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Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment

Bioactive Materials 2023年第5期23卷 314-327页

作者： Reihaneh Haghniaz Han-Jun Kim Hossein Montazerian Avijit Baidya Maryam Tavafoghi Yi Chen Yangzhi Zhu Solmaz Karamikamkar amir sheikhi Ali Khademhosseini Department of Bioengineering University of CaliforniaLos Angeles410 Westwood PlazaLos AngelesCA90095United States California NanoSystems Institute University of CaliforniaLos Angeles570 Westwood PlazaLos AngelesCA90095United States Terasaki Institute for Biomedical Innovation 11570 W Olympic BoulevardLos AngelesCA90024United States Department of Chemical Engineering The Pennsylvania State UniversityUniversity ParkPA16802United States Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPA16802United States

Blood loss by hemorrhaging wounds accounts for over one-third of~5 million trauma fatalities worldwide every year.If not controlled in a timely manner,exsanguination can take lives within a few minutes.Developing new biomaterials that are easy to use by non-expert patients and promote rapid blood coagulation is an unmet medical need.Here,biocompatible,and biodegradable microneedle arrays(MNAs)based on gelatin methacryloyl(GelMA)biomaterial hybridized with silicate nanoplatelets(SNs)are developed for hemorrhage control.The SNs render the MNAs hemostatic,while the needle-shaped structure increases the contact area with blood,synergistically accelerating the clotting time from 11.5 min to 1.3 min in vitro.The engineered MNAs reduce bleeding by~92%compared with the untreated injury group in a rat liver bleeding model.SN-containing MNAs outperform the hemostatic effect of needle-free patches and a commercial hemostat in vivo via combining micro-and nanoengineered features.Furthermore,the tissue adhesive properties and mechanical interlocking support the suitability of MNAs for wound closure applications.These hemostatic MNAs may enable rapid hemorrhage control,particularly for patients in developing countries or remote areas with limited or no immediate access to hospitals.

关键词： Hemostat Microneedles Hemorrhage Bleeding Gelatin methacryloyl Silicate nanoplatelets

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Nanoengineered Shear-Thinning Hydrogel Barrier for Preventing Postoperative Abdominal Adhesions

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Nano-Micro Letters 2021年第12期13卷 452-467页

作者： Guillermo U.Ruiz-Esparza Xichi Wang Xingcai Zhang Sofia Jimenez-Vazquez Liliana Diaz-Gomez Anne-Marie Lavoie Samson Afewerki Andres AFuentes-Baldemar Roberto Parra-Saldivar Nan Jiang Nasim Annabi Bahram Saleh Ali K.Yetisen amir sheikhi Thomas H.Jozefiak Su Ryon Shin Nianguo Dong Ali Khademhosseini Biomaterials Innovation Research Center Division of Engineering in MedicineDepartment of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA 02139USA Division of Health Sciences and Technology Harvard University-Massachusetts Institute of TechnologyCambridgeMA 02139USA Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022People’s Republic of China School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA School of Engineering and Science Tecnologico de MonterreyCampus MonterreyMonterreyNuevo Leon 64849Mexico School of Medicine and Health Science Campus GuadalajaraZapopanJalisco 45201Mexico West China School of Basic Medical Sciences and Forensic Medicine Sichuan UniversityChengdu 610041China Department of Chemical and Biomolecular Engineering University of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Chemical Engineering Northeastern UniversityBostonMA 02115USA Department of Chemical Engineering Imperial College LondonLondon SW72AZUK Department of Chemical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Terasaki Institute for Biomedical Innovation 11570 W Olympic BlvdLos AngelesCA 90024USA

More than 90%of surgical patients develop postoper-ative adhesions,and the incidence of hospital re-admissions can be as high as 20%.Current adhesion barriers present limited efficacy due to difficulties in application and incompatibility with minimally invasive interventions.To solve thisclinical limitation,we developed an injectable and sprayable shear-thinning hydrogel barrier(STHB)composed of silicate nanoplatelets and poly(ethylene oxide).We optimized this technology to recover mechanical integrity after stress,enabling its delivery though inject-able and sprayable methods.We also demonstrated limited cell adhesion and cytotoxicity to STHB compositions in vitro.The STHB was then tested in a rodent model of peritoneal injury to determine its e cacy preventing the formation of postoperative adhesions.After two weeks,the peritoneal adhesion index was used as a scoring method to determine the formation of postoperative adhesions,and STHB formulations presented superior e cacy compared to a commercially available adhesion barrier.Histological and immunohistochemical examination showed reduced adhesion formation and minimal immune infiltration in STHB formulations.Our technology demonstrated increased e cacy,ease of use in complex anatomies,and compatibility with di erent delivery methods,providing a robust universal platform to prevent postoperative adhesions in a wide range of surgical interventions.

关键词： Postoperative adhesions Shear-thinning hydrogel Silicate nanoplatelets Nanotechnology Nanomedicine

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Investigation and evaluation of ultrasound reactor for reduction of fungi from sewage

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第7期8卷 493-497页

作者： DEHGHANI Mohammad Hadi MAHVI amir Hossein JAHED Gholam Reza sheikhi Razieh Department of Environmental Health Engineering School of Public Health Medical Sciences/University of Tehran P.O. Box 14155-6145 Tehran I.R. Iran

The objective of the investigation was to study the application of ultrasound reactor technology (USRT) as a disin-fectant for reduction of fungi from sewage effluent. Fungi are carbon heterotrophs that require preformed organic compounds as carbon sources. USRT is an attractive means to improve water quality because of the system simplicity and no production of toxic by-products. An ultrasound reactor produces strong cavitation in aqueous solution causing shock waves and reactive free radicals by the violent collapse of the cavitation bubble. These effects should contribute to the physical disruption of microbial structures and inactivation of organisms. There was significant reduction in fungal growth, with decreased fungal growth with increasing USRT. In this study, ultrasound irradiation at a frequency of 42 kHz was used to expose suspensions of fungi to evaluate the disinfection efficacy of the ultrasound reactor. Also, this study showed that in this system more than 99% reduction of sewage fungi was achieved after 60 min.

关键词：污水超声因子气穴现象频率

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Optimal Operation and Size for an Energy Hub with CCHP

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Energy and Power Engineering 2011年第5期3卷 641-649页

作者： Ali Mohammad Ranjbar amir Moshari Hashem Oraee Aras sheikhi 不详

The interest in distributed generation has been increasing in recent years, especially due to technical devel- opment on generation systems that meet environmental and energy policy concerns. One of the most impor- tant distributed energy technologies is Combined Cooling, Heat and Power (CCHP) systems. CCHP is a small and self-contained electric, heating and cooling generation plant that can provide power for households, commercial or industrial facilities. It can reduce power loss and enhance service reliability in distribution systems. The proposed method in this paper determines the optimal size and operation of CCHP, auxiliary boiler and also heat storage unit as elements of an energy hub, for users by an integrated view of electricity and natural gas network. Authors apply cost and benefit analysis in the optimization. To confirm the proposed method, the optimum sizes of these elements are determined for a hotel in Tehran as a case study.

关键词： Combined Cooling Heating And Power (CCHP) Cost And Benefit Analysis Energy Hub Optimal Operation Optimal Size

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Application of Random PWM Techniques for Reducing the Electromagnetic Interference of Vienna Rectifiers in Distribution Power System

Application of Random PWM Techniques for Reducing the Electr...

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2009 IEEE 6th International Power Electronics and Motion Control Conference-ECCE Asia

作者： Shahriyar Kaboli amir Hossein Rajaei Aras sheikhi Center of Excellence in Power System Management and Control Department of Electrical Engineering Sharif University of Technology Department of Electrical and Computer Engineering Tarbiat Modares University

Random pulse width modulation （RPWM） technique has been employed to generate the control signals of Vienna-type rectifier. This technique is compared to two conventional techniques （Hysteresis-band and ramp comparison with fix frequency carrier signal）. Simulation results are illustrated for three approaches. The results verify significantly reduction of high frequency harmonics magnitude;and consequently overcome electromagnetic interference （EMI） problem in this active type of rectifier.

关键词： Pulse width modulation Electromagnetic interference Rectifiers Power systems Pulse power systems Power system simulation Frequency Space vector pulse width modulation Pulse generation Signal generators

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