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Limb Lengthening and Reconstruction Society orthopedic surgeons in the United States:An analysis of geographical distribution,academic,leadership,and demographic characteristics

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World Journal of Orthopedics 2024年第2期15卷 147-155页

作者： amir human hoveidaei Reza Niakan Seyed Hossein Hosseini-Asl Abijith Annasamudram Janet D Conway International Center for Limb Lengthening Rubin Institute for Advanced OrthopedicsSinai Hospital of BaltimoreBaltimoreMD 21215United States Student Research Committee Shiraz University of Medical SciencesShiraz 73Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran

BACKGROUND The Limb Lengthening and Reconstruction Society(LLRS)is a premier orthopedic specialty organization that promotes limb reconstruction for all *** membership characteristics,however,are poorly *** study delineates orthopedic surgeon LLRS members’demographic traits,academic achievement,leadership attainment,and geographical distribution across the United *** To inform aspiring orthopedic professionals,as well as to promote growth and diversity in both the LLRS organization and overarching *** This cross-sectional study examined United States LLRS members’academic,leadership,demographic,and geographical *** reviewing the 2023 LLRS member directory,Google search results were matched to the listings and appended to the compiled *** and ethnicity were evaluated visually utilizing retrieved *** Hirsch index(H-index)of academic activity,residency and fellowship training,other graduate degrees,leadership positions,practice type(academic or non-academic),and spoken languages were *** members per state and capita determined geographic *** Mann Whitney U test was applied to compare H-index between males and females,as well as to assess member differences pertaining to affiliation with academic vs non-academic practice *** The study included 101 orthopedic surgeons,78(77.23%)Caucasian and 23(22.77%)non-Caucasian,79(78.22%)male and 22(21.78%)*** with DO degrees comprised only 3.96%(4)of the cohort,while the vast majority held MDs[96.04%(97)].Mean H-index was 10.55,with male surgeons having a significantly higher score(P=0.002).Most orthopedic surgeons(88.12%,)practiced in academic *** those professionals who occupied leadership positions,14%were women,while 86%were ***,19(37.25%)United States regions and the District of Columbia lacked an LLRS-member orthopedic *** per capita rate across the United States was 0.30 LLRS orthopedic

关键词： Limb lengthening and reconstruction Orthopedic surgeon demographics Orthopedic surgeon societal membership Orthopedic fellowships

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Impacts of radiation therapy on quality of life and pain relief in patients with bone metastases

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World Journal of Orthopedics 2024年第9期15卷 841-849页

作者： Armin hoveidaei Mehdi Karimi Vida Khalafi Patrick Fazeli amir human hoveidaei Students’Scientific Research Center Exceptional Talents Development CenterTehran University of Medical SciencesTehran ***Iran Bogomolets National Medical University Kyiv 01601Ukraine Student Research Committee Jahrom University of Medical SciencesJahrom ***Iran Brown University ProvidenceRI 02912United States International Center for Limb Lengthening Rubin Institute for Advanced OrthopedicsSinai Hospital of BaltimoreBaltimoreMD 21215United States

Bone metastases(BM)are a common complication in advanced cancer patients,significantly contributing to morbidity and mortality due to their ability to cause pain,fractures,and spinal cord *** therapy(RT)is vital in managing these complications by targeting metastatic lesions to ease pain,improve mobility,and reduce the risk of skeletal-related events such as *** supports the effectiveness of RT in pain relief,showing its ability to provide significant palliation and lessen the need for opioid painkillers,thereby enhancing the overall quality of life(QoL)for patients with ***,optimizing RT outcomes involves considerations such as the choice of radiation technique,dose fractionation schedules,and the integration of supportive care measures to mitigate treatment-related side effects like fatigue and skin *** factors highlight the importance of personalized treatment planning tailored to individual patient needs and tumor *** mini-review aims to provide comprehensive insights into the multifaceted impacts of RT on pain management and QoL enhancement in BM patients,with implications for refining clinical practices and advancing patient care through the synthesis of findings from various studies.

关键词： Radiation therapy Radiotherapy Quality of life Pain relief Bone metastases Bone cancer

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Aging: A cell source limiting factor in tissue engineering

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World Journal of Stem Cells 2019年第10期11卷 787-802页

作者： Mohammadhossein Khorraminejad-Shirazi Mohammadreza Dorvash Alireza Estedlal amir human hoveidaei Mohsen Mazloomrezaei Pouria Mosaddeghi Student Research Committee Shiraz University of Medical SciencesShiraz ***Iran Cell and Molecular Medicine Student Research Group School of MedicineShiraz University of Medical SciencesShiraz ***Iran Pharmaceutical Sciences Research Center Shiraz University of Medical SciencesShiraz ***Iran

Tissue engineering has yet to reach its ideal goal,*** profitable off-theshelf tissues and organs,designing scaffolds and three-dimensional tissue architectures that can maintain the blood supply,proper biomaterial selection,and identifying the most efficient cell source for use in cell therapy and tissue *** are still the major challenges in this *** the identification of the most appropriate cell source,aging as a factor that affects both somatic and stem cells and limits their function and applications is a preventable and,at least to some extents,a reversible ***,we reviewed different stem cell types,namely embryonic stem cells,adult stem cells,induced pluripotent stem cells,and genetically modified stem cells,as well as their sources,***,allogeneic,and xenogeneic ***,we approached aging by discussing the functional decline of aged stem cells and different intrinsic and extrinsic factors that are involved in stem cell aging including replicative senescence and Hayflick limit,autophagy,epigenetic changes,miRNAs,mTOR and AMPK pathways,and the role of mitochondria in stem cell ***,various interventions for rejuvenation and geroprotection of stem cells are *** interventions can be applied in cell therapy and tissue engineering methods to conquer aging as a limiting factor,both in original cell source and in the in vitro proliferated cells.

关键词： Aging Senescence Rejuvenation Geroprotection Tissue engineering Stem cell therapy

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Combined medial patellofemoral ligament and medial patellotibial ligament reconstruction in recurrent patellar instability:A systematic review and meta-analysis

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World Journal of Clinical Cases 2023年第19期11卷 4625-4634页

作者： Ahmad Abbaszadeh Mohsen Saeedi amir human hoveidaei Haleh Dadgostar Saeed Razi Mohammad Razi Department of Orthopedic Emam Khomeini Teaching HospitalAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran Sports Medicine Research Center Tehran University of Medical SciencesTehran 14395-578Iran Department of Sports and Exercise Medicine School of MedicineRasool Akram Medical ComplexIran University of Medical SciencesTehran ***Iran Bone and Joint Reconstruction Research Center Department of OrthopedicsSchool of MedicineIran University of Medical SciencesTehran ***Iran Department of Orthopedic Surgery Rasoul Akram HospitalIran University of Medical SciencesTehran ***Iran

BACKGROUND The medial patellofemoral ligament(MPFL),along with the medial patellotibial ligament(MPTL)and medial patellomeniscal ligament,aid in the stabilization of the patellofemoral *** the MPFL is the primary stabilizer and the MPTL is a secondary limiter,this ligament is critical in maintaining joint *** have been few studies on the combined MPFL and MPTL reconstruction and its *** To look into the outcomes of combined MPFL and MPTL reconstruction in frequent patellar *** By May 8,2022,four electronic databases were searched:Medline(PubMed),Scopus,Web of Science,and Google *** keywords such as"patellar instability,""patellar dislocation,""MPFL,""medial patellofemoral ligament,""MPTL,"and"medial patellotibial ligament"were co-searched to increase the sensitivity of the *** The pooled effects of combined MPFL and MPTL reconstruction for Kujala score(12-mo followup)and Kujala score(24-mo follow-up)were positive and incremental,according to the findings of this *** mean difference between the Cincinnati scores was also positive,but not statistically *** combination of the two surgeries reduces *** to cumulative meta-analysis,the trend of pain reduction in various studies is declining over *** The combined MPFL and MPTL reconstruction has good clinical results in knee function and,in addition to providing good control to maintain patellofemoral joint balance,the patient's pain level decreases over time,making it a valid surgical method for patella stabilization.

关键词： Medial patellofemoral ligament reconstruction Medial patellotibial ligament patella dislocation Patella instability

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Unhappy triad of the knee:What are the current concepts and opinions?

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World Journal of Orthopedics 2023年第5期14卷 268-274页

作者： amir human hoveidaei Reza Sattarpour Haleh Dadgostar Saeed Razi Mohammad Razi Sports Medicine Research Center Tehran University of Medical SciencesTehran 14395-578Iran School of Medicine Tehran University of Medical SciencesTehran ***Iran Department of Sports and Exercise Medicine School of MedicineRasool Akram Medical ComplexIran University of Medical SciencesTehran ***Iran Bone and Joint Reconstruction Research Center Department of OrthopedicsSchool of MedicineIran University of Medical SciencesTehran ***Iran Department of Orthopedic Surgery Rasoul Akram HospitalIran University of Medical SciencesTehran ***Iran

The association between injuries to the anterior cruciate ligament,medial collateral ligament,and medial meniscus(MM)has been known to orthopedic surgeons since 1936;O’Donoghue first used the term"unhappy triad"of the knee to describe this condition in *** studies revealed that involvement of the lateral meniscus is more common than MM in these cases,leading to a change in the *** studies have revealed that this triad may be primarily linked to knee anterolateral complex *** there is not a definite management protocol for this triad,we try to mention the most recent concepts about it in addition to expert opinions.

关键词： Anterior cruciate ligament Lateral meniscus Anterolateral complex Medial collateral ligament Medial meniscus

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Underwater image clarifying based on human visual colour constancy using double-opponency

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CAAI Transactions on Intelligence Technology 2024年第3期9卷 632-648页

作者： Bin Kong Jing Qian Pinhao Song Jing Yang amir Hussain Institute of Intelligent Machines Chinese Academy of SciencesHefeiChina Peng Cheng Laboratory ShenzhenChina Anhui Key Laboratory of Biomimetic Sensing and Advanced Robot Technology HefeiChina University of Science and Technology of China HefeiChina Peking University Shenzhen Graduate School ShenzhenChina Edinburgh Napier University EdinburghScotland

Underwater images are often with biased colours and reduced contrast because of the absorption and scattering effects when light propagates in *** images with degradation cannot meet the needs of underwater *** main problem in classic underwater image restoration or enhancement methods is that they consume long calcu-lation time,and often,the colour or contrast of the result images is still *** of using the complicated physical model of underwater imaging degradation,we propose a new method to deal with underwater images by imitating the colour constancy mechanism of human vision using ***,the original image is converted to the LMS *** the signals are linearly combined,and Gaussian convolutions are per-formed to imitate the function of receptive fields(RFs).Next,two RFs with different sizes work together to constitute the double-opponency ***,the underwater light is estimated to correct the colours in the *** contrast stretching on the luminance is *** show that the proposed method can obtain clarified underwater images with higher quality than before,and it spends significantly less time cost compared to other previously published typical methods.

关键词： computers computer vision image processing image reconstruction

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Assessment of rehabilitation strategies for lakes affected by anthropogenic and climatic changes: A case study of the Urmia Lake, Iran

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Journal of Arid Land 2024年第6期16卷 752-767页

作者： Seyed Morteza MOUSAVI Hossein BABAZADEH Mahdi SARAI-TABRIZI amir KHOSROJERDI Department of Water Science and Engineering Science and Research BranchIslamic Azad UniversityTehran 147789-3855Iran

Over the last three decades,more than half of the world's large lakes and wetlands have experienced significant shrinkage,primarily due to climate change and extensive water consumption for agriculture and other human *** desiccation of lakes leads to severe environmental,economic,and social *** Lake,located in northwestern Iran and representing a vital natural ecosystem,has experienced a volume reduction of over 90.0%.Our research evaluated diverse water management strategies within the Urmia Lake basin and prospects of inter-basin water *** study focused on strategies to safeguard the environmental water rights of the Urmia Lake by utilizing the modeling and simulating(MODSIM)*** model simulated changes in the lake's water volume under various *** included diverting water from incoming rivers,cutting agricultural water use by 40.0%,releasing dam water in non-agricultural seasons,treated wastewater utilization,and inter-basin *** hierarchy process(AHP)was utilized to analyze the simulation *** opinions with AHP analysis,acted as a multi-criteria decision-making tool to evaluate the simulation and determine the optimal water supply source priority for the Urmia *** findings underscore the critical importance of reducing agricultural water consumption as the foremost step in preserving the *** this,inter-basin water transfers are suggested,with a detailed consideration of the inherent challenges and limitations faced by the source *** is imperative to conduct assessments on the impacts of these transfers on the downstream users and the potential environmental risks,advocating for a diplomatic and cooperative approach with adjacent *** study also aims to forecast the volumes of water that can be transferred under different climatic conditions—drought,normal,and wet years—to inform strategic water management planning for the Urmia *** to our proj

关键词： climate change drought lake ecological level agricultural water demand inter-basin water transfer

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Carbamazepine in osteoarthritis treatment:A novel approach targeting Nav1.7 channels

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World Journal of Orthopedics 2024年第6期15卷 602-604页

作者： Rayyan Vaid Afra Sohail Nabiha amir Department of Medicine Karachi Medical and Dental CollegeKarachi 75500Pakistan

Osteoarthritis(OA)presents a growing health concern,with substantial societal and healthcare *** management focuses on symptom relief,lacking disease-modifying *** research suggests the sodium channel Nav1.7 as a pivotal target in OA *** studies demonstrate carbamazepine's efficacy in Nav1.7 blockade,offering significant joint protection in animal ***,human trials are needed to validate these ***'s repurposing holds promise for OA management,potentially revolutionizing treatment *** research is essential to bridge the gap between preclinical evidence and clinical application,offering hope for improved OA management and enhanced patient quality of life.

关键词： Osteoarthritis Joint illness Treatment approaches Pain management Healthcare expenses

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Biological,pathological,and multifaceted therapeutic functions of exosomes to target cancer

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Oncology Research 2024年第1期32卷 73-94页

作者： VIGNESH BALAJI E DIVYA RAMESH MANISHA CHUNGAN SHAJU AKSHARA KUMAR SAMYAK PANDEY RAKSHA NAYAK V.ALKA SRISHTI MUNJAL amir SALIMI K.SREEDHARA RANGANATH PAI SHANKAR M.BAKKANNAVAR Department of Pharmacology Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Forensic Medicine and Toxicology Kasturba Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India School of Health and Community Services Durham CollegeOshawaOntarioL1G2G5Canada Department of Pharmaceutical Regulatory Affairs and Management Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India Department of Clinical Psychology Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Speech and Hearing Manipal College of Health ProfessionsManipal Academy of Higher EducationManipalKarnataka576104India Department of Pharmacy Practice Manipal College of Pharmaceutical SciencesManipal Academy of Higher EducationManipalKarnataka576104India

Exosomes,small tiny vesicle contains a large number of intracellular particles that employ to cause various diseases and prevent several pathological events as well in the human *** is considered a“double-edged sword”,and depending on its biological source,the action of exosomes varies under physiological ***,the isolation and characterization of the exosomes should be performed accurately and the methodology also will vary depending on the exosome ***,the uptake of exosomes from the recipients’cells is a vital and initial step for all the physiological *** are different mechanisms present in the exosomes’cellular uptake to deliver their cargo to acceptor *** the exosomal uptake takes place,it releases the intracellular particles that leads to activate the physiological *** though exosomes have lavish functions,there are some challenges associated with every step of their preparation to bring potential therapeutic ***,overcoming the pitfalls would give a desired quantity of exosomes with high purity.

关键词： Exosomes Physiology Cancer Therapeutics Challenges

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Microbiome as an endocrine organ and its relationship with eye diseases:Effective factors and new targeted approaches

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World Journal of Gastrointestinal Pathophysiology 2024年第5期15卷 1-18页

作者： Leila Haghshenas Sara Banihashemi Yalda Malekzadegan Roberto Catanzaro amir Moghadam Ahmadi Francesco Marotta Department of Clinical Bioinformatics Harvard Medical SchoolBostonMA 02115United States Department of Bioscience School of Science and TechnologyNottingham Trend UniversityNottingham NG14FQUnited KingdomDepartment of BioscienceSchool of Science and TechnologyNottingham Trend UniversityNottingham NG14FQUnited Kingdom Department of Microbiology Saveh University of Medical SciencesSaveh ***Iran Department of Clinical and Experimental Medicine University of CataniaCatania 95123CataniaItaly Department of Neuroimmunology Thomas Jefferson University HospitalPhiladelphiaPA 19107United States Department of human Nutrition and Food Sciences Texas Women UniversityMilano 20154Italy

Microbiome is an endocrine organ that refers to both the complicated biological system of microbial species that colonize our bodies and their genomes and *** studies confirm the connection between the microbiome and eye diseases,which are involved in the pathogenesis of eye diseases,including age-related macular disorders,diabetic retinopathy,glaucoma,retinitis pigmentosa,dry eye,and *** aim of this review is to investigate the microbiome in relation to eye ***,a brief introduction of the characteristics of the gut microorganisms terms of composition and work,the role of dysbiosis,the gut microbiome and the eye microbiome in the progression of eye illnesses are highlighted,then the relationship among the microbiome and the function of the immune system and eye diseases,the role of inflammation and aging and the immune system,It has been reviewed and finally,the control and treatment goals of microbiome and eye diseases,the role of food factors and supplements,biotherapy and antibiotics in relation to microbiome and eye health have been reviewed.

关键词： Dysbiosis Gut microbiome Eye diseases Inflammation Diabetic retinopatyhy Aging Nutrient supplementation

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