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Providing a Therapeutic Scheduling for HIV Infected Individuals with Genetic Algorithms Using a Cellular Automata Model of HIV Infection in the Peripheral Blood Stream

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Journal of Biomedical Science and Engineering 2017年第3期10卷 77-106页

作者： Gelayol Nazari Golpayegani amir Homayoun jafari Nader Jafarnia Dabanloo Department of Biomedical Engineering Science and Research Branch Islamic Azad University Tehran Iran Medical Physics and Biomedical Engineering Department School of Medicine Tehran University of Medical Science Tehran Iran Research Center for Biomedical Technologies and Robotics (RCBTR) Tehran University of Medical Sciences Tehran Iran

The aim of this study is to develop two-dimensional cellular automata model of HIV infection that depicts the dynamics involved in the interactions between acquired immune system and HIV infection in the peripheral blood stream. The appropriate biological rules of cellular automata model have been extracted from expert knowledge and the model has been simulated with determined initial conditions. Obtained results have been validated through comparing with the accepted AIDS reference curve. The new rules and states were added to the proposed model to show the effects of applying combined antiretroviral therapy. Our results showed that by applying RTI and PI drugs with maximum drug effectiveness, comparing with cases in which no treatment was applied, the steady state concentrations of healthy (infected) CD4+T cells were increased (decreased) 53% (41%). Also, the use of cART with maximum drug effectiveness led to a 69% reduction in the steady state level of viral load. At this time, obtained results have been validated through comparing with available clinical data. Our results showed good agreement with both reference curve and the clinical data. In the second phase of this study, by applying genetic algorithms, a therapeutic schedule has been provided that its use, while maintaining the quality of the treatment, leads to a 47% reduction in both drug dosage and the side effects of antiretroviral drugs.

关键词： HIV Infection Cellular Automata Model Combined Antiretroviral Therapy Genetic Algorithms

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Investigation of litigation in trauma orthopaedic surgery

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World Journal of Clinical Cases 2023年第5期11卷 1000-1008页

作者： Maryam Salimi Mohammad Bagher Heidari Zohre Ravandi Seyedarad Mosalamiaghili Peyman Mirghaderi Meisam jafari Kafiabadi Farsad Biglari amirhossein Salimi amir Sabaghzadeh Irani Seyyed Saeed Khabiri Department of Orthopaedic Surgery Shiraz University of Medical SciencesShiraz ***Iran Department of General Surgery Kermanshah University of Medical SciencesKermanshah ***Iran Student Research Committee Kermanshah University of Medical SciencesShiraz ***Iran Student Research Committee Shiraz University of Medical SciencesShiraz 716549834Iran Students’Scientific Research Center(SSRC) Tehran University of Medical SciencesTehran 714356743Iran Clinical Research Development Unit of Shohada-e Tajrish Hospital Shahid Beheshti University of Medical SciencesTehran 715643498Iran Student Research Committee Shahid Sadoughi University of Medical SciencesYazd 719167534Iran

BACKGROUND It has been said that the number of orthopaedic claims has increased in the last few years. Investigation through the most prevalent cause would help to prevent further *** To review the cases of medical complaints in orthopedic patients who had been involved in a traumatic *** A retrospective multi-center review of trauma orthopaedic-related malpractice lawsuits from 2010 to 2021 was conducted utilizing the regional medicolegal database. Defendant and plaintiff characteristics along with fracture location, allegations, and litigation outcomes were *** A total of 228 claims referred to trauma-related conditions with a mean age of 31.29 ± 12.56 were enrolled. The most common injuries were at hand, thigh, elbow, and forearm, ***, the most common alleged complication was related to malunion or nonunion. In 47% of the cases, the main problem that led to the complaint was the inappropriate or insufficient explanation to the patient, and in 53%, there was a problem in the surgery. Eventually, 76% of the complaints resulted in a defense verdict, and 24% resulted in a plaintiff *** Surgical treatment of hand injuries and surgery in non-educational hospitals received the most complaints. The majority of litigation outcomes were caused by a physician’s failure to fully explain and educate the traumatic orthopedic patients and technological errors.

关键词： Clinical negligence Litigation Medicolegal claims Mismanagement Patient satisfaction

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Long COVID in children and adolescents

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World Journal of Pediatrics 2021年第5期17卷 495-499页

作者： Ali A.Asadi-Pooya Hamid Nemati Mina Shahisavandi Ali Akbari amir Emami Mehrzad Lotfi Mahtab Rostamihosseinkhani Zohreh Barzegar Maryam Kabiri Zahra Zeraatpisheh Mohsen Farjoud-Kouhanjani Anahita jafari Fateme Sasannia Shayan Ashrafi Masoume Nazeri Sara Nasiri Epilepsy Research Center Shiraz University of Medical SciencesShirazIran Department of Ncurology Jefferson Comprehensive Epilepsy CenterThomas Jefferson UniversityPhiladelphiaPAUSA Department of Anesthesiology School of Medicine.Shiraz University of Medical SciencesShirazIran Burn&Wound Healing Research Center Shiraz University of Medical SciencesShirazIran Medical Imaging Research Center Shiraz University of Medical SciencesShirazIran

Background To identify the prevalence and also the full spectrum of symptoms/complaints of children and adolescents who are suffering from long ***,we investigated the risk factors of long COVID in children and *** All consecutive children and adolescents who were referred to the hospitals anywhere in Fars province,Iran,from 19 February 2020 until 20 November 2020 were *** patients had a confirmed diagnosis of *** *** call to patients/parents,at least 3 months after their discharge from the hospital,we obtained their current status and information if their parents agreed to *** In total,58 children and adolescents fulillel the inclusion ***-six(448%)children/adolescents reported symptoms/complaints of long *** symptoms included fatigue in 12(21%),shortness of breath in 7(12%),exer-cise intolerance in 7(12%),weakness in 6(10%),and walking intolerance in 5(9%)*** age,muscle pain on admission,and intensive care unit admission were significantly associated with long *** Long COVID is a frequent condition in children and *** scientific community should inves-tigate and explore the pathophysiology of long COVID to ensure that these patients receive appropriate treatments for their condition.

关键词： Adolescents Children COVID-19 Coronavirus Chronic Pediatrics

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Erratum to:Effect of extrusion process on microstructure and mechanical and corrosion properties of biodegradable Mg-5Zn-1.5Y magnesium alloy

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International Journal of Minerals,Metallurgy and Materials 2022年第6期29卷 1305-1305页

作者： jafari, Hassan Tehrani, amir Houshang Mojiri Heydari, Mahsa Materials Engineering Department Faculty of Materials Engineering and Interdisciplinary Science Shahid Rajaee Teacher Training University Tehran Iran

Erratum to:International Journal of Minerals,Metallurgy and Materials Volume 29,Number 3,March 2022,Page 490 https://***/10.1007/s12613-021-2275-5 The original version of this article unfortunately contained a *** author’s name in the original version is incorrect,which is:Hassan jafari,amir Houshang Mojiri Tehrani,Mojiri Tehrani,and Mahsa Heydari The correct version is given below:Hassan jafari,amir Houshang Mojiri Tehrani,and Mahsa Heydari The original version PDF file has been replaced by the corrected version PDF file.

关键词： microstructure corrosion alloy

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Quantification of Steroid Receptors Gene Expression in Breast Cancer Patients: Possible Correlation with Serum Level of Adipocytokines

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Journal of Cancer Therapy 2011年第5期2卷 659-665页

作者： Rana Jahanban Esfahlan Nosratollah Zarghami Μohammad Rahmati-Yamchi amir Monfaredan Samira Valiyari Ali Jahanban Esfahlan Raziallah jafari Jozani Morteza Gojazadeh Fereidoun Mamaghani Majid Mobasseri 不详

Background: While the role of adipocyte-derived hormones in breast cancer pathogenesis well studied, it is speculated that there is a crosstalk between adipocytokines and Esterogen receptor(ER) signaling. To test this hypothesis we evaluate the possible correlation between serum levels of adipocytokins with steroid hormone receptors gene expression in breast cancer patients. Methods: In this case-control study, 70 women with breast cancer participated with different grades of obesity (36 none obese, BMI 0.05). In case of leptin, we observed a positive correlation between leptin and ERα and PR mRNA. (r = 0.553, n = 64, p < 0.001, r = 0.359, n = 64, p = 0.002 and a reverse significant correlation between leptin and ERβ (r= –0.506, n = 64 and p < 0.001). We also observed a significant correlation between TNFα and IL6 with steroid receptors gene expression in samples (P < 0.05). Conclusion: As the presence of steroid receptors are used as the most common prognostic markers in breast cancer patients, so targeting adipocytokines as potential regulators of steroid receptorsgene expression can be a new approach in treatment of obese breast cancer subjects.

关键词： Obesity Breast Cancer Steroid Receptors Adipocytokines

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