression programming Sand Formulation

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New insight into prediction of phase behavior of natural gas hydrate by different cubic equations of state coupled with various mixing rules

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Petroleum Science 2017年第4期14卷 780-790页

作者： amir hossein Saeedi Dehaghani Deparlment of Petroleum Engineering Faculty of Chemical EngineeringTarbiat Modares UniversityTehranlran

Progress in hydrate thermodynamic study necessitates robust and fast models to be incorporated in reservoir simulation softwares. However, numerous models presented in the literature makes selection of the best,proper predictive model a cumbersome task. It is of industrial interest to make use of cubic equations of state(EOS) for modeling hydrate equilibria. In this regard, this study focuses on evaluation of three common EOSs including Peng–Robinson, Soave–Redlich–Kwong and Valderrama–Patel–Teja coupled with van der Waals and Platteeuw theory to predict hydrate P–T equilibrium of a real natural gas sample. Each EOS was accompanied with three mixing rules, including van der Waals(vd W),Avlonitis non-density dependent(ANDD) and general nonquadratic(GNQ). The prediction of cubic EOSs was in sufficient agreement with experimental data and with overall AARD% of less than unity. In addition, PR plus ANDD proved to be the most accurate model in this study for prediction of hydrate equilibria with AARD% of *** was observed that the accuracy of cubic EOSs studied in this paper depends on mixing rule coupled with them,especially at high-pressure conditions. Lastly, the present study does not include any adjustable parameter to be correlated with hydrate phase equilibrium data.

关键词： Gas Hydrate Cubic equation of state Mixing rule Thermodynamic modeling

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Enhancing the Robustness of Visual Object Tracking via Style Transfer

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Computers, Materials & Continua 2022年第1期70卷 981-997页

作者： Abdollah amirkhani amir hossein Barshooi amir Ebrahimi School of Automotive Engineering Iran University of Science and TechnologyTehran16846-13114Iran School of Electrical Engineering and Computing The University of NewcastleCallaghan2308Australia

The performance and accuracy of computer vision systems are affected by noise in different *** numerous solutions and algorithms have been presented for dealing with every type of noise,a comprehensive technique that can cover all the diverse noises and mitigate their damaging effects on the performance and precision of various systems is still *** this paper,we have focused on the stability and robustness of one computer vision branch(i.e.,visual object tracking).We have demonstrated that,without imposing a heavy computational load on a model or changing its algorithms,the drop in the performance and accuracy of a system when it is exposed to an unseen noise-laden test dataset can be prevented by simply applying the style transfer technique on the train dataset and training the model with a combination of these and the original untrained *** verify our proposed approach,it is applied on a generic object tracker by using regression *** method’s validity is confirmed by testing it on an exclusive benchmark comprising 50 image sequences,with each sequence containing 15 types of noise at five different intensity *** OPE curves obtained show a 40%increase in the robustness of the proposed object tracker against noise,compared to the other trackers considered.

关键词： Style transfer visual object tracking robustness corruption

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Chaos detection and control in a typical power system

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Chinese Physics B 2013年第1期22卷 119-123页

作者： hossein Gholizadeh amir Hassannia Azita Azarfar Faculty of Electrical & Robotic Engineering Shahrood University of Technology

In this paper, a new chaotic system is introduced. The proposed system is a conventional power network that demonstrates a chaotic behavior under special operating conditions. Some features such as Lyapunov exponents and a strange attractor show the chaotic behavior of the system, which decreases the system performance. Two different controllers are proposed to control the chaotic system. The first one is a nonlinear conventional controller that is simple and easy to construct, but the second one is developed based on the finite time control theory and optimized for faster control. A MATLAB-based simulation verifies the results.

关键词： chaos detection chaos control finite time control theory synchronous generator

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Weak gravitational lensing of quantum perturbed lukewarm black holes and cosmological constant effect

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Research in Astronomy and Astrophysics 2017年第6期17卷 17-36页

作者： hossein Ghaffarnejad Mojtaba amir Mojahedi Faculty of Physics Semnan University Semnan 35131-19111 Iran

The aim of the paper is to study weak gravitational lensing of quantum （perturbed） and classical lukewarm black holes （QLBHs and CLBHs respectively） in the presence of cosmological parameter A. We apply a numerical method to evaluate the deflection angle of bending light rays, image locations θ of sample sourceβ = π- 4, and corresponding magnifications μ. There are no obtained real values for Einstein ring locations θE（β = 0） for CLBHs but we calculate them for QLBHs. As an experimental test of our calculations, we choose mass M of 60 types of the most massive observed galactic black holes acting as a gravitational lens and study quantum matter field effects on the angle of bending light rays in the presence of cosmological constant effects. We calculate locations of non-relativistic images and corresponding magnifications. Numerical diagrams show that the quantum matter effects cause absolute values of the quantum deflection angle to be reduced with respect to the classical ones. The sign of the quantum deflection angle is changed with respect to the classical values in the presence of the cosmological constant. This means dominance of the anti-gravity counterpart of the cosmological horizon on the angle of bending light rays with respect to absorbing effects of 60 local types of the most massive observed black holes. Variations of the image positions and magnifications are negligible when increasing dimensionless cosmological constant ∈ = 16AM2 /2The deflection angle takes positive （negative） values for CLBHs （QLBHs） and they decrease very fast （slowly） by increasing the closest distance x0 of bending light ray and/or dimensionless cosmological parameter for sample giant black holes with 0.001 〈 ∈ 〈 0.01.

关键词： gravitational lensing weak - strong - micro - stars black holes

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Removal of Reactive Red 198 from aqueous solution by combined method multi-walled carbon nanotubes and zero-valent iron:Equilibrium,kinetics,and thermodynamic

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Chinese Journal of Chemical Engineering 2016年第10期24卷 1448-1455页

作者： Sudabeh Pourfakari Nader Yousefi amir hossein Mahvi Department of Environmental Health Engineering School of HealthShiraz University of Medical SdencesShirazIran Department of Environmental Health Engineering School of Public HealthTehran University of Medical SciencesTehranIran Center for Solid Waste Research Institute for Environmental ResearchTehran University of Medical SciencesTehranIran National Institute of Health Research Tehran University of Medical SciencesTehranIran

Dyes often include toxic, carcinogenic compounds and are harmful to humans＇ health. Therefore, removal of dyes from textile industw wastewater is essential. The present study aimed to evaluate the efficiency of the combination of zero valent iron （ZVI） powder and multi-walled carbon nanotubes （MWCNTs） in the removal of Reactive Red 198 （RR198） dye from aqueous solution. This applied research was performed in a batch system in the laboratory scale. This study investigated the effect of various factors influencing dye removal, including contact time, pH, adsorbent dose, iron powder dose, initial dye concentration, and temperature. The equilibrium adsorption data were analyzed using three common adsorption models： Langmuir, Freundlich and Temkin. Besides, kinetic and thermodynamic parameters were used to establish the adsorption mechanism. The results showed, in pH = 3, contact time = 100 min, ZVI dose = 5000 mg· L- 1, and MWCNTs dose = 600 mg· L- 1 in 100 mg· L- 1 dye concentration, the adsorption efficiency increased to 99.16%. Also, adsorption kinetics was best described by the pseudo-second-order model. Equilibrium data fitted well with the Freundlich isotherm （R2 = 0.99）. The negative values of AGo and the positive value of △H0 （91.76） indicate that the RR198 adsorption process is spontaneous and endothermic. According to the results, the combination of MWCNTs and ZVI was highly efficient in the removal of azo dyes.

关键词： Reactive Red 198 MWCNTs Adsorption ZVI Dye

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Processing of nanostructured metallic matrix composites by a modified accumulative roll bonding method with structural and mechanical considerations

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International Journal of Minerals,Metallurgy and Materials 2012年第10期19卷 951-956页

作者： amir hossein Yaghtin Erfan Salahinejad Ali Khosravifard Department of Materials Science and Engineering(Shiraz Branch) Islamic Azad UniversityShiraz 71955Iran Department of Materials Science and Engineering School of EngineeringShiraz UniversityShiraz ***Iran

Particulate reinforced metallic matrix composites have attracted considerable attention due to their lightweight, high strength, high specific modulus, and good wear resistance. A1/B4C composite strips were produced in this work by a modified accumulative roll bonding process where the strips were rotated 90° around the normal direction between successive passes. Transmission electron microscopy and X-ray diffraction analyses reveal the development of nanostructures in the Al matrix after seven passes. It is found that the B4C reinforcement distribution in the matrix is improved by progression of the process. Additionally, the tensile yield strength and elongation of the processed materials are increased with the increase of passes.

关键词： metallic matrix composites particle reinforced composites nanostructures aluminum boron carbide roll bonding tensile properties

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Energy efficiency of small buildings with smart cooling system in the summer

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Frontiers in Energy 2022年第4期16卷 651-660页

作者： Yazdan DANESHVAR Majid SABZEHPARVAR Seyed amir hossein HASHEMI Department of Civil Engineering Qazvin BranchIslamic Azad UniversityQazvin 314199-15195Iran Department of Industrial Engineering Collage of EngineeringKaraj BranchIslamic Azad UniversityKaraj 31499-68111Iran

In this paper,a novel cooling control strategy as part of the smart energy system that can balance thermal comfort against building energy consumption by using the sensing and machine programming technology was *** this goal,a general form of a building was coupled by the smart cooling system(SCS)and the consumption of energy with thermal comfort cooling of persons simulated by using the EnergyPlus software and compared with similar buildings without *** the beginning of the research,using the data from a survey in a randomly selected group of hundreds and by analyzing and verifying the results of the specific relationship between the different groups of people in the statistical society,the body mass index(BMI)and their thermal comfort temperature were obtained,and the sample building was modeled using the EnergyPlus *** result show that if an intelligent ventilation system that can calculate the thermal comfort temperature was used in accordance with the BMI of persons,it can save up to 35%of the cooling load of the building yearly.

关键词： smart home heating and cooling systems saving energy optimal consumption of energy

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Effect of intermetallic compounds on the fracture behavior of dissimilar friction stir welding joints of Mg and Al alloys

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International Journal of Minerals,Metallurgy and Materials 2019年第10期26卷 1285-1298页

作者： amir hossein Baghdadi Zainuddin Sajuri Nor Fazilah Mohamad Selamat Mohd Zaidi Omar Yukio Miyashita amir hossein Kokabi Centre for Materials Engineering and Smart Manufacturing Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor 43600Malaysia Department of Mechanical Engineering Nagaoka University of TechnologyNagaoka940-2188Japan Department of Materials Science and Engineering Sharif University of TechnologyTehran 11365-11155Iran

Joining Mg to Al is challenging because of the deterioration of mechanical properties caused by the formation of intermetallic compounds(IMCs) at the Mg/Al interface. This study aims to improve the mechanical properties of welded samples by preventing the fracture location at the Mg/Al interface. Friction stir welding was performed to join Mg to Al at different rotational and travel speeds. The microstructure of the welded samples showed the IMCs layers containing Al12Mg17(γ) and Al3Mg2(β) at the welding zone with a thickness(< 3.5 μm). Mechanical properties were mainly affected by the thickness of the IMCs, which was governed by welding parameters. The highest tensile strength was obtained at 600 r/min and 40 mm/min with a welding efficiency of 80%. The specimens could fracture along the boundary at the thermo-mechanically affected zone in the Mg side of the welded joint.

关键词： aluminum alloy magnesium alloy intermetallic compounds dissimilar welded joint friction stir welding

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