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Traditional herbal remedies for managing COVID-19 major symptoms: A case study of Kole district, Northern Uganda

TMR Pharmacology Research 2021年第4期1卷 20-28页

作者： Rebecca Nakaziba Maxson Kenneth Anyolitho amir Kabunga Department of Pharmacology and Therapeutics Faculty of MedicineLira University Department of Public health Faculty of Health SciencesLira University Department of Psychiatry Faculty of MedicineLira University

Background:Today,the world is battling COVID-19 which has claimed millions of lives within a short *** biotechnological research is in progress,it’s expedient to explore alternative sources of *** plants that have been used in the management of COVID-19 related symptoms for ages may unveil a potential treatment option for this ***,therefore,conducted a study in Kole district,Northern Uganda to document the plants that are used in the management of the four key COVID-19 related symptoms including flue,cough,sore throat,and difficulty in *** and Methods:We employed a cross-sectional quantitative survey *** used stratified sampling to select 50 participants from each of the five sub-counties in the district,and convenience sampling to select a total of 250 participants and administered interviewer-administered ***:We identified over 50 herbs that are used in the treatment of COVID-19 related ***,we were able to report on the fourteen most common ones that belonged to 12 families in this *** hirsute Perr.&Guill,(68.0%)and Citrus limon burm.F.(30.8%);Eucalyptus grandis M.,(49.2%)and Zingibar officinalis,(28.0%);Conyza floribunda h.B.K.(26.4%)and Allium sativum A.(23.6%);Capparis tomentosa Lam.(19.4%)and Acacia hockii De Wild,(17.4%):for the treatment of flu,cough,sore throat and breathing difficulties *** plant parts of the diverse plant species were used in treating the *** Clematis hirsute Perr.&Guill,all plant parts were used differently to treat each of the 4 ***:Kole district possesses a multitude of herbs with the potential of treating COVID-19 *** is a need for further pharmacological investigations to validate their activity and possible development for clinical use in the management of COVID-19.

关键词： herbal remedies COVID-19 major symptoms Uganda

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神经胶质细胞炎症反应的RNA调控及其作为中枢神经系统疾病治疗靶点的潜力

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神经损伤与功能重建 2023年第2期18卷 F0003-F0003页

作者： Abhishek Guha Mohammed amir husain Ying Si L Burt Nabors Natalia Filippova Grace Promer Reed Smith Peter h King 杜一星(编译) Department Neurology The University of Alabama at BirminghamBirminghamAlabamaUSA Department Cell Developmentaland Integrative BiologyThe University of Alabama at BirminghamBirminghamAlabamaUSA Birmingham Department of Veterans health Care System BirminghamAlabamaUSA Center for Neurodegeneration and Experimental Therapeutics The University of Alabama at BirminghamBirminghamUSA 不详

神经炎症的一个主要标志是小胶质细胞和星形胶质细胞的激活以及炎症介质(如il-1β、TNF-α、iNOS和il-6)的诱导。神经炎症会导致从急性中枢神经系统创伤到慢性神经退行性疾病等多种神经系统疾病的进展。mRNA稳定性的转录后调控途径和翻... 详细信息

神经炎症的一个主要标志是小胶质细胞和星形胶质细胞的激活以及炎症介质(如il-1β、TNF-α、iNOS和il-6)的诱导。神经炎症会导致从急性中枢神经系统创伤到慢性神经退行性疾病等多种神经系统疾病的进展。mRNA稳定性的转录后调控途径和翻译效率是这些炎症介质表达的主要驱动因素。这一调节水平的一个共同元素以富含腺嘌呤和尿苷的元素(ARE)为中心,该元素存在于编码这些炎症介质的mRNA的3’非翻译区(UTR)中。(ARE)-结合蛋白(AUBPs)——如人类抗原R(huR)、三四脯氨酸(TTP)和Kh型剪接调节蛋白(KSRP)——是指导这些转录后通路的关键节点,可以促进(huR)或抑制(TTP和KSRP)胶质细胞产生炎症介质。本综述将讨论ARE介导的RNA调节的基本概念及其对胶质细胞驱动的神经炎症性疾病的影响。还将讨论针对这种新的基因调控水平以达到治疗效果的策略,并对其治疗神经系统疾病潜力的初步研究进行回顾性分析。

关键词：富含AU元件人类抗原R 趋化因子细胞因子神经胶质细胞神经炎症转录后调控

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Aetiological factors of Budd-Chiari syndrome in Algeria

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World Journal of hepatology 2015年第6期7卷 903-909页

作者： Nawel Afredj Nawal Guessab Abdelbasset Nani Sid Ahmed Faraoun Ibtissem Ouled Cheikh Rafik Kerbouche Djouhar hannoun Zine Charef amir hayet Ait Kaci Kamel Bentabak Aurélie Plessier Dominique-Charles Valla Valerie Cazals-hatem Marie-hélène Denninger Tadjeddine Boucekkine Nabil Debzi hepatology Unit Department of Medicine Mustapha Hospital Radiology Unit Centre Pierre and Marie Curie National Institute of Public health (INSP) Pathology Unit CHU Mustapha Pathology Unit Centre Pierre and Marie Curie Surgery Unit Centre Pierre and Marie Curie hepatology Unit Beaujon Hospital Pathology Unit Beaujon Hospital Immunohematology Laboratory Beaujon Hospital

AIM: To study the clinical presentation of Budd-Chiari syndrome(BCS) and identify the aetiologies of this disease in Algeria. METhODS: Patients with BCS, hospitalised in our unit from January 2004 until June 2010 were included and the aetiological factors were assessed. Patients presenting a BCS in the setting of advanced-stage cirrhosis or a liver transplantation were excluded from the study. The diagnosis was established when an obstruction of hepatic venous outflow(thrombosis, stenosis or compression) was demonstrated. We diagnosed myeloproliferative disease(MPD) by bone marrow biopsy and V617 F JAK2 mutation. Anti-phospholipid syndrome(APLS) was detected by the presence of anticardiolipin antibodies, anti-β2 glycoprotein antibodies and Lupus anticoagulant. We also detected paroxysmal nocturnal haemoglobinuria(PNh) by flow cytometry. Celiac disease and Behcet disease were systematically investigated in our patients. hereditary anticoagulant protein deficiencies were also assessed. We tested our patients for the G20210 A mutation at Beaujon hospital. Imaging procedures were performed to determine a local cause of BCS, such as a hydatid cyst or a liver ***: One hundred and fifteen patients were included. Mean follow up: 32.12 mo. Mean age: 34.41 years, M/F = 0.64. Chronic presentation was frequent:63.5%. The revealing symptoms for the BCS were ascites(74.8%) and abdominal pain(42.6%). The most common site of thrombosis was the hepatic veins(72.2%). Involvement of the inferior vena cava alone was observed in 3 patients. According to the radiological investigations, BCS was primary in 94.7% of the cases(n = 109) and secondary in 5.2%(n = 6). An aetiology was identified in 77.4% of the patients(n = 89); it was multifactorial in 27%(n = 31). The predominant aetiology of BCS in our patients was a myeloproliferative disease, observed in 34.6% of cases. APLS was found in 21.7% and celiac disease in 11.4%. Other acquired conditions were: PNh(n = 4), systemic dis

关键词：阿尔及利亚 Etiologie 腹的疾病 Budd-Chiari 血栓

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Automatic horizontal Road Design Information Extraction from Georeferenced Polygonals： A Brazilian Federal highway Network Study

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Journal of Civil Engineering and Architecture 2015年第12期9卷 1513-1522页

作者： Alexandre h. Coelho Nataniel P. Borges Jr. Nicolas P. Borges Marcos D. Gallo amir M. Valente Department of Civil Engineering Federal University of Santa Catarina (UFSC) Florianopolis SC 88040-970 Brazil Transportation and Logistics Laboratory (Lab Trans) Federal University of Santa Catarina (UFSC) Florianopolis SC 88040-970Brazil

Road geometric design data are a vital input for diverse transportation studies. This information is usually obtained from the road design project. however, these are not always available and the as-built course of the road may diverge considerably from its projected one, rendering subsequent studies inaccurate or impossible. Moreover, the systematic acquisition of this data for the entire road network of a country or even a state represents a very challenging and laborious task. This study"s goal was the extraction of geometric design data for the paved segments of the Brazilian federal highway network, containing more than 47,000 km of highways. It presents the details of the method"s adoption process, the particularities of its application to the dataset and the obtained geometric design information. Additionally, it provides a first overview of the Brazilian federal highway network composition (curves and tangents) and geometry.

关键词：道路设计信息提取公路网联邦巴西地理坐标动水设计数据

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产前邻苯二甲酸盐暴露与6~10岁儿童的神经行为发展评分

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环境与职业医学 2014年第8期31卷 604-604页

作者： Roni W.Kobrosly Sarah Evans amir Miodovnik Emily S.Barrett Sally W.Thurston Antonia M.Calafat Shanna h.Swan

[背景]人们关注产前邻苯二甲酸酯暴露对神经行为的潜在影响,但是现有的数据并不一致。[目的]探讨产前尿中邻苯二甲酸酯代谢物的浓度与儿童神经行为得分之间的相关性。[方法]在一个多中心的队列研究——未来家庭研究(Study for Future Fa... 详细信息

[背景]人们关注产前邻苯二甲酸酯暴露对神经行为的潜在影响,但是现有的数据并不一致。[目的]探讨产前尿中邻苯二甲酸酯代谢物的浓度与儿童神经行为得分之间的相关性。[方法]在一个多中心的队列研究——未来家庭研究(Study for Future Families)中,测定153名妊娠妇女尿液样本中邻苯二甲酸酯代谢物的浓度。当儿童年龄在6~10岁时,由母亲完成儿童行为量表。用调整后的多元回归交互模型,评估邻苯二甲酸酯浓度与儿童行为(总体以及性别特异性)之间的相关性。[结果]男童中,单异丁基邻苯二甲酸浓度与如下项目的较高得分相关:注意力不集中(β=0.27;95%CI:0.04~0.50)、违规行为(β=0.20;95%CI:0.01~0.38)、攻击性(β=0.34,95%CI:0.09~0.59)和品行问题(β=0.39;95%CI:0.20~0.58),而二(2-乙基己基)邻苯二甲酸酯代谢物的摩尔总数与躯体问题的较高得分相关(β=0.15;95%CI:0.03~0.28)。较高的单苄基邻苯二甲酸浓度与男童中对抗行为(β=0.16;95%CI:0.01~0.32)和品行问题(β=0.21;95%CI:0.06~0.37)的较高得分相关,但与女童中较低的焦虑得分(β=-0.20;95%CI:-0.39^-0.01)相关。通常,在女童中上述相关性接近于零。模型系数表明,平方根转化后的结果得分的差异与对数变换的代谢产物每增加1个单位相关。[结论]上述研究结果提示,妊娠后期某些邻苯二甲酸盐暴露与男童的行为问题之间存在相关性。鉴于有关这一课题的研究很少,以及在研究中存在方法学和人群的差异,因此需要进行更多的研究。

关键词：神经行为儿童年龄邻苯二甲酸盐行为发展产前邻苯二甲酸酯评分儿童行为量表

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将光子学与硅基纳米电子学相结合,用于下一代片上系统

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家电科技 2018年第5期 6-6页

作者： amir h. Alabaki Sajjad Moazeni Fabio Pavanello hayk Gevorgyan 刘斐莹

电子和光子学技术改变了我们的生活——从计算和移动设备到信息技术和互联网。未来,我们在这些领域的需求,不仅依赖于对每种技术的单独创新,也取决于我们通过集成解决方案利用其互补物理特性的能力。

关键词：纳米电子学光子学技术片上系统硅基集成解决方案信息技术移动设备物理特性

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An Investigation on New Nonbuckling Composite Structures

An Investigation on New Nonbuckling Composite Structures

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第十三届国际复合材料会议

作者： h.hosseini-Toudeshky M.Sadeghi Aerospace Eng. Dept. Amir-Kabir University of Technology Tehran Iran h.F.Dorna Aerospace Co

＜正＞Since wing ribs and fuselage frames compose a considerable parts of the aircraft weight, it is important to make them as safety permits and be efficient relative to the cost of fabrication and assembly. In the composite flight vehicle structures, wing ribs, spar webs and fuselage frames subjected to compressive loads are usually made by sandwiched structures, e.g. Aluminum or Nomex honeycomb and P.V.C foam core. In this paper, new techniques based on the techniques already used for metallic components are studied. Three types of shear resistant, nonbuckling webs are frequently used in the metallic web design namely: a) Web with formed vertical

关键词： nonbuckllng composite structure web with beads finite element analyses

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隐源性卒中的心电监测策略：2015年卒中诊断和监测专题组的报告

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国际脑血管病杂志 2017年第7期25卷 592-600页

作者： Gregory W. Albers Richard A. Bernstein Johannes Brachmann John Camm J. Donald Easton Peter Fromm Shinya Goto Christopher B. Granger Stefan h. hohnloser Elaine hylek amir K. Jaffer Derk W. Krieger Rod Passman Jesse M. Pines Shelby D. Reed Peter M. Rothwell Peter R. Kowey 地力木拉提·阿米提朱沂李红燕牛晓珊 Department of Neurology and Neurological Sciences Stanford University Stanford CA Davee Department of Neurology Feinberg School of Medicine of Northwestern University Chicago IL hospital Klinikum Coburg Teaching Hospital of the University of Wurzburg Coburg Germany Cardiovascular and Cell Sciences Research Institute St. George's University of London and Imperial College London LK Department of Neurology University of California San Francisco Sandier Neurosciences Center San Francisco CA Center for Cardiovascular health South Nassau Communities hospital Oeeanside NY Department of Medicine Tokai University School of Medicine Isehara Japan Cardiac Care Unit Duke University Medical Center Durham NC Division of Clinical Electrophysiology Department of Cardiology J.W. Goethe University Frankfurt Germany Boston University School of Medicine Boston MA Department of Medicine Rush Lhiversity Medical Center Chicago IL Faculty of health and Medical Science University of Copenhagen Denmark German Neuroscience Center Dubal Healthcare City Dubai UAE Bluhm Cardiovascular Institute Northwestern University Feinberg School of Medicine Chicago IL Office for Clinical Practice Innovation George Washington Lhiversity Washington DC Duke Clinical Research Institute Duke University Durham NC Stroke Prevention Research Unit Nuffield Department of Clinical Neurosciences University of Oxford UK Division of Cardiovascular Diseases Lankenau Heart Institute Wyrmewood PA Department of Medicine Jefferson Medical College Philadelphia PA 新疆维吾尔自治区人民医院神经内科乌鲁木齐830001

卒中是一个重要的全球性公共卫生问题。2010年全世界总共发生3300万例卒中，其中1690万为首发卒中。卒中是仅次于心脏病的第二大全球人口死亡原因，占全部死亡的10％以上。卒中是一类异质性疾病，其病因可以是血管破裂（出血性）或血管... 详细信息

卒中是一个重要的全球性公共卫生问题。2010年全世界总共发生3300万例卒中，其中1690万为首发卒中。卒中是仅次于心脏病的第二大全球人口死亡原因，占全部死亡的10％以上。卒中是一类异质性疾病，其病因可以是血管破裂（出血性）或血管闭塞（缺血性）。缺血性卒中约占全部卒中的85％，可根据发病机制进行分类。

关键词：缺血性卒中心电监测隐源性专题诊断公共卫生问题死亡原因异质性疾病

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